JPWO2019092989A1 - マイクロ流体チップおよびマイクロ流体デバイス - Google Patents
マイクロ流体チップおよびマイクロ流体デバイス Download PDFInfo
- Publication number
- JPWO2019092989A1 JPWO2019092989A1 JP2019551902A JP2019551902A JPWO2019092989A1 JP WO2019092989 A1 JPWO2019092989 A1 JP WO2019092989A1 JP 2019551902 A JP2019551902 A JP 2019551902A JP 2019551902 A JP2019551902 A JP 2019551902A JP WO2019092989 A1 JPWO2019092989 A1 JP WO2019092989A1
- Authority
- JP
- Japan
- Prior art keywords
- flow path
- hole
- microfluidic
- flat plate
- plate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004891 communication Methods 0.000 claims abstract description 87
- 239000007788 liquid Substances 0.000 claims abstract description 70
- 229920001971 elastomer Polymers 0.000 claims abstract description 20
- 239000000806 elastomer Substances 0.000 claims abstract description 20
- 230000001681 protective effect Effects 0.000 description 16
- 239000012530 fluid Substances 0.000 description 14
- 238000000034 method Methods 0.000 description 14
- 238000010586 diagram Methods 0.000 description 7
- 239000003822 epoxy resin Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 229920000647 polyepoxide Polymers 0.000 description 7
- 229920002379 silicone rubber Polymers 0.000 description 7
- 239000004945 silicone rubber Substances 0.000 description 7
- 125000006850 spacer group Chemical group 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 6
- 238000012986 modification Methods 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 238000004528 spin coating Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000012780 transparent material Substances 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 239000006082 mold release agent Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 229920002120 photoresistant polymer Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- -1 polydimethylsiloxane Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- LLHKCFNBLRBOGN-UHFFFAOYSA-N propylene glycol methyl ether acetate Chemical compound COCC(C)OC(C)=O LLHKCFNBLRBOGN-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
- B81B1/006—Microdevices formed as a single homogeneous piece, i.e. wherein the mechanical function is obtained by the use of the device, e.g. cutters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
- B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
- B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
- B81C1/00119—Arrangement of basic structures like cavities or channels, e.g. suitable for microfluidic systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N37/00—Details not covered by any other group of this subclass
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0689—Sealing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0874—Three dimensional network
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C2045/0094—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor injection moulding of small-sized articles, e.g. microarticles, ultra thin articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C33/00—Moulds or cores; Details thereof or accessories therefor
- B29C33/38—Moulds or cores; Details thereof or accessories therefor characterised by the material or the manufacturing process
- B29C33/3842—Manufacturing moulds, e.g. shaping the mould surface by machining
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/17—Component parts, details or accessories; Auxiliary operations
- B29C45/26—Moulds
- B29C45/2628—Moulds with mould parts forming holes in or through the moulded article, e.g. for bearing cages
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2083/00—Use of polymers having silicon, with or without sulfur, nitrogen, oxygen, or carbon only, in the main chain, as moulding material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2083/00—Use of polymers having silicon, with or without sulfur, nitrogen, oxygen, or carbon only, in the main chain, as moulding material
- B29K2083/005—LSR, i.e. liquid silicone rubbers, or derivatives thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2863/00—Use of EP, i.e. epoxy resins or derivatives thereof as mould material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
- B29L2031/00—Other particular articles
- B29L2031/756—Microarticles, nanoarticles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2201/00—Specific applications of microelectromechanical systems
- B81B2201/05—Microfluidics
- B81B2201/057—Micropipets, dropformers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2203/00—Basic microelectromechanical structures
- B81B2203/03—Static structures
- B81B2203/0323—Grooves
- B81B2203/0338—Channels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B2203/00—Basic microelectromechanical structures
- B81B2203/03—Static structures
- B81B2203/0353—Holes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
- B81C2201/00—Manufacture or treatment of microstructural devices or systems
- B81C2201/03—Processes for manufacturing substrate-free structures
- B81C2201/034—Moulding
Abstract
Description
前記流路板に重ねられて前記凹部を閉塞して前記流路を画定するとともに、前記凹部に通ずる連通貫通孔が形成された平板と、
前記流路板と前記平板の少なくとも一方の外面に接触するよう配置されるか、前記外面に形成され、前記連通孔と前記連通貫通孔の少なくとも一方を囲む、エラストマーから形成された環状シールとを
備えることを特徴とするマイクロ流体チップ。
ことを特徴とする条項1に記載のマイクロ流体チップ。
前記平板には、前記流路板の前記複数の固定用貫通孔にそれぞれ重なる複数の固定用貫通孔が形成されている
ことを特徴とする条項1または2に記載のマイクロ流体チップ。
ことを特徴とする条項1から3のいずれか1項に記載のマイクロ流体チップ。
1つの前記マイクロ流体チップの前記連通孔または前記連通貫通孔が、近接する他の1つの前記マイクロ流体チップの前記連通孔または前記連通貫通孔に重なるように、前記複数のマイクロ流体チップが積層されている
ことを特徴とするマイクロ流体デバイス。
ことを特徴とする条項5に記載のマイクロ流体デバイス。
2 支持平板
2C 貫通孔
3,4,5,51,52 マイクロ流体チップ
6 保護平板
6A,6B 貫通孔
7,9,11,54,56 平板
8,10,12,40,53,55 流路板
2h,3h,4h,5h,6h,7h,8h,9h,10h,11h,12h 固定用貫通孔
16 ピン
18 ナット18(固定具)
8P,10P,12P 流路
8Q,10Q,12Q 凹部
7C,9B,11A 連通貫通孔
8A,8B,10B,12A 連通孔
9A,10A,11B,12B 貫通孔
13A,13B,14A,14B,42,57,58,59,60 環状シール
Claims (4)
- 液体の流路となる凹部と、前記凹部に通ずる連通孔が形成された流路板と、
前記流路板に重ねられて前記凹部を閉塞して前記流路を画定するとともに、前記凹部に通ずる連通貫通孔が形成された平板と、
前記流路板と前記平板の少なくとも一方の外面に接触するよう配置されるか、前記外面に形成され、前記連通孔と前記連通貫通孔の少なくとも一方を囲む、エラストマーから形成された環状シールとを
備えることを特徴とするマイクロ流体チップ。 - 前記流路板と前記平板の少なくとも一方は、前記環状シールと一体にエラストマーから形成されている
ことを特徴とする請求項1に記載のマイクロ流体チップ。 - 前記流路板には、複数の固定用貫通孔が形成され、
前記平板には、前記流路板の前記複数の固定用貫通孔にそれぞれ重なる複数の固定用貫通孔が形成されている
ことを特徴とする請求項1または2に記載のマイクロ流体チップ。 - 異なるタイプの前記流路をそれぞれ備える請求項1から3のいずれかに記載の複数のマイクロ流体チップを備え、
1つの前記マイクロ流体チップの前記連通孔または前記連通貫通孔が、近接する他の1つの前記マイクロ流体チップの前記連通孔または前記連通貫通孔に重なるように、前記複数のマイクロ流体チップが積層されている
ことを特徴とするマイクロ流体デバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017217170 | 2017-11-10 | ||
JP2017217170 | 2017-11-10 | ||
PCT/JP2018/034615 WO2019092989A1 (ja) | 2017-11-10 | 2018-09-19 | マイクロ流体チップおよびマイクロ流体デバイス |
Publications (1)
Publication Number | Publication Date |
---|---|
JPWO2019092989A1 true JPWO2019092989A1 (ja) | 2020-10-01 |
Family
ID=66438781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019551902A Pending JPWO2019092989A1 (ja) | 2017-11-10 | 2018-09-19 | マイクロ流体チップおよびマイクロ流体デバイス |
Country Status (5)
Country | Link |
---|---|
US (1) | US11478790B2 (ja) |
EP (1) | EP3708531A4 (ja) |
JP (1) | JPWO2019092989A1 (ja) |
CN (1) | CN110678414A (ja) |
WO (1) | WO2019092989A1 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020175458A1 (ja) * | 2019-02-27 | 2020-09-03 | 京セラ株式会社 | 粒子分離計測デバイスおよび粒子分離計測装置 |
WO2022147426A1 (en) * | 2020-12-28 | 2022-07-07 | The Trustees Of The University Of Pennsylvania | Microfluidic platforms for large scale nanoparticle formulations |
GB202118922D0 (en) * | 2021-12-23 | 2022-02-09 | Osler Diagnostics Ltd | Liquid handling device |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004529749A (ja) * | 2001-02-15 | 2004-09-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | マイクロコンポーネント連結用デバイス |
JP2005507775A (ja) * | 2001-11-06 | 2005-03-24 | ツェーペーツェー−セルラー・プロセス・ケミストリー・システムズ・ゲーエムベーハー | マイクロリアクターシステム |
US20070048189A1 (en) * | 2005-08-26 | 2007-03-01 | Applera Corporation | Fluid processing device, system, kit, and method |
JP2007092904A (ja) * | 2005-09-29 | 2007-04-12 | Nichias Corp | シート状ガスケット及びその製造方法 |
JP2007147456A (ja) * | 2005-11-28 | 2007-06-14 | Seiko Epson Corp | マイクロ流体システム、試料分析装置、及び標的物質の検出または測定方法 |
JP2008292379A (ja) * | 2007-05-25 | 2008-12-04 | Tokyo Metropolitan Industrial Technology Research Institute | 流路形成部材及び分注装置 |
US20090270274A1 (en) * | 2008-04-25 | 2009-10-29 | Plexigen, Inc. | Biochips and related automated analyzers and methods |
JP2011133402A (ja) * | 2009-12-25 | 2011-07-07 | Asahi Rubber Inc | バイオチップ基板の製造方法 |
JP2012112511A (ja) * | 2010-11-29 | 2012-06-14 | Ud Trucks Corp | ガスケット |
JP2013208619A (ja) * | 2013-06-21 | 2013-10-10 | Nisso Engineering Co Ltd | マイクロリアクタ |
US20140363838A1 (en) * | 2013-06-11 | 2014-12-11 | William Marsh Rice University | Microperfusion imaging platform |
JP2015123012A (ja) * | 2013-12-26 | 2015-07-06 | 高砂電気工業株式会社 | マイクロ流体チップ装置 |
WO2016098722A1 (ja) * | 2014-12-15 | 2016-06-23 | 日本電気株式会社 | マイクロチップ、液体移送方法及びマイクロチップ制御装置 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7601270B1 (en) * | 1999-06-28 | 2009-10-13 | California Institute Of Technology | Microfabricated elastomeric valve and pump systems |
EP1560642A4 (en) | 2002-10-09 | 2006-05-03 | Univ Illinois | MICROFLUIDIC SYSTEMS AND COMPONENTS |
CA2554240A1 (en) * | 2004-01-25 | 2005-08-11 | Fluidigm Corporation | Crystal forming devices and systems and methods for making and using the same |
GB0421529D0 (en) * | 2004-09-28 | 2004-10-27 | Landegren Gene Technology Ab | Microfluidic structure |
US7297285B2 (en) * | 2005-08-05 | 2007-11-20 | Roger Chang | Manufacturing process of emboss type flexible or rigid printed circuit board |
JP5104316B2 (ja) * | 2006-01-12 | 2012-12-19 | 住友ベークライト株式会社 | 受動型一方弁及びマイクロ流体デバイス |
WO2007134189A2 (en) * | 2006-05-10 | 2007-11-22 | Board Of Regents, The University Of Texas System | Detecting tumor biomarker in oral cancer |
US20160184789A1 (en) * | 2013-08-23 | 2016-06-30 | Asahi Fr R&D Co., Ltd. | Microchemical chip and reaction device |
-
2018
- 2018-09-19 US US16/609,258 patent/US11478790B2/en active Active
- 2018-09-19 EP EP18876943.4A patent/EP3708531A4/en active Pending
- 2018-09-19 JP JP2019551902A patent/JPWO2019092989A1/ja active Pending
- 2018-09-19 CN CN201880034720.6A patent/CN110678414A/zh active Pending
- 2018-09-19 WO PCT/JP2018/034615 patent/WO2019092989A1/ja unknown
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004529749A (ja) * | 2001-02-15 | 2004-09-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | マイクロコンポーネント連結用デバイス |
JP2005507775A (ja) * | 2001-11-06 | 2005-03-24 | ツェーペーツェー−セルラー・プロセス・ケミストリー・システムズ・ゲーエムベーハー | マイクロリアクターシステム |
US20070048189A1 (en) * | 2005-08-26 | 2007-03-01 | Applera Corporation | Fluid processing device, system, kit, and method |
JP2007092904A (ja) * | 2005-09-29 | 2007-04-12 | Nichias Corp | シート状ガスケット及びその製造方法 |
JP2007147456A (ja) * | 2005-11-28 | 2007-06-14 | Seiko Epson Corp | マイクロ流体システム、試料分析装置、及び標的物質の検出または測定方法 |
JP2008292379A (ja) * | 2007-05-25 | 2008-12-04 | Tokyo Metropolitan Industrial Technology Research Institute | 流路形成部材及び分注装置 |
US20090270274A1 (en) * | 2008-04-25 | 2009-10-29 | Plexigen, Inc. | Biochips and related automated analyzers and methods |
JP2011133402A (ja) * | 2009-12-25 | 2011-07-07 | Asahi Rubber Inc | バイオチップ基板の製造方法 |
JP2012112511A (ja) * | 2010-11-29 | 2012-06-14 | Ud Trucks Corp | ガスケット |
US20140363838A1 (en) * | 2013-06-11 | 2014-12-11 | William Marsh Rice University | Microperfusion imaging platform |
JP2013208619A (ja) * | 2013-06-21 | 2013-10-10 | Nisso Engineering Co Ltd | マイクロリアクタ |
JP2015123012A (ja) * | 2013-12-26 | 2015-07-06 | 高砂電気工業株式会社 | マイクロ流体チップ装置 |
WO2016098722A1 (ja) * | 2014-12-15 | 2016-06-23 | 日本電気株式会社 | マイクロチップ、液体移送方法及びマイクロチップ制御装置 |
Also Published As
Publication number | Publication date |
---|---|
WO2019092989A1 (ja) | 2019-05-16 |
EP3708531A1 (en) | 2020-09-16 |
US11478790B2 (en) | 2022-10-25 |
CN110678414A (zh) | 2020-01-10 |
EP3708531A4 (en) | 2020-09-23 |
US20200061614A1 (en) | 2020-02-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9341284B2 (en) | Microfluidic devices with mechanically-sealed diaphragm valves | |
JPWO2019092989A1 (ja) | マイクロ流体チップおよびマイクロ流体デバイス | |
US7060227B2 (en) | Microfluidic devices with raised walls | |
US8573259B2 (en) | Modular microfluidic assembly block and system including the same | |
US20080131327A1 (en) | System and method for interfacing with a microfluidic chip | |
US8961906B2 (en) | Fluid connector devices and methods of making and using the same | |
Chen et al. | Fit-to-Flow (F2F) interconnects: Universal reversible adhesive-free microfluidic adaptors for lab-on-a-chip systems | |
JP6172711B2 (ja) | マイクロチップ用の流体制御デバイスおよびその利用 | |
US20080112854A1 (en) | Microfluidic apparatus including microfluidic device and method of manufacturing the microfluidic apparatus | |
US20070160502A1 (en) | Microfluidic device and method of fabricating the same | |
KR20080090410A (ko) | 정밀한 라인 접합 및/또는 밀봉 시스템과 그 방법 | |
Skafte-Pedersen et al. | Modular microfluidic systems using reversibly attached PDMS fluid control modules | |
Wagler et al. | General-purpose, parallel and reversible microfluidic interconnects | |
US8747778B2 (en) | Method of producing microfluidic device | |
WO2015090339A1 (en) | Fluidic microsystem and method of manufacturing thereof | |
US20040061257A1 (en) | Packaging technique for elastomeric microfluidic chips and microfluidic device prepared thereby | |
JP2019181427A (ja) | アダプタ | |
US20120024405A1 (en) | Guiding devices and methods of making and using the same | |
KR20110102654A (ko) | 마이크로 채널을 가진 구조물의 제조 방법 및 그 구조물 | |
CN108311177B (zh) | 一种3d pdms微流控芯片对准组装结构的制作方法 | |
CN216756490U (zh) | 一种夹具及其微流控芯片装置 | |
Gray | Fluidic Interconnects for Microfluidics: Chip to Chip and World to Chip | |
Toh et al. | Modular membrane valves for universal integration within thermoplastic devices | |
WO2019218262A1 (zh) | 基因测序仪 | |
WO2019102865A1 (ja) | 流体チップ、流体デバイスおよびそれらの製造方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191029 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200825 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20211130 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20220118 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220316 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220823 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20221007 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20230118 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20230127 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20230228 |