DE60136566D1 - Verfahren zur herstellung von optisch aktiven 2,4-dihydrobenzofuranverbindungen - Google Patents
Verfahren zur herstellung von optisch aktiven 2,4-dihydrobenzofuranverbindungenInfo
- Publication number
- DE60136566D1 DE60136566D1 DE60136566T DE60136566T DE60136566D1 DE 60136566 D1 DE60136566 D1 DE 60136566D1 DE 60136566 T DE60136566 T DE 60136566T DE 60136566 T DE60136566 T DE 60136566T DE 60136566 D1 DE60136566 D1 DE 60136566D1
- Authority
- DE
- Germany
- Prior art keywords
- optically active
- dihydrobenzofuran
- optionally substituted
- dihydrobenzofuran compounds
- preparing optically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- NCWZVNVJFSXADS-UHFFFAOYSA-N 2,4-dihydro-1-benzofuran Chemical class C1=CCC2=CCOC2=C1 NCWZVNVJFSXADS-UHFFFAOYSA-N 0.000 title 1
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical class C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 abstract 3
- -1 2,3-dihydrobenzofuran compound Chemical class 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003449 preventive effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229940126585 therapeutic drug Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000400531 | 2000-12-28 | ||
| PCT/JP2001/011510 WO2002053551A1 (fr) | 2000-12-28 | 2001-12-27 | Procede de preparation de composes a base de 2,3-dihydrobenzofurane a activite optique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60136566D1 true DE60136566D1 (de) | 2008-12-24 |
Family
ID=18865111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60136566T Expired - Lifetime DE60136566D1 (de) | 2000-12-28 | 2001-12-27 | Verfahren zur herstellung von optisch aktiven 2,4-dihydrobenzofuranverbindungen |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6878831B2 (de) |
| EP (1) | EP1346988B1 (de) |
| AT (1) | ATE414070T1 (de) |
| CA (1) | CA2432410A1 (de) |
| DE (1) | DE60136566D1 (de) |
| ES (1) | ES2312399T3 (de) |
| WO (1) | WO2002053551A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050148650A1 (en) * | 2002-03-01 | 2005-07-07 | Shigenori Ohkawa | Antidepressant |
| JP4227061B2 (ja) * | 2004-03-30 | 2009-02-18 | シャープ株式会社 | アミン化合物、該アミン化合物を用いた電子写真感光体およびそれを備える画像形成装置 |
| WO2006022311A1 (ja) * | 2004-08-27 | 2006-03-02 | Takeda Pharmaceutical Company Limited | アゾ化合物とその製造方法 |
| TW200833374A (en) * | 2006-11-09 | 2008-08-16 | Takeda Pharmaceutical | Pharmaceutical composition |
| RU2473538C2 (ru) | 2008-10-13 | 2013-01-27 | Интерким, С.А. | СПОСОБ ПОЛУЧЕНИЯ (S)-(-)-2-(N-ПРОПИЛАМИНО)-5-МЕТОКСИТЕТРАЛИНА И (S)-(-)-2-(N-ПРОПИЛАМИНО)-5-ГИДРОКСИТЕТРАЛИНА, ИХ СОЛИ С N-(3,5-ДИНИТРОБЕНЗОИЛ)-α-ФЕНИЛГЛИЦИНОМ, СПОСОБ ПОЛУЧЕНИЯ (6S)-(-)-5,6,7,8-ТЕТРАГИДРО-6-[ПРОПИЛ(2-ТИЕНИЛ)ЭТИЛ]АМИНО-1-НАФТОЛА (РОТИГОТИНА) (ВАРИАНТЫ) |
| CN105384710B (zh) * | 2015-11-04 | 2017-11-10 | 重庆天春科技有限公司 | 一种药物中间体呋喃类化合物的合成方法 |
| CN105330621B (zh) * | 2015-11-04 | 2017-11-10 | 重庆天春科技有限公司 | 一种呋喃酯类化合物的合成方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8403224A (nl) * | 1984-10-24 | 1986-05-16 | Oce Andeno Bv | Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen. |
| IE68675B1 (en) * | 1990-11-01 | 1996-07-10 | Takeda Chemical Industries Ltd | Aminocoumaran derivatives their production and use |
| EP1136477B1 (de) | 1998-12-04 | 2004-03-10 | Takeda Chemical Industries, Ltd. | Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen |
| AU7949900A (en) * | 1999-10-22 | 2001-05-08 | Takeda Chemical Industries Ltd. | Process for producing optically active naphthalene derivative and optical resolver therefor |
-
2001
- 2001-12-27 WO PCT/JP2001/011510 patent/WO2002053551A1/ja active Application Filing
- 2001-12-27 ES ES01272539T patent/ES2312399T3/es not_active Expired - Lifetime
- 2001-12-27 CA CA002432410A patent/CA2432410A1/en not_active Abandoned
- 2001-12-27 US US10/451,723 patent/US6878831B2/en not_active Expired - Fee Related
- 2001-12-27 EP EP01272539A patent/EP1346988B1/de not_active Expired - Lifetime
- 2001-12-27 AT AT01272539T patent/ATE414070T1/de not_active IP Right Cessation
- 2001-12-27 DE DE60136566T patent/DE60136566D1/de not_active Expired - Lifetime
-
2005
- 2005-02-09 US US11/054,371 patent/US7420070B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6878831B2 (en) | 2005-04-12 |
| US7420070B2 (en) | 2008-09-02 |
| EP1346988A4 (de) | 2004-03-17 |
| ES2312399T3 (es) | 2009-03-01 |
| EP1346988B1 (de) | 2008-11-12 |
| EP1346988A1 (de) | 2003-09-24 |
| WO2002053551A1 (fr) | 2002-07-11 |
| US20040077712A1 (en) | 2004-04-22 |
| CA2432410A1 (en) | 2002-07-11 |
| US20050171184A1 (en) | 2005-08-04 |
| ATE414070T1 (de) | 2008-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |