IT1244706B - Plasmide pctd isolato da chlamydia trachomatis serotipo d, suoi geni e proteine da essi codificate; plasmidi ricombinanti per l'espressionedi detti geni in sistemi eterologhi come proteine ricombinanti di fusione, preparazione di dette proteine ricombinanti e loro uso nella formulazione di vaccini e/o diagnostici - Google Patents
Plasmide pctd isolato da chlamydia trachomatis serotipo d, suoi geni e proteine da essi codificate; plasmidi ricombinanti per l'espressionedi detti geni in sistemi eterologhi come proteine ricombinanti di fusione, preparazione di dette proteine ricombinanti e loro uso nella formulazione di vaccini e/o diagnosticiInfo
- Publication number
- IT1244706B IT1244706B ITMI910314A ITMI910314A IT1244706B IT 1244706 B IT1244706 B IT 1244706B IT MI910314 A ITMI910314 A IT MI910314A IT MI910314 A ITMI910314 A IT MI910314A IT 1244706 B IT1244706 B IT 1244706B
- Authority
- IT
- Italy
- Prior art keywords
- recombinant
- proteins
- genes
- vaccines
- formulation
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 241000606153 Chlamydia trachomatis Species 0.000 title abstract 3
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 3
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 229940038705 chlamydia trachomatis Drugs 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000013612 plasmid Substances 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/295—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Chlamydiales (O)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/125—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Chlamydiales (O)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
E' descritto un plasmide isolato da Chlamydia trachomatis comprendente otto geni codificanti proteine utili nella formulazione di vaccini o di test diagnostici per la determinazione del batterio o di anticorpi specifici generati nel corso di infezioni da C. trachomatis; in particolare è descritta la proteina ricombinante di fusione MS2-pgp3D comprendente sequenze polipeptidiche codificate da pCT ed immunogeniche nel corso di infezioni nell'uomo. E' descritto inoltre un metodo per la preparazione di detta proteina in E. coli.
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI910314A IT1244706B (it) | 1991-02-07 | 1991-02-07 | Plasmide pctd isolato da chlamydia trachomatis serotipo d, suoi geni e proteine da essi codificate; plasmidi ricombinanti per l'espressionedi detti geni in sistemi eterologhi come proteine ricombinanti di fusione, preparazione di dette proteine ricombinanti e loro uso nella formulazione di vaccini e/o diagnostici |
DE69131319T DE69131319T2 (de) | 1991-02-07 | 1991-04-17 | Isoliertes PCTD Plasmid aus Chlamydia trachomatis von Serotyp D, dessen Genen und davon kodierten Proteine, rekombinante Plasmide für die Expression von deren Genen als Fusionsproteine in einem keterologen System, und ihre Verwendung als Impfstoff- und/oder Diagnostiekformulierung |
DK91106110T DK0499681T3 (da) | 1991-02-07 | 1991-04-17 | pCTD-plasmid isoleret fra Chlamydia trachomatis serotype D, dets gener og proteiner, som kodes af dem; rekombinante plasmid |
AT91106110T ATE181104T1 (de) | 1991-02-07 | 1991-04-17 | Isoliertes pctd plasmid aus chlamydia trachomatis von serotyp d, dessen genen und davon kodierten proteine, rekombinante plasmide für die expression von deren genen als fusionsproteine in einem keterologen system, und ihre verwendung als impfstoff- und/oder diagnostiekformulierung |
ES91106110T ES2136062T3 (es) | 1991-02-07 | 1991-04-17 | Plasmido pctd aislado de chlamydia trachomatis serotipo d, genes y proteinas codificados por el mismo; plasmidos recombinantes para la expresion de dichos genes en sistemas heterologos como proteinas recombinantes de fusion, preparacion de dichas proteinas recombinantes y ... |
EP91106110A EP0499681B1 (en) | 1991-02-07 | 1991-04-17 | PCTD plasmid isolated from chlamydia trachomatis serotype D, its genes and proteins encoded by them; recombinant plasmids for the expression of said genes in heterologous systems as fused recombinant proteins, preparation of said recombinant proteins and their use in the formulation of vaccines and/or dianostics |
US08/444,189 US6110705A (en) | 1991-02-07 | 1995-05-18 | Recombinant Chlamydia trachomatis pgp3 fusion protein |
US08/468,544 US6248563B1 (en) | 1991-02-07 | 1995-06-06 | Chlamydia trachomatis serotype D genes |
US08/969,644 US6096519A (en) | 1991-02-07 | 1997-11-13 | Chlamydia trachomatis serotype D proteins |
GR990401491T GR3030447T3 (en) | 1991-02-07 | 1999-06-10 | PCTD plasmid isolated from chlamydia trachomatis serotype D, its genes and proteins encoded by them; recombinant plasmids for the expression of said genes in heterologous systems as fused recombinant proteins, preparation of said recombinant proteins and their use in the formulation of vaccines and/or dianostics |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI910314A IT1244706B (it) | 1991-02-07 | 1991-02-07 | Plasmide pctd isolato da chlamydia trachomatis serotipo d, suoi geni e proteine da essi codificate; plasmidi ricombinanti per l'espressionedi detti geni in sistemi eterologhi come proteine ricombinanti di fusione, preparazione di dette proteine ricombinanti e loro uso nella formulazione di vaccini e/o diagnostici |
Publications (3)
Publication Number | Publication Date |
---|---|
ITMI910314A0 ITMI910314A0 (it) | 1991-02-07 |
ITMI910314A1 ITMI910314A1 (it) | 1992-08-07 |
IT1244706B true IT1244706B (it) | 1994-08-08 |
Family
ID=11358472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITMI910314A IT1244706B (it) | 1991-02-07 | 1991-02-07 | Plasmide pctd isolato da chlamydia trachomatis serotipo d, suoi geni e proteine da essi codificate; plasmidi ricombinanti per l'espressionedi detti geni in sistemi eterologhi come proteine ricombinanti di fusione, preparazione di dette proteine ricombinanti e loro uso nella formulazione di vaccini e/o diagnostici |
Country Status (8)
Country | Link |
---|---|
US (2) | US6110705A (it) |
EP (1) | EP0499681B1 (it) |
AT (1) | ATE181104T1 (it) |
DE (1) | DE69131319T2 (it) |
DK (1) | DK0499681T3 (it) |
ES (1) | ES2136062T3 (it) |
GR (1) | GR3030447T3 (it) |
IT (1) | IT1244706B (it) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5629167A (en) | 1994-04-19 | 1997-05-13 | Biocine S.P.A. | Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay |
US5814490A (en) * | 1996-06-11 | 1998-09-29 | Becton, Dickinson And Company | Amplification and detection of chlamydia trachomatis nucleic acids |
IL119938A (en) * | 1996-12-30 | 2005-08-31 | Yissum Res Dev Co | Peptides capable of eliciting protective immunity against toxic shock induced by pyrogenic exotoxins or of antagonizing toxin-mediated activation of t cells |
GB9828000D0 (en) | 1998-12-18 | 1999-02-10 | Chiron Spa | Antigens |
US7090973B1 (en) * | 1999-04-09 | 2006-08-15 | Oscient Pharmaceuticals Corporation | Nucleic acid sequences relating to Bacteroides fragilis for diagnostics and therapeutics |
GB0016814D0 (en) | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (3) |
CA2469620A1 (en) | 2001-12-12 | 2003-06-19 | Chiron Srl. | Immunisation against chlamydia trachomatis |
EP2517725A1 (en) * | 2007-05-01 | 2012-10-31 | Board Of Regents, The University Of Texas | Chlamydial antigens as reagents for diagnosis and treatment of chlamydial infection and disease |
WO2010042206A1 (en) | 2008-10-09 | 2010-04-15 | Board Of Regents, University Of Texas System | Methods and compositions for chlamydial antigens for diagnosis and treatment of chlamydial infection and disease |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3650571T2 (de) * | 1985-01-14 | 1997-02-27 | Chiron Corp | Hauptprotein der Aussenmembran von Chlamydia |
GB8709746D0 (en) * | 1987-04-24 | 1987-05-28 | Wenman W M | Chlamydia vaccine |
IT1224253B (it) * | 1988-04-08 | 1990-09-26 | Sclavo Spa | Oligonucleotidi sintetici utili per la determinazione di chlamydia trachomatis in un campione biologico |
-
1991
- 1991-02-07 IT ITMI910314A patent/IT1244706B/it active IP Right Grant
- 1991-04-17 ES ES91106110T patent/ES2136062T3/es not_active Expired - Lifetime
- 1991-04-17 DK DK91106110T patent/DK0499681T3/da active
- 1991-04-17 EP EP91106110A patent/EP0499681B1/en not_active Expired - Lifetime
- 1991-04-17 DE DE69131319T patent/DE69131319T2/de not_active Expired - Lifetime
- 1991-04-17 AT AT91106110T patent/ATE181104T1/de not_active IP Right Cessation
-
1995
- 1995-05-18 US US08/444,189 patent/US6110705A/en not_active Expired - Lifetime
-
1997
- 1997-11-13 US US08/969,644 patent/US6096519A/en not_active Expired - Fee Related
-
1999
- 1999-06-10 GR GR990401491T patent/GR3030447T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ITMI910314A1 (it) | 1992-08-07 |
ATE181104T1 (de) | 1999-06-15 |
US6110705A (en) | 2000-08-29 |
DE69131319D1 (de) | 1999-07-15 |
GR3030447T3 (en) | 1999-09-30 |
US6096519A (en) | 2000-08-01 |
DE69131319T2 (de) | 1999-12-16 |
ITMI910314A0 (it) | 1991-02-07 |
EP0499681B1 (en) | 1999-06-09 |
EP0499681A1 (en) | 1992-08-26 |
ES2136062T3 (es) | 1999-11-16 |
DK0499681T3 (da) | 1999-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970226 |