NO330662B1 - Mikrofabrikerte elastomere ventil- og pumpesystemer - Google Patents

Mikrofabrikerte elastomere ventil- og pumpesystemer Download PDF

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Publication number
NO330662B1
NO330662B1 NO20016268A NO20016268A NO330662B1 NO 330662 B1 NO330662 B1 NO 330662B1 NO 20016268 A NO20016268 A NO 20016268A NO 20016268 A NO20016268 A NO 20016268A NO 330662 B1 NO330662 B1 NO 330662B1
Authority
NO
Norway
Prior art keywords
elastomeric
elastomer
microfabricated
channel
membrane
Prior art date
Application number
NO20016268A
Other languages
English (en)
Norwegian (no)
Other versions
NO20016268L (no
NO20016268D0 (no
Inventor
Marc A Unger
Hou-Pu Chou
Todd A Thorsen
Axel Scherer
Stephen R Quake
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Publication of NO20016268D0 publication Critical patent/NO20016268D0/no
Publication of NO20016268L publication Critical patent/NO20016268L/no
Publication of NO330662B1 publication Critical patent/NO330662B1/no

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B7/00—Microstructural systems; Auxiliary parts of microstructural devices or systems
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C51/00—Shaping by thermoforming, i.e. shaping sheets or sheet like preforms after heating, e.g. shaping sheets in matched moulds or by deep-drawing; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B5/00—Devices comprising elements which are movable in relation to each other, e.g. comprising slidable or rotatable elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00119—Arrangement of basic structures like cavities or channels, e.g. suitable for microfluidic systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
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    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
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    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C1/00—Circuit elements having no moving parts
    • F15C1/02—Details, e.g. special constructional devices for circuits with fluid elements, such as resistances, capacitive circuit elements; devices preventing reaction coupling in composite elements ; Switch boards; Programme devices
    • F15C1/06—Constructional details; Selection of specified materials ; Constructional realisation of one single element; Canal shapes; Jet nozzles; Assembling an element with other devices, only if the element forms the main part
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C5/00—Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K1/00—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces
    • F16K1/16—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members
    • F16K1/18—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps
    • F16K1/20—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps with axis of rotation arranged externally of valve member
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
    • F16K11/10—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with two or more closure members not moving as a unit
    • F16K11/20—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with two or more closure members not moving as a unit operated by separate actuating members
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K13/00—Other constructional types of cut-off apparatus; Arrangements for cutting-off
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K31/00—Actuating devices; Operating means; Releasing devices
    • F16K31/12—Actuating devices; Operating means; Releasing devices actuated by fluid
    • F16K31/126—Actuating devices; Operating means; Releasing devices actuated by fluid the fluid acting on a diaphragm, bellows, or the like
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0015—Diaphragm or membrane valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
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    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
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    • F16K99/0046—Electric operating means therefor using magnets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
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    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0048—Electric operating means therefor using piezoelectric means
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0051—Electric operating means therefor using electrostatic means
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0059—Operating means specially adapted for microvalves actuated by fluids actuated by a pilot fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B33Y80/00—Products made by additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T137/0491—Valve or valve element assembling, disassembling, or replacing
    • Y10T137/0497—Fluid actuated or retarded
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/2224—Structure of body of device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/87249—Multiple inlet with multiple outlet
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/87917—Flow path with serial valves and/or closures
    • Y10T137/87981—Common actuator
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24479—Structurally defined web or sheet [e.g., overall dimension, etc.] including variation in thickness
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24744—Longitudinal or transverse tubular cavity or cell

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  • Engineering & Computer Science (AREA)
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  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Micromachines (AREA)
  • Reciprocating Pumps (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Diaphragms And Bellows (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Injection Moulding Of Plastics Or The Like (AREA)
  • Safety Valves (AREA)
  • Closures For Containers (AREA)
  • Moulds For Moulding Plastics Or The Like (AREA)
NO20016268A 1999-06-28 2001-12-20 Mikrofabrikerte elastomere ventil- og pumpesystemer NO330662B1 (no)

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US14150399P 1999-06-28 1999-06-28
US14719999P 1999-08-03 1999-08-03
US18685600P 2000-03-03 2000-03-03
PCT/US2000/017740 WO2001001025A2 (fr) 1999-06-28 2000-06-27 Obturateur elastomere micro-usine et systemes de pompe

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Families Citing this family (727)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US7052594B2 (en) 2002-01-31 2006-05-30 Sri International Devices and methods for controlling fluid flow using elastic sheet deflection
US6833242B2 (en) * 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6780591B2 (en) 1998-05-01 2004-08-24 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
US7875440B2 (en) 1998-05-01 2011-01-25 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and DNA molecules
JP3703721B2 (ja) 1999-04-26 2005-10-05 ジーエムピー ヴィジョン ソルーションズ インコーポレイテッド 緑内障を治療するためのシャント装置
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7195670B2 (en) 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US7217321B2 (en) 2001-04-06 2007-05-15 California Institute Of Technology Microfluidic protein crystallography techniques
US7459022B2 (en) * 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
ATE215673T1 (de) * 1999-06-28 2002-04-15 California Inst Of Techn Elastomerische mikropumpen- und mikroventilsysteme
US8550119B2 (en) * 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US8052792B2 (en) 2001-04-06 2011-11-08 California Institute Of Technology Microfluidic protein crystallography techniques
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US6929030B2 (en) * 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7306672B2 (en) 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US20080277007A1 (en) * 1999-06-28 2008-11-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
CA2290731A1 (fr) * 1999-11-26 2001-05-26 D. Jed Harrison Appareil et methode de piegeage de reactifs en forme de perles, dans le cadre d'un systeme d'analyse de microfluides
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
DE60132185T2 (de) * 2000-02-23 2009-01-02 Caliper Life Sciences, Inc., Mountain View Mehrfach-reservoir-drucksteuersystem
US20020012926A1 (en) * 2000-03-03 2002-01-31 Mycometrix, Inc. Combinatorial array for nucleic acid analysis
US20050118073A1 (en) * 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US7236831B2 (en) * 2000-07-13 2007-06-26 Northstar Neuroscience, Inc. Methods and apparatus for effectuating a lasting change in a neural-function of a patient
US6669669B2 (en) * 2001-10-12 2003-12-30 Insulet Corporation Laminated patient infusion device
EP1334347A1 (fr) 2000-09-15 2003-08-13 California Institute Of Technology Dispositifs a debit transversal microfabriques et procedes associes
US6508988B1 (en) * 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
WO2002029106A2 (fr) * 2000-10-03 2002-04-11 California Institute Of Technology Dispositifs microfluidiques et procedes d'utilisation
US7097809B2 (en) * 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
EP1336097A4 (fr) * 2000-10-13 2006-02-01 Fluidigm Corp Systeme d'injection d'echantillons utilisant un dispositif microfluidique, pour dispositifs d'analyse
US7232109B2 (en) 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
DE60103924T2 (de) * 2000-11-06 2005-07-14 Nanostream, Inc., Pasadena Mikrofluidische durchflussregelvorrichtung
US8097471B2 (en) 2000-11-10 2012-01-17 3M Innovative Properties Company Sample processing devices
US20020121443A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for the combined electrical and optical identification, characterization and/or sorting of particles
US6936811B2 (en) * 2000-11-13 2005-08-30 Genoptix, Inc. Method for separating micro-particles
US20020160470A1 (en) * 2000-11-13 2002-10-31 Genoptix Methods and apparatus for generating and utilizing linear moving optical gradients
US20020123112A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for increasing detection sensitivity in optical dielectric sorting systems
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US6951632B2 (en) * 2000-11-16 2005-10-04 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
EP1343973B2 (fr) 2000-11-16 2020-09-16 California Institute Of Technology Appareil et procedes pour effectuer des dosages et des criblages a haut rendement
FR2817974B1 (fr) * 2000-12-12 2003-09-12 Commissariat Energie Atomique Micro-actionneur optique, composant optique utilisant le micro-actionneur, et procede de realisation d'un micro-actionneur optique
CA2697026A1 (fr) * 2000-12-12 2002-06-12 Bayer Healthcare Llc Technique de fabrication d'un vaisseau capillaire
WO2002053290A2 (fr) * 2001-01-08 2002-07-11 President And Fellows Of Harvard College Vannes et pompes destinees a des systemes microfluidiques et procede de realisation de systemes microfluidiques
US20020098122A1 (en) * 2001-01-22 2002-07-25 Angad Singh Active disposable microfluidic system with externally actuated micropump
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US6904784B2 (en) * 2001-02-27 2005-06-14 Teledyne Isco, Inc. Liquid chromatographic method and system
US20050196785A1 (en) * 2001-03-05 2005-09-08 California Institute Of Technology Combinational array for nucleic acid analysis
EP1384076B1 (fr) 2001-03-19 2012-07-25 Gyros Patent Ab Caracterisation de variables de reaction
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6752922B2 (en) * 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
US20020164816A1 (en) * 2001-04-06 2002-11-07 California Institute Of Technology Microfluidic sample separation device
JP5162074B2 (ja) 2001-04-06 2013-03-13 フルイディグム コーポレイション ポリマー表面修飾
EP1679121A3 (fr) * 2001-04-06 2006-07-26 Fluidigm Corporation Éléments et applications de circuit fluidique microfabriqués
EP1661623A3 (fr) * 2001-04-06 2006-06-07 Fluidigm Corporation Systeme de distribution microfluidique
US6802342B2 (en) 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
WO2002080811A2 (fr) 2001-04-07 2002-10-17 Glaukos Corporation Stent de glaucome et procedes destines au traitement d'un glaucome
US20030124516A1 (en) * 2001-04-27 2003-07-03 Genoptix, Inc. Method of using optical interrogation to determine a biological property of a cell or population of cells
US20040023310A1 (en) * 2001-04-27 2004-02-05 Genoptix, Inc Quantitative determination of protein kinase C activation using optophoretic analysis
US20030194755A1 (en) * 2001-04-27 2003-10-16 Genoptix, Inc. Early detection of apoptotic events and apoptosis using optophoretic analysis
US7318912B2 (en) * 2001-06-07 2008-01-15 Nanostream, Inc. Microfluidic systems and methods for combining discrete fluid volumes
US6729352B2 (en) 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US20020186263A1 (en) * 2001-06-07 2002-12-12 Nanostream, Inc. Microfluidic fraction collectors
GB0116384D0 (en) * 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
KR100421359B1 (ko) * 2001-07-24 2004-03-06 엘지전자 주식회사 탄성 재질의 기판 내에서 유체를 이송하는 방법 및 이를위한 장치
US6734436B2 (en) 2001-08-07 2004-05-11 Sri International Optical microfluidic devices and methods
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
US7075162B2 (en) * 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
SG106631A1 (en) * 2001-08-31 2004-10-29 Agency Science Tech & Res Liquid delivering device
DE20115733U1 (de) * 2001-09-25 2001-12-20 Festo Ag & Co Ventileinrichtung
US20030073961A1 (en) * 2001-09-28 2003-04-17 Happ Dorrie M. Medical device containing light-protected therapeutic agent and a method for fabricating thereof
US20030108664A1 (en) * 2001-10-05 2003-06-12 Kodas Toivo T. Methods and compositions for the formation of recessed electrical features on a substrate
US8440093B1 (en) * 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
AU2002359329A1 (en) * 2001-10-30 2003-05-12 The Texas A And M University System Method and apparatus for temperature gradient microfluidics
US20030087455A1 (en) * 2001-11-07 2003-05-08 Eggers Mitchell D Sample carrier system
GB0128350D0 (en) * 2001-11-27 2002-01-16 Lab901 Ltd Non-rigid apparatus for microfluidic applications
CA2467587A1 (fr) 2001-11-30 2003-06-12 Fluidigm Corporation Dispositif microfluidique et procedes d'utilisation de ce dernier
US7691333B2 (en) * 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US6848462B2 (en) 2001-12-06 2005-02-01 Nanostream, Inc. Adhesiveless microfluidic device fabrication
US6622746B2 (en) 2001-12-12 2003-09-23 Eastman Kodak Company Microfluidic system for controlled fluid mixing and delivery
US6739576B2 (en) 2001-12-20 2004-05-25 Nanostream, Inc. Microfluidic flow control device with floating element
GB2383546B (en) * 2001-12-28 2006-03-01 Norchip As Fluid manipulation in a microfabricated reaction chamber system
US7867757B2 (en) * 2001-12-28 2011-01-11 Norchip As Fluid manipulation in a microfabricated reaction chamber systems
US7289132B1 (en) * 2003-12-19 2007-10-30 Apple Inc. Method and apparatus for image acquisition, organization, manipulation, and publication
US6568799B1 (en) 2002-01-23 2003-05-27 Eastman Kodak Company Drop-on-demand ink jet printer with controlled fluid flow to effect drop ejection
US7524459B2 (en) * 2002-01-24 2009-04-28 California Institute Of Technology In Pasadena Optoelectronic and microfluidic integration for miniaturized spectroscopic devices
US6814859B2 (en) 2002-02-13 2004-11-09 Nanostream, Inc. Frit material and bonding method for microfluidic separation devices
US6561224B1 (en) * 2002-02-14 2003-05-13 Abbott Laboratories Microfluidic valve and system therefor
GB0204009D0 (en) * 2002-02-20 2002-04-03 Xaar Technology Ltd Actuation device and use thereof in droplet deposition
US20030180711A1 (en) * 2002-02-21 2003-09-25 Turner Stephen W. Three dimensional microfluidic device having porous membrane
US6958119B2 (en) * 2002-02-26 2005-10-25 Agilent Technologies, Inc. Mobile phase gradient generation microfluidic device
JP4557551B2 (ja) * 2002-02-27 2010-10-06 ミシガン大学リージェンツ 運動性精子選別法
CA2480728A1 (fr) * 2002-04-01 2003-10-16 Fluidigm Corporation Systemes d'analyse de particules microfluidiques
US6637476B2 (en) 2002-04-01 2003-10-28 Protedyne Corporation Robotically manipulable sample handling tool
US6872645B2 (en) * 2002-04-02 2005-03-29 Nanosys, Inc. Methods of positioning and/or orienting nanostructures
US6877528B2 (en) * 2002-04-17 2005-04-12 Cytonome, Inc. Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US6808075B2 (en) 2002-04-17 2004-10-26 Cytonome, Inc. Method and apparatus for sorting particles
US6976590B2 (en) 2002-06-24 2005-12-20 Cytonome, Inc. Method and apparatus for sorting particles
US9943847B2 (en) 2002-04-17 2018-04-17 Cytonome/St, Llc Microfluidic system including a bubble valve for regulating fluid flow through a microchannel
US20030211461A1 (en) * 2002-05-01 2003-11-13 Genoptix, Inc Optophoretic detection of durgs exhibiting inhibitory effect on Bcr-Abl positive tumor cells
US20040033539A1 (en) * 2002-05-01 2004-02-19 Genoptix, Inc Method of using optical interrogation to determine a biological property of a cell or population of cells
DE10220371A1 (de) * 2002-05-07 2003-11-27 Fraunhofer Ges Forschung Freistrahldosiermodul und Verfahren zu seiner Herstellung
US20030208936A1 (en) * 2002-05-09 2003-11-13 Lee Charles Hee Method for manufacturing embroidery decorated cards and envelopes
US7059348B2 (en) * 2002-05-13 2006-06-13 Fluidigm Corporation Drug delivery system
US7125510B2 (en) * 2002-05-15 2006-10-24 Zhili Huang Microstructure fabrication and microsystem integration
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US7217426B1 (en) 2002-06-21 2007-05-15 Advanced Cardiovascular Systems, Inc. Coatings containing polycationic peptides for cardiovascular therapy
US8168139B2 (en) * 2002-06-24 2012-05-01 Fluidigm Corporation Recirculating fluidic network and methods for using the same
US20040124085A1 (en) * 2002-06-26 2004-07-01 California Institute Of Technology Microfluidic devices and methods with electrochemically actuated sample processing
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
US7135147B2 (en) * 2002-07-26 2006-11-14 Applera Corporation Closing blade for deformable valve in a microfluidic device and method
US7201881B2 (en) * 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
US7452509B2 (en) * 2002-07-26 2008-11-18 Applied Biosystems Inc. Microfluidic device including displaceable material trap, and system
DE10241294A1 (de) * 2002-09-04 2004-03-18 Basf Ag Hybriddispersionen aus Polyadditionsprodukten und radikalischen Polymerisaten
AU2003251307A1 (en) * 2002-09-10 2004-04-30 The Trustees Of The University Pennsylvania Carbon nanotubes: high solids dispersions and nematic gels thereof
EP1403209A1 (fr) * 2002-09-24 2004-03-31 The Technology Partnership Limited Dispositif d'acheminement de fluide
US8220494B2 (en) * 2002-09-25 2012-07-17 California Institute Of Technology Microfluidic large scale integration
EP2298448A3 (fr) * 2002-09-25 2012-05-30 California Institute of Technology Intégration microfluidique à large échelle
TW590982B (en) * 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
WO2004032228A2 (fr) * 2002-09-30 2004-04-15 Siemens Aktiengesellschaft Substrat comprenant une section superficielle plane, procede de production d'un film de materiau sur la section superficielle du substrat et utilisation de ce substrat
US8871446B2 (en) 2002-10-02 2014-10-28 California Institute Of Technology Microfluidic nucleic acid analysis
GB0224121D0 (en) * 2002-10-16 2002-11-27 Microemissive Displays Ltd Method of patterning a functional material on to a substrate
US7163385B2 (en) * 2002-11-21 2007-01-16 California Institute Of Technology Hydroimpedance pump
DE10254312B4 (de) * 2002-11-21 2005-04-21 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Variabler Flußwiderstand
WO2004052046A2 (fr) * 2002-11-27 2004-06-17 Northwestern University Transducteur a membrane mince
US6920203B2 (en) * 2002-12-02 2005-07-19 General Electric Company Method and apparatus for selectively attenuating a radiation source
AU2003293399A1 (en) 2002-12-04 2004-06-23 Spinx, Inc. Devices and methods for programmable microscale manipulation of fluids
US20040121307A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Early detection of cellular differentiation using optophoresis
US20040121474A1 (en) * 2002-12-19 2004-06-24 Genoptix, Inc Detection and evaluation of chemically-mediated and ligand-mediated t-cell activation using optophoretic analysis
KR20050088476A (ko) 2002-12-30 2005-09-06 더 리전트 오브 더 유니버시티 오브 캘리포니아 병원균 검출과 분석을 위한 방법과 기구
US6866233B2 (en) * 2003-01-03 2005-03-15 Orbital Research Inc. Reconfigurable porous technology for fluid flow control and method of controlling flow
US7090471B2 (en) * 2003-01-15 2006-08-15 California Institute Of Technology Integrated electrostatic peristaltic pump method and apparatus
DE602004021239D1 (de) * 2003-03-10 2009-07-09 Univ Michigan Intergrierte mikrofluidische kontrollvorrichtung mit programmierbaren taktilen stellgliedern
US6844953B2 (en) * 2003-03-12 2005-01-18 Hewlett-Packard Development Company, L.P. Micro-mirror device including dielectrophoretic liquid
US20040179972A1 (en) * 2003-03-14 2004-09-16 Nanostream, Inc. Systems and methods for detecting manufacturing defects in microfluidic devices
US7279027B2 (en) * 2003-03-21 2007-10-09 Air Products And Chemicals, Inc. Planar ceramic membrane assembly and oxidation reactor system
US7249529B2 (en) 2003-03-28 2007-07-31 Protedyne Corporation Robotically manipulable sample handling tool
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
GB0307428D0 (en) 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
US7666361B2 (en) 2003-04-03 2010-02-23 Fluidigm Corporation Microfluidic devices and methods of using same
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US20050145496A1 (en) * 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
WO2006102264A1 (fr) 2005-03-18 2006-09-28 Fluidigm Corporation Dispositif de reaction thermique et son procede d'utilisation
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
JP2006523142A (ja) * 2003-04-10 2006-10-12 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体種の形成および制御
US6929969B2 (en) * 2003-04-23 2005-08-16 Taiwan Semiconductor Manufacturing Company Reflective spatial light modulator mirror device manufacturing process and layout method
US8791171B2 (en) * 2003-05-01 2014-07-29 Abbott Cardiovascular Systems Inc. Biodegradable coatings for implantable medical devices
WO2004101151A1 (fr) * 2003-05-08 2004-11-25 Nanostream, Inc. Preparation d'echantillons pour la chromatographie parallele
US20050002025A1 (en) * 2003-05-15 2005-01-06 Toshiba Ceramics Co., Ltd. Channel structure and process for production thereof
EP1636017A2 (fr) 2003-05-20 2006-03-22 Fluidigm Corporation Procede et systeme pour dispositif microfluidique et son imagerie
US6962658B2 (en) * 2003-05-20 2005-11-08 Eksigent Technologies, Llc Variable flow rate injector
FR2855076B1 (fr) * 2003-05-21 2006-09-08 Inst Curie Dispositif microfluidique
US7381361B2 (en) * 2003-06-26 2008-06-03 Intel Corporation Fabricating structures in micro-fluidic channels based on hydrodynamic focusing
US7115230B2 (en) * 2003-06-26 2006-10-03 Intel Corporation Hydrodynamic focusing devices
US20050042656A1 (en) * 2003-07-09 2005-02-24 Davis James C. Room temperature elution of nucleic acids
WO2005007223A2 (fr) * 2003-07-16 2005-01-27 Sasha John Systemes et procedes d'administration programmable de medicaments pour l'administration de fluides et de concentrations multiples
EP1654066B1 (fr) 2003-07-31 2014-11-12 Handylab, Inc. Traitement d'echantillons contenant des particules
US7413712B2 (en) * 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
CA2535566A1 (fr) * 2003-08-11 2005-07-07 California Institute Of Technology Integration microfluide a grande echelle
US20050051489A1 (en) 2003-08-20 2005-03-10 California Institute Of Technology IC-processed polymer nano-liquid chromatography system on-a-chip and method of making it
KR20070029618A (ko) 2003-08-27 2007-03-14 더 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 유체종의 전자적 제어
WO2005022147A1 (fr) * 2003-08-28 2005-03-10 Celula, Inc. Procedes et appareil pour le tri de cellules mettant en oeuvre un commutateur optique dans un reseau de canaux microfluidiques
US7247778B2 (en) * 2003-08-29 2007-07-24 Spencer Chase Addressable pneumatic valve system
US7296592B2 (en) 2003-09-16 2007-11-20 Eksigent Technologies, Llc Composite polymer microfluidic control device
US7998435B2 (en) * 2003-09-19 2011-08-16 Life Technologies Corporation High density plate filler
US7695688B2 (en) * 2003-09-19 2010-04-13 Applied Biosystems, Llc High density plate filler
US9492820B2 (en) 2003-09-19 2016-11-15 Applied Biosystems, Llc High density plate filler
US8277760B2 (en) * 2003-09-19 2012-10-02 Applied Biosystems, Llc High density plate filler
US20050220675A1 (en) * 2003-09-19 2005-10-06 Reed Mark T High density plate filler
US20050226782A1 (en) * 2003-09-19 2005-10-13 Reed Mark T High density plate filler
US20060272738A1 (en) * 2003-09-19 2006-12-07 Gary Lim High density plate filler
US20060233673A1 (en) * 2003-09-19 2006-10-19 Beard Nigel P High density plate filler
US20060233671A1 (en) * 2003-09-19 2006-10-19 Beard Nigel P High density plate filler
US7407630B2 (en) * 2003-09-19 2008-08-05 Applera Corporation High density plate filler
CN1997691B (zh) * 2003-09-23 2011-07-20 北卡罗来纳大学查珀尔希尔分校 光固化的全氟聚醚用作微流体器件中的新材料
US20050232817A1 (en) * 2003-09-26 2005-10-20 The University Of Cincinnati Functional on-chip pressure generator using solid chemical propellant
US7284966B2 (en) * 2003-10-01 2007-10-23 Agency For Science, Technology & Research Micro-pump
US20050100712A1 (en) * 2003-11-12 2005-05-12 Simmons Blake A. Polymerization welding and application to microfluidics
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
EP1542074A1 (fr) * 2003-12-11 2005-06-15 Heptagon OY Fabrication d'un outil de replication
US7351380B2 (en) * 2004-01-08 2008-04-01 Sandia Corporation Microfluidic structures and methods for integrating a functional component into a microfluidic device
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
US20050164373A1 (en) * 2004-01-22 2005-07-28 Oldham Mark F. Diffusion-aided loading system for microfluidic devices
SG10202107927VA (en) * 2004-01-25 2021-08-30 Fluidigm Corp Crystal forming devices and systems and methods for making and using the same
US20050182312A1 (en) * 2004-02-12 2005-08-18 Medtronic Xomed, Inc. Contact tonometer using MEMS technology
CN101189271A (zh) * 2004-02-13 2008-05-28 北卡罗来纳大学查珀尔希尔分校 制造微流体设备的功能材料和新型方法
ATE463584T1 (de) 2004-02-19 2010-04-15 Helicos Biosciences Corp Verfahren zur analyse von polynukleotidsequenzen
US20050196321A1 (en) * 2004-03-03 2005-09-08 Zhili Huang Fluidic programmable array devices and methods
WO2005087314A1 (fr) * 2004-03-11 2005-09-22 Advanced Neuromodulation Systems, Inc. Systeme et procede de stimulation du cerveau
US20050221339A1 (en) 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
SG2013006333A (en) * 2004-05-02 2014-08-28 Fluidigm Corp Thermal reaction device and method for using the same
CN101811074B (zh) * 2004-05-02 2012-09-12 弗卢丁公司 热反应设备及使用其的方法
JP5344817B2 (ja) 2004-05-03 2013-11-20 ハンディーラブ インコーポレイテッド ポリヌクレオチド含有サンプルの処理
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
US7694694B2 (en) * 2004-05-10 2010-04-13 The Aerospace Corporation Phase-change valve apparatuses
US8642353B2 (en) * 2004-05-10 2014-02-04 The Aerospace Corporation Microfluidic device for inducing separations by freezing and associated method
US7419639B2 (en) * 2004-05-12 2008-09-02 The Board Of Trustees Of The Leland Stanford Junior University Multilayer microfluidic device
KR101506727B1 (ko) 2004-05-13 2015-04-03 나노바이오심 인크. 나노-ｐｃｒ: 핵산 증폭 및 검출을 위한 방법 및 장치
JP2008509226A (ja) * 2004-05-24 2008-03-27 ジェンボールト コーポレイション 回収可能な形式での安定なタンパク質保管および安定な核酸保管
US8197234B2 (en) * 2004-05-25 2012-06-12 California Institute Of Technology In-line actuator for electromagnetic operation
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
CN100583434C (zh) 2004-06-07 2010-01-20 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
US7650910B2 (en) * 2004-06-24 2010-01-26 The Aerospace Corporation Electro-hydraulic valve apparatuses
US7686040B2 (en) * 2004-06-24 2010-03-30 The Aerospace Corporation Electro-hydraulic devices
US7721762B2 (en) * 2004-06-24 2010-05-25 The Aerospace Corporation Fast acting valve apparatuses
US9477233B2 (en) 2004-07-02 2016-10-25 The University Of Chicago Microfluidic system with a plurality of sequential T-junctions for performing reactions in microdroplets
JP4412081B2 (ja) * 2004-07-07 2010-02-10 株式会社日立製作所 ガスタービンとガスタービンの冷却方法
US20060018795A1 (en) * 2004-07-23 2006-01-26 General Electric Company Fabrication methods and multifunctional substrate materials for chemical and biological analysis in microfluidic systems
US7244443B2 (en) 2004-08-31 2007-07-17 Advanced Cardiovascular Systems, Inc. Polymers of fluorinated monomers and hydrophilic monomers
DE102004042578A1 (de) * 2004-09-02 2006-03-23 Roche Diagnostics Gmbh Mikropumpe zur Förderung von Flüssigkeiten mit niedrigen Förderraten im Druck/Saug-Betrieb
DE102004042987A1 (de) * 2004-09-06 2006-03-23 Roche Diagnostics Gmbh Push-Pull betriebene Pumpe für ein mikrofluidisches System
US20070248958A1 (en) 2004-09-15 2007-10-25 Microchip Biotechnologies, Inc. Microfluidic devices
JP3922280B2 (ja) * 2004-09-30 2007-05-30 セイコーエプソン株式会社 配線パターンの形成方法及びデバイスの製造方法
US20060073035A1 (en) * 2004-09-30 2006-04-06 Narayan Sundararajan Deformable polymer membranes
US20070243627A1 (en) * 2004-09-30 2007-10-18 Shuichi Takayama Computerized control method and system for microfluidics and computer program product for use therein
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
US7832429B2 (en) * 2004-10-13 2010-11-16 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
DE102004051394B4 (de) * 2004-10-21 2006-08-17 Advalytix Ag Verfahren zur Bewegung von kleinen Flüssigkeitsmengen in Mikrokanälen und Mikrokanalsystem
US20060088449A1 (en) * 2004-10-26 2006-04-27 Massachusetts Institute Of Technology Systems and methods for transferring a fluid sample
KR100661347B1 (ko) * 2004-10-27 2006-12-27 삼성전자주식회사 미소 박막 구조물 및 이를 이용한 ｍｅｍｓ 스위치 그리고그것들을 제조하기 위한 방법
WO2006071470A2 (fr) * 2004-12-03 2006-07-06 California Institute Of Technology Dispositifs microfluidiques a circuits de reactions chimiques
WO2006060748A2 (fr) 2004-12-03 2006-06-08 California Institute Of Technology Soupapes a tamis microfluidiques
US9260693B2 (en) 2004-12-03 2016-02-16 Cytonome/St, Llc Actuation of parallel microfluidic arrays
WO2006072383A1 (fr) 2005-01-05 2006-07-13 Advalytix Ag Procede et dispositif de dosage et de melange de petites quantites de liquide
DE102005000835B3 (de) * 2005-01-05 2006-09-07 Advalytix Ag Verfahren und Vorrichtung zur Dosierung kleiner Flüssigkeitsmengen
US7328882B2 (en) * 2005-01-06 2008-02-12 Honeywell International Inc. Microfluidic modulating valve
CA2591951C (fr) * 2005-01-10 2011-10-11 Silverbrook Research Pty Ltd Procede de production d'une tete d'impression par jet d'encre
US7465545B2 (en) * 2005-01-29 2008-12-16 Samsung Electronics Co., Ltd. Microfluidic chip and manipulating apparatus having the same
US7235750B1 (en) 2005-01-31 2007-06-26 United States Of America As Represented By The Secretary Of The Air Force Radio frequency MEMS switch contact metal selection
US7601554B1 (en) 2005-01-31 2009-10-13 The United States Of America As Represented By The Secretary Of The Air Force Shaped MEMS contact
DE102005005121A1 (de) * 2005-02-04 2006-08-17 Forschungszentrum Jülich GmbH Verfahren zur Herstellung eines Elastomers und Elastomer
US20080009835A1 (en) * 2005-02-17 2008-01-10 Kriesel Marshall S Fluid dispensing apparatus with flow rate control
US20070054119A1 (en) * 2005-03-04 2007-03-08 Piotr Garstecki Systems and methods of forming particles
EP2248578B1 (fr) * 2005-03-04 2012-06-06 President and Fellows of Harvard College Procédé pour former des émulsions multiples
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
KR20070120605A (ko) * 2005-04-14 2007-12-24 더 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 미세제작을 위한 희생층의 조절가능한 용해도
US7618391B2 (en) * 2005-04-20 2009-11-17 Children's Medical Center Corporation Waveform sensing and regulating fluid flow valve
US7883669B2 (en) 2005-04-20 2011-02-08 Fluidigm Corporation Analysis engine and database for manipulating parameters for fluidic systems on a chip
US7512959B2 (en) * 2005-05-09 2009-03-31 Searete Llc Rotation responsive disk activation and deactivation mechanisms
US8140745B2 (en) 2005-09-09 2012-03-20 The Invention Science Fund I, Llc Data retrieval methods
US7519980B2 (en) * 2005-05-09 2009-04-14 Searete Llc Fluid mediated disk activation and deactivation mechanisms
US8218262B2 (en) 2005-05-09 2012-07-10 The Invention Science Fund I, Llc Method of manufacturing a limited use data storing device including structured data and primary and secondary read-support information
US7668068B2 (en) * 2005-06-09 2010-02-23 Searete Llc Rotation responsive disk activation and deactivation mechanisms
US7770028B2 (en) * 2005-09-09 2010-08-03 Invention Science Fund 1, Llc Limited use data storing device
US8220014B2 (en) 2005-05-09 2012-07-10 The Invention Science Fund I, Llc Modifiable memory devices having limited expected lifetime
US7596073B2 (en) 2005-05-09 2009-09-29 Searete Llc Method and system for fluid mediated disk activation and deactivation
US8099608B2 (en) 2005-05-09 2012-01-17 The Invention Science Fund I, Llc Limited use data storing device
US7907486B2 (en) 2006-06-20 2011-03-15 The Invention Science Fund I, Llc Rotation responsive disk activation and deactivation mechanisms
US7916615B2 (en) 2005-06-09 2011-03-29 The Invention Science Fund I, Llc Method and system for rotational control of data storage devices
US8121016B2 (en) 2005-05-09 2012-02-21 The Invention Science Fund I, Llc Rotation responsive disk activation and deactivation mechanisms
US8462605B2 (en) * 2005-05-09 2013-06-11 The Invention Science Fund I, Llc Method of manufacturing a limited use data storing device
US9396752B2 (en) 2005-08-05 2016-07-19 Searete Llc Memory device activation and deactivation
US7565596B2 (en) 2005-09-09 2009-07-21 Searete Llc Data recovery systems
US7748012B2 (en) * 2005-05-09 2010-06-29 Searete Llc Method of manufacturing a limited use data storing device
US7694316B2 (en) * 2005-05-09 2010-04-06 The Invention Science Fund I, Llc Fluid mediated disk activation and deactivation mechanisms
US8159925B2 (en) 2005-08-05 2012-04-17 The Invention Science Fund I, Llc Limited use memory device with associated information
US7668069B2 (en) * 2005-05-09 2010-02-23 Searete Llc Limited use memory device with associated information
US7916592B2 (en) 2005-05-09 2011-03-29 The Invention Science Fund I, Llc Fluid mediated disk activation and deactivation mechanisms
WO2007044091A2 (fr) 2005-06-02 2007-04-19 Fluidigm Corporation Analyse utilisant des dispositifs de separation microfluidiques
US20060275852A1 (en) 2005-06-06 2006-12-07 Montagu Jean I Assays based on liquid flow over arrays
TWI288116B (en) * 2005-06-07 2007-10-11 Chien-Chung Fu Method of manufacturing a LIGA mold by backside exposure
US8309057B2 (en) * 2005-06-10 2012-11-13 The Invention Science Fund I, Llc Methods for elevating neurotrophic agents
KR101264673B1 (ko) * 2005-06-24 2013-05-20 엘지디스플레이 주식회사 소프트 몰드를 이용한 미세 패턴 형성방법
TWI256905B (en) * 2005-06-29 2006-06-21 Univ Nat Cheng Kung Method of forming micro-droplets and chips thereof
US8628055B2 (en) 2005-07-27 2014-01-14 The Board Of Trustees Of The University Of Illinois Bi-direction rapid action electrostatically actuated microvalve
EP2537657A3 (fr) 2005-08-09 2016-05-04 The University of North Carolina At Chapel Hill Procédés et matériaux permettant de fabriquer des dispositifs microfluidiques
US20070048192A1 (en) * 2005-08-10 2007-03-01 Emil Kartalov Integrated microfluidic vias, overpasses, underpasses, septums, microfuses, nested bioarrays and methods for fabricating the same
US7666593B2 (en) 2005-08-26 2010-02-23 Helicos Biosciences Corporation Single molecule sequencing of captured nucleic acids
US20070054293A1 (en) * 2005-08-30 2007-03-08 California Institute Of Technology Microfluidic chaotic mixing systems and methods
US8480053B2 (en) * 2005-09-02 2013-07-09 California Institute Of Technology Method and apparatus for the mechanical actuation of valves in fluidic devices
US20070183928A1 (en) * 2005-09-09 2007-08-09 Eksigent Technologies, Llc Variable flow rate system for column chromatography
US20070074972A1 (en) * 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
US7390377B1 (en) * 2005-09-22 2008-06-24 Sandia Corporation Bonding thermoplastic polymers
US7611673B2 (en) * 2005-09-28 2009-11-03 California Institute Of Technology PMDS microfluidic components and methods of operation of the same
EP1940543B1 (fr) * 2005-09-29 2012-03-07 Siemens Medical Solutions USA, Inc. Puce microfluidique capable de synthetiser des molecules radiomarquees a une echelle adaptee a l'imagerie humaine par tomographie par emission de positrons
US8123834B2 (en) * 2005-10-06 2012-02-28 The Board Of Trustees Of The University Of Illinois High gain selective metal organic framework preconcentrators
US8822206B2 (en) * 2005-10-11 2014-09-02 The Johns Hopkins University Device for high-throughput stimulation, immunostaining, and visualization of single cells
US8449837B2 (en) * 2005-10-11 2013-05-28 The Johns Hopkins University Microfluidic device for high-throughput cellular gradient and dose response studies
US7727473B2 (en) 2005-10-19 2010-06-01 Progentech Limited Cassette for sample preparation
US8206975B2 (en) * 2005-10-28 2012-06-26 California Institute Of Technology Method and device for regulating fluid flow in microfluidic devices
US7913928B2 (en) 2005-11-04 2011-03-29 Alliant Techsystems Inc. Adaptive structures, systems incorporating same and related methods
US20070106200A1 (en) * 2005-11-08 2007-05-10 Brian Levy Intraocular shunt device and method
US8992511B2 (en) 2005-11-09 2015-03-31 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
US8998886B2 (en) 2005-12-13 2015-04-07 The Invention Science Fund I, Llc Remote control of osmotic pump device
US20070106277A1 (en) * 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Remote controller for substance delivery system
US7942867B2 (en) 2005-11-09 2011-05-17 The Invention Science Fund I, Llc Remotely controlled substance delivery device
US8273071B2 (en) 2006-01-18 2012-09-25 The Invention Science Fund I, Llc Remote controller for substance delivery system
US8936590B2 (en) 2005-11-09 2015-01-20 The Invention Science Fund I, Llc Acoustically controlled reaction device
WO2007056561A2 (fr) * 2005-11-09 2007-05-18 Liquidia Technologies, Inc. Dispositif medical, materiaux et procedes
US9254256B2 (en) 2005-11-09 2016-02-09 The Invention Science Fund I, Llc Remote controlled in vivo reaction method
US8083710B2 (en) 2006-03-09 2011-12-27 The Invention Science Fund I, Llc Acoustically controlled substance delivery device
EP1790861A1 (fr) 2005-11-25 2007-05-30 Bonsens AB Système microfluidique
US7986686B2 (en) 2005-11-25 2011-07-26 Cisco Technology, Inc. Techniques for distributing network provider digital content to customer premises nodes
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
DE102006002924B3 (de) * 2006-01-20 2007-09-13 Albert-Ludwigs-Universität Freiburg Fluidhandhabungsvorrichtung und Verfahren zum Handhaben eines Fluids
US8021582B2 (en) * 2006-01-23 2011-09-20 National Cheng Kung University Method for producing microparticles in a continuous phase liquid
US20070248971A1 (en) * 2006-01-26 2007-10-25 California Institute Of Technology Programming microfluidic devices with molecular information
EP2263787A3 (fr) * 2006-01-27 2012-02-22 President and Fellows of Harvard College Coalescence de gouttelettes fluidiques
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
CA2641271A1 (fr) 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Dispositifs microfluidiques
US8124015B2 (en) 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
US7862000B2 (en) * 2006-02-03 2011-01-04 California Institute Of Technology Microfluidic method and structure with an elastomeric gas-permeable gasket
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
CA2833354C (fr) 2006-03-14 2015-12-15 University Of Southern California Dispositif mems et procede de livraison d'agents therapeutiques
US7766033B2 (en) 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
JP2009534033A (ja) 2006-04-21 2009-09-24 ナノバイオシン，インコーポレイテッド 薬物発見のための単一分子プラットホーム：抗癌剤および抗ウイルス剤の発見を含む薬物発見のための方法および装置
US8828661B2 (en) 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
WO2007125468A2 (fr) * 2006-05-01 2007-11-08 Koninklijke Philips Electronics N.V. dispositif de transport d'échantillon de fluide avec volume mort réduit permettant de traiter, CONTROLER et/ou détecter un échantillon de fluide
US20070260174A1 (en) * 2006-05-05 2007-11-08 Searete Llc Detecting a failure to maintain a regimen
WO2007133710A2 (fr) * 2006-05-11 2007-11-22 Raindance Technologies, Inc. Dispositifs microfluidiques et leurs procédés d'utilisation
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
JP4721227B2 (ja) * 2006-05-22 2011-07-13 アイダエンジニアリング株式会社 マイクロ流路チップ及びその製造方法
WO2007140417A2 (fr) 2006-05-31 2007-12-06 Sequenom, Inc. Procédés et compositions destinés à l'extraction et l'amplification d'un acide nucléique à partir d'un échantillon
US8431080B2 (en) * 2006-06-02 2013-04-30 The Board Of Trustees Of The University Of Illinois Soft MEMS
US20090016333A1 (en) * 2006-06-14 2009-01-15 Derek Wang Content-based adaptive jitter handling
US8432777B2 (en) 2006-06-19 2013-04-30 The Invention Science Fund I, Llc Method and system for fluid mediated disk activation and deactivation
US8264928B2 (en) 2006-06-19 2012-09-11 The Invention Science Fund I, Llc Method and system for fluid mediated disk activation and deactivation
DE102006030068A1 (de) 2006-06-28 2008-01-03 M2P-Labs Gmbh Vorrichtung und Verfahren zur Zu- und Abfuhr von Fluiden in geschüttelten Mikroreaktoren Arrays
US9028859B2 (en) 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
CA2657435A1 (fr) 2006-07-10 2008-07-03 Medipacs, Inc. Hydrogel epoxy super-elastique
US20080021364A1 (en) * 2006-07-17 2008-01-24 Industrial Technology Research Institute Fluidic device
US7794665B2 (en) * 2006-07-17 2010-09-14 Industrial Technology Research Institute Fluidic device
US7959876B2 (en) * 2006-07-17 2011-06-14 Industrial Technology Research Institute Fluidic device
TWI404929B (zh) * 2006-07-17 2013-08-11 Ind Tech Res Inst 流體裝置及其控制方法
WO2008091294A2 (fr) * 2006-07-28 2008-07-31 California Institute Of Technology Système nanoélectromécanique polymère pour la physiologie cellulaire et système de positionnement de cellules microfabriquées pour micro-biocalorimètre
CA2659046A1 (fr) * 2006-08-02 2008-02-07 The Regents Of The University Of Michigan Dispositifs et procedes d'actionnement de soupape hydraulique multiplexes
WO2008021123A1 (fr) 2006-08-07 2008-02-21 President And Fellows Of Harvard College Tensioactifs fluorocarbonés stabilisateurs d'émulsions
US7817698B2 (en) * 2006-08-11 2010-10-19 California Institute Of Technology Mechanically tunable elastomeric optofluidic distributed feedback dye lasers
TW200808957A (en) * 2006-08-15 2008-02-16 Univ Nat Cheng Kung Chip for cell culture
US8050516B2 (en) 2006-09-13 2011-11-01 Fluidigm Corporation Methods and systems for determining a baseline during image processing
US8055034B2 (en) 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
US20080131327A1 (en) * 2006-09-28 2008-06-05 California Institute Of Technology System and method for interfacing with a microfluidic chip
CN101523215B (zh) * 2006-10-12 2014-07-30 皇家飞利浦电子股份有限公司 磁性和/或电子标签辅助检测系统和方法
US8123192B2 (en) * 2006-10-18 2012-02-28 California Institute Of Technology Control arrangement for microfluidic devices and related methods and systems
US7790118B2 (en) * 2006-10-18 2010-09-07 California Institute Of Technology Microfluidic devices and related methods and systems
WO2008052138A2 (fr) 2006-10-25 2008-05-02 The Regents Of The University Of California Microdispositif à injection en ligne et système d'analyse d'adn intégré micro-usiné faisant intervenir ce microdispositif
DE602006009405D1 (de) * 2006-10-28 2009-11-05 Sensirion Holding Ag Mehrzellenpumpe
US8540677B2 (en) * 2006-11-02 2013-09-24 Becton, Dickinson And Company Vascular access device chamber venting
WO2008061043A2 (fr) 2006-11-10 2008-05-22 Glaukos Corporation Dérivation uvéosclérale et procédés pour son implantation
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
WO2008060604A2 (fr) 2006-11-14 2008-05-22 Handylab, Inc. Système microfluidique utilisé pour amplifier et détecter des polynucléotides en parallèle
WO2008066485A1 (fr) * 2006-11-28 2008-06-05 Åstc Aerospace Ab Système de vanne micromécanique à action lente
US8473216B2 (en) 2006-11-30 2013-06-25 Fluidigm Corporation Method and program for performing baseline correction of amplification curves in a PCR experiment
US8128393B2 (en) 2006-12-04 2012-03-06 Liquidia Technologies, Inc. Methods and materials for fabricating laminate nanomolds and nanoparticles therefrom
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US8681743B2 (en) * 2006-12-08 2014-03-25 Samsung Electronics Co., Ltd. Apparatus and method for selecting frame structure in multihop relay broadband wireless access communication system
US7932034B2 (en) 2006-12-20 2011-04-26 The Board Of Trustees Of The Leland Stanford Junior University Heat and pH measurement for sequencing of DNA
US20080160603A1 (en) * 2006-12-28 2008-07-03 Narayan Sundararajan Flow stabilization in micro-and nanofluidic devices
US20080163946A1 (en) * 2006-12-28 2008-07-10 The Trustees Of California State University Magnetically controlled valve for flow manipulation in polymer microfluidic devices
GB2445739A (en) * 2007-01-16 2008-07-23 Lab901 Ltd Polymeric laminates containing heat seals
US8157434B2 (en) 2007-01-19 2012-04-17 Fluidigm Corporation High efficiency and high precision microfluidic devices and methods
WO2008091694A2 (fr) * 2007-01-23 2008-07-31 Siemens Medical Solutions Usa, Inc. Système microfluidique entièrement automatisé pour réaliser la synthèse de biomarqueurs radiomarqués pour tomographie par émission de positons
KR20100028526A (ko) 2007-02-05 2010-03-12 마이크로칩 바이오테크놀로지스, 인크. 마이크로유체 및 나노유체 장치, 시스템 및 응용
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US7871570B2 (en) * 2007-02-23 2011-01-18 Joseph Zhili Huang Fluidic array devices and systems, and related methods of use and manufacturing
WO2008108481A1 (fr) * 2007-03-05 2008-09-12 Nec Corporation Mécanisme de commande d'écoulement pour micropuce
CN102014871A (zh) * 2007-03-28 2011-04-13 哈佛大学 乳液及其形成技术
US20080258036A1 (en) * 2007-03-30 2008-10-23 Labrador Research Llc System for dimensional stability of elastomeric microdevices
US7906074B2 (en) * 2007-04-09 2011-03-15 Auburn University Microfluidic array system for biological, chemical, and biochemical assessments
US8071035B2 (en) * 2007-04-12 2011-12-06 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis system for positron emission tomography biomarkers
WO2008130623A1 (fr) 2007-04-19 2008-10-30 Brandeis University Manipulation de fluides, composants fluidiques et réactions dans des systèmes microfluidiques
WO2008141183A2 (fr) * 2007-05-09 2008-11-20 Fluidigm Corporation Procédé et système de cristallisation et criblage par diffraction de rayons x
WO2009006318A1 (fr) 2007-06-29 2009-01-08 Artificial Muscle, Inc. Transducteurs polymères électroactifs pour des applications de rétroaction sensorielle
WO2009009131A2 (fr) 2007-07-11 2009-01-15 California Institute Of Technology Système d'assistance cardiaque utilisant un arrangement hélicoïdal de bandes contractiles et dispositif d'assistance cardiaque exerçant une torsion hélicoïdale
ES2877602T3 (es) 2007-07-13 2021-11-17 Handylab Inc Materiales de captura de polinucleótidos y procedimientos de uso de los mismos
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
AU2013205255C1 (en) * 2007-07-13 2016-02-18 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
WO2009015296A1 (fr) 2007-07-24 2009-01-29 The Regents Of The University Of California Générateur de gouttelettes microfabriqué
US8206025B2 (en) * 2007-08-07 2012-06-26 International Business Machines Corporation Microfluid mixer, methods of use and methods of manufacture thereof
KR101321912B1 (ko) * 2007-08-28 2013-10-30 삼성전자주식회사 탄성 밸브 및 이를 구비한 미세유동 장치
US9404150B2 (en) 2007-08-29 2016-08-02 Sequenom, Inc. Methods and compositions for universal size-specific PCR
EA018555B1 (ru) 2007-09-07 2013-08-30 Флуидигм Корпорейшн Определение вариаций количества копий, способы и системы
CA2700946A1 (fr) * 2007-09-28 2009-04-02 University Of Toronto Systeme, appareil et procede permettant d'appliquer une force mecanique a un materiau
JP5404638B2 (ja) 2007-11-07 2014-02-05 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア マイクロ流体デバイスおよびその使用方法
JP2009128037A (ja) * 2007-11-20 2009-06-11 Canon Inc マイクロ流体装置
US8152136B2 (en) * 2007-11-26 2012-04-10 The Hong Kong Polytechnic University Polymer microvalve with actuators and devices
DE102007060352A1 (de) 2007-12-12 2009-06-18 Richter, Andreas, Dr. Ansteuerung für integrierte aktive Mikrosysteme auf Hydrogelbasis
US8561963B2 (en) * 2007-12-19 2013-10-22 Palo Alto Research Center Incorporated Electrostatically addressable microvalves
US9308124B2 (en) 2007-12-20 2016-04-12 University Of Southern California Apparatus and methods for delivering therapeutic agents
US8152908B2 (en) 2008-01-16 2012-04-10 The Board Of Trustees Of The University Of Illinois Micromachined gas chromatography columns for fast separation of Organophosphonate and Organosulfur compounds and methods for deactivating same
EP3360972B1 (fr) 2008-01-17 2019-12-11 Sequenom, Inc. Procédés d'analyse de séquence d'acide nucléique à molécule unique
WO2009092106A1 (fr) * 2008-01-18 2009-07-23 The Regents Of The University Of California Micromélangeur précis et rapide pour dispositifs microfluidiques intégrés
WO2009108260A2 (fr) 2008-01-22 2009-09-03 Microchip Biotechnologies, Inc. Système de préparation d’échantillon universel et utilisation dans un système d’analyse intégré
US9157116B2 (en) 2008-02-08 2015-10-13 Fluidigm Corporation Combinatorial amplification and detection of nucleic acids
KR100952056B1 (ko) * 2008-02-29 2010-04-07 아주대학교산학협력단 기계적 자극에 대한 줄기세포 분화의 최적의 조건을 검출할수 있는 셀-칩 및 이의 자동 제어 시스템
CA2717320A1 (fr) 2008-03-11 2009-09-17 Sequenom, Inc. Tests adn pour determiner le sexe d'un bebe avant sa naissance
US8623294B2 (en) 2008-03-24 2014-01-07 Nec Corporation Flow passage control mechanism for microchip
US8269029B2 (en) 2008-04-08 2012-09-18 The Board Of Trustees Of The University Of Illinois Water repellent metal-organic frameworks, process for making and uses regarding same
EP2280905B1 (fr) 2008-04-11 2016-07-06 Fluidigm Corporation Systèmes et procédés microfluidiques à plusieurs niveaux
US8096784B2 (en) * 2008-04-16 2012-01-17 National Taiwan Ocean University Bi-directional continuous peristaltic micro-pump
US8961902B2 (en) * 2008-04-23 2015-02-24 Bioscale, Inc. Method and apparatus for analyte processing
MX2010012213A (es) 2008-05-08 2011-05-03 Minipumps Llc Bombas implantables y cánulas para las mismas.
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
US8231609B2 (en) 2008-05-08 2012-07-31 Minipumps, Llc Drug-delivery pumps and methods of manufacture
WO2009139898A2 (fr) 2008-05-16 2009-11-19 President And Fellows Of Harvard College Vannes et autre régulation du débit dans des systèmes fluidiques incluant des systèmes microfluidiques
TWI350891B (en) * 2008-05-27 2011-10-21 Ying Chyi Chou Omnibus quasi-hydrosystem
US7999257B2 (en) * 2008-06-02 2011-08-16 Taiwan Semiconductor Manufacturing Company, Ltd. Process for eliminating delamination between amorphous silicon layers
DE102008002336A1 (de) 2008-06-10 2009-12-24 Robert Bosch Gmbh Quetschventil und Verfahren zu dessen Herstellung
JP2011525166A (ja) * 2008-06-13 2011-09-15 エメラルド バイオストラクチャーズ， インコーポレイテッド ナノ体積マイクロキャピラリー結晶化システム
US20100209957A1 (en) * 2008-06-20 2010-08-19 Genvault Corporation Biosample storage devices and methods of use thereof
US20090314368A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Microfluidic System Comprising Pinch Valve and On-Chip MEMS Pump
US20090315126A1 (en) * 2008-06-20 2009-12-24 Silverbrook Research Pty Ltd Bonded Microfluidic System Comprising Thermal Bend Actuated Valve
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010004721A1 (fr) * 2008-07-08 2010-01-14 パナソニック株式会社 Dispositif de transport de fluide faisant intervenir un polymère conducteur de l'électricité
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
EP2143492A1 (fr) * 2008-07-11 2010-01-13 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Procédé et dispositif microfluide pour associer des composants de réaction contenus dans des liquides
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
EP2315629B1 (fr) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Bibliothèque de gouttelettes
US7976789B2 (en) * 2008-07-22 2011-07-12 The Board Of Trustees Of The University Of Illinois Microfluidic device for preparing mixtures
WO2010011852A1 (fr) 2008-07-25 2010-01-28 Fluidigm Corporation Procédé et système de fabrication de puces fluidiques intégrées
US8617488B2 (en) 2008-08-07 2013-12-31 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
DE102008038462B4 (de) * 2008-08-20 2010-06-17 Advanced Display Technology Ag Vorrichtung zur fluidischen Anzeige und Verfahren dazu
US20100059120A1 (en) * 2008-09-11 2010-03-11 General Electric Company Microfluidic device and methods for droplet generation and manipulation
WO2010031007A2 (fr) 2008-09-12 2010-03-18 Genvault Corporation Matrices et support pour le stockage et la stabilisation de biomolécules
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
EP3103871B1 (fr) 2008-09-16 2020-07-29 Sequenom, Inc. Procédés pour l'enrichissiment en acide nucleic fétal d'un échantillon maternel, basé sur la méthylation et utilisation pour la quantification de l'acide nucleique fétal
US8476013B2 (en) * 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8082810B2 (en) * 2008-09-29 2011-12-27 Ysi Incorporated Microfluidic elastic micro-aliquotter
US20100093098A1 (en) * 2008-10-14 2010-04-15 Siemens Medical Solutions Nonflow-through appratus and mehod using enhanced flow mechanisms
US20100102261A1 (en) * 2008-10-28 2010-04-29 Microfluidic Systems, Inc. Microfluidic valve mechanism
DK2376226T3 (en) 2008-12-18 2018-10-15 Opko Diagnostics Llc IMPROVED REAGENT STORAGE IN MICROFLUIDIC SYSTEMS AND RELATED ARTICLES AND PROCEDURES
JP4824743B2 (ja) * 2008-12-26 2011-11-30 アイダエンジニアリング株式会社 マイクロ流路チップ
EP2384429A1 (fr) 2008-12-31 2011-11-09 Integenx Inc. Instrument doté d'une puce microfluidique
US8058630B2 (en) * 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
EP3722810A3 (fr) 2009-02-11 2021-01-13 Caris MPI, Inc. Profilage moléculaire de tumeurs
US8989230B2 (en) 2009-02-20 2015-03-24 Vixar Method and apparatus including movable-mirror mems-tuned surface-emitting lasers
US9700038B2 (en) 2009-02-25 2017-07-11 Genea Limited Cryopreservation of biological cells and tissues
EP2408936A4 (fr) * 2009-03-18 2013-01-30 Sequenom Inc Utilisation d'endonucléases thermostables pour générer des molécules rapporteuses
EP2411148B1 (fr) 2009-03-23 2018-02-21 Raindance Technologies, Inc. Manipulation de gouttelettes microfluidiques
AU2010232439C1 (en) 2009-04-02 2017-07-13 Fluidigm Corporation Multi-primer amplification method for barcoding of target nucleic acids
EP3514244B1 (fr) 2009-04-03 2021-07-07 Sequenom, Inc. Procédés de préparation d'acides nucléiques
EP2239793A1 (fr) 2009-04-11 2010-10-13 Bayer MaterialScience AG Montage de film polymère électrique commutable et son utilisation
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
DE102009023430B4 (de) * 2009-05-29 2013-07-25 Siemens Aktiengesellschaft Vorrichtung und Verfahren zum Steuern von Fluidströmen in Lab-on-a-Chip-Systemen sowie Verfahren zum Herstellen der Vorrichtung
DE102009023429B4 (de) 2009-05-29 2013-08-14 Siemens Aktiengesellschaft Ventil für Lab-on-a-Chip-Systeme, Verfahren zum Betätigen und zur Herstellung des Ventils
CN102459565A (zh) 2009-06-02 2012-05-16 尹特根埃克斯有限公司 具有隔膜阀的流控设备
GB2483402B (en) 2009-06-04 2014-04-09 Lockheed Corp Multiple-sample microfluidic chip for DNA analysis
RU2559541C2 (ru) 2009-06-05 2015-08-10 Интедженкс Инк. Универсальная система подготовки образцов и применение в интегрированной системе анализа
US8623288B1 (en) 2009-06-29 2014-01-07 Nanosys, Inc. Apparatus and methods for high density nanowire growth
US8551787B2 (en) 2009-07-23 2013-10-08 Fluidigm Corporation Microfluidic devices and methods for binary mixing
JP5758388B2 (ja) 2009-08-18 2015-08-05 ミニパンプス， エルエルシー 適応制御を有する電解質薬物送達ポンプ
KR101274113B1 (ko) * 2009-09-01 2013-06-13 한국전자통신연구원 금속볼을 이용한 자기력 마이크로밸브 및 그 제조방법
JP5869482B2 (ja) 2009-09-02 2016-02-24 プレジデント アンド フェローズ オブ ハーバード カレッジ ジェッティングおよび他の技術を使用して生成された多重エマルジョン
SG169918A1 (en) 2009-10-02 2011-04-29 Fluidigm Corp Microfluidic devices with removable cover and methods of fabrication and application
KR101252829B1 (ko) * 2009-10-06 2013-04-11 한국전자통신연구원 단일세포 분주용 어레이 장치
EP2486409A1 (fr) 2009-10-09 2012-08-15 Universite De Strasbourg Nanomatériau marqué à base de silice à propriétés améliorées et ses utilisations
WO2011056688A2 (fr) 2009-10-27 2011-05-12 Caris Life Sciences, Inc. Profilage moléculaire pour médecine personnalisée
US8145114B2 (en) 2009-10-29 2012-03-27 Eastman Kodak Company Digital manufacture of a microfluidic device
US20110143378A1 (en) * 2009-11-12 2011-06-16 CyVek LLC. Microfluidic method and apparatus for high performance biological assays
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
JP5701894B2 (ja) 2009-11-23 2015-04-15 サイヴェク・インコーポレイテッド アッセイを行う方法及び装置
WO2013134741A2 (fr) 2012-03-08 2013-09-12 Cyvek, Inc. Procédés et systèmes de fabrication de systèmes d'analyse de microréseaux, de mise en oeuvre d'analyses microfluidiques, et de surveillance et de balayage pour obtenir des résultats d'analyse microfluidique
US10022696B2 (en) 2009-11-23 2018-07-17 Cyvek, Inc. Microfluidic assay systems employing micro-particles and methods of manufacture
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
WO2011066588A1 (fr) 2009-11-30 2011-06-03 Fluidigm Corporation Régénération d'un dispositif microfluidique
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
IT1397819B1 (it) * 2009-12-17 2013-02-04 Silicon Biosystems Spa Sistema microfluidico
ES2577017T3 (es) 2009-12-22 2016-07-12 Sequenom, Inc. Procedimientos y kits para identificar la aneuploidia
US10837883B2 (en) 2009-12-23 2020-11-17 Bio-Rad Laboratories, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
CN102740976B (zh) 2010-01-29 2016-04-20 精密公司 取样-应答微流体盒
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US8535889B2 (en) 2010-02-12 2013-09-17 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
JP5808349B2 (ja) 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー セラノーシスのためのバイオマーカー
KR101177981B1 (ko) * 2010-03-04 2012-08-28 전북대학교산학협력단 3차원 나선형 액추에이터의 제조방법
IT1399361B1 (it) * 2010-03-31 2013-04-16 Milano Politecnico Metodo per la realizzazione di un dispositivo microfluidico e dispositivo derivante dallo stesso
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
WO2011134038A1 (fr) 2010-04-26 2011-11-03 National Research Council Of Canada Vanne micro-fluidique fermée de façon semi-permanente
US9267618B2 (en) 2010-05-18 2016-02-23 Samsung Electronics Co., Ltd. Microvalve device and method of manufacturing the same
US9374995B2 (en) 2010-05-28 2016-06-28 Genea Limited Micromanipulation and storage apparatus and methods
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
KR20110136629A (ko) * 2010-06-15 2011-12-21 삼성전자주식회사 마이크로 밸브를 갖는 미세 유체 소자
WO2011159246A1 (fr) * 2010-06-18 2011-12-22 Myfc Ab Soupape actionnée de façon électrochimique
GB2481425A (en) 2010-06-23 2011-12-28 Iti Scotland Ltd Method and device for assembling polynucleic acid sequences
US9125655B2 (en) 2010-07-16 2015-09-08 California Institute Of Technology Correction and optimization of wave reflection in blood vessels
US8763642B2 (en) 2010-08-20 2014-07-01 Integenx Inc. Microfluidic devices with mechanically-sealed diaphragm valves
EP2606154B1 (fr) 2010-08-20 2019-09-25 Integenx Inc. Système d'analyse intégrée
EP3447155A1 (fr) 2010-09-30 2019-02-27 Raindance Technologies, Inc. Dosages en sandwich dans des gouttelettes
US8961764B2 (en) 2010-10-15 2015-02-24 Lockheed Martin Corporation Micro fluidic optic design
US9353406B2 (en) 2010-10-22 2016-05-31 Fluidigm Corporation Universal probe assay methods
DE102010051743B4 (de) 2010-11-19 2022-09-01 C. Miethke Gmbh & Co. Kg Programmierbares Hydrocephalusventil
EP3859011A1 (fr) 2011-02-11 2021-08-04 Bio-Rad Laboratories, Inc. Procédés permettant de former des gouttelettes mélangées
WO2012112804A1 (fr) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions et méthodes de marquage moléculaire
KR20120096175A (ko) * 2011-02-22 2012-08-30 엘지전자 주식회사 태양전지 모듈용 프레임 시스템
US9553254B2 (en) 2011-03-01 2017-01-24 Parker-Hannifin Corporation Automated manufacturing processes for producing deformable polymer devices and films
CN103703404A (zh) 2011-03-22 2014-04-02 拜耳知识产权有限责任公司 电活化聚合物致动器双凸透镜系统
JP5978287B2 (ja) 2011-03-22 2016-08-24 サイヴェク・インコーポレイテッド マイクロ流体装置並びに製造及び使用の方法
US9168531B2 (en) 2011-03-24 2015-10-27 Fluidigm Corporation Method for thermal cycling of microfluidic samples
WO2012142516A1 (fr) 2011-04-15 2012-10-18 Becton, Dickinson And Company Thermocycleur microfluidique en temps réel à balayage et procédés synchronisés de thermocyclage et de détection optique à balayage
WO2012145301A2 (fr) * 2011-04-20 2012-10-26 California Institute Of Technology Systèmes microfluidiques de carte de circuits imprimés monocouche
EP3378954B1 (fr) 2011-04-29 2021-02-17 Sequenom, Inc. Quantification d'une minorité d'espèces d'acide nucléique
US8857275B2 (en) 2011-05-02 2014-10-14 California Institute Of Technology NEMS sensors for cell force application and measurement
EP3081301B1 (fr) 2011-05-04 2019-08-14 Luminex Corporation Appareil et procédé pour la préparation, la réaction et la détection intégrées d'échantillons
CN108342453A (zh) 2011-05-09 2018-07-31 富鲁达公司 基于探针的核酸检测
US9644231B2 (en) 2011-05-09 2017-05-09 Fluidigm Corporation Nucleic acid detection using probes
WO2012162296A2 (fr) 2011-05-23 2012-11-29 President And Fellows Of Harvard College Génération d'émulsions et, notamment, d'émulsions multiples
JP4934750B1 (ja) * 2011-05-31 2012-05-16 株式会社メトラン ポンプユニット、呼吸補助装置
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
EP3216872B1 (fr) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Quantification d'enzyme
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
CN103764265A (zh) 2011-07-06 2014-04-30 哈佛学院院长等 多重乳剂和用于配制多重乳剂的技术
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US9088134B2 (en) 2011-07-27 2015-07-21 Vixar Inc. Method and apparatus including improved vertical-cavity surface-emitting lasers
ES2825905T3 (es) 2011-09-30 2021-05-17 Becton Dickinson Co Tira reactiva unificada
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US8894946B2 (en) 2011-10-21 2014-11-25 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
EP2773892B1 (fr) 2011-11-04 2020-10-07 Handylab, Inc. Dispositif de préparation d'échantillons de polynucléotides
WO2013072790A1 (fr) 2011-11-16 2013-05-23 International Business Machines Corporation Dispositif microfluidique à clapet déformable
BR112014018995B1 (pt) 2012-02-03 2021-01-19 Becton, Dickson And Company sistemas para executar ensaio automatizado
EP2834425A4 (fr) * 2012-02-21 2016-05-11 Fluidigm Corp Procédé et systèmes pour des dispositifs logiques microfluidiques
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
FR2987282B1 (fr) 2012-02-24 2017-12-29 Fonds De L'espci Georges Charpak Microcanal avec dispositif d'ouverture et/ou fermeture et/ou pompage
CN104350374B (zh) 2012-02-29 2018-04-27 富鲁达公司 用于使用微流体的多个单细胞捕获和处理的方法、系统和设备
EP4155401A1 (fr) 2012-03-02 2023-03-29 Sequenom, Inc. Méthodes et procédés d'évaluation non invasive de variations génétiques
US9373427B2 (en) 2012-03-05 2016-06-21 Empire Technology Development Llc Flexible circuits
EP2847249A4 (fr) 2012-03-14 2016-12-28 Medipacs Inc Matériaux polymères intelligents contenant un excès de molécules réactives
EP2828901B1 (fr) 2012-03-21 2017-01-04 Parker Hannifin Corporation Procédés de fabrication de rouleau à rouleau pour la production de dispositifs à polymère électroactif autoréparant
US20150050172A1 (en) * 2012-03-26 2015-02-19 Alere San Diego, Inc. Microfluidic pump
EP3342380A3 (fr) 2012-03-26 2018-11-14 Glaukos Corporation Système et procédé pour distribuer de multiples implants oculaires
WO2013149186A1 (fr) 2012-03-30 2013-10-03 Insulet Corporation Dispositif d'administration de fluide avec outil d'accès transcutané, mécanisme d'insertion et contrôle de glycémie destine à être utilisé avec le dispositif
AU2013204332B2 (en) 2012-04-16 2015-07-16 Commonwealth Scientific And Industrial Research Organisation Methods and systems for detecting an analyte or classifying a sample
US9238833B2 (en) 2012-04-17 2016-01-19 California Institute Of Technology Thermally controlled chamber with optical access for high-performance PCR
US9080941B2 (en) 2012-04-27 2015-07-14 General Electric Company Microfluidic flow cell assemblies for imaging and method of use
US9150907B2 (en) 2012-04-27 2015-10-06 General Electric Company Microfluidic flow cell assemblies and method of use
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
EP2852682B1 (fr) 2012-05-21 2017-10-04 Fluidigm Corporation Analyse de particules uniques de populations de particules
US9761790B2 (en) 2012-06-18 2017-09-12 Parker-Hannifin Corporation Stretch frame for stretching process
US20140004105A1 (en) 2012-06-29 2014-01-02 Sequenom, Inc. Age-related macular degeneration diagnostics
CA2878979C (fr) 2012-07-13 2021-09-14 Sequenom, Inc. Procedes et compositions pour enrichissement base sur la methylation en acide nucleique foetal dans un echantillon maternel, utiles pour les diagnostics prenatals non invasifs
US8519644B1 (en) * 2012-08-15 2013-08-27 Transmute, Inc. Accelerator having acceleration channels formed between covalently bonded chips
US20150247790A1 (en) * 2012-09-14 2015-09-03 President And Fellows Of Harvard College Microfluidic Assisted Cell Screening
GB2506630A (en) * 2012-10-04 2014-04-09 Univ Leiden Method and apparatus for processing a liquid
WO2014055790A2 (fr) 2012-10-04 2014-04-10 Sequenom, Inc. Procédés et processus d'évaluation non invasive de variations génétiques
WO2014062719A2 (fr) 2012-10-15 2014-04-24 Nanocellect Biomedical, Inc. Systèmes, appareil et procédés de tri de particules
EP4170031A1 (fr) 2012-10-23 2023-04-26 Caris Science, Inc. Aptamères et leurs utilisations
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
US9590193B2 (en) 2012-10-24 2017-03-07 Parker-Hannifin Corporation Polymer diode
US9857333B2 (en) 2012-10-31 2018-01-02 Berkeley Lights, Inc. Pens for biological micro-objects
US9233225B2 (en) 2012-11-10 2016-01-12 Curvo Medical, Inc. Coaxial bi-directional catheter
US9549666B2 (en) 2012-11-10 2017-01-24 Curvo Medical, Inc. Coaxial micro-endoscope
US20140142438A1 (en) * 2012-11-19 2014-05-22 Biosense Webster (Israel), Ltd. Using location and force measurements to estimate tissue thickness
WO2014100434A1 (fr) 2012-12-19 2014-06-26 Caris Science, Inc. Compositions et procédés pour le criblage d'aptamères
WO2014100732A1 (fr) 2012-12-21 2014-06-26 Micronics, Inc. Circuits fluidiques et procédés de fabrication associés
EP3549674B1 (fr) 2012-12-21 2020-08-12 PerkinElmer Health Sciences, Inc. Films à faible élasticité pour utilisation micro-fluidique
KR20150097764A (ko) 2012-12-21 2015-08-26 마이크로닉스 인코포레이티드. 휴대형 형광 검출 시스템 및 미량분석 카트리지
CA2897219C (fr) 2013-01-07 2021-10-19 Genea Limited Procede, systeme et appareil destines a une micromanipulation et a un stockage ameliores
US20150352752A1 (en) * 2013-01-16 2015-12-10 General Electric Company An aqueous -solvent based process for continuous manufacturing of supported ion selective membranes
US9863542B2 (en) 2013-02-01 2018-01-09 Swagelok Company Diaphragm valve with welded diaphragm seat carrier
DE102013202623A1 (de) * 2013-02-19 2014-08-21 Robert Bosch Gmbh Ventil mit verbesserter Kaltstartfähigkeit
EP2971100A1 (fr) 2013-03-13 2016-01-20 Sequenom, Inc. Amorces pour analyse de la méthylation de l'adn
US9039993B2 (en) 2013-03-14 2015-05-26 Formulatrix, Inc. Microfluidic device
US9163277B2 (en) 2013-03-14 2015-10-20 Formulatrix, Inc. Microfluidic device
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
JP2016521350A (ja) 2013-03-15 2016-07-21 フリューダイム・コーポレイション 規定された多細胞の組み合わせの分析のための方法および装置
WO2014182831A1 (fr) 2013-05-07 2014-11-13 Micronics, Inc. Procédés de préparation d'échantillons d'acides nucléiques faisant appel à des minéraux argileux et à des solutions alcalines
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
WO2014182847A1 (fr) 2013-05-07 2014-11-13 Micronics, Inc. Dispositif pour la préparation et l'analyse d'acides nucléiques
ITTO20130447A1 (it) * 2013-05-31 2014-12-01 St Microelectronics Srl Valvola microfluidica a membrana e procedimento per fabbricare una valvola microfluidica a membrana
JP2016533752A (ja) 2013-08-28 2016-11-04 カリス ライフ サイエンシズ スウィッツァーランド ホー オリゴヌクレオチドプローブおよびその使用
WO2015050998A2 (fr) 2013-10-01 2015-04-09 The Broad Institute, Inc. Crépines, circuits microfluidiques, dispositifs microfluidiques et procédé d'isolement d'analyte
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US10136636B2 (en) 2013-10-15 2018-11-27 The Regents Of The University Of Michigan Vitrification of biological material
IL283153B2 (en) 2013-10-22 2023-04-01 Berkeley Lights Inc Microfluidic devices with isolation pens and methods for testing microbiological items using them
US9889445B2 (en) 2013-10-22 2018-02-13 Berkeley Lights, Inc. Micro-fluidic devices for assaying biological activity
SG11201602336UA (en) 2013-10-22 2016-05-30 Berkeley Lights Inc Micro-fluidic devices for assaying biological activity
WO2015073999A1 (fr) 2013-11-18 2015-05-21 Integenx Inc. Cartouches et instruments pour l'analyse d'échantillons
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
WO2015103367A1 (fr) 2013-12-31 2015-07-09 Raindance Technologies, Inc. Système et procédé de détection d'une espèce d'arn
US10344753B2 (en) 2014-02-28 2019-07-09 Encite Llc Micro pump systems
US11365447B2 (en) 2014-03-13 2022-06-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2015148808A1 (fr) 2014-03-26 2015-10-01 Zhenyu Li Systèmes et procédés de manipulation de fluides portatifs
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
JP6655610B2 (ja) 2014-05-29 2020-02-26 グローコス コーポレーション 制御された薬物送達機能を備えるインプラント及びそれを使用する方法
US10081816B1 (en) 2014-07-03 2018-09-25 Nant Holdings Ip, Llc Mechanical transfection devices and methods
US10760040B1 (en) * 2014-07-03 2020-09-01 NanoCav, LLC Mechanical transfection devices and methods
CN113092563B (zh) 2014-10-22 2024-06-07 尹特根埃克斯有限公司 用于样品制备、处理和分析的系统和方法
US10330095B2 (en) 2014-10-31 2019-06-25 Encite Llc Microelectromechanical systems fabricated with roll to roll processing
EP3229961B1 (fr) 2014-12-08 2019-11-13 Berkeley Lights, Inc. Structures microfluidiques actionnées pour un flux dirigé dans un dispositif microfluidique et procédés d'utilisation de celles-ci
EP3230718B1 (fr) * 2014-12-09 2022-03-02 Berkeley Lights, Inc. Détection automatisée de zones d'analyse positives ou de quantités d'analytes dans des dispositifs microfluidiques
WO2016145128A1 (fr) 2015-03-09 2016-09-15 Caris Science, Inc. Sondes oligonucléotidiques et utilisations de celles-ci
CA3176115A1 (fr) 2015-04-22 2016-10-27 Berkeley Lights, Inc. Dispositif microfluidique pour la culture de cellules biologiques et methodes d'utilisation connexes
WO2016172623A1 (fr) 2015-04-22 2016-10-27 Berkeley Lights, Inc. Manipulation de noyaux cellulaires dans un dispositif microfluidique
NL2014801B1 (en) * 2015-05-13 2017-01-27 Berkin Bv Fluid flow device, comprising a valve unit, as well as method of manufacturing the same.
US9907210B2 (en) * 2015-06-25 2018-02-27 International Business Machines Corporation Active perforation for advanced server cooling
US10136563B2 (en) 2015-06-25 2018-11-20 International Business Machines Corporation Active perforation for advanced server cooling
AU2016287499B2 (en) 2015-06-29 2022-08-04 Caris Science, Inc. Therapeutic oligonucleotides
US9956557B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: microwell plate interface
US9956558B2 (en) 2015-07-24 2018-05-01 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: homogeneous assays
US9733239B2 (en) 2015-07-24 2017-08-15 HJ Science & Technology, Inc. Reconfigurable microfluidic systems: scalable, multiplexed immunoassays
CA2993652A1 (fr) 2015-07-28 2017-02-02 Caris Science, Inc. Oligonucleotides cibles
WO2017040856A1 (fr) * 2015-09-01 2017-03-09 The Regents Of The Univesity Of California Guide d'ondes optique à micro-vanne reconfigurable
US11925578B2 (en) 2015-09-02 2024-03-12 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US10598166B2 (en) 2015-09-09 2020-03-24 Massachusetts Institute Of Technology Atherofluidics-on-chip
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
JP7296210B2 (ja) 2015-11-23 2023-06-22 バークレー ライツ，インコーポレイテッド インサイチュー生成マイクロ流体分離構造、そのキット、及びその使用方法
CN105258738B (zh) * 2015-11-26 2018-01-30 黑龙江大学 一种压力/二维磁场单片集成传感器
US10203604B2 (en) 2015-11-30 2019-02-12 Applied Materials, Inc. Method and apparatus for post exposure processing of photoresist wafers
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
SG11201804275TA (en) 2015-12-08 2018-06-28 Berkeley Lights Inc Microfluidic devices and kits and methods for use thereof
CN108698814A (zh) 2015-12-30 2018-10-23 伯克利之光生命科技公司 用于光学驱动的对流和移位的微流体设备、试剂盒及其方法
US10857536B2 (en) 2016-01-08 2020-12-08 Hewlett-Packard Development Company, L.P. Polymerase chain reaction device
CN105510101B (zh) * 2016-01-28 2018-02-13 哈尔滨理工大学 一种用于研究干式空心电抗器匝间绝缘老化过程的试样的制作方法及片状试样
WO2017160991A1 (fr) 2016-03-16 2017-09-21 Lavieu Gregory G Procédés, systèmes et dispositifs pour la sélection et la génération de clones résultant d'une édition génomique
EP3922716A1 (fr) 2016-03-17 2021-12-15 Berkeley Lights, Inc. Sélection et clonage de lymphocytes t dans un dispositif microfluidique
US10731166B2 (en) 2016-03-18 2020-08-04 Caris Science, Inc. Oligonucleotide probes and uses thereof
KR102038116B1 (ko) * 2016-03-21 2019-12-02 주식회사 엘지화학 플렉서블 디스플레이용 보호 필름
CA3020976A1 (fr) 2016-04-15 2017-10-19 Berkeley Lights, Inc. Procedes, systemes et kits pour dosages in pen
US11318043B2 (en) 2016-04-20 2022-05-03 Dose Medical Corporation Bioresorbable ocular drug delivery device
CA3025486A1 (fr) 2016-05-25 2017-11-30 Caris Science, Inc. Sondes oligonucleotidiques et utilisations de celles-ci
SG11201809539RA (en) 2016-05-26 2018-12-28 Berkeley Lights Inc Covalently modified surfaces, kits, and methods of preparation and use
US11454563B2 (en) * 2016-08-05 2022-09-27 Encite Llc Micro pressure sensor
WO2018035051A1 (fr) 2016-08-14 2018-02-22 Insulet Corporation Dispositif d'administration de médicament avec détection de position du piston
WO2018051242A1 (fr) 2016-09-14 2018-03-22 Ecole Polytechnique Federale De Lausanne (Epfl) Dispositif destiné à des études à haut débit de cellules uniques
WO2018067645A1 (fr) 2016-10-07 2018-04-12 Insulet Corporation Système d'administration à plusieurs étages
US10780217B2 (en) 2016-11-10 2020-09-22 Insulet Corporation Ratchet drive for on body delivery system
AU2017358067B2 (en) 2016-11-14 2024-04-18 PPB Technology Pty Ltd Protease sensor molecules
CN106767551A (zh) * 2016-11-18 2017-05-31 合肥工业大学 一种微纳米测量设备用高精度高灵敏弹性簧片的制作方法
AT15707U1 (de) * 2016-11-18 2018-04-15 Secop Gmbh Kältemittelkompressor
US10767742B2 (en) * 2016-12-08 2020-09-08 Ford Global Technologies, Llc Transaxle having chain final drive
US10732712B2 (en) 2016-12-27 2020-08-04 Facebook Technologies, Llc Large scale integration of haptic devices
TWI621794B (zh) * 2017-01-05 2018-04-21 研能科技股份有限公司 流體控制裝置
WO2018136699A1 (fr) 2017-01-19 2018-07-26 Insulet Corporation Réduction du volume de rétention de cartouche
US10695485B2 (en) 2017-03-07 2020-06-30 Insulet Corporation Very high volume user filled drug delivery device
US11982611B2 (en) 2017-03-20 2024-05-14 Nanocellect Biomedical, Inc. Systems, apparatuses, and methods for cell sorting and flow cytometry
JP6992079B2 (ja) 2017-04-23 2022-01-13 ヒューレット－パッカード デベロップメント カンパニー エル．ピー． 粒子分離
US11946035B2 (en) 2017-05-16 2024-04-02 The Regents Of The University Of California Microfluidic-enabled multiwell cell culture devices and systems for precision culture, control and monitoring of living cells
WO2018226876A1 (fr) 2017-06-06 2018-12-13 The Regents Of The University Of California Systèmes et procédés de génération rapide de banques de gouttelettes
AU2018304543A1 (en) 2017-07-21 2020-02-13 Berkeley Lights, Inc. Antigen-presenting synthetic surfaces, covalently functionalized surfaces, activated T cells, and uses thereof
US10973978B2 (en) 2017-08-03 2021-04-13 Insulet Corporation Fluid flow regulation arrangements for drug delivery devices
EP4375504A3 (fr) 2017-08-03 2024-06-26 Insulet Corporation Pompe à micro-piston
KR102660777B1 (ko) 2017-08-08 2024-04-24 커먼웰쓰 사이언티픽 앤드 인더스트리얼 리서치 오가니제이션 탄수화물 센서
WO2019046690A1 (fr) * 2017-09-01 2019-03-07 Complete Genomics, Inc. Une cartouche microfluidique/fluidique moulée par injection intégrée avec capteur à base de silicium
US11786668B2 (en) 2017-09-25 2023-10-17 Insulet Corporation Drug delivery devices, systems, and methods with force transfer elements
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
WO2019075476A2 (fr) 2017-10-15 2019-04-18 Berkeley Lights, Inc. Procédés, systèmes et kits pour essais « en enclos »
US11046575B2 (en) 2017-10-31 2021-06-29 Encite Llc Broad range micro pressure sensor
US20190142111A1 (en) * 2017-11-10 2019-05-16 Head Technology Gmbh Liner for sports shoes
JPWO2019092989A1 (ja) * 2017-11-10 2020-10-01 Nok株式会社 マイクロ流体チップおよびマイクロ流体デバイス
WO2019103729A1 (fr) 2017-11-22 2019-05-31 Hewlett-Packard Development Company, L.P. Dispositifs microfluidiques à couvercle de chargement de fluide
WO2019116306A1 (fr) 2017-12-13 2019-06-20 Ecole Polytechnique Federale De Lausanne (Epfl) Système de capture ou d'immunoprécipitation d'un complexe protéine-adn
US11154864B2 (en) 2018-01-17 2021-10-26 Qiagen Sciences, Llc Microfluidic device with vented microchambers
WO2019169060A1 (fr) * 2018-03-02 2019-09-06 President And Fellows Of Harvard College Dispositifs et techniques microfluidiques en couches
JP7452927B2 (ja) 2018-03-02 2024-03-19 ナショナル リサーチ カウンシル オブ カナダ 高分子マイクロ流体バルブ
EP3774047A1 (fr) 2018-03-29 2021-02-17 Yeda Research and Development Co. Ltd Utilisation de gradients de champ électrique pour commander l'expression génique
DE102018107585B3 (de) * 2018-03-29 2019-03-28 Universität Rostock Vorrichtung zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen mit Wirkstoffdepots, sowie Verfahren zur Herstellung von 3D-gedruckten Wirkstofffreisetzungssystemen
DE102018109314A1 (de) * 2018-04-19 2019-10-24 Eisenhuth Gmbh & Co. Kg Elektrochemischer Fällungsreaktor mit bewegter Elektrode
EP3787795A4 (fr) 2018-04-30 2022-01-26 Protein Fluidics, Inc. Puce d'écoulement de commutation fluidique sans valve et ses utilisations
US10874803B2 (en) 2018-05-31 2020-12-29 Insulet Corporation Drug cartridge with drive system
CA3100701A1 (fr) 2018-05-31 2019-12-05 Berkeley Lights, Inc. Detection et caracterisation automatiques de micro-objets dans des dispositifs microfluidiques
US11229736B2 (en) 2018-06-06 2022-01-25 Insulet Corporation Linear shuttle pump for drug delivery
WO2020018687A1 (fr) 2018-07-17 2020-01-23 Insulet Corporation Éléments semi-rigides et souples pour réservoir de dispositif d'administration de médicament portable
US10611995B2 (en) 2018-08-15 2020-04-07 Deepcell, Inc. Systems and methods for particle analysis
US11815507B2 (en) 2018-08-15 2023-11-14 Deepcell, Inc. Systems and methods for particle analysis
CN108843855B (zh) * 2018-08-31 2024-03-12 湖南乐准智芯生物科技有限公司 一种微流控系统及常闭微阀、控制方法
EP3847280A1 (fr) 2018-09-07 2021-07-14 Sequenom, Inc. Procédés et systèmes pour détecter un rejet de greffe
BR112020026480A2 (pt) 2018-11-16 2021-05-18 Illumina, Inc. aparelho e método de circuito fluídico laminado para um cartucho de fluido
WO2020113006A1 (fr) 2018-11-28 2020-06-04 Insulet Corporation Système de pompe à navette d'administration de médicament et ensemble soupape
WO2020113237A1 (fr) 2018-11-30 2020-06-04 Caris Mpi, Inc. Profilage moléculaire de nouvelle génération
CN109718875B (zh) * 2018-12-24 2021-08-24 东南大学 一种基于pdms微流体结构上集成聚氨酯薄膜的方法
CA3128894A1 (fr) 2019-02-19 2020-08-27 Sequenom, Inc. Compositions, procedes et systemes pour detecter un etat de transplantation de cellules souches hematopoietiques
DE102019105191A1 (de) * 2019-02-28 2020-09-03 Prominent Gmbh Verdrängerpumpe mit strömungsbegünstigten Oberflächen
USD919833S1 (en) 2019-03-06 2021-05-18 Princeton Biochemicals, Inc Micro valve for controlling path of fluids in miniaturized capillary connections
CN116174068A (zh) 2019-04-30 2023-05-30 伯克利之光生命科技公司 用于包封和测定细胞的方法
WO2020263234A1 (fr) 2019-06-25 2020-12-30 Hewlett-Packard Development Company, L.P. Structures moulées pourvues de canaux
AU2020329166A1 (en) 2019-08-09 2022-03-03 Nutcracker Therapeutics, Inc. Microfluidic apparatus and methods of use thereof
IL269674B (en) 2019-09-25 2020-08-31 Roy Bar Ziv Assembling protein complexes on a chip
GB2604481A (en) 2019-10-10 2022-09-07 1859 Inc Methods and systems for microfluidic screening
CN110586216A (zh) * 2019-10-16 2019-12-20 陕西优博特生物科技有限公司 一种用于微控流芯片实验的试样采加样系统
US11369735B2 (en) 2019-11-05 2022-06-28 Insulet Corporation Component positioning of a linear shuttle pump
CA3157134A1 (fr) 2019-11-07 2021-05-14 Renjith MENON Prelevement de salive et systeme de test
CA3157616A1 (fr) 2019-11-17 2021-05-20 Darshan THAKER Systemes et procedes pour analyses d'echantillons biologiques
WO2021112918A1 (fr) 2019-12-02 2021-06-10 Caris Mpi, Inc. Prédicteur de réponse au platine dans une approche pan-cancer
EP3845790B1 (fr) * 2019-12-30 2024-04-17 Imec VZW Dispositif microfluidique pour commander des microvalves pneumatiques
EP4090464A1 (fr) 2020-01-17 2022-11-23 F. Hoffmann-La Roche AG Dispositif microfluidique et procédé de synthèse automatisée par division de groupe
WO2021148488A2 (fr) 2020-01-22 2021-07-29 F. Hoffmann-La Roche Ag Dispositifs microfluidiques de piégeage de billes et procédés de préparation de banque de séquences de nouvelle génération
EP4110953A2 (fr) 2020-02-28 2023-01-04 Laboratory Corporation of America Holdings Compositions, méthodes et systèmes de détermination de paternité
JP7477378B2 (ja) * 2020-06-19 2024-05-01 シスメックス株式会社 粒子ソーター、粒子分取方法およびマイクロ流路カートリッジ
CN116490239A (zh) 2020-11-09 2023-07-25 敏捷设备有限公司 用于操纵导管的装置
CN112452365B (zh) * 2020-11-23 2021-12-07 无锡市夸克微智造科技有限责任公司 微加工流体装置
WO2023035003A1 (fr) 2021-09-03 2023-03-09 Elegen Corp. Dispositifs de tri par billes à voies multiples, systèmes et procédés d'utilisation de ceux-ci au moyen de sources de pression
DE102022107894A1 (de) * 2022-04-01 2023-10-05 Eberhard Karls Universität Tübingen, Körperschaft des öffentlichen Rechts Verfahren zum Herstellen eines Reaktors, Reaktoren und Anordnungen
WO2023196802A1 (fr) 2022-04-04 2023-10-12 The Broad Institute, Inc. Variantes de cas9 ayant des spécificités pam non canoniques et leurs utilisations
USD1024314S1 (en) 2022-06-01 2024-04-23 Insulet Corporation Automated drug delivery device
WO2023238132A1 (fr) 2022-06-07 2023-12-14 Yeda Research And Development Co. Ltd. Dispositif microfluidique d'analyse des réactions biologiques à l'état stable
ES2958141A1 (es) * 2022-07-07 2024-02-02 Univ Madrid Carlos Iii Material conductivo autorreparable
CN115445678B (zh) * 2022-08-23 2023-08-01 电子科技大学 一种驱动磁流体水平运动的方法、装置及应用
DE102022132929A1 (de) 2022-12-12 2024-06-13 Gemü Gebr. Müller Apparatebau Gmbh & Co. Kommanditgesellschaft Verfahren, Prozessarmatur, Armaturanordnung

Family Cites Families (220)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US186856A (en) 1877-01-30 Improvement in sheet-metal cans
US499312A (en) * 1893-06-13 Alonzo g
US141503A (en) 1873-08-05 Improvement in treating cotton-seed oil to render it drying
US147199A (en) 1874-02-03 Improvement in revolving horse hay-rakes
US409832A (en) * 1889-08-27 Compound fire-proof column
US2260938A (en) * 1940-06-24 1941-10-28 Standard Railway Equipment Mfg Hatch construction
US2620938A (en) 1949-09-02 1952-12-09 Package Devices Inc Container closure
US3495608A (en) 1967-05-04 1970-02-17 Pitney Bowes Inc Fluidic elements and devices thereof
US3570515A (en) 1969-06-19 1971-03-16 Foxboro Co Aminar stream cross-flow fluid diffusion logic gate
GB1362952A (en) 1970-07-21 1974-08-07 Rasmussen O B Conjugate fibre and method of manufacturing same
NL7102074A (fr) 1971-02-17 1972-08-21
DE2138491B1 (de) * 1971-07-31 1973-02-15 Hoffman-Rheem Maschinen Gmbh, 5000 Koeln Hand Dampf und Bugelplatte
GB1520402A (en) * 1974-07-30 1978-08-09 Mitsubishi Electric Corp Combustion apparatus
FR2287606A1 (fr) 1974-10-08 1976-05-07 Pegourie Jean Pierre Circuits logiques pneumatiques et leurs circuits integres
JPS5941169B2 (ja) * 1975-12-25 1984-10-05 シチズン時計株式会社 エラストマ−ヒヨウジソウチ
US4153655A (en) * 1976-07-23 1979-05-08 Minnick Leonard J Products from molten fly ash and scrubber sludge including fly ash
US4153855A (en) 1977-12-16 1979-05-08 The United States Of America As Represented By The Secretary Of The Army Method of making a plate having a pattern of microchannels
US4245673A (en) 1978-03-01 1981-01-20 La Telemechanique Electrique Pneumatic logic circuit
US4434704A (en) 1980-04-14 1984-03-06 Halliburton Company Hydraulic digital stepper actuator
US4581624A (en) 1984-03-01 1986-04-08 Allied Corporation Microminiature semiconductor valve
US5088515A (en) 1989-05-01 1992-02-18 Kamen Dean L Valve system with removable fluid interface
DE3882011T2 (de) 1987-10-27 1993-09-30 Fujitsu Ltd Verfahren und Vorrichtung zur Herstellung von Biopolymer-Einkristall.
US4852851A (en) * 1987-12-11 1989-08-01 Integrated Fluidics, Inc. Valve with flexible sheet member
US4848722A (en) 1987-12-11 1989-07-18 Integrated Fluidics, Inc. Valve with flexible sheet member
US4898582A (en) 1988-08-09 1990-02-06 Pharmetrix Corporation Portable infusion device assembly
EP0374313B2 (fr) 1988-12-20 1997-07-02 E.I. Du Pont De Nemours And Company Résine de polyester chargée de fibres de verre pur adhésives
US4992312A (en) 1989-03-13 1991-02-12 Dow Corning Wright Corporation Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby
CH679555A5 (fr) 1989-04-11 1992-03-13 Westonbridge Int Ltd
DE3917396A1 (de) 1989-05-29 1990-12-06 Buerkert Gmbh Mikroventil
JPH04501449A (ja) 1989-06-14 1992-03-12 ウエストンブリッジ　インターナショナル　リミティド マイクロポンプ
US5238223A (en) * 1989-08-11 1993-08-24 Robert Bosch Gmbh Method of making a microvalve
JP2555193B2 (ja) * 1989-08-22 1996-11-20 ファナック株式会社 オルダム継手
KR910012538A (ko) 1989-12-27 1991-08-08 야마무라 가쯔미 마이크로 펌프 및 그 제조 방법
DE4006152A1 (de) 1990-02-27 1991-08-29 Fraunhofer Ges Forschung Mikrominiaturisierte pumpe
US6054034A (en) * 1990-02-28 2000-04-25 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5096388A (en) 1990-03-22 1992-03-17 The Charles Stark Draper Laboratory, Inc. Microfabricated pump
US5429856A (en) 1990-03-30 1995-07-04 Minnesota Mining And Manufacturing Company Composite materials and process
SE470347B (sv) * 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Mikrostruktur för vätskeflödessystem och förfarande för tillverkning av ett sådant system
DE69106240T2 (de) 1990-07-02 1995-05-11 Seiko Epson Corp Mikropumpe und Verfahren zur Herstellung einer Mikropumpe.
US5108682A (en) * 1990-07-24 1992-04-28 Bridgestone/Firestone, Inc. Coextrusion apparatus and method using an elastic die for varying the outer profile of a tubular extrudate
US5164558A (en) 1991-07-05 1992-11-17 Massachusetts Institute Of Technology Micromachined threshold pressure switch and method of manufacture
JP3328300B2 (ja) 1991-07-18 2002-09-24 アイシン精機株式会社 流体制御装置
DE4143343C2 (de) 1991-09-11 1994-09-22 Fraunhofer Ges Forschung Mikrominiaturisierte, elektrostatisch betriebene Mikromembranpumpe
US5265327A (en) 1991-09-13 1993-11-30 Faris Sadeg M Microchannel plate technology
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
DE4220077A1 (de) 1992-06-19 1993-12-23 Bosch Gmbh Robert Mikropumpe
US5364742A (en) * 1992-09-21 1994-11-15 International Business Machines Corporation Micro-miniature structures and method of fabrication thereof
JP2812629B2 (ja) 1992-11-25 1998-10-22 宇宙開発事業団 結晶成長セル
US5290240A (en) 1993-02-03 1994-03-01 Pharmetrix Corporation Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid
US5670102A (en) * 1993-02-11 1997-09-23 Minnesota Mining And Manufacturing Company Method of making thermoplastic foamed articles using supercritical fluid
US5387329A (en) 1993-04-09 1995-02-07 Ciba Corning Diagnostics Corp. Extended use planar sensors
US5400741A (en) 1993-05-21 1995-03-28 Medical Foundation Of Buffalo, Inc. Device for growing crystals
EP0700485B1 (fr) 1993-05-27 1997-08-13 Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V. Microvanne
SE501713C2 (sv) * 1993-09-06 1995-05-02 Pharmacia Biosensor Ab Ventil av membrantyp, speciellt för vätskehanteringsblock med mikroflödeskanaler
US5642015A (en) * 1993-07-14 1997-06-24 The University Of British Columbia Elastomeric micro electro mechanical systems
US5417235A (en) * 1993-07-28 1995-05-23 Regents Of The University Of Michigan Integrated microvalve structures with monolithic microflow controller
US5659171A (en) 1993-09-22 1997-08-19 Northrop Grumman Corporation Micro-miniature diaphragm pump for the low pressure pumping of gases
DE4332720C2 (de) 1993-09-25 1997-02-13 Karlsruhe Forschzent Mikromembranpumpe
US5423267A (en) * 1993-12-30 1995-06-13 Eklund; Byron G. Pocket rerailer
CH689836A5 (fr) 1994-01-14 1999-12-15 Westonbridge Int Ltd Micropompe.
US5538223A (en) * 1994-04-21 1996-07-23 Scace; Gregory Single line multiple purchase block and tackle system
US5472053A (en) * 1994-09-14 1995-12-05 Halliburton Company Leakproof floating apparatus and method for fabricating said apparatus
DE4433894A1 (de) * 1994-09-22 1996-03-28 Fraunhofer Ges Forschung Verfahren und Vorrichtung zur Ansteuerung einer Mikropumpe
EP0706004B1 (fr) 1994-10-07 2003-08-06 Bayer Corporation Robinet de décharge
US5571410A (en) * 1994-10-19 1996-11-05 Hewlett Packard Company Fully integrated miniaturized planar liquid sample handling and analysis device
US5788468A (en) 1994-11-03 1998-08-04 Memstek Products, Llc Microfabricated fluidic devices
JP3398749B2 (ja) 1994-11-10 2003-04-21 オーキッド バイオ サイエンシズ， インコーポレイテッド 液体分配システム
JP3094880B2 (ja) 1995-03-01 2000-10-03 住友金属工業株式会社 有機化合物の結晶化制御方法およびそれに用いる結晶化制御用固体素子
US5775371A (en) 1995-03-08 1998-07-07 Abbott Laboratories Valve control
US5876187A (en) 1995-03-09 1999-03-02 University Of Washington Micropumps with fixed valves
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
CA2183478C (fr) 1995-08-17 2004-02-24 Stephen A. Carter Systeme numerique de gazometrie a l'aide de solenoides bistables et tristables
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US5598033A (en) 1995-10-16 1997-01-28 Advanced Micro Devices, Inc. Micro BGA stacking scheme
US5958344A (en) 1995-11-09 1999-09-28 Sarnoff Corporation System for liquid distribution
US5705018A (en) 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
KR100207410B1 (ko) 1995-12-19 1999-07-15 전주범 광로 조절 장치의 제조방법
US5660370A (en) * 1996-03-07 1997-08-26 Integrated Fludics, Inc. Valve with flexible sheet member and two port non-flexing backer member
US5724677A (en) 1996-03-08 1998-03-10 Minnesota Mining And Manufacturing Company Multi-part headband and respirator mask assembly and process for making same
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5810325A (en) 1996-06-25 1998-09-22 Bcam International, Inc. Microvalve
US5779868A (en) 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
WO1998002601A1 (fr) 1996-07-15 1998-01-22 Sumitomo Metal Industries, Ltd. Equipement de croissance de cristaux et procede pour la croissance de cristaux utilisant cet equipement
US5876157A (en) * 1996-07-17 1999-03-02 Wethered; William Drill centering jig and forming tool guide
US6136212A (en) 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
US5738799A (en) * 1996-09-12 1998-04-14 Xerox Corporation Method and materials for fabricating an ink-jet printhead
US5788488A (en) * 1996-09-23 1998-08-04 Precision Dental International, Inc. Dental reamer stop dispenser
US6221654B1 (en) 1996-09-25 2001-04-24 California Institute Of Technology Method and apparatus for analysis and sorting of polynucleotides based on size
US5865417A (en) 1996-09-27 1999-02-02 Redwood Microsystems, Inc. Integrated electrically operable normally closed valve
US5839722A (en) * 1996-11-26 1998-11-24 Xerox Corporation Paper handling system having embedded control structures
US5971355A (en) * 1996-11-27 1999-10-26 Xerox Corporation Microdevice valve structures to fluid control
US6123316A (en) * 1996-11-27 2000-09-26 Xerox Corporation Conduit system for a valve array
FR2757906A1 (fr) * 1996-12-31 1998-07-03 Westonbridge Int Ltd Micropompe avec piece intermediaire integree
US6436529B1 (en) 1997-01-21 2002-08-20 3M Innovative Properties Company Elatomeric laminates and composites
US6376971B1 (en) * 1997-02-07 2002-04-23 Sri International Electroactive polymer electrodes
US5882496A (en) * 1997-02-27 1999-03-16 The Regents Of The University Of California Porous silicon structures with high surface area/specific pore size
US6069392A (en) 1997-04-11 2000-05-30 California Institute Of Technology Microbellows actuator
US6116863A (en) * 1997-05-30 2000-09-12 University Of Cincinnati Electromagnetically driven microactuated device and method of making the same
US5922604A (en) 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
US6304364B1 (en) 1997-06-11 2001-10-16 President & Fellows Of Harvard College Elastomeric light valves
AU8275998A (en) 1997-06-27 1999-01-19 Immunetics, Inc. Rapid flow-through binding assay apparatus and method
AU8492998A (en) 1997-07-16 1999-02-10 Diversified Scientific, Inc. Method for acquiring, storing and analyzing crystal images
US5932799A (en) * 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US6073482A (en) * 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5965410A (en) 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US5999307A (en) 1997-09-04 1999-12-07 The University Of British Columbia Method and apparatus for controllable frustration of total internal reflection
US20020092767A1 (en) * 1997-09-19 2002-07-18 Aclara Biosciences, Inc. Multiple array microfluidic device units
US7214298B2 (en) * 1997-09-23 2007-05-08 California Institute Of Technology Microfabricated cell sorter
US6833242B2 (en) 1997-09-23 2004-12-21 California Institute Of Technology Methods for detecting and sorting polynucleotides based on size
US6540895B1 (en) 1997-09-23 2003-04-01 California Institute Of Technology Microfabricated cell sorter for chemical and biological materials
US5836750A (en) * 1997-10-09 1998-11-17 Honeywell Inc. Electrostatically actuated mesopump having a plurality of elementary cells
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5958694A (en) 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US6345502B1 (en) * 1997-11-12 2002-02-12 California Institute Of Technology Micromachined parylene membrane valve and pump
US6174675B1 (en) 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
WO1999036714A2 (fr) 1998-01-20 1999-07-22 Triconex, Incorporated Systeme solenoide tolerant avec selection en mode deux sur trois
US6790526B2 (en) * 1998-01-30 2004-09-14 Integument Technologies, Inc. Oxyhalopolymer protective multifunctional appliqués and paint replacement films
US6451674B1 (en) * 1998-02-18 2002-09-17 Matsushita Electronics Corporation Method for introducing impurity into a semiconductor substrate without negative charge buildup phenomenon
US6376619B1 (en) 1998-04-13 2002-04-23 3M Innovative Properties Company High density, miniaturized arrays and methods of manufacturing same
AU3491299A (en) 1998-04-14 1999-11-01 Lumenal Technologies, L.P. Test cartridge with a single inlet port
AU4719399A (en) 1998-06-26 2000-01-17 University Of Washington Crystallization media
US6225243B1 (en) 1998-08-03 2001-05-01 Bba Nonwovens Simpsonville, Inc. Elastic nonwoven fabric prepared from bi-component filaments
US6221483B1 (en) 1998-09-10 2001-04-24 Avery Dennison Corporation Reversibly extensible film
US6482306B1 (en) * 1998-09-22 2002-11-19 University Of Washington Meso- and microfluidic continuous flow and stopped flow electroösmotic mixer
RU2143343C1 (ru) * 1998-11-03 1999-12-27 Самсунг Электроникс Ко., Лтд. Микроинжектор и способ изготовления микроинжектора
US6958865B1 (en) 1998-11-12 2005-10-25 California Institute Of Technology Microlicensing particles and applications
US6240962B1 (en) 1998-11-16 2001-06-05 California Institute Of Technology Parylene micro check valve and fabrication method thereof
WO2000050871A1 (fr) * 1999-02-26 2000-08-31 Orchid Biosciences, Inc. Microstructures destinees a etre utilisees dans des dosages et des reactions biologiques
JP2000314381A (ja) * 1999-03-03 2000-11-14 Ngk Insulators Ltd ポンプ
MXPA01009999A (es) 1999-04-06 2003-07-14 Uab Research Foundation Metodo para examinar las condiciones de cristalizacion en el crecimiento de cristales en solucion.
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US6406605B1 (en) * 1999-06-01 2002-06-18 Ysi Incorporated Electroosmotic flow controlled microfluidic devices
US6296673B1 (en) 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US7306672B2 (en) 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US6929030B2 (en) 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7459022B2 (en) 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7144616B1 (en) 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
ATE215673T1 (de) 1999-06-28 2002-04-15 California Inst Of Techn Elastomerische mikropumpen- und mikroventilsysteme
WO2001006575A1 (fr) 1999-07-20 2001-01-25 Sri International Polymeres electroactifs ameliores
EP1206697A2 (fr) 1999-08-02 2002-05-22 Emerald Biostructures Inc. Procede et systeme de creation d'une base de donnees de resultats de cristallisation
US7255506B2 (en) * 2000-06-02 2007-08-14 The Procter & Gamble Company Semi-enclosed applicator for distributing a substance onto a target surface
US20020112961A1 (en) * 1999-12-02 2002-08-22 Nanostream, Inc. Multi-layer microfluidic device fabrication
US20020012926A1 (en) 2000-03-03 2002-01-31 Mycometrix, Inc. Combinatorial array for nucleic acid analysis
JP4927287B2 (ja) 2000-03-31 2012-05-09 マイクロニックス、インコーポレーテッド タンパク質の結晶化のマイクロ流動体装置
US7867763B2 (en) 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US20050118073A1 (en) 2003-11-26 2005-06-02 Fluidigm Corporation Devices and methods for holding microfluidic devices
WO2001087487A2 (fr) * 2000-05-15 2001-11-22 Tecan Trading Ag Dispositifs microfluidiques centrifuges a ecoulement bidirectionnel
US6431212B1 (en) * 2000-05-24 2002-08-13 Jon W. Hayenga Valve for use in microfluidic structures
US7351376B1 (en) 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US7062418B2 (en) 2000-06-27 2006-06-13 Fluidigm Corporation Computer aided design method and system for developing a microfluidic system
US6885982B2 (en) 2000-06-27 2005-04-26 Fluidigm Corporation Object oriented microfluidic design method and system
US6301055B1 (en) 2000-08-16 2001-10-09 California Institute Of Technology Solid immersion lens structures and methods for producing solid immersion lens structures
EP1334347A1 (fr) 2000-09-15 2003-08-13 California Institute Of Technology Dispositifs a debit transversal microfabriques et procedes associes
US6508988B1 (en) 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
WO2002029106A2 (fr) 2000-10-03 2002-04-11 California Institute Of Technology Dispositifs microfluidiques et procedes d'utilisation
US7097809B2 (en) 2000-10-03 2006-08-29 California Institute Of Technology Combinatorial synthesis system
US7678547B2 (en) 2000-10-03 2010-03-16 California Institute Of Technology Velocity independent analyte characterization
EP1336097A4 (fr) 2000-10-13 2006-02-01 Fluidigm Corp Systeme d'injection d'echantillons utilisant un dispositif microfluidique, pour dispositifs d'analyse
US7232109B2 (en) 2000-11-06 2007-06-19 California Institute Of Technology Electrostatic valves for microfluidic devices
US6951632B2 (en) 2000-11-16 2005-10-04 Fluidigm Corporation Microfluidic devices for introducing and dispensing fluids from microfluidic systems
EP1343973B2 (fr) 2000-11-16 2020-09-16 California Institute Of Technology Appareil et procedes pour effectuer des dosages et des criblages a haut rendement
US6752922B2 (en) 2001-04-06 2004-06-22 Fluidigm Corporation Microfluidic chromatography
AU2002307152A1 (en) 2001-04-06 2002-10-21 California Institute Of Technology Nucleic acid amplification utilizing microfluidic devices
US6802342B2 (en) 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
JP5162074B2 (ja) 2001-04-06 2013-03-13 フルイディグム コーポレイション ポリマー表面修飾
US7075162B2 (en) 2001-08-30 2006-07-11 Fluidigm Corporation Electrostatic/electrostrictive actuation of elastomer structures using compliant electrodes
JP2005505441A (ja) 2001-10-08 2005-02-24 カリフォルニア インスティテュート オブ テクノロジー 微小加工レンズ、その製造の方法および応用
US7192629B2 (en) 2001-10-11 2007-03-20 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
CA2467587A1 (fr) 2001-11-30 2003-06-12 Fluidigm Corporation Dispositif microfluidique et procedes d'utilisation de ce dernier
CA2480728A1 (fr) 2002-04-01 2003-10-16 Fluidigm Corporation Systemes d'analyse de particules microfluidiques
US7059348B2 (en) 2002-05-13 2006-06-13 Fluidigm Corporation Drug delivery system
US8168139B2 (en) 2002-06-24 2012-05-01 Fluidigm Corporation Recirculating fluidic network and methods for using the same
EP2298448A3 (fr) 2002-09-25 2012-05-30 California Institute of Technology Intégration microfluidique à large échelle
US8871446B2 (en) 2002-10-02 2014-10-28 California Institute Of Technology Microfluidic nucleic acid analysis
GB0302302D0 (en) 2003-01-31 2003-03-05 Glaxo Group Ltd Microfluidic apparatus and method
US8828663B2 (en) 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US7476363B2 (en) 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
US7666361B2 (en) 2003-04-03 2010-02-23 Fluidigm Corporation Microfluidic devices and methods of using same
EP1685282A2 (fr) 2003-04-17 2006-08-02 Fluidigm Corporation Dispositifs et systemes de cristallogenese et methodes d'utilisation de ceux-ci
EP1636017A2 (fr) 2003-05-20 2006-03-22 Fluidigm Corporation Procede et systeme pour dispositif microfluidique et son imagerie
US7583853B2 (en) 2003-07-28 2009-09-01 Fluidigm Corporation Image processing method and system for microfluidic devices
US7042649B2 (en) 2003-08-11 2006-05-09 California Institute Of Technology Microfabricated rubber microscope using soft solid immersion lenses
US7413712B2 (en) 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
WO2005054441A2 (fr) 2003-12-01 2005-06-16 California Institute Of Technology Dispositif permettant d'immobiliser des especes chimiques et biochimiques et procedes d'utilisation correspondants
US7407799B2 (en) 2004-01-16 2008-08-05 California Institute Of Technology Microfluidic chemostat
TW200600492A (en) * 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
CN100583434C (zh) 2004-06-07 2010-01-20 先锋生物科技股份有限公司 用于微流体器件的光学透镜系统和方法
WO2006006100A1 (fr) * 2004-07-07 2006-01-19 Philips Intellectual Property & Standards Gmbh Systeme et procede de correction d'artefacts temporels dans des images tomographiques
WO2006071470A2 (fr) 2004-12-03 2006-07-06 California Institute Of Technology Dispositifs microfluidiques a circuits de reactions chimiques
WO2006060748A2 (fr) 2004-12-03 2006-06-08 California Institute Of Technology Soupapes a tamis microfluidiques
US7883669B2 (en) 2005-04-20 2011-02-08 Fluidigm Corporation Analysis engine and database for manipulating parameters for fluidic systems on a chip
WO2007044091A2 (fr) 2005-06-02 2007-04-19 Fluidigm Corporation Analyse utilisant des dispositifs de separation microfluidiques
US20070048192A1 (en) * 2005-08-10 2007-03-01 Emil Kartalov Integrated microfluidic vias, overpasses, underpasses, septums, microfuses, nested bioarrays and methods for fabricating the same
US20070054293A1 (en) 2005-08-30 2007-03-08 California Institute Of Technology Microfluidic chaotic mixing systems and methods
US20070074972A1 (en) 2005-09-13 2007-04-05 Fluidigm Corporation Microfluidic assay devices and methods
US8206975B2 (en) 2005-10-28 2012-06-26 California Institute Of Technology Method and device for regulating fluid flow in microfluidic devices
US20070248971A1 (en) 2006-01-26 2007-10-25 California Institute Of Technology Programming microfluidic devices with molecular information
EP1984107A4 (fr) 2006-01-26 2013-12-04 California Inst Of Techn Programmation de dispositifs microfluidiques avec une information moleculaire
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
US8828661B2 (en) 2006-04-24 2014-09-09 Fluidigm Corporation Methods for detection and quantification of nucleic acid or protein targets in a sample
US8055034B2 (en) 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
WO2008043046A2 (fr) 2006-10-04 2008-04-10 Fluidigm Corporation Clapets de non-retour microfluidiques
US8473216B2 (en) 2006-11-30 2013-06-25 Fluidigm Corporation Method and program for performing baseline correction of amplification curves in a PCR experiment
US8157434B2 (en) 2007-01-19 2012-04-17 Fluidigm Corporation High efficiency and high precision microfluidic devices and methods
WO2008141183A2 (fr) 2007-05-09 2008-11-20 Fluidigm Corporation Procédé et système de cristallisation et criblage par diffraction de rayons x
EA018555B1 (ru) 2007-09-07 2013-08-30 Флуидигм Корпорейшн Определение вариаций количества копий, способы и системы
US9157116B2 (en) 2008-02-08 2015-10-13 Fluidigm Corporation Combinatorial amplification and detection of nucleic acids
US9487822B2 (en) 2008-03-19 2016-11-08 Fluidigm Corporation Method and apparatus for determining copy number variation using digital PCR
WO2010011852A1 (fr) 2008-07-25 2010-01-28 Fluidigm Corporation Procédé et système de fabrication de puces fluidiques intégrées
US8617488B2 (en) 2008-08-07 2013-12-31 Fluidigm Corporation Microfluidic mixing and reaction systems for high efficiency screening
SG10201404682WA (en) 2008-12-08 2014-10-30 Fluidigm Corp Programmable microfluidic digital array
US8058630B2 (en) 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods

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WO2001001025A9 (fr) 2002-07-25
CA2378190C (fr) 2011-01-25
US20010054778A1 (en) 2001-12-27
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US20010029983A1 (en) 2001-10-18
EP1065378B1 (fr) 2002-04-03
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