RU2004121149A - Иммунизация против chlamydia trachomatis - Google Patents

Иммунизация против chlamydia trachomatis Download PDF

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Publication number
RU2004121149A
RU2004121149A RU2004121149/13A RU2004121149A RU2004121149A RU 2004121149 A RU2004121149 A RU 2004121149A RU 2004121149/13 A RU2004121149/13 A RU 2004121149/13A RU 2004121149 A RU2004121149 A RU 2004121149A RU 2004121149 A RU2004121149 A RU 2004121149A
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protein
nucleic acid
chlamydia trachomatis
sequence
patient
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RU2004121149/13A
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RU2331435C2 (ru
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Гвидо ГРАНДИ (IT)
Гвидо ГРАНДИ
Джулио РАТТИ (IT)
Джулио РАТТИ
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Чирон Срл. (It)
Чирон Срл.
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Priority claimed from GB0129732A external-priority patent/GB0129732D0/en
Priority claimed from GB0218233A external-priority patent/GB0218233D0/en
Priority claimed from GB0218924A external-priority patent/GB0218924D0/en
Application filed by Чирон Срл. (It), Чирон Срл. filed Critical Чирон Срл. (It)
Publication of RU2004121149A publication Critical patent/RU2004121149A/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/118—Chlamydiaceae, e.g. Chlamydia trachomatis or Chlamydia psittaci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (12)

1. Применение белка в приготовлении лекарственного средства для лечения или предупреждения инфекции, вызываемой Chlamydia trachomatis, где указанный белок является (а) белком, содержащим аминокислотную последовательность, выбранную из группы, состоящей из SEQ ID NO:l, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159, 161, 163, 165, 167, 169, 171, 173, 175, 177, 179, 181, 183, 185, 187, 189, 191, 193, 195, 197, 199, 201, 203, 205, 207, 209, 211, 213, 215, 217, 219, 221, 223, 225, 227, 229, 231, 233, 235, 237, 239, 241, 243, 245, 247, 249, 251, 253, 255, 257, 259 и 261, (b) белком, содержащим аминокислотную последовательность, имеющую 50% или большую идентичность последовательности относительно аминокислотной последовательности (а), или (с) белком, содержащим фрагмент из, по меньшей мере, 7 последовательных аминокислот из аминокислотной последовательности (а).
2. Применение нуклеиновой кислоты в приготовлении лекарственного средства для лечения или предупреждения инфекции, вызываемой Chlamydia trachomatis, где указанная нуклеиновая кислота является (а) нуклеиновой кислотой, содержащей нуклеотидную последовательность, выбранную из группы, состоящей из SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 160, 162, 164, 166, 168, 170, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194, 196, 198, 200, 202, 204, 206, 208, 210, 212, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232, 234, 236, 238, 240, 242, 244, 246, 248, 250, 252, 254, 256, 258, 260 и 262, (b) нуклеиновой кислотой, содержащей нуклеотидную последовательность, имеющую 50% или большую идентичность последовательности относительно нуклеотидной последовательности (а), или (с) нуклеиновой кислотой, содержащей фрагмент из, по меньшей мере, 7 последовательных нуклеотидов из последовательности (а).
3. Применение по п.1 или 2, где инфекцию лечат или предупреждают лекарственным средством, вызывающим иммунный ответ, который является специфическим в отношении элементарного тела Chlamydia.
4. Применение белка по п.1 или нуклеиновой кислоты по п.2 в приготовлении лекарственного средства для нейтрализации элементарных тел Chlamydia trachomatis.
5. Иммуногенная композиция, содержащая белок и адъювант, где указанный белок является (а) белком, содержащим аминокислотную последовательность, выбранную из группы, состоящей из SEQ ID NO:1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 73, 75, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159, 161, 163, 165, 167, 169, 171, 173, 175, 177, 179, 181, 183, 185, 187, 189, 191, 193, 195, 197, 199, 201, 203, 205, 207, 209, 211, 213, 215, 217, 219, 221, 223, 225, 227, 229, 231, 233, 235, 237, 239, 241, 243, 245, 247, 249, 251, 253, 255, 257, 259 и 261, (b) белком, содержащим аминокислотную последовательность, имеющую 50% или большую идентичность последовательности относительно аминокислотной последовательности (а), или (с) белком, содержащим фрагмент из, по меньшей мере, 7 последовательных аминокислот из аминокислотной последовательности (а).
6. Иммуногенная композиция, содержащая нуклеиновую кислоту и адъювант, где указанная нуклеиновая кислота является (а) нуклеиновой кислотой, содержащей нуклеотидную последовательность, выбранную из группы, состоящей из SEQ ID NO:2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 160, 162, 164, 166, 168, 170, 172, 174, 176, 178, 180, 182, 184, 186, 188, 190, 192, 194, 196, 198, 200, 202, 204, 206, 208, 210, 212, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232, 234, 236, 238, 240, 242, 244, 246, 248, 250, 252, 254, 256, 258, 260 и 262, (b) нуклеиновой кислотой, содержащей нуклеотидную последовательность, имеющую 50% или большую идентичность последовательности относительно нуклеотидной последовательности (а), или (с) нуклеиновой кислотой, содержащей фрагмент из, по меньшей мере, 7 последовательных нуклеотидов из последовательности (а).
7. Композиция по п.5 или п.6 для применения в качестве фармацевтического средства.
8. Способ нейтрализации инфективности Chlamydia trachomatis в пациенте, предусматривающий стадию введения пациенту композиции по п.5 или по п.6 или антитела, которое узнает белок по п.1.
9. Способ иммунизации пациента против Chlamydia trachomatis, предусматривающий введение пациенту композиции по п.5 или 6.
10. Способ индукции антител, специфических в отношении элементарных тел Chlamydia trachomatis, предусматривающий введение пациенту композиции по п.5 или 6.
11. Способ индукции антител, которые узнают белок по п.1, предусматривающий стадию введения пациенту элементарного тела Chlamydia trachomatis.
12. Способ обнаружения элементарного тела Chlamydia trachomatis в биологическом образце, предусматривающий стадию контактирования этого образца с антителом, которое узнает белок по п.1.
RU2004121149/13A 2001-12-12 2002-12-12 Иммунизация против chlamydia trachomatis RU2331435C2 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0129732.4 2001-12-12
GB0129732A GB0129732D0 (en) 2001-12-12 2001-12-12 Immunisation against chlamydia trachomatis
GB0218233A GB0218233D0 (en) 2001-12-12 2002-08-06 Immunisation against chlamydia trachomatis
GB0218233.5 2002-08-06
GB0218924A GB0218924D0 (en) 2001-12-12 2002-08-14 Immunisation against chlamydia trachtomatis
GB0218924.9 2002-08-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2007148891/13A Division RU2007148891A (ru) 2001-12-12 2007-12-25 Иммунизация против chlamydia trachomatis

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RU2004121149A true RU2004121149A (ru) 2005-04-20
RU2331435C2 RU2331435C2 (ru) 2008-08-20

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US (3) US20050106162A1 (ru)
EP (4) EP2335723A1 (ru)
JP (3) JP4413617B2 (ru)
KR (1) KR100982204B1 (ru)
CN (1) CN100515494C (ru)
AT (1) ATE406912T1 (ru)
AU (1) AU2002366592B2 (ru)
CA (1) CA2469620A1 (ru)
DE (1) DE60228758D1 (ru)
ES (2) ES2386386T3 (ru)
NZ (3) NZ546711A (ru)
RU (1) RU2331435C2 (ru)
WO (1) WO2003049762A2 (ru)

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