NO313226B1 - Farmasöytisk sammensetning som omfater en insulinsensitivitetsenhancer i kombinasjon med eninsulinsekresjonsenhancer og anvendelse av disse - Google Patents
Farmasöytisk sammensetning som omfater en insulinsensitivitetsenhancer i kombinasjon med eninsulinsekresjonsenhancer og anvendelse av disse Download PDFInfo
- Publication number
- NO313226B1 NO313226B1 NO19962606A NO962606A NO313226B1 NO 313226 B1 NO313226 B1 NO 313226B1 NO 19962606 A NO19962606 A NO 19962606A NO 962606 A NO962606 A NO 962606A NO 313226 B1 NO313226 B1 NO 313226B1
- Authority
- NO
- Norway
- Prior art keywords
- formula
- enhancer
- insulin
- pharmaceutical composition
- insulin secretion
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Landscapes
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- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15350095 | 1995-06-20 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO962606D0 NO962606D0 (no) | 1996-06-19 |
| NO962606L NO962606L (no) | 1996-12-23 |
| NO313226B1 true NO313226B1 (no) | 2002-09-02 |
Family
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Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19962606A NO313226B1 (no) | 1995-06-20 | 1996-06-19 | Farmasöytisk sammensetning som omfater en insulinsensitivitetsenhancer i kombinasjon med eninsulinsekresjonsenhancer og anvendelse av disse |
| NO20004345A NO314065B1 (no) | 1995-06-20 | 2000-09-01 | Farmasöytisk sammensetning omfattende en insulinsensitivitetsenhancer og etbiguanid ved behandling av diabetes |
| NONO/SPC/2A NO317341B1 (no) | 1995-06-20 | 2002-03-08 | Vorikonazol |
| NO2007001C NO2007001I2 (no) | 1995-06-20 | 2007-01-04 | Pioglitazon/metformin. |
| NO2007007C NO2007007I2 (no) | 1995-06-20 | 2007-06-04 | Pioglitazon/Glimepiride |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
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| NO20004345A NO314065B1 (no) | 1995-06-20 | 2000-09-01 | Farmasöytisk sammensetning omfattende en insulinsensitivitetsenhancer og etbiguanid ved behandling av diabetes |
| NONO/SPC/2A NO317341B1 (no) | 1995-06-20 | 2002-03-08 | Vorikonazol |
| NO2007001C NO2007001I2 (no) | 1995-06-20 | 2007-01-04 | Pioglitazon/metformin. |
| NO2007007C NO2007007I2 (no) | 1995-06-20 | 2007-06-04 | Pioglitazon/Glimepiride |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI238064B (en) | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| NZ286920A (en) * | 1995-07-03 | 1997-06-24 | Sankyo Co | Use of combination of hmg-coa reductase inhibitors and of insulin sensitizers for the prevention/treatment of arteriosclerosis or xanthoma |
| CA2221241A1 (en) | 1995-08-10 | 1997-02-20 | Warner-Lambert Company | A method of reducing the amount of exogenous insulin administered to a patient having noninsulin-dependent diabetes mellitus |
| GB9600464D0 (en) * | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
| CA2577233C (en) | 1996-04-05 | 2009-08-18 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition containing angiotensin ii antagonist |
| DK1175902T3 (da) | 1996-07-15 | 2005-12-19 | Sankyo Co | Anvendelse CS-866 (olmesartan) til fremstillingen af et medikament til behandling af arteriosclerose |
| FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
| US6011049A (en) * | 1997-02-19 | 2000-01-04 | Warner-Lambert Company | Combinations for diabetes |
| US5859037A (en) * | 1997-02-19 | 1999-01-12 | Warner-Lambert Company | Sulfonylurea-glitazone combinations for diabetes |
| US6291495B1 (en) | 1997-02-24 | 2001-09-18 | Robert B. Rieveley | Method and composition for the treatment of diabetes |
| NZ501163A (en) * | 1997-06-18 | 2002-02-01 | Smithkline Beecham P | Treatment of diabetes with thiazolidinedione and sulphonylurea (glibenclamide, glipizide, gliclazide, glimepiride, tolazamide and tolbutamide |
| AU783539B2 (en) * | 1997-06-18 | 2005-11-10 | Smithkline Beecham Plc | Treatment of diabetes with thiazolidinedione and sulphonylurea |
| CN1274282A (zh) * | 1997-06-18 | 2000-11-22 | 史密丝克莱恩比彻姆有限公司 | 用噻唑烷二酮和α－葡糖苷酶抑制剂治疗糖尿病 |
| US20020004515A1 (en) * | 1997-06-18 | 2002-01-10 | Smith Stephen Alistair | Treatment of diabetes with thiazolidinedione and metformin |
| US20010049380A1 (en) * | 1997-06-18 | 2001-12-06 | Smith Stephen Alistair | Treatment of diabetes with thiazolidinedione and sulphonylurea |
| AP1279A (en) * | 1997-06-18 | 2004-05-20 | Smithkline Beecham Plc | Treatment of diabetes with thiazolidinedione and metformin. |
| AU778947B2 (en) * | 1997-06-18 | 2004-12-23 | Smithkline Beecham Plc | Treatment of diabetes with thiazolidinedione and metformin |
| US20020028768A1 (en) * | 1997-06-18 | 2002-03-07 | Smithkline Beecham P.L.C. | Treatment of diabetes with rosiglitazone and insulin |
| GB9715306D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
| US20020016287A1 (en) * | 1997-07-18 | 2002-02-07 | Smithkline Beecham P.L.C. | Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide |
| GB9715295D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
| GB9715298D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
| AU782419B2 (en) * | 1997-07-18 | 2005-07-28 | Smithkline Beecham Plc | Treatment of diabetes with thiazolidinedione, insulin secretagogue and diguanide |
| HUP0004132A3 (en) * | 1997-10-20 | 2006-06-28 | Dainippon Sumitomo Pharma Co | Rapidly soluble drug composition |
| ES2317688T3 (es) | 1998-01-29 | 2009-04-16 | Amgen Inc. | Moduladores ppar-gamma. |
| US6583157B2 (en) | 1998-01-29 | 2003-06-24 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| US6099859A (en) | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| JP2000080047A (ja) * | 1998-06-30 | 2000-03-21 | Takeda Chem Ind Ltd | 医 薬 |
| DK1093370T3 (da) * | 1998-06-30 | 2006-05-22 | Takeda Pharmaceutical | Farmaceutisk præparat til behandling af diabetes |
| DK0974356T3 (da) | 1998-07-15 | 2003-10-27 | Merck Sante Sas | Tabletter omfattende en kombination af metformin og glibenclamid |
| US6376549B1 (en) * | 1998-09-17 | 2002-04-23 | Akesis Pharmaceuticals, Inc. | Metforimin-containing compositions for the treatment of diabetes |
| WO2000025781A1 (en) | 1998-10-29 | 2000-05-11 | Board Of Regents, The University Of Texas System | Use of thiazolidinediones derivatives for preventing uterine contractions in premature labour or lactation |
| AP1692A (en) * | 1998-11-12 | 2006-12-12 | Smithkline Beecham Plc | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent. |
| DZ2937A1 (fr) * | 1998-11-12 | 2004-03-15 | Smithkline Beecham Plc | Compositions nouvelles de sensibilidants à l'insuline. |
| WO2000028989A1 (en) * | 1998-11-12 | 2000-05-25 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| US20040081697A1 (en) * | 1998-11-12 | 2004-04-29 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| US20030153607A1 (en) * | 1998-11-12 | 2003-08-14 | Smithkline Beecham P.L.C. | Novel composition and use |
| US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
| US6958324B2 (en) * | 1998-12-02 | 2005-10-25 | Inotek Pharmaceuticals Corporation | Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease |
| US20080269265A1 (en) * | 1998-12-22 | 2008-10-30 | Scott Miller | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas |
| WO2000038666A2 (en) * | 1998-12-24 | 2000-07-06 | Metabasis Therapeutics, Inc. | A COMBINATION OF FBPase INHIBITORS AND INSULIN SENSITIZERS FOR THE TREATMENT OF DIABETES |
| US6756360B1 (en) | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
| JP4799720B2 (ja) * | 1999-01-29 | 2011-10-26 | 武田薬品工業株式会社 | コーティング処理を施した打錠用杵 |
| US6787082B1 (en) * | 1999-01-29 | 2004-09-07 | Takeda Chemical Industries, Ltd. | Compressing mallet with coating treatment |
| GB0001662D0 (en) * | 1999-02-06 | 2000-03-15 | Zeneca Ltd | Pharmaceutical compositions |
| CN1329359C (zh) * | 1999-04-01 | 2007-08-01 | 埃斯佩里安医疗公司 | 醚化合物,及其组合物和用途 |
| US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| JP2000355550A (ja) * | 1999-04-14 | 2000-12-26 | Takeda Chem Ind Ltd | ケトーシス改善剤 |
| TWI249401B (en) * | 1999-04-14 | 2006-02-21 | Takeda Chemical Industries Ltd | Agent for improving ketosis |
| IL146110A0 (en) * | 1999-04-23 | 2002-07-25 | Smithkline Beecham Plc | Thiazolidinedione derivative and its use as antidiabetic |
| GB9910693D0 (en) * | 1999-05-07 | 1999-07-07 | Univ Liverpool | A compound for use in medicine |
| US6214842B1 (en) * | 1999-05-12 | 2001-04-10 | Michael S. Malamas | Amino-thiazolidinediones useful in the treatment of insulin resistance and hyperglycemia |
| WO2000078313A1 (en) * | 1999-06-18 | 2000-12-28 | Merck & Co., Inc. | Arylthiazolidinedione and aryloxazolidinedione derivatives |
| DE60036367T2 (de) | 1999-06-21 | 2008-05-29 | Eli Lilly And Co., Indianapolis | Synergitische verwendung von thiazolidinedionen und glucagon-ähnlichem peptid-1 und dessen agonisten für die behandlung von nicht-insulin-abhängigen diabetes |
| AU5760900A (en) * | 1999-06-25 | 2001-01-31 | Minimed, Inc. | Multiple agent diabetes therapy |
| AU779730B2 (en) * | 1999-06-30 | 2005-02-10 | Amgen, Inc. | Compounds for the modulation of PPARgamma activity |
| DK1192137T3 (da) * | 1999-06-30 | 2013-11-11 | Amgen Inc | Forbindelser til modulering af PPAR-gamma aktivitet |
| US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| US6878749B2 (en) * | 1999-09-17 | 2005-04-12 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
| AU2005200818B2 (en) * | 1999-09-17 | 2008-07-17 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
| US6559188B1 (en) | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
| CO5200844A1 (es) * | 1999-09-17 | 2002-09-27 | Novartis Ag | Una combinacion que comprende nateglinida y cuando por menos otro compuesto antidiabetico usada para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con dibetes |
| US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| EP1228756A4 (en) * | 1999-10-06 | 2004-06-09 | Kurokawa Kiyoshi | ACTIVE AGENTS AGAINST CARBONYL STRESS |
| EP1218015A2 (en) * | 1999-10-08 | 2002-07-03 | Novartis AG | Pharmaceutical composition of nateglinide and another antidiabetic agent |
| US6274622B1 (en) * | 1999-10-27 | 2001-08-14 | Frederick H. Hausheer | Method of treating diabetic ophthalmopathy |
| SK287810B6 (sk) | 1999-11-03 | 2011-10-04 | Bristol-Myers Squibb Company | Farmaceutický prostriedok obsahujúci nízkodávkovú kombináciu metformínu a glyburidu |
| US6586438B2 (en) * | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| AR030920A1 (es) * | 1999-11-16 | 2003-09-03 | Smithkline Beecham Plc | Composiciones farmaceuticas para el tratamiento de la diabetes mellitus y condiciones asociadas con la diabetes mellitus, y procedimientos para preparar dichas composiciones |
| US6660021B1 (en) | 1999-12-23 | 2003-12-09 | Advanced Cardiovascular Systems, Inc. | Intravascular device and system |
| US6575997B1 (en) | 1999-12-23 | 2003-06-10 | Endovascular Technologies, Inc. | Embolic basket |
| US6402771B1 (en) | 1999-12-23 | 2002-06-11 | Guidant Endovascular Solutions | Snare |
| WO2001047509A2 (en) * | 1999-12-24 | 2001-07-05 | Smithkline Beecham P.L.C. | Composition for the treatment diabetes mellitus containing an insuline sensitizer and agent used in the treatment of cardiac conditions |
| GB9930688D0 (en) * | 1999-12-24 | 2000-02-16 | Smithkline Beecham Plc | Novel method of treatment |
| US7918820B2 (en) | 1999-12-30 | 2011-04-05 | Advanced Cardiovascular Systems, Inc. | Device for, and method of, blocking emboli in vessels such as blood arteries |
| US6695813B1 (en) | 1999-12-30 | 2004-02-24 | Advanced Cardiovascular Systems, Inc. | Embolic protection devices |
| US6540722B1 (en) | 1999-12-30 | 2003-04-01 | Advanced Cardiovascular Systems, Inc. | Embolic protection devices |
| US20010036479A1 (en) | 2000-01-14 | 2001-11-01 | Gillian Cave | Glyburide composition |
| AU2001229601A1 (en) * | 2000-01-24 | 2001-07-31 | Inotek Corporation | Method and composition for modulating an immune response |
| US6540982B1 (en) * | 2000-01-25 | 2003-04-01 | Aeropharm Technology Incorporated | Medical aerosol formulation |
| US20030060488A1 (en) * | 2000-02-10 | 2003-03-27 | Yasuo Sugiyama | Drug comprising combination |
| CA2401356A1 (en) * | 2000-02-24 | 2001-08-30 | Takeda Chemical Industries, Ltd. | Combination drug |
| US6451342B2 (en) * | 2000-05-01 | 2002-09-17 | Aeropharm Technology Incorporated | Core formulation comprised of troglitazone and a biguanide |
| US6548049B1 (en) * | 2000-05-01 | 2003-04-15 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| US6296874B1 (en) * | 2000-05-01 | 2001-10-02 | Aeropharm Technology Incorporated | Core formulation comprising troglitazone and abiguanide |
| US6610272B1 (en) * | 2000-05-01 | 2003-08-26 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| US6461639B2 (en) * | 2000-05-01 | 2002-10-08 | Aeropharm Technology, Inc. | Core formulation |
| US6524621B2 (en) | 2000-05-01 | 2003-02-25 | Aeropharm Technology Inc. | Core formulation |
| WO2001082916A2 (en) | 2000-05-03 | 2001-11-08 | Tularik Inc. | Combination therapeutic compositions and methods of use |
| US6270797B1 (en) * | 2000-05-18 | 2001-08-07 | Usv Limited | Sustained release pharmaceutical composition containing glipizide and method for producing same |
| US6939362B2 (en) * | 2001-11-27 | 2005-09-06 | Advanced Cardiovascular Systems, Inc. | Offset proximal cage for embolic filtering devices |
| US20030171399A1 (en) | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| US7563774B2 (en) | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| US6964670B1 (en) | 2000-07-13 | 2005-11-15 | Advanced Cardiovascular Systems, Inc. | Embolic protection guide wire |
| US20060089389A1 (en) * | 2000-08-22 | 2006-04-27 | Malcolm Allison | Combination |
| AR033390A1 (es) * | 2000-08-22 | 2003-12-17 | Novartis Ag | Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes |
| US7276249B2 (en) * | 2002-05-24 | 2007-10-02 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| US20080241070A1 (en) * | 2000-09-21 | 2008-10-02 | Elan Pharma International Ltd. | Fenofibrate dosage forms |
| US20030224058A1 (en) * | 2002-05-24 | 2003-12-04 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| DE60135000D1 (de) * | 2000-10-12 | 2008-09-04 | Nissan Chemical Ind Ltd | Wirkstoffe zur vorbeugung und behandlung von komplikationen im zusammenhang mit diabetes |
| US6537294B1 (en) | 2000-10-17 | 2003-03-25 | Advanced Cardiovascular Systems, Inc. | Delivery systems for embolic filter devices |
| US6893451B2 (en) | 2000-11-09 | 2005-05-17 | Advanced Cardiovascular Systems, Inc. | Apparatus for capturing objects beyond an operative site utilizing a capture device delivered on a medical guide wire |
| US6506203B1 (en) | 2000-12-19 | 2003-01-14 | Advanced Cardiovascular Systems, Inc. | Low profile sheathless embolic protection system |
| MXPA03006217A (es) | 2001-01-12 | 2004-10-15 | Sun Pharmaceutical Ind Ltd | Sistema de administracion espaciada de farmacos. |
| WO2002067969A2 (en) | 2001-02-21 | 2002-09-06 | Medtronic Minimed, Inc. | Stabilized insulin formulations |
| ES2240657T3 (es) | 2001-02-28 | 2005-10-16 | Pfizer Products Inc. | Compuestos de sulfonilpiridazinona utiles como inhibidores de aldosa reductasa. |
| CA2439793A1 (en) * | 2001-03-02 | 2002-09-12 | Lichtwer Pharma Ag | Composition for the treatment of diabetes mellitus |
| KR200249057Y1 (ko) * | 2001-03-22 | 2001-10-19 | 김진환 | 뚜껑, 받침대에 합체된 하수역류. 악취방지 장치 |
| YU71403A (sh) | 2001-03-30 | 2006-05-25 | Pfizer Products Inc. | Piridazinoni kao inhibitori aldoza reduktaze |
| US20040097529A1 (en) * | 2001-04-03 | 2004-05-20 | Akira Fujimori | Novel use of arylethene sulfonamide derivative |
| MXPA03008997A (es) * | 2001-04-10 | 2004-02-12 | Sun Pharmaceutical Ind Ltd | Composicion de liberacion por impulso temporizado. |
| SE0101982D0 (sv) * | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | Pharmaceutical combination |
| JP2002360666A (ja) * | 2001-06-11 | 2002-12-17 | Takeda Chem Ind Ltd | コバルト合金を用いた打錠用杵臼 |
| US6737401B2 (en) | 2001-06-28 | 2004-05-18 | Metronic Minimed, Inc. | Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom |
| US6599307B1 (en) | 2001-06-29 | 2003-07-29 | Advanced Cardiovascular Systems, Inc. | Filter device for embolic protection systems |
| US7338510B2 (en) | 2001-06-29 | 2008-03-04 | Advanced Cardiovascular Systems, Inc. | Variable thickness embolic filtering devices and method of manufacturing the same |
| AU2001273310B2 (en) * | 2001-07-10 | 2004-10-07 | Kos Life Sciences, Inc. | A core formulation |
| EP1429747A4 (en) * | 2001-07-10 | 2005-01-05 | Kos Life Sciences Inc | CORE FORMULATION WITH PIOGLITAZONE HYDROCHLORIDE AND A BIGUANIDE |
| US6638294B1 (en) | 2001-08-30 | 2003-10-28 | Advanced Cardiovascular Systems, Inc. | Self furling umbrella frame for carotid filter |
| US6592606B2 (en) | 2001-08-31 | 2003-07-15 | Advanced Cardiovascular Systems, Inc. | Hinged short cage for an embolic protection device |
| US8262689B2 (en) | 2001-09-28 | 2012-09-11 | Advanced Cardiovascular Systems, Inc. | Embolic filtering devices |
| US7163952B2 (en) | 2001-12-03 | 2007-01-16 | Japan Tobacco Inc. | Azole compound and medicinal use thereof |
| US7241304B2 (en) | 2001-12-21 | 2007-07-10 | Advanced Cardiovascular Systems, Inc. | Flexible and conformable embolic filtering devices |
| DE10200138A1 (de) * | 2002-01-04 | 2003-07-17 | Karl Winkler | Kombination von einem PPAR-Agonisten mit PPAR-alpha Aktivität mit einem Induktor des LDL-Rezeptors |
| TWI327462B (en) * | 2002-01-18 | 2010-07-21 | Sumitomo Chemical Co | Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| US20030187074A1 (en) * | 2002-03-04 | 2003-10-02 | Javed Hussain | Oral compositions for treatment of diabetes |
| AR039090A1 (es) * | 2002-03-22 | 2005-02-09 | Novartis Ag | Combinacion de compuestos organicos |
| US20050142065A1 (en) * | 2002-04-26 | 2005-06-30 | Koki Kato | Screening method |
| US20070264348A1 (en) * | 2002-05-24 | 2007-11-15 | Elan Pharma International, Ltd. | Nanoparticulate fibrate formulations |
| US8911781B2 (en) | 2002-06-17 | 2014-12-16 | Inventia Healthcare Private Limited | Process of manufacture of novel drug delivery system: multilayer tablet composition of thiazolidinedione and biguanides |
| US6887258B2 (en) | 2002-06-26 | 2005-05-03 | Advanced Cardiovascular Systems, Inc. | Embolic filtering devices for bifurcated vessels |
| US7172614B2 (en) | 2002-06-27 | 2007-02-06 | Advanced Cardiovascular Systems, Inc. | Support structures for embolic filtering devices |
| US7214387B2 (en) | 2002-08-02 | 2007-05-08 | Penwest Pharmaceuticals Company | Sustained release formulations of metformin |
| US7232828B2 (en) * | 2002-08-10 | 2007-06-19 | Bethesda Pharmaceuticals, Inc. | PPAR Ligands that do not cause fluid retention, edema or congestive heart failure |
| US9060941B2 (en) * | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7785627B2 (en) | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| KR20100137023A (ko) | 2002-09-20 | 2010-12-29 | 안드렉스 랩스 엘엘씨 | 약제학적 정제 |
| US7959946B2 (en) | 2002-09-20 | 2011-06-14 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US8084058B2 (en) | 2002-09-20 | 2011-12-27 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7252675B2 (en) | 2002-09-30 | 2007-08-07 | Advanced Cardiovascular, Inc. | Embolic filtering devices |
| US7331973B2 (en) | 2002-09-30 | 2008-02-19 | Avdanced Cardiovascular Systems, Inc. | Guide wire with embolic filtering attachment |
| UA80991C2 (en) * | 2002-10-07 | 2007-11-26 | Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes | |
| US20040088000A1 (en) | 2002-10-31 | 2004-05-06 | Muller Paul F. | Single-wire expandable cages for embolic filtering devices |
| DE10252666A1 (de) * | 2002-11-11 | 2004-08-05 | Grünenthal GmbH | N-Piperidyl-cyclohexan-Derivate |
| IN192749B (enExample) * | 2002-11-15 | 2004-05-15 | Ranbaxy Lab Ltd | |
| DE10261067A1 (de) * | 2002-12-24 | 2004-08-05 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Cholesterinsenkendes Mittel, enthaltend eine n-3-Fettsäure |
| HRP20050696B1 (en) | 2003-01-14 | 2008-10-31 | Arena Pharmaceuticals Inc. | 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia |
| US6794401B2 (en) * | 2003-01-17 | 2004-09-21 | Bexel Pharmaceuticals, Inc. | Amino acid phenoxy ethers |
| US7179941B2 (en) | 2003-01-23 | 2007-02-20 | Sanofi-Aventis Deutschland Gmbh | Carbonylamino-substituted acyl phenyl urea derivatives, process for their preparation and their use |
| DE10302452B4 (de) * | 2003-01-23 | 2005-02-24 | Aventis Pharma Deutschland Gmbh | Carbonylamino-substituierte Acyl-phenyl-harnstoffderivate, Verfahren zu deren Herstellung und deren Verwendung |
| BRPI0407074A (pt) | 2003-01-29 | 2006-01-24 | Takeda Pharmaceutical | Método para produção de uma preparação revestida, preparação revestida, e, método para melhorar a dissolução do cloridreto de pioglitazona de uma preparação revestida com cloridreto de pioglitazona |
| US7572910B2 (en) * | 2003-02-20 | 2009-08-11 | Pfizer, Inc. | Pyridazinone aldose reductase inhibitors |
| US8591540B2 (en) | 2003-02-27 | 2013-11-26 | Abbott Cardiovascular Systems Inc. | Embolic filtering devices |
| WO2004108067A2 (en) * | 2003-04-03 | 2004-12-16 | Sun Pharmaceutical Industries Limited | Programmed drug delivery system |
| TW200500362A (en) * | 2003-04-09 | 2005-01-01 | Japan Tobacco Inc | 5-membered heteroaromatic ring compound and pharmaceutical use thereof |
| US7820158B2 (en) * | 2003-04-10 | 2010-10-26 | Surmodics, Inc. | Ligand-coupled initiator polymers and methods of use |
| EP1621210B1 (en) * | 2003-04-28 | 2013-06-19 | Daiichi Sankyo Company, Limited | Adiponectin production enhancer |
| US7772272B2 (en) * | 2003-04-28 | 2010-08-10 | Daiichi Sankyo Company, Limited | Method for enhancing glucose uptake into warm-blooded animal adipocytes |
| CN1812988A (zh) * | 2003-05-13 | 2006-08-02 | 斯索恩有限公司 | 制备噻唑烷二酮衍生物的方法及其化合物 |
| US7230016B2 (en) * | 2003-05-13 | 2007-06-12 | Synthon Ip Inc. | Pioglitazone salts, such as pioglitazone sulfate, and pharmaceutical compositions and processes using the same |
| US20050004179A1 (en) * | 2003-05-22 | 2005-01-06 | Pedersen Ward A. | Methods and materials for treating, detecting, and reducing the risk of developing Alzheimer's Disease |
| JP2007506649A (ja) * | 2003-06-27 | 2007-03-22 | ドクター レディーズ リサーチ ファンデーション | バラグリタゾンとさらなる抗糖尿病化合物とを含む組成物 |
| US20050013863A1 (en) | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
| JP2007508241A (ja) * | 2003-07-31 | 2007-04-05 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | Ｐｄｅ１０ａ阻害剤を用いる糖尿病および関連障害の処置方法 |
| EP1510208A1 (en) * | 2003-08-22 | 2005-03-02 | Fournier Laboratories Ireland Limited | Pharmaceutical composition comprising a combination of metformin and statin |
| US20050054731A1 (en) * | 2003-09-08 | 2005-03-10 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity |
| US7223761B2 (en) | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| US20070004623A1 (en) * | 2003-10-27 | 2007-01-04 | Innodia Inc. | Use of hydroxylated amino acids for treating diabetes |
| PL1677792T3 (pl) | 2003-10-31 | 2016-05-31 | Takeda Pharmaceuticals Co | Stały preparat zawierający pioglitazon, glimepiryd i ester polioksyetylenosorbitanu z kwasem tłuszczowym |
| US7892251B1 (en) | 2003-11-12 | 2011-02-22 | Advanced Cardiovascular Systems, Inc. | Component for delivering and locking a medical device to a guide wire |
| EP1841414A1 (en) * | 2003-12-31 | 2007-10-10 | Alpharma, Inc. | Rosiglitazone and metformin formulations |
| EP1732513A2 (en) * | 2003-12-31 | 2006-12-20 | Alpharma, Inc. | Rosiglitazone formulations |
| US7360069B2 (en) * | 2004-01-13 | 2008-04-15 | Hewlett-Packard Development Company, L.P. | Systems and methods for executing across at least one memory barrier employing speculative fills |
| JP2005200419A (ja) * | 2004-01-16 | 2005-07-28 | National Health Research Inst | 癌治療法 |
| WO2005074909A1 (ja) * | 2004-02-09 | 2005-08-18 | Aska Pharmaceutical Co., Ltd. | 併用医薬 |
| EP1716144A2 (en) * | 2004-02-20 | 2006-11-02 | Synthon B.V. | Processes for making pioglitazone and compounds of the processes |
| WO2005084666A1 (en) * | 2004-03-02 | 2005-09-15 | Abeille Pharmaceuticals, Inc. | Co-formulations of kits of bioactive agents |
| US7678129B1 (en) | 2004-03-19 | 2010-03-16 | Advanced Cardiovascular Systems, Inc. | Locking component for an embolic filter assembly |
| US7161756B2 (en) * | 2004-05-10 | 2007-01-09 | Tandberg Data Storage Asa | Method and system for communication between a tape drive and an external device |
| CN1327840C (zh) * | 2004-06-08 | 2007-07-25 | 天津药物研究院 | 一种药物组合物及其在制备用于治疗糖尿病中的应用 |
| AU2005271526B2 (en) * | 2004-08-03 | 2011-12-08 | Emisphere Technologies, Inc. | Antidiabetic oral insulin-biguanide combination |
| WO2006032011A2 (en) * | 2004-09-14 | 2006-03-23 | Elixir Pharmaceuticals, Inc. | Combination therapy for controlled carbohydrate digestion |
| MXPA04009236A (es) * | 2004-09-23 | 2006-03-27 | Jorge Luis Rosado Loria | Composicion sinergistica para el tratamiento de diabetes y sus comorbilidades. |
| JP2008019169A (ja) * | 2004-10-25 | 2008-01-31 | Osaka Univ | 新規ｐｐａｒ調節剤およびそのスクリーニング方法 |
| US20060089387A1 (en) * | 2004-10-26 | 2006-04-27 | Le Huang | Stabilized pharmaceutical composition comprising antidiabetic agent |
| US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
| TW200619204A (en) * | 2004-12-10 | 2006-06-16 | Kowa Co | Method for reduction, stabilization and prevention of rupture of lipid rich plaque |
| US9259305B2 (en) | 2005-03-31 | 2016-02-16 | Abbott Cardiovascular Systems Inc. | Guide wire locking mechanism for rapid exchange and other catheter systems |
| US20100028439A1 (en) * | 2005-05-23 | 2010-02-04 | Elan Pharma International Limited | Nanoparticulate stabilized anti-hypertensive compositions |
| GT200600218A (es) * | 2005-06-10 | 2007-03-28 | Formulación y proceso de compresión directa | |
| CN101217965B (zh) * | 2005-07-07 | 2012-07-18 | 学校法人浦项工科大学校 | 葡萄糖吸收调节剂和用于治疗糖尿病或糖尿病并发症的方法 |
| US20070015839A1 (en) * | 2005-07-14 | 2007-01-18 | Franco Folli | Daily Dosage Regimen for Treating Diabetes, Obesity, Metabolic Syndrome and Polycystic Ovary Syndrome |
| CA2615975C (en) * | 2005-07-22 | 2012-11-27 | The Procter & Gamble Company | Compositions for reducing the incidence of drug induced arrhythmia |
| MXPA05013220A (es) * | 2005-12-06 | 2007-06-05 | Leopoldo De Jesus Espinosa Abdala | Composiciones farmaceuticas que comprenden sustancias antidiabeticas combinadas para su uso en diabetes mellitus tipo 2. |
| HRP20160679T1 (hr) | 2005-12-22 | 2016-07-15 | Takeda Pharmaceutical Company Limited | Kruti pripravak koji sadrži senzibilizator inzulina |
| FR2896157B1 (fr) | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents de stimulation de secretion d'insuline. |
| WO2007105730A1 (ja) * | 2006-03-13 | 2007-09-20 | Kyowa Hakko Kogyo Co., Ltd. | インスリン抵抗性改善剤 |
| RU2445957C2 (ru) | 2006-03-16 | 2012-03-27 | Метаболик Солюшнз Девелопмент Компани | Аналоги тиазолидиндиона |
| JP2009532372A (ja) * | 2006-03-31 | 2009-09-10 | ウェルスタット セラピューティクス コーポレイション | 代謝障害の併用治療 |
| EP2010457B1 (en) * | 2006-04-11 | 2011-09-07 | Sorbwater Technology AS | Method for removal of materials from a liquid stream |
| US7435741B2 (en) | 2006-05-09 | 2008-10-14 | Teva Pharmaceutical Industries, Ltd. | 2-N{5-[[4-[2-(methyl-2-pyridinylamino) ethoxy] phenyl]methyl]-2,4-thiazolidinedione} butanedioic acid, methods of preparation and compositions with rosiglitazone maleate |
| EP2452683A3 (en) | 2006-06-26 | 2012-08-22 | Amgen Inc. | Methods for treating atherosclerosis |
| US7752724B2 (en) * | 2006-06-27 | 2010-07-13 | Lumino, Inc. | Method of cutting blinds |
| WO2008026668A1 (en) * | 2006-08-31 | 2008-03-06 | Daiichi Sankyo Company, Limited | Medicinal composition containing insulin resistance improving agent |
| US20080182880A1 (en) * | 2006-09-28 | 2008-07-31 | Mailatur Sivaraman Mohan | Pioglitazone composition |
| US8217025B2 (en) * | 2006-11-17 | 2012-07-10 | Harbor Therapeutics, Inc. | Drug screening and treatment methods |
| EP2016076A2 (en) * | 2007-01-22 | 2009-01-21 | Teva Pharmaceutical Industries Ltd. | Polymorphic forms of rosiglitazone hydrobromide and processes for preparation thereof |
| EP2106260B8 (en) | 2007-01-25 | 2018-04-04 | Naia Metabolic, Inc. | Insulin sensitisers and methods of treatment |
| ME01239B (me) * | 2007-02-01 | 2013-06-20 | Takeda Pharmaceuticals Co | Čvrsti preparat koji sadrži alogliptin i pioglitazon |
| US20080249156A1 (en) * | 2007-04-09 | 2008-10-09 | Palepu Nageswara R | Combinations of statins and anti-obesity agent and glitazones |
| ES2830073T3 (es) * | 2007-04-11 | 2021-06-02 | Omeros Corp | Composiciones y métodos para la profilaxis y el tratamiento de adicciones |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US20160331729A9 (en) | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US8216209B2 (en) | 2007-05-31 | 2012-07-10 | Abbott Cardiovascular Systems Inc. | Method and apparatus for delivering an agent to a kidney |
| JP5546451B2 (ja) | 2007-06-04 | 2014-07-09 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| RU2345771C1 (ru) * | 2007-06-19 | 2009-02-10 | Илья Николаевич Медведев | Способ нормализации тромбопластинообразования у больных метаболическим синдромом |
| US7867273B2 (en) | 2007-06-27 | 2011-01-11 | Abbott Laboratories | Endoprostheses for peripheral arteries and other body vessels |
| CN101855344B (zh) | 2007-07-26 | 2015-12-09 | 安姆根有限公司 | 修饰的卵磷脂-胆固醇酰基转移酶 |
| AU2008301905B2 (en) * | 2007-09-14 | 2013-06-27 | Cirius Therapeutics, Inc. | Thiazolidinedione analogues for the treatment of hypertension |
| WO2009038107A1 (ja) * | 2007-09-21 | 2009-03-26 | Kissei Pharmaceutical Co., Ltd. | ２型糖尿病治療用の組合せ医薬 |
| WO2009073627A1 (en) * | 2007-11-30 | 2009-06-11 | The Research Foundation Of State University Of New York | Metabolic fuel switching biomarker |
| US8551524B2 (en) | 2008-03-14 | 2013-10-08 | Iycus, Llc | Anti-diabetic combinations |
| EP2190417A2 (en) * | 2008-03-26 | 2010-06-02 | Teva Pharmaceutical Industries Ltd. | Pharmaceutical compositions comprising insulin sensitizer and insulin secretagogue |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| NZ710443A (en) | 2008-08-12 | 2019-03-29 | Zinfandel Pharmaceuticals Inc | Method of identifying disease risk factors |
| US8846315B2 (en) | 2008-08-12 | 2014-09-30 | Zinfandel Pharmaceuticals, Inc. | Disease risk factors and methods of use |
| TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| KR101767273B1 (ko) | 2009-03-11 | 2017-08-10 | 오메로스 코포레이션 | 중독의 예방 및 치료용 조성물 및 방법 |
| US20110038848A1 (en) * | 2009-08-12 | 2011-02-17 | Melaleuca, Inc. | Dietary supplement compositions for cardiovascular health |
| CN102655866B (zh) | 2009-11-13 | 2013-11-13 | 东丽株式会社 | 糖尿病的治疗或预防药 |
| JP5802676B2 (ja) * | 2009-12-04 | 2015-10-28 | センワ バイオサイエンシズ インコーポレイテッド | Ｃｋ２阻害剤としてのピラゾロピリミジンおよび関連複素環化合物 |
| NZ600421A (en) * | 2009-12-15 | 2014-06-27 | Metabolic Solutions Dev Co Llc | Ppar-sparing thiazolidinediones and combinations for the treatment of neurodegenerative diseases |
| HUE038042T2 (hu) * | 2009-12-15 | 2018-09-28 | Cirius Therapeutics Inc | PPAR helyettesítõ tiazolidindion sók metabolikus betegségek kezelésére |
| JP2013523681A (ja) | 2010-03-30 | 2013-06-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｇｌｔ２インヒビター及びｐｐａｒ−ガンマアゴニストを含む医薬組成物並びにその使用 |
| WO2011127051A1 (en) * | 2010-04-06 | 2011-10-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| RU2526153C2 (ru) * | 2010-07-15 | 2014-08-20 | Олег Ильич Эпштейн | Способ повышения фармакологической активности действующего вещества лекарственного средства и фармацевтическая композиция |
| EP2611434A1 (en) | 2010-09-01 | 2013-07-10 | Lupin Limited | Pharmaceutical composition comprising metformin and pioglitazone |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| MX2013003184A (es) | 2010-09-22 | 2013-06-07 | Arena Pharm Inc | Moduladores del receptor gpr119 y el tratamiento de transtornos relacionados con el mismo. |
| AU2012205798B2 (en) | 2011-01-10 | 2016-02-25 | Takeda Pharmaceutical Company Limited | Methods and drug products for treating Alzheimer's disease |
| RS54447B1 (sr) * | 2011-01-20 | 2016-06-30 | Bionevia Pharmaceuticals Inc. | Modifikovano oslobađajuće kompozicije epalrestata ili njegovih derivata i postupci njihove upotrebe |
| WO2013034174A1 (en) | 2011-09-06 | 2013-03-14 | ZENTIVA Saglik Ürünleri Sanayi ve Ticaret A.S. | Solid preparations of pioglitazone and glimepiride |
| EA030839B1 (ru) | 2011-10-28 | 2018-10-31 | ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи | Ингибиторы рециклинга желчных кислот при лечении холестатических заболеваний печени у детей |
| WO2013063526A1 (en) | 2011-10-28 | 2013-05-02 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
| AU2012347540A1 (en) | 2011-12-08 | 2014-06-26 | Amgen Inc. | Agonistic human LCAT antigen binding proteins and their use in therapy |
| US9504679B2 (en) | 2011-12-19 | 2016-11-29 | Bjoern Colin Kahrs | Pharmaceutical compositions comprising glitazones and Nrf2 activators |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| HK1220696A1 (zh) | 2013-03-15 | 2017-05-12 | Bausch Health Ireland Limited | 鸟苷酸环化酶激动剂及其用途 |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| EP4424697A3 (en) | 2013-06-05 | 2024-12-25 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| EP3065757A4 (en) | 2013-10-09 | 2017-08-23 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for downregulation of pro-inflammatory cytokines |
| RU2572706C1 (ru) * | 2014-06-30 | 2016-01-20 | Олег Ильич Эпштейн | Способ повышения фармакологической активности действующего вещества лекарственного средства и фармацевтическая композиция |
| ES2905872T3 (es) | 2015-02-06 | 2022-04-12 | Intercept Pharmaceuticals Inc | Composiciones farmacéuticas para terapia combinada |
| BR112017027656B1 (pt) | 2015-06-22 | 2023-12-05 | Arena Pharmaceuticals, Inc. | Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo |
| EP3568134A1 (en) | 2017-01-16 | 2019-11-20 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods and pharmaceutical compositions for reducing cd95- mediated cell motility |
| BR112020024762A2 (pt) | 2018-06-06 | 2021-03-23 | Arena Pharmaceuticals, Inc. | métodos de tratamento de condições relacionadas ao receptor s1p1 |
| JP2021528738A (ja) | 2018-06-14 | 2021-10-21 | アストラゼネカ・ユーケイ・リミテッドＡｓｔｒａＺｅｎｅｃａ ＵＫ Ｌｉｍｉｔｅｄ | メトホルミン医薬組成物を用いて血糖を低下させるための方法 |
| WO2020243590A1 (en) | 2019-05-30 | 2020-12-03 | Intercept Pharmaceuticals, Inc. | Pharmaceutical compositions comprising a fxr agonist and a fibrate for use in the treatment of cholestatic liver disease |
| CN115461344B (zh) | 2020-04-01 | 2024-01-12 | 杭州中美华东制药有限公司 | 一种glp-1受体激动剂的晶型a及其制备方法 |
| WO2021196951A1 (zh) | 2020-04-01 | 2021-10-07 | 杭州中美华东制药有限公司 | Glp-1受体激动剂游离碱的药学上可接受的酸式盐及其制备方法 |
| CN112869173A (zh) * | 2021-01-18 | 2021-06-01 | 广州富诺营养科技有限公司 | 一种复合维生素矿物质制剂及其制备方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3454635A (en) | 1965-07-27 | 1969-07-08 | Hoechst Ag | Benzenesulfonyl-ureas and process for their manufacture |
| JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
| JPS5728073A (en) * | 1980-07-29 | 1982-02-15 | Takeda Chem Ind Ltd | Inhibitor for aldose reducing enzyme |
| US4863922A (en) | 1984-12-12 | 1989-09-05 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use |
| AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
| DE3543999A1 (de) * | 1985-12-13 | 1987-06-19 | Bayer Ag | Hochreine acarbose |
| EP0306525A4 (en) * | 1987-03-20 | 1991-04-24 | Alcon Laboratories Inc | Use of aldose reductase inhibitors to enhance insulin sensitivity in diabetes mellitus |
| DE3729209A1 (de) * | 1987-09-01 | 1989-03-09 | Boehringer Mannheim Gmbh | Verwendung von bezafibrat zur behandlung von diabetes |
| EP0306228B1 (en) | 1987-09-04 | 1999-11-17 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| US4895862A (en) * | 1989-04-21 | 1990-01-23 | American Home Products Corp. | Novel benzyl-3H-1,2,3,5-oxathiadiazole 2-oxides useful as antihyperglycemic agents |
| US5068342A (en) * | 1989-10-27 | 1991-11-26 | American Home Products Corporation | 5-[(1- and 2-naphthalenyl)thio and sulfonyl]-2,4-thiazolidinediones and derivatives thereof |
| US5356913A (en) * | 1990-02-09 | 1994-10-18 | The Upjohn Company | Use of insulin sensitizing agents to treat hypertension |
| JPH0466579A (ja) * | 1990-07-04 | 1992-03-02 | Yamanouchi Pharmaceut Co Ltd | チアゾリジン誘導体 |
| JPH0469383A (ja) * | 1990-07-06 | 1992-03-04 | Yamanouchi Pharmaceut Co Ltd | 置換チアゾリジン誘導体 |
| US5260275A (en) | 1990-08-14 | 1993-11-09 | Amylin Pharmaceuticals, Inc. | Hypoglycemics |
| CA2052014A1 (en) * | 1990-10-19 | 1992-04-20 | Henry Y. Pan | Method for preventing diabetic complications employing a cholesterol lowering drug alone or in combination with an ace inhibitor |
| JP2686861B2 (ja) * | 1991-03-30 | 1997-12-08 | キッセイ薬品工業株式会社 | 新規なベンジリデンコハク酸誘導体 |
| CA2106967C (en) * | 1991-04-11 | 2003-12-09 | Takashi Sohda | Thiazolidinedione derivatives, production and use thereof |
| WO1993003724A1 (en) * | 1991-08-26 | 1993-03-04 | The Upjohn Company | Pharmaceutical composition containing 3-guanidinopropionic acid and pioglitazone glibenclamide or glimepiride |
| JPH05202042A (ja) * | 1992-01-24 | 1993-08-10 | Sankyo Co Ltd | 糖尿病性合併症治療剤 |
| JPH07316144A (ja) * | 1994-03-29 | 1995-12-05 | Sankyo Co Ltd | ジフェニルメチルピペラジン誘導体 |
| TW403748B (en) * | 1994-11-02 | 2000-09-01 | Takeda Chemical Industries Ltd | An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same |
| US5674900A (en) * | 1995-06-06 | 1997-10-07 | Shaman Pharmaceuticals, Inc. | Terpenoid-type quinones for treatment of diabetes |
| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| NZ286920A (en) * | 1995-07-03 | 1997-06-24 | Sankyo Co | Use of combination of hmg-coa reductase inhibitors and of insulin sensitizers for the prevention/treatment of arteriosclerosis or xanthoma |
| US5859037A (en) | 1997-02-19 | 1999-01-12 | Warner-Lambert Company | Sulfonylurea-glitazone combinations for diabetes |
| US6011049A (en) | 1997-02-19 | 2000-01-04 | Warner-Lambert Company | Combinations for diabetes |
| GB9715298D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
| US6001049A (en) * | 1998-02-12 | 1999-12-14 | Frey; Mark P. | Light weight exercise apparatus |
-
1996
- 1996-06-12 TW TW090105054A patent/TWI238064B/zh not_active IP Right Cessation
- 1996-06-12 TW TW085107042A patent/TW438587B/zh not_active IP Right Cessation
- 1996-06-18 SK SK794-96A patent/SK287351B6/sk not_active IP Right Cessation
- 1996-06-18 SK SK1449-2001A patent/SK287287B6/sk not_active IP Right Cessation
- 1996-06-18 JP JP15672596A patent/JP3148973B2/ja not_active Expired - Lifetime
- 1996-06-19 RU RU2002104459/63A patent/RU2327455C2/ru active
- 1996-06-19 ZA ZA9605190A patent/ZA965190B/xx unknown
- 1996-06-19 RU RU96111958/63A patent/RU2323004C2/ru active
- 1996-06-19 NO NO19962606A patent/NO313226B1/no not_active IP Right Cessation
- 1996-06-19 CN CNB961110635A patent/CN1212117C/zh not_active Expired - Lifetime
- 1996-06-19 AR ARP960103195A patent/AR005641A1/es not_active Application Discontinuation
- 1996-06-19 CN CNB021491313A patent/CN1289082C/zh not_active Expired - Fee Related
- 1996-06-19 US US08/667,979 patent/US5952356A/en not_active Expired - Lifetime
- 1996-06-19 CN CNA021491321A patent/CN1530106A/zh active Pending
- 1996-06-19 RU RU2002104459/14K patent/RU2223760C2/ru active IP Right Maintenance
- 1996-06-19 RU RU96111958/14K patent/RU2198682C2/ru active IP Right Maintenance
- 1996-06-19 MX MX9602399A patent/MX9602399A/es active IP Right Grant
- 1996-06-19 CZ CZ19961811A patent/CZ291624B6/cs not_active IP Right Cessation
- 1996-06-20 DE DE200912000064 patent/DE122009000064I1/de active Pending
- 1996-06-20 DK DK01203170T patent/DK1174135T3/da active
- 1996-06-20 KR KR1019960022615A patent/KR970000233A/ko not_active Ceased
- 1996-06-20 EP EP98200252A patent/EP0861666B1/en not_active Revoked
- 1996-06-20 AT AT01203170T patent/ATE438397T1/de active
- 1996-06-20 EP EP10012501A patent/EP2289556A3/en not_active Withdrawn
- 1996-06-20 CA CA2533845A patent/CA2533845C/en not_active Expired - Fee Related
- 1996-06-20 MY MYPI96002486A patent/MY127530A/en unknown
- 1996-06-20 EP EP96304570A patent/EP0749751A3/en not_active Ceased
- 1996-06-20 ES ES98200252T patent/ES2212208T3/es not_active Expired - Lifetime
- 1996-06-20 CA CA002179584A patent/CA2179584C/en not_active Expired - Lifetime
- 1996-06-20 DE DE69631157T patent/DE69631157T2/de not_active Expired - Lifetime
- 1996-06-20 EP EP01203170.4A patent/EP1174135B2/en not_active Expired - Lifetime
- 1996-06-20 EP EP06022352A patent/EP1764110A1/en not_active Withdrawn
- 1996-06-20 PT PT98200252T patent/PT861666E/pt unknown
- 1996-06-20 ES ES01203170.4T patent/ES2327383T5/es not_active Expired - Lifetime
- 1996-06-20 DK DK98200252T patent/DK0861666T3/da active
- 1996-06-20 DE DE69637988T patent/DE69637988D1/de not_active Expired - Lifetime
- 1996-06-20 EP EP10012500A patent/EP2292268A1/en not_active Withdrawn
- 1996-06-20 HU HU9601698A patent/HUP9601698A3/hu not_active Application Discontinuation
- 1996-06-20 PT PT01203170T patent/PT1174135E/pt unknown
- 1996-06-20 CA CA002531834A patent/CA2531834C/en not_active Expired - Lifetime
- 1996-06-20 AT AT98200252T patent/ATE256463T1/de active
-
1997
- 1997-12-26 JP JP36075697A patent/JP3973280B2/ja not_active Expired - Lifetime
-
1998
- 1998-04-09 US US09/057,465 patent/US5965584A/en not_active Expired - Lifetime
-
1999
- 1999-03-30 US US09/280,710 patent/US6150383A/en not_active Expired - Lifetime
- 1999-04-30 US US09/302,470 patent/US6166042A/en not_active Expired - Lifetime
- 1999-04-30 US US09/303,497 patent/US6156773A/en not_active Expired - Lifetime
- 1999-04-30 US US09/302,468 patent/US6169099B1/en not_active Expired - Lifetime
- 1999-04-30 US US09/302,469 patent/US6133293A/en not_active Expired - Lifetime
- 1999-04-30 US US09/303,492 patent/US6166043A/en not_active Expired - Lifetime
- 1999-04-30 US US09/303,496 patent/US6121295A/en not_active Expired - Lifetime
- 1999-04-30 US US09/303,495 patent/US6172090B1/en not_active Expired - Lifetime
- 1999-04-30 US US09/303,494 patent/US6172089B1/en not_active Expired - Lifetime
- 1999-04-30 US US09/303,493 patent/US6150384A/en not_active Expired - Lifetime
- 1999-04-30 US US09/302,508 patent/US6214848B1/en not_active Expired - Lifetime
- 1999-05-27 US US09/321,099 patent/US6133295A/en not_active Expired - Lifetime
- 1999-05-27 US US09/321,098 patent/US6080765A/en not_active Expired - Lifetime
- 1999-05-27 US US09/321,097 patent/US6225326B1/en not_active Expired - Lifetime
- 1999-05-27 US US09/321,095 patent/US6174904B1/en not_active Expired - Lifetime
- 1999-05-27 US US09/321,096 patent/US6121294A/en not_active Expired - Lifetime
- 1999-08-31 US US09/386,504 patent/US6169100B1/en not_active Expired - Lifetime
- 1999-08-31 US US09/386,457 patent/US6103742A/en not_active Expired - Lifetime
- 1999-12-03 US US09/453,521 patent/US6329404B1/en not_active Expired - Lifetime
-
2000
- 2000-06-29 US US09/605,704 patent/US6303640B1/en not_active Expired - Lifetime
- 2000-06-29 US US09/606,176 patent/US6211205B1/en not_active Expired - Lifetime
- 2000-07-06 US US09/610,994 patent/US6218409B1/en not_active Expired - Lifetime
- 2000-07-06 US US09/610,993 patent/US6232330B1/en not_active Expired - Lifetime
- 2000-07-06 US US09/610,992 patent/US6288090B1/en not_active Expired - Lifetime
- 2000-07-18 US US09/618,634 patent/US6323225B1/en not_active Expired - Lifetime
- 2000-07-18 US US09/618,636 patent/US6239153B1/en not_active Expired - Lifetime
- 2000-07-18 US US09/618,635 patent/US6251924B1/en not_active Expired - Lifetime
- 2000-07-19 US US09/619,641 patent/US6211207B1/en not_active Expired - Lifetime
- 2000-07-19 US US09/619,640 patent/US6211206B1/en not_active Expired - Lifetime
- 2000-09-01 NO NO20004345A patent/NO314065B1/no not_active IP Right Cessation
- 2000-11-28 US US09/722,330 patent/US6274605B1/en not_active Expired - Lifetime
- 2000-11-28 US US09/722,291 patent/US6277869B1/en not_active Expired - Lifetime
- 2000-11-28 US US09/722,597 patent/US6271243B1/en not_active Expired - Lifetime
-
2001
- 2001-07-19 US US09/907,768 patent/US20020002186A1/en not_active Abandoned
- 2001-10-11 US US09/973,689 patent/US6384062B1/en not_active Expired - Lifetime
-
2002
- 2002-02-21 HK HK02101272.5A patent/HK1041203B/en not_active IP Right Cessation
- 2002-02-28 US US10/084,479 patent/US20020123512A1/en not_active Abandoned
- 2002-03-08 NO NONO/SPC/2A patent/NO317341B1/no not_active IP Right Cessation
- 2002-03-13 US US10/095,453 patent/US6599923B2/en not_active Expired - Lifetime
- 2002-07-15 CZ CZ20022453A patent/CZ292093B6/cs not_active IP Right Cessation
-
2003
- 2003-06-17 US US10/462,793 patent/US6911459B2/en not_active Expired - Fee Related
- 2003-10-20 RU RU2003130978/14A patent/RU2286148C2/ru not_active IP Right Cessation
-
2004
- 2004-02-19 CY CY0400010A patent/CY2424B1/xx unknown
- 2004-07-26 US US10/898,316 patent/US20040266830A1/en not_active Abandoned
- 2004-09-10 US US10/937,494 patent/US7144900B2/en not_active Expired - Fee Related
- 2004-10-07 KR KR1020040079966A patent/KR20070081135A/ko not_active Ceased
-
2006
- 2006-09-20 US US11/523,771 patent/US7538125B2/en not_active Expired - Fee Related
- 2006-12-20 LU LU91298C patent/LU91298I2/fr unknown
-
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- 2007-01-04 NO NO2007001C patent/NO2007001I2/no unknown
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- 2007-01-25 NL NL300258C patent/NL300258I2/nl unknown
- 2007-04-25 JP JP2007115861A patent/JP4809806B2/ja not_active Expired - Lifetime
- 2007-05-28 AR ARP070102280A patent/AR061195A2/es not_active Application Discontinuation
- 2007-06-04 NO NO2007007C patent/NO2007007I2/no unknown
- 2007-12-20 KR KR1020070134272A patent/KR20080005162A/ko not_active Ceased
-
2008
- 2008-02-20 AR ARP080100677A patent/AR065389A2/es not_active Application Discontinuation
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2009
- 2009-03-20 US US12/382,691 patent/US7842706B2/en not_active Expired - Fee Related
- 2009-09-09 LU LU91606C patent/LU91606I2/fr unknown
- 2009-10-20 CY CY0900011A patent/CY2608B2/xx unknown
- 2009-10-23 FR FR09C0055C patent/FR09C0055I2/fr active Active
- 2009-12-01 CY CY2009018C patent/CY2009018I1/el unknown
-
2010
- 2010-01-15 NL NL300432C patent/NL300432I2/en unknown
- 2010-10-19 US US12/923,975 patent/US20110034518A1/en not_active Abandoned
-
2011
- 2011-01-06 AR ARP110100033 patent/AR091289A2/es not_active Application Discontinuation
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