JPS5728073A - Inhibitor for aldose reducing enzyme - Google Patents

Inhibitor for aldose reducing enzyme

Info

Publication number
JPS5728073A
JPS5728073A JP10471780A JP10471780A JPS5728073A JP S5728073 A JPS5728073 A JP S5728073A JP 10471780 A JP10471780 A JP 10471780A JP 10471780 A JP10471780 A JP 10471780A JP S5728073 A JPS5728073 A JP S5728073A
Authority
JP
Japan
Prior art keywords
inhibitor
compound
reducing enzyme
sorbitol
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10471780A
Other languages
Japanese (ja)
Other versions
JPH0135831B2 (en
Inventor
Yutaka Kawamatsu
Yujiro Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SENJIYU SEIYAKU KK
Senju Pharmaceutical Co Ltd
Takeda Pharmaceutical Co Ltd
Original Assignee
SENJIYU SEIYAKU KK
Senju Pharmaceutical Co Ltd
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SENJIYU SEIYAKU KK, Senju Pharmaceutical Co Ltd, Takeda Chemical Industries Ltd filed Critical SENJIYU SEIYAKU KK
Priority to JP10471780A priority Critical patent/JPS5728073A/en
Publication of JPS5728073A publication Critical patent/JPS5728073A/en
Publication of JPH0135831B2 publication Critical patent/JPH0135831B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: An inhibitor for aldose reducing enzyme useful for preventing and remedying diabetic cataract, neurosis, retinopathy, etc., comprising a thazolidine derivative.
CONSTITUTION: An inhibitor for aldose reducing enzyme comprising a thiazolidine derivative shown by the formula (R is H, lower alkyl, OH, alkoxy, nitro, amino, lower acylamino, halogen, or CF3). The compound suppresses the reduction from glucose to sorbitol, prevents or reduces the accumulation of sorbitol in the lens, peripheral nervous system, and liver of diabetic patient, and controls complicating diseases. A compound shown by the formula wherein R is H or halogen other than F is a novel compound. A dose per adult is 0.2W1,000mg per day, and the compound is used as 0.001W1wt% solution for instillation.
COPYRIGHT: (C)1982,JPO&Japio
JP10471780A 1980-07-29 1980-07-29 Inhibitor for aldose reducing enzyme Granted JPS5728073A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10471780A JPS5728073A (en) 1980-07-29 1980-07-29 Inhibitor for aldose reducing enzyme

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10471780A JPS5728073A (en) 1980-07-29 1980-07-29 Inhibitor for aldose reducing enzyme

Publications (2)

Publication Number Publication Date
JPS5728073A true JPS5728073A (en) 1982-02-15
JPH0135831B2 JPH0135831B2 (en) 1989-07-27

Family

ID=14388230

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10471780A Granted JPS5728073A (en) 1980-07-29 1980-07-29 Inhibitor for aldose reducing enzyme

Country Status (1)

Country Link
JP (1) JPS5728073A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59137474A (en) * 1983-01-17 1984-08-07 ファイザ−・インコ−ポレ−テッド 5-(2-alkoxyphenyl)thiazolidindiones inhibiting aldose reductase
US4602026A (en) * 1984-08-03 1986-07-22 Senju Pharmaceutical Co., Ltd. Ophthalmic topical agent for remedy of diseases of iris and ciliary body
US4617312A (en) * 1983-01-17 1986-10-14 Pfizer Inc. Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones
WO1992014719A1 (en) * 1991-02-25 1992-09-03 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivative, salt thereof, and production of the same
WO1992014730A1 (en) * 1991-02-25 1992-09-03 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivative, salt thereof, and production thereof
WO1997022600A1 (en) * 1995-12-18 1997-06-26 Kyorin Pharmaceutical Co., Ltd. N-substituted dioxothiazolidylbenzamide derivatives and process for producing the same
JPH10167986A (en) * 1995-06-20 1998-06-23 Takeda Chem Ind Ltd Medicine

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59137474A (en) * 1983-01-17 1984-08-07 ファイザ−・インコ−ポレ−テッド 5-(2-alkoxyphenyl)thiazolidindiones inhibiting aldose reductase
US4617312A (en) * 1983-01-17 1986-10-14 Pfizer Inc. Aldose reductase inhibiting 5-(2-alkoxyphenyl) thiazolidinediones
JPH0329073B2 (en) * 1983-01-17 1991-04-23 Pfizer
US4602026A (en) * 1984-08-03 1986-07-22 Senju Pharmaceutical Co., Ltd. Ophthalmic topical agent for remedy of diseases of iris and ciliary body
US5308856A (en) * 1991-02-25 1994-05-03 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivatives, salts and preparation processes thereof
WO1992014730A1 (en) * 1991-02-25 1992-09-03 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivative, salt thereof, and production thereof
WO1992014719A1 (en) * 1991-02-25 1992-09-03 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivative, salt thereof, and production of the same
US5342850A (en) * 1991-02-25 1994-08-30 Kyorin Pharmaceutical Co., Ltd. Thiazolidine-2,4-dione derivatives, their salts and their preparation processes
JPH10167986A (en) * 1995-06-20 1998-06-23 Takeda Chem Ind Ltd Medicine
JP3973280B2 (en) * 1995-06-20 2007-09-12 武田薬品工業株式会社 Medicine
US7538125B2 (en) 1995-06-20 2009-05-26 Takeda Pharmaceutical Company Limited Pharmaceutical composition
US7842706B2 (en) 1995-06-20 2010-11-30 Takeda Pharmaceutical Company Limited Pharmaceutical composition
WO1997022600A1 (en) * 1995-12-18 1997-06-26 Kyorin Pharmaceutical Co., Ltd. N-substituted dioxothiazolidylbenzamide derivatives and process for producing the same

Also Published As

Publication number Publication date
JPH0135831B2 (en) 1989-07-27

Similar Documents

Publication Publication Date Title
JPS5671074A (en) 1,2-disubstituted-4-halogenoimidazole-5-acetic acid derivative
DE3177092D1 (en) Medicinal composition for treatment of allergic diseases
NO860424L (en) PROCEDURE FOR THE PREPARATION OF 6-THIOXANTHIN DERIVATIVES.
JPS5728073A (en) Inhibitor for aldose reducing enzyme
CA1182472A (en) N-[(2-naphthalenyl)thioxomethyl]glycine derivatives
JPS5767516A (en) Novel analgesic agent
PL295932A1 (en) Method of obtaining novel bezazepine compounds
GB2010675A (en) Method of treating hypertension and medicaments therefor
JPS56156273A (en) Acetic derivative
TW245717B (en)
JPS57123175A (en) Preparation of thiazolidine derivative
IE832854L (en) Spiro-3-hetero-azolones for treatment of diabetic¹complications.
EG16563A (en) Aldose reductase inhibiting 5-(2-alkoxyphenyl)thiazolidinediones
ES523461A0 (en) A PROCEDURE FOR PREPARING 3- (2- (AZABICICLO) ETIL) -1,2,3,4-TETRAHIDRO-5H- (1) BENZOPYRAN (3,4-C) PIRIDIN-5-ONAS
JPS5598163A (en) Cinnamylmoranoline derivative
CA1211116A (en) Naphthalenylthiazole derivatives
IL95377A0 (en) Therapeutic agent for the treatment of peptic ulcer disease containing xanthine derivatives and some novel compounds of this type
JPS5675428A (en) Hypoglycemic agent containing procainamide hydrochloride
JPS55102516A (en) Remedy for glaucoma
JPS57181012A (en) Drug composed of polyprenyl compound
ES8504144A1 (en) Aldose reductase inhibiting 5-(2-alkoxy-3-substituted phenyl)hydantoins
JPS5716821A (en) Remedy for disease due to immunological dysfunction
JPS57140713A (en) Novel preventing agent and remedy for allergic disease
JPS5610173A (en) Analgesic
JPS5495734A (en) Antiphlogistic analgesic agent