NO312434B1 - Farmasöytiske preparater, samt anvendelse og fremgangsmåte for fremstilling derav - Google Patents
Farmasöytiske preparater, samt anvendelse og fremgangsmåte for fremstilling derav Download PDFInfo
- Publication number
- NO312434B1 NO312434B1 NO20003967A NO20003967A NO312434B1 NO 312434 B1 NO312434 B1 NO 312434B1 NO 20003967 A NO20003967 A NO 20003967A NO 20003967 A NO20003967 A NO 20003967A NO 312434 B1 NO312434 B1 NO 312434B1
- Authority
- NO
- Norway
- Prior art keywords
- tribasic
- pharmaceutical composition
- composition according
- phosphate
- salt
- Prior art date
Links
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- 238000000034 method Methods 0.000 title claims description 6
- 238000002360 preparation method Methods 0.000 title description 3
- 239000000203 mixture Substances 0.000 claims description 39
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 28
- 239000004135 Bone phosphate Substances 0.000 claims description 25
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 24
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 24
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 22
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 17
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- 150000001768 cations Chemical class 0.000 claims description 16
- 239000011230 binding agent Substances 0.000 claims description 14
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- 239000000945 filler Substances 0.000 claims description 13
- BPRHUIZQVSMCRT-VEUZHWNKSA-N rosuvastatin Chemical compound CC(C)C1=NC(N(C)S(C)(=O)=O)=NC(C=2C=CC(F)=CC=2)=C1\C=C\[C@@H](O)C[C@@H](O)CC(O)=O BPRHUIZQVSMCRT-VEUZHWNKSA-N 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
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- 239000008109 sodium starch glycolate Substances 0.000 claims description 12
- 229940079832 sodium starch glycolate Drugs 0.000 claims description 12
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 11
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 11
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- 239000004322 Butylated hydroxytoluene Substances 0.000 claims description 10
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 10
- 239000004480 active ingredient Substances 0.000 claims description 10
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- 159000000007 calcium salts Chemical class 0.000 claims description 4
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- 238000010348 incorporation Methods 0.000 claims description 3
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/2004—Excipients; Inactive ingredients
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| GBGB0001621.2A GB0001621D0 (en) | 2000-01-26 | 2000-01-26 | Pharmaceutical compositions |
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| NO20003968A NO327675B1 (no) | 2000-01-26 | 2000-08-04 | Farmasoytisk preparat inneholdende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksyhept-6-ensyre eller et farmasoytisk akseptabelt salt derav. |
| NO20071303A NO327554B1 (no) | 2000-01-26 | 2007-03-09 | Farmasoytisk preparat inneholdende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksyhept-6-ensyre eller et farmasoytisk akseptabelt salt derav. |
| NO2010005C NO2010005I1 (no) | 2000-01-26 | 2010-03-10 | (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)amino]pyrimidin-5-yl]-(3R,SS)-3,5-dihydroksyhept-6-ensyre eller et farmasøytisk akseptabeltsalt og et tribasisk fosfatsalt hvor kationet er flerverdig |
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| NO20003968A NO327675B1 (no) | 2000-01-26 | 2000-08-04 | Farmasoytisk preparat inneholdende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksyhept-6-ensyre eller et farmasoytisk akseptabelt salt derav. |
| NO20071303A NO327554B1 (no) | 2000-01-26 | 2007-03-09 | Farmasoytisk preparat inneholdende (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)amino]pyrimidin-5-yl]-(3R,5S)-3,5-dihydroksyhept-6-ensyre eller et farmasoytisk akseptabelt salt derav. |
| NO2010005C NO2010005I1 (no) | 2000-01-26 | 2010-03-10 | (E)-7-[4-(4-fluorfenyl)-6-isopropyl-2-[metyl(metylsulfonyl)amino]pyrimidin-5-yl]-(3R,SS)-3,5-dihydroksyhept-6-ensyre eller et farmasøytisk akseptabeltsalt og et tribasisk fosfatsalt hvor kationet er flerverdig |
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Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0001621D0 (en) * | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
| GB0003305D0 (en) | 2000-02-15 | 2000-04-05 | Zeneca Ltd | Pyrimidine derivatives |
| ATE524163T1 (de) † | 2000-04-10 | 2011-09-15 | Teva Pharma | Stabile pharmazeutische zusammensetzungen enthaltend 7-substituierte-3,5- dihydroxyheptansäuren oder 7-substituierte-3,5- dihydroxyheptensäuren |
| USRE44578E1 (en) | 2000-04-10 | 2013-11-05 | Teva Pharmaceutical Industries, Ltd. | Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids |
| NZ535261A (en) * | 2000-08-08 | 2004-12-24 | Smithkline Beecham P | A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide |
| US6777552B2 (en) | 2001-08-16 | 2004-08-17 | Teva Pharmaceutical Industries, Ltd. | Processes for preparing calcium salt forms of statins |
| GB0028429D0 (en) * | 2000-11-22 | 2001-01-10 | Astrazeneca Ab | Therapy |
| EP1911462A3 (en) * | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
| US7842308B2 (en) * | 2001-01-30 | 2010-11-30 | Smithkline Beecham Limited | Pharmaceutical formulation |
| US20050175687A1 (en) * | 2001-01-30 | 2005-08-11 | Mcallister Stephen M. | Pharmaceutical formulations |
| GB0102342D0 (en) * | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US7883721B2 (en) * | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
| US20060039967A1 (en) * | 2002-08-12 | 2006-02-23 | Motohiro Ohta | Amino acid-containing chewable |
| GB0218781D0 (en) | 2002-08-13 | 2002-09-18 | Astrazeneca Ab | Chemical process |
| US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
| US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
| SI21402A (sl) | 2003-02-12 | 2004-08-31 | LEK farmacevtska dru�ba d.d. | Obloženi delci in farmacevtske oblike |
| GB0312896D0 (en) | 2003-06-05 | 2003-07-09 | Astrazeneca Ab | Chemical process |
| TW200526274A (en) * | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
| CA2657076A1 (en) * | 2003-08-28 | 2005-03-17 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of rosuvastatin calcium |
| UY28501A1 (es) | 2003-09-10 | 2005-04-29 | Astrazeneca Uk Ltd | Compuestos químicos |
| TR201910177T4 (tr) * | 2003-09-12 | 2019-08-21 | Amgen Inc | Bir sinakalset HCl içeren hızlı çözünme formülasyonu. |
| GB0322552D0 (en) | 2003-09-26 | 2003-10-29 | Astrazeneca Uk Ltd | Therapeutic treatment |
| GB0324791D0 (en) | 2003-10-24 | 2003-11-26 | Astrazeneca Ab | Chemical process |
| US7777034B2 (en) * | 2003-11-24 | 2010-08-17 | Teva Pharmaceutical Industries Ltd. | Crystalline ammonium salts of rosuvastatin |
| ES2364143T3 (es) * | 2003-12-02 | 2011-08-25 | Teva Pharmaceutical Industries Ltd. | Estandar de referencia para caracterización de rosuvastatina. |
| US8158362B2 (en) * | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
| US20100216863A1 (en) * | 2004-01-30 | 2010-08-26 | Decode Genetics Ehf. | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment |
| PE20060003A1 (es) * | 2004-03-12 | 2006-03-01 | Smithkline Beecham Plc | Formulacion farmaceutica polimerica para moldear por inyeccion |
| NZ550942A (en) * | 2004-05-04 | 2011-02-25 | Innophos Inc | Directly compressible tricalcium phosphate |
| GB0411378D0 (en) * | 2004-05-21 | 2004-06-23 | Astrazeneca Ab | Pharmaceutical compositions |
| CN1323665C (zh) * | 2004-06-16 | 2007-07-04 | 鲁南制药集团股份有限公司 | 治疗高血脂症的组合物 |
| CA2573857A1 (en) * | 2004-07-13 | 2006-02-16 | Teva Pharmaceutical Industries Ltd. | A process for the preparation of rosuvastatin involving a tempo-mediated oxidation step |
| AU2005271407A1 (en) * | 2004-08-06 | 2006-02-16 | Transform Pharmaceuticals, Inc. | Novel fenofibrate formulations and related methods of treatment |
| US20070037979A1 (en) * | 2005-02-22 | 2007-02-15 | Valerie Niddam-Hildesheim | Preparation of rosuvastatin |
| TWI345562B (en) | 2005-02-22 | 2011-07-21 | Teva Pharma | Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof |
| US20070167625A1 (en) * | 2005-02-22 | 2007-07-19 | Anna Balanov | Preparation of rosuvastatin |
| CN101500555A (zh) * | 2005-08-04 | 2009-08-05 | 变换药品公司 | 包含非诺贝特和他汀的新型制剂及相关治疗方法 |
| MX2007004427A (es) * | 2005-08-16 | 2007-06-14 | Teva Pharma | Intermedio de rosuvastatina cristalina. |
| EP2292209A3 (en) | 2005-09-12 | 2011-05-04 | Actelion Pharmaceuticals Ltd. | Stable pharmaceutical composition comprising a pyramidine-sulfamide |
| PT1944029E (pt) * | 2005-10-31 | 2012-02-09 | Nissan Chemical Ind Ltd | Preparação farmacêutica com excelente fotoestabilidade |
| CA2630704C (en) * | 2005-12-20 | 2014-08-19 | Lek Pharmaceuticals D.D. | Pharmaceutical composition |
| HU227696B1 (en) * | 2006-04-13 | 2011-12-28 | Egyt Gyogyszervegyeszeti Gyar | Zinc salt of rosuvastatin, process for its preparation and pharmaceutical compositions containing it |
| US8455640B2 (en) * | 2006-05-03 | 2013-06-04 | Msn Laboratories Limited | Process for statins and its pharmaceutically acceptable salts thereof |
| HU227610B1 (en) * | 2006-09-18 | 2011-09-28 | Richter Gedeon Nyrt | Pharmaceutical compositions containing rosuvastatin potassium |
| ES2567171T3 (es) * | 2006-10-09 | 2016-04-20 | Msn Laboratories Private Limited | Nuevo procedimiento para la preparación de estatinas y sus sales farmacéuticamente aceptables |
| WO2008124121A1 (en) * | 2007-04-06 | 2008-10-16 | Scidose, Llc | Co-therapy with and combinations of statins and 1,4-dihydropyridine-3,5-dicarboxydiesters |
| WO2008124120A1 (en) * | 2007-04-09 | 2008-10-16 | Scidose, Llc | Combinations of statins and anti-obesity agent |
| US20080249156A1 (en) * | 2007-04-09 | 2008-10-09 | Palepu Nageswara R | Combinations of statins and anti-obesity agent and glitazones |
| CN101336920B (zh) * | 2007-07-05 | 2013-06-05 | 江苏正大天晴药业股份有限公司 | 一种稳定的药物组合物 |
| EP2285353A1 (en) * | 2008-01-30 | 2011-02-23 | Lupin Limited | Modified release formulations of hmg coa reductase inhibitors |
| WO2009112870A1 (en) * | 2008-03-11 | 2009-09-17 | Belupo-Lijekovi I Kozmetika D.D. | Pharmaceutical composition comprising rosuvastatin calcium and magnesium carbonate hydroxide pentahydrate as a stabilizer |
| US8653265B2 (en) | 2008-05-27 | 2014-02-18 | Changzhou Pharmaceutical Factory | Preparation method of rosuvastatin calcium and its intermediates |
| AU2009256572A1 (en) * | 2008-06-13 | 2009-12-17 | Capsugel Belgium Nv | Hydroxypropyl cellulose capsule shell |
| EP2138165A1 (en) | 2008-06-27 | 2009-12-30 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition comprising a statin |
| TR201101807T2 (tr) * | 2008-06-27 | 2012-02-21 | Abd� �Brah�M �La� Sanay� Ve T�Caret Anon�M ��Rket�@ | Rosuvastatin kalsiyumun farmasotik bileşimleri |
| EP2309992B1 (en) * | 2008-06-27 | 2017-10-25 | KRKA, tovarna zdravil, d.d., Novo mesto | Pharmaceutical composition comprising a statin |
| PL386051A1 (pl) * | 2008-09-09 | 2010-03-15 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Stabilna doustna kompozycja farmaceutyczna zawierająca farmaceutycznie dopuszczalną sól kwsu [(E)-7-[4-(4-fluorofenylo)-6-izopropylo-2-[metylo(metylosulfonylo)amino]pirymidyn-5-ylo] (3R,5S)-3,5-dihydroksyhept-6-enowego |
| HU230877B1 (hu) * | 2008-09-30 | 2018-11-29 | EGIS Gyógyszergyár NyR | Stabil kombinációs gyógyszerkészítmény |
| MX344885B (es) * | 2008-11-10 | 2017-01-10 | Psicofarma S A De C V | Proceso para la obtencion de una composicion de rosuvastatina calcica y producto obtenido. |
| WO2010089770A2 (en) | 2009-01-19 | 2010-08-12 | Msn Laboratories Limited | Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof |
| TR200902077A2 (tr) | 2009-03-17 | 2010-01-21 | Sanovel İlaç San.Veti̇c.A.Ş. | Stabil rosuvastatin kompozisyonları |
| US8470805B2 (en) * | 2009-04-30 | 2013-06-25 | Kaohsiung Medical University | Processes for preparing piperazinium salts of KMUP and use thereof |
| TR200904341A2 (tr) | 2009-06-03 | 2010-12-21 | Bi̇lgi̇ç Mahmut | Rosuvastatin kalsiyum içeren kararlı farmasötik bileşimler. |
| EP2464344A2 (en) | 2009-08-13 | 2012-06-20 | Synthon B.V. | Pharmaceutical tablet comprising rosuvastatin calcium |
| EP2526099B1 (en) | 2010-01-18 | 2016-03-30 | MSN Laboratories Limited | Improved process for the preparation of amide intermediates and their use thereof |
| CN101766578B (zh) * | 2010-02-09 | 2011-06-08 | 鲁南贝特制药有限公司 | 一种含瑞舒伐他汀钙的片剂及其制备工艺 |
| WO2011139256A2 (en) | 2010-05-04 | 2011-11-10 | Bilgic Mahmut | Stable rosuvastatin formulations |
| TR201009397A2 (tr) | 2010-11-11 | 2012-05-21 | Bi̇lgi̇ç Mahmut | Rosuvastatin içeren farmasötik bileşimler. |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| TWI462739B (zh) | 2010-11-02 | 2014-12-01 | Univ Kaohsiung Medical | Ｓｉｌｄｅｎａｆｉｌ－同族物四級銨哌嗪鹽類之製備及醫療用途 |
| JP5988963B2 (ja) * | 2011-04-12 | 2016-09-07 | 沢井製薬株式会社 | ピタバスタチン含有製剤及びその製造方法 |
| US20140294959A1 (en) * | 2011-05-20 | 2014-10-02 | Astrazeneca Uk Limited | Pharmaceutical Composition of Rosuvastatin Calcium |
| RU2508109C2 (ru) * | 2011-05-27 | 2014-02-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Фармацевтическая композиция для лечения нарушений липидного обмена |
| US10952968B2 (en) * | 2012-05-14 | 2021-03-23 | Shionogi & Co., Ltd. | Preparation containing 6,7-unsaturated-7-carbamoyl morphinan derivatives |
| AR091706A1 (es) * | 2012-07-11 | 2015-02-25 | Teva Pharma | Formulaciones de laquinimod sin agentes alcalinizantes |
| EP2977048A4 (en) | 2013-03-12 | 2017-04-26 | LG Life Sciences Ltd. | Complex preparation including valsartan and rosuvastatin calcium and manufacturing method therefor |
| RO129060B1 (ro) | 2013-04-25 | 2014-11-28 | Antibiotice S.A. | Compoziţie farmaceutică stabilă cu rosuvastatină calcică amorfă |
| RU2547574C2 (ru) * | 2013-07-09 | 2015-04-10 | Общество с ограниченной ответственностью "Трейдсервис" | Лекарственная форма гиполипидемического действия и способ ее изготовления |
| KR101597004B1 (ko) | 2013-07-25 | 2016-02-23 | 씨제이헬스케어 주식회사 | 서방형 메트포르민과 속방형 HMG-CoA 환원효소 억제제를 포함하는 복합제제 |
| BR112017009521A2 (pt) | 2014-11-11 | 2017-12-19 | Shionogi & Co | comprimido de múltiplas camadas que contém um fármaco instável à luz |
| JP2016169198A (ja) * | 2015-03-13 | 2016-09-23 | 大原薬品工業株式会社 | ロスバスタチンカルシウムを含有する錠剤 |
| JP6095176B2 (ja) * | 2015-04-24 | 2017-03-15 | 大原薬品工業株式会社 | ロスバスタチンカルシウムの光安定性が向上したフィルムコーティング錠剤 |
| AU2016342374B2 (en) | 2015-10-23 | 2022-08-04 | Lyndra Therapeutics, Inc. | Gastric residence systems for sustained release of therapeutic agents and methods of use thereof |
| KR20180090881A (ko) | 2015-12-08 | 2018-08-13 | 린드라 인코퍼레이티드 | 위 체류 시스템을 위한 기하 구성형태 |
| EP3243506A1 (en) | 2016-05-09 | 2017-11-15 | Adamed sp. z o.o. | Pharmaceutical composition |
| AU2017268840B2 (en) | 2016-05-27 | 2022-02-10 | Lyndra Therapeutics, Inc. | Materials architecture for gastric residence systems |
| AU2017336154B2 (en) | 2016-09-30 | 2023-11-09 | Lyndra Therapeutics, Inc. | Gastric residence systems for sustained delivery of adamantane-class drugs |
| CN107913257A (zh) * | 2016-10-10 | 2018-04-17 | 北京阜康仁生物制药科技有限公司 | 一种包含瑞舒伐他汀钙的药物组合物及其制备方法 |
| US10600502B2 (en) | 2016-12-20 | 2020-03-24 | Astrazeneca Uk Ltd. | Systems and methods for dispensing a statin medication over the counter |
| WO2018227147A1 (en) | 2017-06-09 | 2018-12-13 | Lyndra, Inc. | Gastric residence systems with release rate-modulating films |
| JP2018027987A (ja) * | 2017-11-24 | 2018-02-22 | 共和薬品工業株式会社 | 医薬組成物 |
| CN112274487A (zh) * | 2019-07-25 | 2021-01-29 | 北京福元医药股份有限公司 | 一种瑞舒伐他汀钙药物制剂 |
| CN110638743B (zh) * | 2019-10-25 | 2023-03-28 | 乐普制药科技有限公司 | 一种含布立西坦的组合物 |
| US20220008519A1 (en) | 2020-07-09 | 2022-01-13 | Costa Rican Social Security Fund / Caja Costarricense de Seguro Social (CCSS) | Treatment of severe acute respiratory syndrome-related coronavirus infection with klotho |
| GB2622822A (en) | 2022-09-28 | 2024-04-03 | Novumgen Ltd | A rapidly disintegrating tablet of rosuvastatin and its process of preparation |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2262229A (en) * | 1939-06-24 | 1941-11-11 | Interchem Corp | Pigment and method of preparation |
| GB653026A (en) | 1947-07-02 | 1951-05-09 | Merck & Co Inc | Vitamin preparations |
| US4743450A (en) | 1987-02-24 | 1988-05-10 | Warner-Lambert Company | Stabilized compositions |
| US4929620A (en) * | 1987-12-10 | 1990-05-29 | Warner-Lambert Company | 5-pyrimidinyl-3,5-dihydroxy-6-heptenoic acid compounds useful as inhibitors of cholesterol biosynthesis |
| NO890521L (no) | 1988-02-25 | 1989-08-28 | Bayer Ag | Substituerte pyrimidiner. |
| US5030447A (en) * | 1988-03-31 | 1991-07-09 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions having good stability |
| KR900701778A (ko) * | 1988-10-06 | 1990-12-04 | 예안 크라머, 한스 루돌프 하우스 | 피리미디닐- 치환된 하이드록시산, 락톤 및 에스테르, 및 이를 함유하는 약학적 조성물 |
| US5004651A (en) | 1989-01-24 | 1991-04-02 | Abbott Laboratories | Stabilizing system for solid dosage forms |
| US5130298A (en) | 1989-05-16 | 1992-07-14 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
| DE69104453T2 (de) | 1990-09-13 | 1995-03-16 | Akzo Nv | Stabilisierte feste chemische Zusammensetzungen. |
| JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
| HU9203780D0 (en) | 1991-12-12 | 1993-03-29 | Sandoz Ag | Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them |
| US5478832A (en) * | 1992-05-08 | 1995-12-26 | The Green Cross Corporation | Quinoline compounds |
| WO1994016693A1 (en) | 1993-01-19 | 1994-08-04 | Warner-Lambert Company | Stable oral ci-981 formulation and process of preparing same |
| TW442301B (en) * | 1995-06-07 | 2001-06-23 | Sanofi Synthelabo | Pharmaceutical compositions containing irbesartan |
| DE69625046T2 (de) * | 1995-12-22 | 2003-04-10 | Kowa Co., Ltd. | Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium |
| ATE220543T1 (de) * | 1996-04-23 | 2002-08-15 | Janssen Pharmaceutica Nv | Rasch-freisetzende ph-unabhängige feste dosisformen enthaltend cisaprid |
| HUP0102260A3 (en) | 1998-06-05 | 2002-12-28 | Warner Lambert Co | Stabilization of compositions containing ace inhibitors using magnesium oxide |
| SI20109A (sl) | 1998-12-16 | 2000-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Stabilna farmacevtska formulacija |
| GB9900339D0 (en) | 1999-01-09 | 1999-02-24 | Zeneca Ltd | Chemical compounds |
| US6150410A (en) | 1999-02-04 | 2000-11-21 | Abbott Laboratories | pH independent extended release pharmaceutical formulation |
| AR022462A1 (es) | 1999-02-06 | 2002-09-04 | Astrazeneca Uk Ltd | Uso de un agente que disminuye el colesterol |
| GB0000710D0 (en) | 1999-02-06 | 2000-03-08 | Zeneca Ltd | Drug combination |
| GB0001662D0 (en) * | 1999-02-06 | 2000-03-15 | Zeneca Ltd | Pharmaceutical compositions |
| GB0001621D0 (en) | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
| EP1253921A4 (en) | 2000-01-28 | 2004-10-13 | Merck & Co Inc | TREATMENT AND PROPHYLAXIS OF PROSTATE CANCER WITH COX-2 SELECTIVE INHIBITORS |
-
2000
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| NO312434B1 (no) | Farmasöytiske preparater, samt anvendelse og fremgangsmåte for fremstilling derav | |
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