BR9905981A - Compostos isocromano e processos para a sua produção. - Google Patents

Compostos isocromano e processos para a sua produção.

Info

Publication number
BR9905981A
BR9905981A BR9905981-9A BR9905981A BR9905981A BR 9905981 A BR9905981 A BR 9905981A BR 9905981 A BR9905981 A BR 9905981A BR 9905981 A BR9905981 A BR 9905981A
Authority
BR
Brazil
Prior art keywords
processes
relates
isochromanic
compounds
production
Prior art date
Application number
BR9905981-9A
Other languages
English (en)
Inventor
Hideo Hirai
Tochio Ichiba
Hiroko Tonai
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR9905981A publication Critical patent/BR9905981A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyrane Compounds (AREA)

Abstract

Patente de Invenção: <B>"COMPOSTOS ISOCROMANO E PROCESSOS PARA A SUA PRODUçãO"<D>. Esta invenção refere-se com o composto isocromano de fórmula (I) ou seus sais farmaceuticamente aceitáveis, que são úteis como inibidores da agregação de amiloidé e para o tratamento da doença de Alzheimer. Esta invenção também refere-se com processos para a produção do composto isocromano, que compreende a cultura de Penicillium simplicissimum FERM BP-6357 e em seguida o isolamento do composto isocromano do meio de fermentação. A presente invenção também refere-se com uma composição farmacêutica compreendendo o composto isocromano.
BR9905981-9A 1999-01-06 1999-12-24 Compostos isocromano e processos para a sua produção. BR9905981A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IBPCT/IB99/00003 1999-01-06

Publications (1)

Publication Number Publication Date
BR9905981A true BR9905981A (pt) 2000-08-29

Family

ID=11004809

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9905981-9A BR9905981A (pt) 1999-01-06 1999-12-24 Compostos isocromano e processos para a sua produção.

Country Status (9)

Country Link
US (1) US6177458B1 (pt)
EP (1) EP1018511B1 (pt)
JP (1) JP3153212B2 (pt)
AT (1) ATE231850T1 (pt)
BR (1) BR9905981A (pt)
CA (1) CA2291931C (pt)
DE (1) DE69905131T2 (pt)
DK (1) DK1018511T3 (pt)
ES (1) ES2189357T3 (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3608417B2 (ja) * 1999-02-02 2005-01-12 セイコーエプソン株式会社 電気光学装置取り付けユニット及びそれを利用した投写型表示装置
US8854595B2 (en) 2008-03-03 2014-10-07 Manufacturing Resources International, Inc. Constricted convection cooling system for an electronic display
US8562770B2 (en) 2008-05-21 2013-10-22 Manufacturing Resources International, Inc. Frame seal methods for LCD
US9173325B2 (en) 2008-03-26 2015-10-27 Manufacturing Resources International, Inc. Heat exchanger for back to back electronic displays
US8773633B2 (en) 2008-03-03 2014-07-08 Manufacturing Resources International, Inc. Expanded heat sink for electronic displays
US8497972B2 (en) 2009-11-13 2013-07-30 Manufacturing Resources International, Inc. Thermal plate with optional cooling loop in electronic display
US8654302B2 (en) 2008-03-03 2014-02-18 Manufacturing Resources International, Inc. Heat exchanger for an electronic display
US8693185B2 (en) 2008-03-26 2014-04-08 Manufacturing Resources International, Inc. System and method for maintaining a consistent temperature gradient across an electronic display
US9573346B2 (en) 2008-05-21 2017-02-21 Manufacturing Resources International, Inc. Photoinitiated optical adhesive and method for using same
US10827656B2 (en) 2008-12-18 2020-11-03 Manufacturing Resources International, Inc. System for cooling an electronic image assembly with circulating gas and ambient gas
US8749749B2 (en) 2008-12-18 2014-06-10 Manufacturing Resources International, Inc. System for cooling an electronic image assembly with manifolds and ambient gas
US10660245B2 (en) 2012-10-16 2020-05-19 Manufacturing Resources International, Inc. Back pan cooling assembly for electronic display
US9648790B2 (en) 2013-03-15 2017-05-09 Manufacturing Resources International, Inc. Heat exchanger assembly for an electronic display
US10524384B2 (en) 2013-03-15 2019-12-31 Manufacturing Resources International, Inc. Cooling assembly for an electronic display
WO2015006335A2 (en) 2013-07-08 2015-01-15 Manufacturing Resources International, Inc. Figure eight closed loop cooling system for electronic display
US9655289B2 (en) 2014-03-11 2017-05-16 Manufacturing Resources International, Inc. Hybrid rear cover and mounting bracket for electronic display
EP3138372B1 (en) 2014-04-30 2019-05-08 Manufacturing Resources International, INC. Back to back electronic display assembly
US9723765B2 (en) 2015-02-17 2017-08-01 Manufacturing Resources International, Inc. Perimeter ventilation system for electronic display
JP6971848B2 (ja) 2015-09-29 2021-11-24 浜松ホトニクス株式会社 純粋なチオフラビンｔを精製する方法、純粋なチオフラビンｔの製造方法、チオフラビンｔを含有する組成物、及びアミロイドの検出方法
US10820445B2 (en) 2016-03-04 2020-10-27 Manufacturing Resources International, Inc. Cooling system for double sided display assembly
AU2018258497B2 (en) 2017-04-27 2020-10-15 Manufacturing Resources International, Inc. System and method for preventing display bowing
US10485113B2 (en) 2017-04-27 2019-11-19 Manufacturing Resources International, Inc. Field serviceable and replaceable display
US10559965B2 (en) 2017-09-21 2020-02-11 Manufacturing Resources International, Inc. Display assembly having multiple charging ports
US10602626B2 (en) 2018-07-30 2020-03-24 Manufacturing Resources International, Inc. Housing assembly for an integrated display unit
US11096317B2 (en) 2019-02-26 2021-08-17 Manufacturing Resources International, Inc. Display assembly with loopback cooling
US10795413B1 (en) 2019-04-03 2020-10-06 Manufacturing Resources International, Inc. Electronic display assembly with a channel for ambient air in an access panel
US11477923B2 (en) 2020-10-02 2022-10-18 Manufacturing Resources International, Inc. Field customizable airflow system for a communications box
US11778757B2 (en) 2020-10-23 2023-10-03 Manufacturing Resources International, Inc. Display assemblies incorporating electric vehicle charging equipment
US11470749B2 (en) 2020-10-23 2022-10-11 Manufacturing Resources International, Inc. Forced air cooling for display assemblies using centrifugal fans
WO2022174006A1 (en) 2021-02-12 2022-08-18 Manufacturing Resourcesinternational, Inc Display assembly using structural adhesive
CN113061631B (zh) * 2021-03-31 2022-09-16 华中科技大学 一种异色满类衍生物及其酶催化合成方法和应用
US11966263B2 (en) 2021-07-28 2024-04-23 Manufacturing Resources International, Inc. Display assemblies for providing compressive forces at electronic display layers
US11762231B2 (en) 2021-08-23 2023-09-19 Manufacturing Resources International, Inc. Display assemblies inducing turbulent flow
US11919393B2 (en) 2021-08-23 2024-03-05 Manufacturing Resources International, Inc. Display assemblies inducing relatively turbulent flow and integrating electric vehicle charging equipment
US11744054B2 (en) 2021-08-23 2023-08-29 Manufacturing Resources International, Inc. Fan unit for providing improved airflow within display assemblies
US11968813B2 (en) 2021-11-23 2024-04-23 Manufacturing Resources International, Inc. Display assembly with divided interior space
US12072561B2 (en) 2022-07-22 2024-08-27 Manufacturing Resources International, Inc. Self-contained electronic display assembly, mounting structure and methods for the same
US12010813B2 (en) 2022-07-22 2024-06-11 Manufacturing Resources International, Inc. Self-contained electronic display assembly, mounting structure and methods for the same
US12035486B1 (en) 2022-07-25 2024-07-09 Manufacturing Resources International, Inc. Electronic display assembly with fabric panel communications box

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3145200B2 (ja) * 1992-09-02 2001-03-12 ファイザー製薬株式会社 新規イソクロマンカルボン酸誘導体

Also Published As

Publication number Publication date
EP1018511A1 (en) 2000-07-12
DK1018511T3 (da) 2003-06-23
ATE231850T1 (de) 2003-02-15
CA2291931C (en) 2003-12-30
ES2189357T3 (es) 2003-07-01
DE69905131T2 (de) 2003-06-05
CA2291931A1 (en) 2000-07-06
US6177458B1 (en) 2001-01-23
EP1018511B1 (en) 2003-01-29
JP3153212B2 (ja) 2001-04-03
DE69905131D1 (de) 2003-03-06
JP2000198781A (ja) 2000-07-18

Similar Documents

Publication Publication Date Title
BR9905981A (pt) Compostos isocromano e processos para a sua produção.
PT1274698E (pt) Perciquinina, metodo para a sua producao e sua utilizacao como medicamento
WO2001028996A3 (en) Pyrrolidine derivatives, their preparation and their use as inhibitors of neuraminidases
EA200501098A1 (ru) Антибактериальные агенты
NO177004C (no) Analogifremgangsmåte for fremstilling av 7-substituerte derivater av 3,5-dihydroksyhept-6-ynsyre
ATE302778T1 (de) N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP1306367A4 (en) SULFONIC ACID DERIVATIVES OF HYDROXAMIC ACIDS AND THEIR USE AS MEDICAL PRODUCTS
ATE310010T1 (de) 6-0-substitutierte eryththromycin-verbindungen und verfahrenen zu ihrer herstellung
CO5690587A2 (es) Derivados de acido bensoilureidopiridil-piperidin-y pirrolidin carboxilico sustituido, metodo para su produccion y su uso
DE60107832D1 (en) Chromenylmethylpyrimidindiamine als antibakterielle wirkstoffe
ATE165822T1 (de) Chinolin-4-carbonylguanidin-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
DE60234024D1 (de) Neue retinoidderivate und eine pharmazeutische anti-krebs-zusammensetzung, die diese verbindungen enthält
DE69917668D1 (de) Substanz gm-95, verfahren zu ihrer herstellung und ihre verwendung
AU8294401A (en) A process for the preparation of alpha&#39; chloroketones
EP1346988A4 (en) METHOD FOR PRODUCING OPTICALLY ACTIVE 2,4-DIHYDROBENZOFURANE COMPOUNDS
UY28574A1 (es) Derivados de bengamida, procedimiento para su preparación y su uso
ATE252566T1 (de) Herstellung von 2-(2-arylmorpholin-2- yl)ethanolderivaten und zwischenprodukte
ATE159517T1 (de) Verfahren zur herstellung von n-carbonylarylimine als zwischenprodukte in der synthese von therapeutisch aktiven taxol-derivaten
BG108151A (en) Caloporoside derivatives, methods for the production thereof and their use
BR0014230A (pt) Antibióticos de ácido 7-acilamino-3-heteroariltio-3-cefem carboxìlico e suas pró-drogas
TR200001161A2 (tr) 8-Siklopentil-6-etil-3-[ikame edilmiş]-5, 8-Dihidro-4H-1, 2, 3A, 7, 8-Pentaaza-As-Indasenlerin hazırlandığı işlem ve burada yararlı ara bağlar.
NO20022690D0 (no) Nye strukturelle analoger av Vitamin D
MXPA04004537A (es) Derivados de gabusectina, metodo para produccion de los mismos y uso de los mismos.
RU93058275A (ru) Производные тиофен-2-карбоновой кислоты, способ их получения, фармацевтическая композиция и способ ее получения
HUP0202462A2 (hu) Eljárás [4S-(4alfa,7alfa,10alfabéta)]-4-amino-5-oxo-oktahidro-7H-pirido-[2,1-b][1,3]tiazepin-7-karbonsav-metil-észter és sói előállítására új diszulfidokon át

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1975 DE 11/11/2008.