PT2612862T - Quinazolinonas como inibidores de fosfatidilinositol 3-quinase delta humana - Google Patents

Info

Publication number

PT2612862T

PT2612862T PT131501108T PT13150110T PT2612862T PT 2612862 T PT2612862 T PT 2612862T PT 131501108 T PT131501108 T PT 131501108T PT 13150110 T PT13150110 T PT 13150110T PT 2612862 T PT2612862 T PT 2612862T

Authority

PT

Portugal

Prior art keywords

compound

shown below

acid

compounds

pi3k5

Prior art date

2004-05-13

Links

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• 239000003112 inhibitor Substances 0.000 title description 71
• 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 title description 54
• 108091007960 PI3Ks Proteins 0.000 title description 29
• 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 title description 26
• 150000001875 compounds Chemical class 0.000 claims description 514
• 150000003839 salts Chemical class 0.000 claims description 35
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• 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
• CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims description 2
• XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 2
• QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 6
• 125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims 1
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• DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 122
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