ES2130271T3 - Anticuerpos monoclonales para glicoproteina p. - Google Patents
Anticuerpos monoclonales para glicoproteina p.Info
- Publication number
- ES2130271T3 ES2130271T3 ES93912996T ES93912996T ES2130271T3 ES 2130271 T3 ES2130271 T3 ES 2130271T3 ES 93912996 T ES93912996 T ES 93912996T ES 93912996 T ES93912996 T ES 93912996T ES 2130271 T3 ES2130271 T3 ES 2130271T3
- Authority
- ES
- Spain
- Prior art keywords
- cells
- pgp
- human
- monoclonal antibody
- sequent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000003886 Glycoproteins Human genes 0.000 title abstract 2
- 108090000288 Glycoproteins Proteins 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 5
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
EN LA INVENCION SE PRESENTA UN ANTICUERPO MONOCLONAL QUE RECONOCE UN EPITOPE ESTRUCTURALMENTE CONTINUO Y UBICADO DE FORMA EXTRACELULAR DE UNA GLICOPROTEINA HUMANA P (PGP) QUE CONSISTE EN UNA SECUENCIA DE AMINOACIDOS QUE FORMA UN EPITOPE CONTINUO ESPECIFICO QUE PREFERENTEMENTE SE ENCUENTRA EN EL CUERPO BUCLE EXTRACELULAR DE UNA PGP HUMANA Y QUE ESPECIALMENTE SE ENCUENTRA DENTRO DEL PEPTIDO CON UN N GUN LA INVENCION LOS ANTICUERPOS PREFERENTES SON LOS QUE SE ENLAZAN DE FORMA ESPECIFICA A LA PGP HUMANA Y CON GRAN AVIDEZ Y POR TANTO SE PUEDEN UTILIZAR PARA IDENTIFICAR LAS CELULAS MDR HUMANAS CUANDO SOLO SE PRESENTAN A MODO DE UNA PROPORCION MUY BAJA DE POBLACIONES DE CELULAS O CUANDO EXPRESAN UNA PGP HUMANA SOLO A NIVELES MUY BAJOS. EL ANTICUERPO MONOCLONAL PUEDE SER UN ANTICUERPO COMPLETO O UN FRAGMENTO DEL MISMO QUE SE ENLAZA A UN ANTIGENO Y SE PUEDE PREPARAR CON UN HIBRIDOMA O MEDIANTE TECNICAS DE ADN RECOMBINANTES. EL ANTICUERPO MONOCLONAL ES UTIL PARA LA IDENTIFICACION O PURIFICACION DE LAS CELULAS QUE EXPRESAN LA PGP HUMANA, EJ., CUANDO SE ENCUENTRAN EN POBLACIONES DE CELULAS HETEROGENEAS Y PARA CONTROLAR EL ESTADO DE RESISTENCIA DE LAS CELULAS A MULTIPLES DROGAS, EJ. DE CELULAS TUMORALES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM920457A IT1257893B (it) | 1992-06-17 | 1992-06-17 | Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2130271T3 true ES2130271T3 (es) | 1999-07-01 |
Family
ID=11401066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93912996T Expired - Lifetime ES2130271T3 (es) | 1992-06-17 | 1993-06-16 | Anticuerpos monoclonales para glicoproteina p. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5766946A (es) |
| EP (1) | EP0648276B1 (es) |
| JP (1) | JPH08501925A (es) |
| KR (1) | KR100301189B1 (es) |
| AT (1) | ATE174967T1 (es) |
| AU (1) | AU672798B2 (es) |
| CA (1) | CA2134752A1 (es) |
| CZ (1) | CZ284847B6 (es) |
| DE (1) | DE69322783T2 (es) |
| DK (1) | DK0648276T3 (es) |
| ES (1) | ES2130271T3 (es) |
| FI (1) | FI945865A (es) |
| GR (1) | GR3029773T3 (es) |
| HU (1) | HU216877B (es) |
| IT (1) | IT1257893B (es) |
| NO (1) | NO944887L (es) |
| NZ (1) | NZ253139A (es) |
| RU (1) | RU2126836C1 (es) |
| SK (1) | SK280272B6 (es) |
| WO (1) | WO1993025700A1 (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994088A (en) * | 1991-03-08 | 1999-11-30 | Board Of Trustees Of The University Of Illinois | Methods and reagents for preparing and using immunological agents specific for P-glycoprotein |
| EP0669941A1 (en) * | 1992-11-02 | 1995-09-06 | NICOLAU, Yves Claude | Method of reducing multidrug resistance in cells and tissues |
| US5686578A (en) | 1994-08-05 | 1997-11-11 | Immunomedics, Inc. | Polyspecific immunoconjugates and antibody composites for targeting the multidrug resistant phenotype |
| AU3482297A (en) * | 1996-06-05 | 1998-01-05 | Eugene Mechetner | Reagents and methods for inhibiting cytokine release by blood cells |
| AU5799199A (en) * | 1998-09-04 | 2000-03-27 | Immunomedics Inc. | Diagnosis of multidrug resistance in cancer and infectious lesions |
| WO2001055218A1 (en) * | 2000-01-31 | 2001-08-02 | The Procter & Gamble Company | Antibodies to the staphylococcal multidrug resistance (smr) protein |
| EP3333182A1 (en) * | 2000-06-05 | 2018-06-13 | The Brigham and Women's Hospital, Inc. | A gene encoding a multidrug resistance human p-glycoprotein homologue on chromosome 7p15-21 and uses thereof |
| EP1223534A1 (en) * | 2001-01-14 | 2002-07-17 | Katz, Emil | Peptides representative of polypeptides of interest and antibodies directed thereagainst, and methods, systems and kits for generating and utilizing each |
| US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
| US7294701B2 (en) * | 2003-04-02 | 2007-11-13 | Technion Research & Development Foundation Ltd. | Antibody fragment capable of modulating multidrug resistance and compositions and kits and methods using same |
| US7807171B2 (en) | 2003-07-25 | 2010-10-05 | Ac Immune Sa | Therapeutic vaccine targeted against P-glycoprotein 170 for inhibiting multidrug resistance in the treatment of cancers |
| FR2857875A1 (fr) * | 2003-07-25 | 2005-01-28 | Univ Reims Champagne Ardenne | Vaccin therapeutique cible contre la p-glycoproteine 170 pour inhiber la resistance multidrogues dans le traitement des cancers |
| US20060068426A1 (en) * | 2004-08-20 | 2006-03-30 | Tam James P | Cyclic peptides and antibodies thereof |
| CA2685492C (en) | 2006-05-31 | 2018-01-16 | The Brigham And Women's Hospital, Inc. | Abcb5 positive mesenchymal stem cells as immunomodulators |
| FR2906533B1 (fr) | 2006-09-28 | 2013-02-22 | Pf Medicament | Procede de generation d'anticorps actifs contre un antigene de resistance,anticorps obtenus par ledit procede et leurs utilisations |
| DK2155248T3 (en) | 2007-04-12 | 2015-09-14 | Brigham & Womens Hospital | Targeting abcb5 for cancer therapy |
| US9289488B2 (en) | 2010-08-12 | 2016-03-22 | Ac Immune Sa | Vaccine engineering |
| EP2632434A1 (en) | 2010-10-26 | 2013-09-04 | AC Immune S.A. | Liposome-based construct comprising a peptide modified through hydrophobic moieties |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206352A (en) * | 1986-03-28 | 1993-04-27 | Board Of Trustees Of The University Of Illinois | Compositions for clones containing DNA sequences associated with multidrug resistance in human cells |
| US5434075A (en) * | 1992-03-20 | 1995-07-18 | Board Of Trustees Of The University Of Illinois | Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses |
| US5773280A (en) * | 1992-03-20 | 1998-06-30 | The Board Of Trustees Of The University Of Illinois | Monoclonal antibody to a human MDR1 multidrug resistance gene product, and uses |
| AU3691093A (en) * | 1992-04-14 | 1993-10-21 | Hybritech Incorporated | Methods of inhibiting the growth of multidrug resistant tumors |
| US5369009A (en) * | 1992-04-17 | 1994-11-29 | Dana Farber Cancer Institute | Antibodies for P-glycoprotein encoded by the mdr1 gene and uses thereof |
-
1992
- 1992-06-17 IT ITRM920457A patent/IT1257893B/it active IP Right Grant
-
1993
- 1993-06-16 WO PCT/EP1993/001533 patent/WO1993025700A1/en active IP Right Grant
- 1993-06-16 NZ NZ253139A patent/NZ253139A/en unknown
- 1993-06-16 JP JP6501138A patent/JPH08501925A/ja active Pending
- 1993-06-16 EP EP93912996A patent/EP0648276B1/en not_active Expired - Lifetime
- 1993-06-16 ES ES93912996T patent/ES2130271T3/es not_active Expired - Lifetime
- 1993-06-16 KR KR1019940704598A patent/KR100301189B1/ko not_active IP Right Cessation
- 1993-06-16 RU RU94046414A patent/RU2126836C1/ru not_active IP Right Cessation
- 1993-06-16 CZ CZ943181A patent/CZ284847B6/cs not_active IP Right Cessation
- 1993-06-16 AT AT93912996T patent/ATE174967T1/de not_active IP Right Cessation
- 1993-06-16 DK DK93912996T patent/DK0648276T3/da active
- 1993-06-16 DE DE69322783T patent/DE69322783T2/de not_active Expired - Fee Related
- 1993-06-16 CA CA002134752A patent/CA2134752A1/en not_active Abandoned
- 1993-06-16 AU AU43266/93A patent/AU672798B2/en not_active Ceased
- 1993-06-16 SK SK1554-94A patent/SK280272B6/sk unknown
- 1993-06-16 US US08/356,272 patent/US5766946A/en not_active Expired - Fee Related
- 1993-06-16 HU HU9403614A patent/HU216877B/hu not_active IP Right Cessation
-
1994
- 1994-12-13 FI FI945865A patent/FI945865A/fi unknown
- 1994-12-16 NO NO944887A patent/NO944887L/no not_active Application Discontinuation
-
1999
- 1999-03-23 GR GR990400860T patent/GR3029773T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69322783T2 (de) | 1999-06-10 |
| FI945865A0 (fi) | 1994-12-13 |
| NO944887D0 (no) | 1994-12-16 |
| FI945865A (fi) | 1995-02-08 |
| DK0648276T3 (da) | 1999-08-23 |
| SK280272B6 (sk) | 1999-10-08 |
| CA2134752A1 (en) | 1993-12-23 |
| IT1257893B (it) | 1996-02-16 |
| NZ253139A (en) | 1996-09-25 |
| EP0648276B1 (en) | 1998-12-23 |
| HU9403614D0 (en) | 1995-02-28 |
| WO1993025700A1 (en) | 1993-12-23 |
| ITRM920457A1 (it) | 1993-12-17 |
| GR3029773T3 (en) | 1999-06-30 |
| HU216877B (hu) | 1999-09-28 |
| JPH08501925A (ja) | 1996-03-05 |
| EP0648276A1 (en) | 1995-04-19 |
| ATE174967T1 (de) | 1999-01-15 |
| HUT70469A (en) | 1995-10-30 |
| DE69322783D1 (de) | 1999-02-04 |
| RU2126836C1 (ru) | 1999-02-27 |
| SK155494A3 (en) | 1995-07-11 |
| NO944887L (no) | 1994-12-16 |
| AU4326693A (en) | 1994-01-04 |
| KR100301189B1 (ko) | 2001-10-22 |
| ITRM920457A0 (it) | 1992-06-17 |
| CZ284847B6 (cs) | 1999-03-17 |
| AU672798B2 (en) | 1996-10-17 |
| RU94046414A (ru) | 1996-11-10 |
| CZ318194A3 (en) | 1995-07-12 |
| US5766946A (en) | 1998-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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