SE0103044L - Förfarande för framställning av ren citalopram - Google Patents

Förfarande för framställning av ren citalopram

Info

Publication number
SE0103044L
SE0103044L SE0103044A SE0103044A SE0103044L SE 0103044 L SE0103044 L SE 0103044L SE 0103044 A SE0103044 A SE 0103044A SE 0103044 A SE0103044 A SE 0103044A SE 0103044 L SE0103044 L SE 0103044L
Authority
SE
Sweden
Prior art keywords
citalopram
preparation
cyanide
subjected
formula
Prior art date
Application number
SE0103044A
Other languages
English (en)
Swedish (sv)
Other versions
SE0103044D0 (sv
Inventor
Andrea Castellin
Giulio Volpe
Federico Sbrogio
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of SE0103044D0 publication Critical patent/SE0103044D0/xx
Publication of SE0103044L publication Critical patent/SE0103044L/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE0103044A 2000-12-28 2001-09-14 Förfarande för framställning av ren citalopram SE0103044L (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001943 2000-12-28
PCT/DK2001/000148 WO2001047877A2 (en) 2000-12-28 2001-03-07 Process for the preparation of pure citalopram

Publications (2)

Publication Number Publication Date
SE0103044D0 SE0103044D0 (sv) 2001-09-14
SE0103044L true SE0103044L (sv) 2002-06-29

Family

ID=8159933

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0103044A SE0103044L (sv) 2000-12-28 2001-09-14 Förfarande för framställning av ren citalopram

Country Status (41)

Country Link
US (2) US6855834B2 (cs)
EP (1) EP1181272B1 (cs)
JP (1) JP2003519121A (cs)
KR (1) KR100430746B1 (cs)
CN (1) CN1366526A (cs)
AR (1) AR029898A1 (cs)
AT (2) ATE222899T1 (cs)
AU (3) AU3920201A (cs)
BE (2) BE1013417A6 (cs)
BG (1) BG106219A (cs)
BR (1) BR0106271A (cs)
CA (1) CA2359810C (cs)
CH (1) CH691536A5 (cs)
CZ (1) CZ293140B6 (cs)
DE (1) DE60100016T2 (cs)
DK (1) DK1181272T3 (cs)
EA (1) EA003459B1 (cs)
ES (2) ES2181663T3 (cs)
FI (2) FI108640B (cs)
FR (1) FR2818977B1 (cs)
GB (2) GB2356199B (cs)
GR (1) GR20010100131A (cs)
HK (1) HK1049332A1 (cs)
HR (1) HRP20020005A2 (cs)
HU (2) HU0101028D0 (cs)
IE (2) IES20010253A2 (cs)
IL (1) IL147162A0 (cs)
IS (1) IS5884A (cs)
IT (1) ITMI20010604A1 (cs)
MX (1) MXPA01013336A (cs)
NL (1) NL1017534C1 (cs)
NO (1) NO313047B1 (cs)
NZ (1) NZ516299A (cs)
PL (1) PL353369A1 (cs)
PT (1) PT1181272E (cs)
SE (1) SE0103044L (cs)
SK (1) SK284418B6 (cs)
TR (1) TR200200018T1 (cs)
UA (1) UA71635C2 (cs)
WO (1) WO2001047877A2 (cs)
ZA (1) ZA200110133B (cs)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
DE69935355T2 (de) 1999-10-25 2007-11-08 H. Lundbeck A/S, Valby Verfahren zur Herstellung von Citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
PL355532A1 (en) 1999-12-28 2004-05-04 H.Lundbeck A/S Method for the preparation of citalopram
CZ20022627A3 (cs) 1999-12-30 2002-10-16 H. Lundbeck A/S Způsob výroby citalopramu
PL197821B1 (pl) 2000-01-14 2008-04-30 Lundbeck & Co As H Sposób wytwarzania 5-cyjanoftalidu
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
AU2001239210A1 (en) * 2000-03-13 2001-09-24 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
JP2003527387A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
DK1265882T3 (da) 2000-03-14 2004-06-01 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
CA2402869A1 (en) * 2000-03-16 2001-09-20 Hans Petersen Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
FI20011622L (fi) 2000-08-18 2002-02-19 Lundbeck & Co As H Menetelmä sitalopraamin valmistamiseksi
SK286283B6 (sk) 2000-12-22 2008-06-06 H. Lundbeck A/S Spôsob výroby čisteného citalopramu
DK1181272T3 (da) 2000-12-28 2002-12-30 Lundbeck & Co As H Fremgangsmåde til fremstilling af rent citalopram
GB2376945A (en) * 2001-06-27 2002-12-31 Cipla Ltd Citalopram preparation
AU2003222435A1 (en) 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
EP1486492A3 (en) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL135959C (cs) 1964-12-23
GB1143703A (cs) 1965-03-18
DE1619713A1 (de) * 1967-03-29 1970-12-17 Leybold Heraeus Gmbh & Co Kg Vorrichtung zur Vakuum- und Kurzwegdestillation
DE2135085C3 (de) 1971-07-14 1981-12-03 Basf Ag, 6700 Ludwigshafen Verfahren zur Wiedergewinnung von Caprolactam aus einem Gemisch, das Caprolactam und dessen Oligomere enthält
DE2442426C2 (de) 1974-09-05 1983-04-07 Bayer Ag, 5090 Leverkusen Diisocyanatodiketene, Verfahren zu deren Herstellung und deren Verwendung
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
IT8020902A0 (it) 1980-03-25 1980-03-25 Snia Viscosa Procedimento ed apparecchiatura per la separazione continua per via termica di miscele liquide dicomposti termolabili.
JPS6082101A (ja) 1983-10-13 1985-05-10 Mitsui Toatsu Chem Inc 高沸点重合性化合物の薄膜蒸留による精製方法
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) * 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
FR2656305B1 (fr) 1989-12-22 1992-04-10 Norsolor Sa Procede de purification du (meth)acrylate de glycidyle.
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
US5582692A (en) 1994-10-07 1996-12-10 Artisan Industries, Inc. Method for the purification of vitamin E
US6136991A (en) * 1996-05-21 2000-10-24 Exxon Chemical Patents Inc. Glycidyl ester adducts having increased glass transition temperatures
JP2001501587A (ja) 1996-05-21 2001-02-06 エクソン・ケミカル・パテンツ・インク エピハロヒドリン及びカルボン酸からのグリシジルエステルの改良された精製方法
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
EP1015416B1 (en) 1997-07-08 2001-09-19 H. Lundbeck A/S Method for the preparation of citalopram
DE19734673A1 (de) 1997-08-11 1999-02-18 Rwe Dea Ag Verfahren zur Herstellung von metallfreien Guerbetalkoholen
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
AU738359B2 (en) 1997-11-11 2001-09-13 H. Lundbeck A/S Method for the preparation of citalopram
DE69920329T3 (de) 1998-06-19 2009-07-09 Shin-Etsu Chemical Co., Ltd. Destillationsverfahren für (Meth)acryloxysilane
CN1129592C (zh) * 1998-10-20 2003-12-03 H·隆德贝克有限公司 制备西酞普兰的方法
ATE236145T1 (de) 1998-12-23 2003-04-15 Lundbeck & Co As H Verfahren zur herstellung von 5-cyanophthalid
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
SK286283B6 (sk) 2000-12-22 2008-06-06 H. Lundbeck A/S Spôsob výroby čisteného citalopramu
DK1181272T3 (da) 2000-12-28 2002-12-30 Lundbeck & Co As H Fremgangsmåde til fremstilling af rent citalopram
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram

Also Published As

Publication number Publication date
ES2170733A1 (es) 2002-08-01
GB2356199B (en) 2001-10-03
GB0117095D0 (en) 2001-09-05
IS5884A (is) 2002-06-28
HU0101028D0 (en) 2001-05-28
HRP20020005A2 (en) 2003-04-30
AU2001100399A4 (en) 2001-11-01
BE1013417A6 (fr) 2001-12-04
US6855834B2 (en) 2005-02-15
CZ2001891A3 (cs) 2002-08-14
DE60100016D1 (de) 2002-10-02
ZA200110133B (en) 2003-01-13
BG106219A (en) 2002-08-30
CH691536A5 (de) 2001-08-15
AU3920201A (en) 2001-07-09
DK1181272T3 (da) 2002-12-30
DE60100016T2 (de) 2003-04-17
GB2361697A (en) 2001-10-31
FR2818977B1 (fr) 2003-12-05
US20030178295A1 (en) 2003-09-25
IES20010253A2 (en) 2002-03-06
CN1366526A (zh) 2002-08-28
HU0102818D0 (en) 2001-09-28
AU750006B1 (en) 2002-07-11
PL353369A1 (en) 2003-11-17
ES2170733B1 (es) 2003-12-16
WO2001047877A3 (en) 2001-12-27
GB0105981D0 (en) 2001-05-02
NL1017534C1 (nl) 2001-04-26
CA2359810C (en) 2002-11-05
EP1181272B1 (en) 2002-08-28
KR100430746B1 (ko) 2004-05-10
FI20011578A0 (fi) 2001-07-26
HUP0102818A3 (en) 2003-07-28
SK18472001A3 (sk) 2002-05-09
ES2181663T3 (es) 2003-03-01
FI20010501A0 (fi) 2001-03-13
GB2356199A (en) 2001-05-16
US20020087012A1 (en) 2002-07-04
CA2359810A1 (en) 2001-07-05
HUP0102818A2 (hu) 2001-12-28
FR2818977A1 (fr) 2002-07-05
AR029898A1 (es) 2003-07-23
IES20010632A2 (en) 2002-03-06
ITMI20010604A0 (it) 2001-03-22
SK284418B6 (sk) 2005-04-01
JP2003519121A (ja) 2003-06-17
IL147162A0 (en) 2002-08-14
ATE222899T1 (de) 2002-09-15
GR20010100131A (el) 2002-10-09
AT4368U1 (de) 2001-06-25
CZ293140B6 (cs) 2004-02-18
EP1181272A2 (en) 2002-02-27
AU2001100399B4 (en) 2002-03-21
NO20011272D0 (no) 2001-03-13
UA71635C2 (uk) 2004-12-15
HK1049332A1 (zh) 2003-05-09
PT1181272E (pt) 2003-01-31
BE1013316A6 (fr) 2001-11-06
NZ516299A (en) 2002-12-20
WO2001047877A2 (en) 2001-07-05
SE0103044D0 (sv) 2001-09-14
EA003459B1 (ru) 2003-06-26
NO313047B1 (no) 2002-08-05
ITMI20010604A1 (it) 2002-09-22
MXPA01013336A (es) 2002-07-09
KR20020073379A (ko) 2002-09-26
TR200200018T1 (tr) 2002-06-21
BR0106271A (pt) 2002-05-21
FI108640B (fi) 2002-02-28
EA200200016A1 (ru) 2002-04-25
NO20011272L (no) 2002-07-01

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