TR201910177T4 - Bir sinakalset HCl içeren hızlı çözünme formülasyonu. - Google Patents
Bir sinakalset HCl içeren hızlı çözünme formülasyonu. Download PDFInfo
- Publication number
- TR201910177T4 TR201910177T4 TR2019/10177T TR201910177T TR201910177T4 TR 201910177 T4 TR201910177 T4 TR 201910177T4 TR 2019/10177 T TR2019/10177 T TR 2019/10177T TR 201910177 T TR201910177 T TR 201910177T TR 201910177 T4 TR201910177 T4 TR 201910177T4
- Authority
- TR
- Turkey
- Prior art keywords
- formulation containing
- fast dissolution
- cinacalcet hcl
- pharmaceutical composition
- dissolution formulation
- Prior art date
Links
- 238000004090 dissolution Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- QANQWUQOEJZMLL-PKLMIRHRSA-N cinacalcet hydrochloride Chemical compound Cl.N([C@H](C)C=1C2=CC=CC=C2C=CC=1)CCCC1=CC=CC(C(F)(F)F)=C1 QANQWUQOEJZMLL-PKLMIRHRSA-N 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Mevcut buluş, terapötik olarak etkili bir miktarda kalsiyum reseptör-aktif bileşiği ve en az bir farmasötik olarak kabul edilebilir eksipiyanı içeren farmasötik bir bileşim ile ilgilidir, burada bileşim, kontrollü bir çözünme profiline sahiptir. Mevcut buluş ayrıca, farmasötik bileşimi üretme yöntemi ve farmasötik bileşimin kullanıldığı hastalığı tedavi etme yöntemi ile ilgilidir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50221903P | 2003-09-12 | 2003-09-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201910177T4 true TR201910177T4 (tr) | 2019-08-21 |
Family
ID=34434844
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/10447T TR201910447T4 (tr) | 2003-09-12 | 2004-09-10 | Sinakalset HCI'nin hızlı çözünme formülasyonu. |
TR2019/10177T TR201910177T4 (tr) | 2003-09-12 | 2004-09-10 | Bir sinakalset HCl içeren hızlı çözünme formülasyonu. |
TR2019/10180T TR201910180T4 (tr) | 2003-09-12 | 2004-09-10 | Sinakalset HCI'nin hızlı çözünme formülasyonu. |
TR2019/09267T TR201909267T4 (tr) | 2003-09-12 | 2004-09-10 | Sinakalset HCl içeren hızlı çözünme formülasyonu. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/10447T TR201910447T4 (tr) | 2003-09-12 | 2004-09-10 | Sinakalset HCI'nin hızlı çözünme formülasyonu. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/10180T TR201910180T4 (tr) | 2003-09-12 | 2004-09-10 | Sinakalset HCI'nin hızlı çözünme formülasyonu. |
TR2019/09267T TR201909267T4 (tr) | 2003-09-12 | 2004-09-10 | Sinakalset HCl içeren hızlı çözünme formülasyonu. |
Country Status (30)
Country | Link |
---|---|
US (7) | US7829595B2 (tr) |
EP (8) | EP3395338B1 (tr) |
JP (3) | JP5026077B2 (tr) |
KR (1) | KR101332058B1 (tr) |
CN (1) | CN1946382B (tr) |
AR (1) | AR045637A1 (tr) |
AU (1) | AU2004279318C1 (tr) |
BR (2) | BR122018013029B1 (tr) |
CA (1) | CA2536487C (tr) |
CY (5) | CY1119609T1 (tr) |
DE (1) | DE19164145T1 (tr) |
DK (6) | DK3260117T3 (tr) |
EA (1) | EA013425B1 (tr) |
ES (7) | ES2735226T3 (tr) |
HR (1) | HRP20130114T4 (tr) |
HU (5) | HUE045411T2 (tr) |
IL (1) | IL173737A (tr) |
IS (1) | IS3027B (tr) |
MX (1) | MXPA06002616A (tr) |
MY (1) | MY142046A (tr) |
NO (1) | NO335739B1 (tr) |
NZ (1) | NZ545498A (tr) |
PL (6) | PL1663182T5 (tr) |
PT (6) | PT2821067T (tr) |
SG (1) | SG146608A1 (tr) |
SI (6) | SI3395340T1 (tr) |
TR (4) | TR201910447T4 (tr) |
TW (1) | TWI344363B (tr) |
WO (1) | WO2005034928A1 (tr) |
ZA (1) | ZA200602710B (tr) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100074949A1 (en) * | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
DK3260117T3 (da) | 2003-09-12 | 2019-07-01 | Amgen Inc | Hurtigt opløsende formulering, der omfatter cinacalcet-hcl |
CN101006076B (zh) | 2004-06-24 | 2010-09-29 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的调控剂 |
ATE443038T1 (de) * | 2005-05-16 | 2009-10-15 | Teva Pharma | Verfahren zur herstellung von cinacalcet hydrochlorid |
JP2008507565A (ja) * | 2005-05-23 | 2008-03-13 | テバ ファーマシューティカル インダストリーズ リミティド | シナカルセトの精製 |
KR20080007376A (ko) * | 2005-05-23 | 2008-01-18 | 테바 파마슈티컬 인더스트리즈 리미티드 | 무정형 시나칼셋 염산염 및 이의 제조 |
BRPI0611409B8 (pt) | 2005-05-26 | 2021-05-25 | Dainippon Sumitomo Pharma Co | preparação oral compreendendo lurasidona |
JP5244597B2 (ja) * | 2005-09-02 | 2013-07-24 | アムジエン・インコーポレーテツド | カルシリティック化合物またはカルシウム模倣性化合物を用いて腸液バランスを調節する方法 |
WO2007062147A1 (en) * | 2005-11-22 | 2007-05-31 | Teva Pharmaceutical Industries Ltd. | Crystal forms of cinacalcet hci and processes for their preparation |
JP5409010B2 (ja) | 2005-12-28 | 2014-02-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | N−[2,4−ビス(1,1−ジメチルエチル)−5−ヒドロキシフェニル]−1,4−ジヒドロ−4−オキソキノリン−3−カルボキサミドの固体形態 |
US8426391B2 (en) | 2006-02-03 | 2013-04-23 | Proventiv Therapeutics, Llc | Treating vitamin D insufficiency and deficiency with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 |
EP2001832A1 (en) * | 2006-03-23 | 2008-12-17 | Amgen Inc. | Methods and compositions for making and using polymorphs of cinacalcet |
KR20080011320A (ko) * | 2006-04-27 | 2008-02-01 | 테바 파마슈티컬 인더스트리즈 리미티드 | 시나칼셋 염기의 제조 방법 |
CA2649616A1 (en) * | 2006-04-27 | 2007-11-08 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of cinacalcet base |
SI2679228T1 (en) | 2006-06-21 | 2018-06-29 | Opko Ireland Global Holdings, Ltd. | THERAPY WITH THE USE OF VITAMIN D ADDITIONAL FIBER AND HORMON RESISTANCE OF VITAMIN D |
US20090258949A1 (en) * | 2006-06-27 | 2009-10-15 | Johannes Ludescher | Amorphous form of cinacalcet |
US20080181959A1 (en) * | 2006-09-01 | 2008-07-31 | Ilan Zalit | Solid composites of a calcium receptor-active compound |
US20080146845A1 (en) * | 2006-11-20 | 2008-06-19 | Boaz Gome | Process for preparing Cinacalcet |
WO2008064202A2 (en) * | 2006-11-20 | 2008-05-29 | Dr. Reddy's Labortories, Ltd. | Modified-release formulations of calcium receptor-active compounds |
TWI573802B (zh) | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
CA2701638A1 (en) * | 2007-04-02 | 2008-10-09 | Concert Pharmaceuticals Inc. | Pharmaceutical calcimimetics |
ES2403107T3 (es) | 2007-04-25 | 2013-05-14 | Cytochroma Inc. | Método de tratamiento de insuficiencia y deficiencia de vitamina D |
DK3342405T3 (da) | 2007-04-25 | 2019-11-11 | Opko Ireland Global Holdings Ltd | Kontrolleret frigivelse af 25-hydroxyvitamin d |
EP2170805B1 (en) | 2007-06-21 | 2016-03-16 | Amgen Inc. | Methods of synthesizing cinacalcet and salts thereof |
WO2009025792A2 (en) * | 2007-08-16 | 2009-02-26 | Teva Pharmaceutical Industries Ltd. | Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof |
EP2300415A2 (en) * | 2008-05-05 | 2011-03-30 | Medichem, S.A. | Process for controlling the particle size of a 3-(trifluoromethyl)phenyl¨-1-aminopropane derivative |
US20100256184A1 (en) * | 2008-08-13 | 2010-10-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
JP2012503613A (ja) * | 2008-09-25 | 2012-02-09 | ラシオファルム ゲーエムベーハー | コンパクト化シナカルセット |
WO2010086129A1 (en) | 2009-01-27 | 2010-08-05 | Rathiopharm Gmbh | Inclusion complex comprising cinacalcet and cyclodextrin |
EP2821400B1 (en) | 2009-03-20 | 2017-09-27 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
JP2012528084A (ja) | 2009-05-27 | 2012-11-12 | レオ ファーマ アクティーゼルスカブ | 新規のカルシウム感知受容体調節化合物およびその医薬用途 |
EP2435404A1 (en) | 2009-05-27 | 2012-04-04 | Leo Pharma A/S | Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof |
EP2314286A1 (de) | 2009-10-21 | 2011-04-27 | Ratiopharm GmbH | Schmelzgranuliertes Cinacalcet |
EP3636280A1 (en) | 2010-03-29 | 2020-04-15 | Opko Ireland Global Holdings, Ltd. | Methods and compositions for reducing parathyroid levels |
CN109745313A (zh) | 2010-08-11 | 2019-05-14 | 德雷克塞尔大学 | 治疗帕金森病中运动障碍的d3多巴胺受体激动剂 |
WO2012071535A2 (en) * | 2010-11-23 | 2012-05-31 | Amgen Inc | Pediatric formulation |
CN103228619A (zh) | 2010-11-26 | 2013-07-31 | 利奥制药有限公司 | 钙传感受体活性化合物 |
JP2014507375A (ja) | 2010-11-26 | 2014-03-27 | レオ ファーマ アクティーゼルスカブ | カルシウム感知受容体活性化合物 |
WO2012069419A1 (en) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Calcium-sensing receptor-active compounds |
WO2012069402A1 (en) | 2010-11-26 | 2012-05-31 | Leo Pharma A/S | Substituted cyclopentyl - azines as casr- active compounds |
MX358358B (es) | 2011-12-19 | 2018-08-15 | Amgen Inc | Polipeptidos de receptores de activina variantes y sus usos. |
WO2013107503A1 (en) | 2012-01-17 | 2013-07-25 | Zentiva Saglik Urunleri San. Ve Tic. A.S. | Method for producing cinacalcet compositions for direct tableting |
MX2014010253A (es) | 2012-02-27 | 2014-11-12 | Vertex Pharma | Composicion farmaceutica y administraciones de la misma. |
CN102885792A (zh) * | 2012-10-12 | 2013-01-23 | 华润赛科药业有限责任公司 | 盐酸西那卡塞的口服固体速释制剂 |
PL2730279T3 (pl) * | 2012-11-09 | 2015-12-31 | K H S Pharma Holding Gmbh | Preparaty cynakalcetu o natychmiastowym uwalnianiu |
HUE051406T2 (hu) | 2012-11-14 | 2021-03-01 | Grace W R & Co | Biológiailag aktív anyagot és rendezetlen szervetlen oxidot tartalmazó kompozíciók |
CA2895881C (en) * | 2012-12-21 | 2020-03-31 | Synthon B.V. | Tablet composition comprising cinacalcet hydrochloride |
MX2015009901A (es) | 2013-02-01 | 2016-04-06 | Santa Maria Biotherapeutics Inc | Administración de un compuesto de antiactivina a a un sujeto. |
KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 d 방출 제형 |
WO2014207691A1 (en) | 2013-06-26 | 2014-12-31 | Jubilant Life Sciences Limited | Disintegrant free composition of cinacalcet |
EP3116487A1 (en) | 2014-03-14 | 2017-01-18 | Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi | Pharmaceutical composition of cinacalcet |
WO2015150944A1 (en) | 2014-03-29 | 2015-10-08 | Wockhardt Limited | Solid oral pharmaceutical compositions comprising cinacalcet or a salt thereof |
SG10201911274TA (en) * | 2014-08-07 | 2020-02-27 | Opko Ireland Global Holdings Ltd | Adjunctive therapy with 25-hydroxyvitamin d |
WO2016057730A1 (en) | 2014-10-07 | 2016-04-14 | Strohmeier Mark | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
CN104721164B (zh) * | 2015-03-25 | 2017-07-07 | 河北仁合益康药业有限公司 | 一种盐酸西那卡塞薄膜衣片组合物 |
SG10201913863TA (en) | 2016-03-28 | 2020-03-30 | Opko Ireland Global Holdings Limited | Methods of vitamin d treatment |
KR20180125574A (ko) | 2016-03-31 | 2018-11-23 | 인터셉트 파마슈티컬즈, 인크. | 용출성이 우수한 경구 제제 |
WO2019034981A1 (en) * | 2017-08-16 | 2019-02-21 | Unichem Laboratories Ltd | PHARMACEUTICAL COMPOSITIONS COMPRISING CINACALCET CHLORHYDRATE AND ONE OR MORE BINDERS |
WO2019186516A1 (en) | 2018-03-30 | 2019-10-03 | Ftf Pharma Private Limited | Liquid dosage forms of cinacalcet or salt thereof |
US10920483B2 (en) | 2018-10-25 | 2021-02-16 | Mark Mutchnik | Window seal for preventing water penetration |
RU2750761C2 (ru) * | 2019-09-17 | 2021-07-02 | Общество с ограниченной ответственностью "АМЕДАРТ" | Ядро таблетки, содержащей цинакальцета гидрохлорид |
CN115666534A (zh) * | 2020-02-29 | 2023-01-31 | 肯法姆股份有限公司 | 包含哌甲酯前药的组合物、其制备和使用方法 |
CN112546010A (zh) * | 2020-12-02 | 2021-03-26 | 普莱赛思(天津)生命科技有限公司 | 一种肾病药物组合物及其制备方法 |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4517179A (en) | 1983-04-29 | 1985-05-14 | Pennwalt Corporation | Rapid dissolving, uniform drug compositions and their preparation |
EP0315249A1 (en) | 1987-11-02 | 1989-05-10 | Merck & Co. Inc. | Phthalazineacetic acid composition and tablet |
EP0357815A1 (de) | 1988-09-06 | 1990-03-14 | Siemens Aktiengesellschaft | Schaltbare Konstantstromquelle mit I2L-Gattern |
IL92484A0 (en) | 1988-11-30 | 1990-08-31 | Schering Corp | Sustained release diltiazem formulation |
NZ231897A (en) * | 1988-12-30 | 1992-09-25 | Monsanto Co | Dry water-soluble granular composition comprising glyphosate and a liquid surfactant |
US5126145A (en) * | 1989-04-13 | 1992-06-30 | Upsher Smith Laboratories Inc | Controlled release tablet containing water soluble medicament |
US4931286A (en) | 1989-04-19 | 1990-06-05 | Aqualon Company | High gloss cellulose tablet coating |
DD299322A5 (de) * | 1989-09-21 | 1992-04-09 | Maschinenfabrik Rieter Ag,Ch | Verfahren und vorrichtung zur feinreinigung von textilfasern |
US5011068A (en) * | 1989-12-05 | 1991-04-30 | Progressive Tool & Industries Co. | Automotive body framing system |
US6031003A (en) | 1991-08-23 | 2000-02-29 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US6001884A (en) * | 1991-08-23 | 1999-12-14 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US6011068A (en) | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
EP0724561B1 (en) | 1991-08-23 | 2004-04-14 | Nps Pharmaceuticals, Inc. | Calcium receptor-active arylalkyl amines |
JP2728564B2 (ja) | 1991-08-23 | 1998-03-18 | エヌピーエス・ファーマシウティカルズ・インコーポレイテッド | カルシウム受容体活性化分子 |
US6313146B1 (en) * | 1991-08-23 | 2001-11-06 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
US5162117A (en) | 1991-11-22 | 1992-11-10 | Schering Corporation | Controlled release flutamide composition |
DE69333527T2 (de) | 1993-02-23 | 2005-06-16 | Brigham & Women's Hospital, Inc., Boston | Calciumrezeptoraktive moleküle |
US6210714B1 (en) * | 1993-11-23 | 2001-04-03 | Euro-Celtique S.A. | Immediate release tablet cores of acetaminophen having sustained-release coating |
UA41909C2 (uk) * | 1994-07-22 | 2001-10-15 | Елі Ліллі Енд Компані | Використання комбінації сполук для інгібірування остеопорозу, фармацевтичний препарат |
ATE287390T1 (de) * | 1994-10-21 | 2005-02-15 | Nps Pharma Inc | Kalzium-rezeptor aktive verbindungen |
GB9424766D0 (en) | 1994-12-07 | 1995-02-08 | Wellcome Found | Pharmaceutical composition |
GB9501127D0 (en) | 1995-01-20 | 1995-03-08 | Wellcome Found | Tablet |
DE19530575A1 (de) | 1995-08-19 | 1997-02-20 | Gruenenthal Gmbh | Schnell zerfallende Arzneiform von Tramadol oder einem Tramadolsalz |
ATE430123T1 (de) | 1996-05-01 | 2009-05-15 | Nps Pharma Inc | Inorganische am ionen-rezeptor aktive verbindungen |
US5837292A (en) * | 1996-07-03 | 1998-11-17 | Yamanouchi Europe B.V. | Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug |
US6362231B1 (en) * | 1996-07-08 | 2002-03-26 | Nps Pharmaceuticals, Inc. | Calcium receptor active compounds |
DE19637082A1 (de) | 1996-09-12 | 1998-03-19 | Boehringer Mannheim Gmbh | Schnellzerfallende Pellets |
TW483881B (en) | 1996-12-03 | 2002-04-21 | Nps Pharma Inc | Calcilytic compounds |
IE970588A1 (en) * | 1997-08-01 | 2000-08-23 | Elan Corp Plc | Controlled release pharmaceutical compositions containing tiagabine |
WO1999009458A1 (de) | 1997-08-13 | 1999-02-25 | OCé PRINTING SYSTEMS GMBH | Druck- oder kopiergerätesystem zum performanceangepassten erstellen einer vorgegebenen blattfolge von monochrom und/oder farbig bedruckten einzelblättern |
AU741992B2 (en) | 1998-03-06 | 2001-12-13 | Adare Pharmaceuticals S.R.L. | Fast disintegrating tablets |
US6525084B2 (en) | 1998-07-23 | 2003-02-25 | Novo Nordisk A/S | Stable pharmaceutical formulation |
CA2347092A1 (en) | 1998-10-14 | 2000-04-20 | Ortho-Mcneil Pharmaceutical, Inc. | 1,2-disubstituted cyclopropanes |
BR9915566B1 (pt) * | 1998-11-23 | 2011-11-01 | composição herbicida e processo herbicida. | |
UA74141C2 (uk) * | 1998-12-09 | 2005-11-15 | Дж.Д. Сірл Енд Ко. | Фармацевтична композиція на основі тонкоподрібненого еплеренону (варіанти), спосіб її одержання та спосіб лікування розладів, опосередкованих альдостероном (варіанти) |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6447809B1 (en) * | 1999-05-11 | 2002-09-10 | Metagenics, Inc. | Composition for promoting healthy bone structure |
US6733780B1 (en) | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
FR2800735B1 (fr) | 1999-11-09 | 2002-02-01 | Centre Nat Rech Scient | Nouvelles aralkyle-1,2-diamines possedant une activite calcimimetique et leur mode de preparation |
MXPA02006150A (es) * | 1999-12-22 | 2004-09-06 | Pharmacia Corp | Formulaciones de liberacion sostenida de un inhibidor de ciclooxigenasa-2. |
GB0001621D0 (en) * | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
AU5066101A (en) * | 2000-04-13 | 2001-10-30 | Synthon B.V. | Modified release formulations containing a hypnotic agent |
US6419954B1 (en) * | 2000-05-19 | 2002-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets and methods for modified release of hydrophilic and other active agents |
FR2809396B1 (fr) | 2000-05-24 | 2005-10-14 | Centre Nat Rech Scient | Nouvelles molecules possedant une activite calcimimetique et leur mode de preparation |
US6656492B2 (en) * | 2000-06-30 | 2003-12-02 | Yamanouchi Pharmaceutical Co., Ltd. | Quick disintegrating tablet in buccal cavity and manufacturing method thereof |
US20040034039A1 (en) | 2000-09-22 | 2004-02-19 | Yoshinori Nakano | Solid preparations |
JP2002167327A (ja) * | 2000-09-22 | 2002-06-11 | Takeda Chem Ind Ltd | 固形製剤 |
US7049283B2 (en) * | 2000-12-06 | 2006-05-23 | Novartis Ag | Pharmaceutical compositions for the oral delivery of pharmacologically active agents |
IN191028B (tr) * | 2001-05-17 | 2003-09-13 | Sun Pharmaceutical Ind Ltd | |
BR0210520A (pt) | 2001-06-22 | 2004-06-22 | Pfizer Prod Inc | Composições farmacêuticas de dispersões de fármacos amorfos misturados com polìmeros |
EP1321142A1 (en) | 2001-12-21 | 2003-06-25 | Novartis AG | Solid pharmaceutical composition for oral administration of Tegaserod |
WO2003086343A2 (en) | 2002-04-05 | 2003-10-23 | Cadila Healthcare Limited | Fast disintegrating oral dosage forms |
US20050147670A1 (en) * | 2002-05-29 | 2005-07-07 | Impax Laboratories Inc. | Oral disintegrating dosage forms |
TW200412956A (en) | 2002-09-30 | 2004-08-01 | Schering Corp | Methods for treating disorders of calcium homeostasis |
GB0230015D0 (en) | 2002-12-23 | 2003-01-29 | Novartis Ag | Organic compounds |
DK3260117T3 (da) | 2003-09-12 | 2019-07-01 | Amgen Inc | Hurtigt opløsende formulering, der omfatter cinacalcet-hcl |
JP4559431B2 (ja) | 2004-08-23 | 2010-10-06 | テバ ファーマシューティカル インダストリーズ リミティド | 固体及び結晶イバンドロネートナトリウム及びその調製方法 |
NL1028867C2 (nl) | 2005-04-26 | 2006-10-27 | Xycarb Ceramics B V | Inrichting voor het ondersteunen van een substraat alsmede een werkwijze voor het vervaardigen van een dergelijke inrichting. |
WO2009111876A1 (en) | 2008-03-11 | 2009-09-17 | The University Of Western Ontario | System and method for magnetic resonance imaging |
-
2004
- 2004-09-10 DK DK17185704.8T patent/DK3260117T3/da active
- 2004-09-10 US US10/937,870 patent/US7829595B2/en active Active
- 2004-09-10 PL PL04781429T patent/PL1663182T5/pl unknown
- 2004-09-10 PT PT141633669T patent/PT2821067T/pt unknown
- 2004-09-10 EA EA200600566A patent/EA013425B1/ru unknown
- 2004-09-10 CA CA2536487A patent/CA2536487C/en active Active
- 2004-09-10 KR KR1020067003448A patent/KR101332058B1/ko active IP Right Grant
- 2004-09-10 TR TR2019/10447T patent/TR201910447T4/tr unknown
- 2004-09-10 HU HUE18175497A patent/HUE045411T2/hu unknown
- 2004-09-10 ES ES18175499T patent/ES2735226T3/es active Active
- 2004-09-10 MX MXPA06002616A patent/MXPA06002616A/es active IP Right Grant
- 2004-09-10 SI SI200432474T patent/SI3395340T1/sl unknown
- 2004-09-10 EP EP18175495.3A patent/EP3395338B1/en not_active Revoked
- 2004-09-10 BR BR122018013029-6A patent/BR122018013029B1/pt active IP Right Grant
- 2004-09-10 ES ES18175495T patent/ES2737348T3/es active Active
- 2004-09-10 TR TR2019/10177T patent/TR201910177T4/tr unknown
- 2004-09-10 EP EP04781429.8A patent/EP1663182B2/en active Active
- 2004-09-10 PT PT47814298T patent/PT1663182E/pt unknown
- 2004-09-10 SI SI200432416T patent/SI2821067T1/en unknown
- 2004-09-10 JP JP2006526096A patent/JP5026077B2/ja active Active
- 2004-09-10 DK DK18175495.3T patent/DK3395338T3/da active
- 2004-09-10 PL PL18175499T patent/PL3395340T3/pl unknown
- 2004-09-10 DE DE19164145.5T patent/DE19164145T1/de active Pending
- 2004-09-10 WO PCT/US2004/026732 patent/WO2005034928A1/en active Application Filing
- 2004-09-10 ES ES17185704T patent/ES2734057T3/es active Active
- 2004-09-10 ES ES18175497T patent/ES2735216T3/es active Active
- 2004-09-10 EP EP19164145.5A patent/EP3578175B1/en active Active
- 2004-09-10 PT PT18175495T patent/PT3395338T/pt unknown
- 2004-09-10 HU HUE14163366A patent/HUE035596T2/en unknown
- 2004-09-10 PT PT17185704T patent/PT3260117T/pt unknown
- 2004-09-10 HU HUE18175495 patent/HUE044279T2/hu unknown
- 2004-09-10 MY MYPI20043684A patent/MY142046A/en unknown
- 2004-09-10 SI SI200432018T patent/SI1663182T2/sl unknown
- 2004-09-10 PL PL18175495T patent/PL3395338T3/pl unknown
- 2004-09-10 EP EP18175499.5A patent/EP3395340B8/en not_active Revoked
- 2004-09-10 PT PT18175497T patent/PT3395339T/pt unknown
- 2004-09-10 DK DK04781429.8T patent/DK1663182T4/da active
- 2004-09-10 ES ES04781429T patent/ES2401769T5/es active Active
- 2004-09-10 EP EP14163366.9A patent/EP2821067B1/en active Active
- 2004-09-10 PL PL17185704T patent/PL3260117T3/pl unknown
- 2004-09-10 NZ NZ545498A patent/NZ545498A/en unknown
- 2004-09-10 SG SG200806469-3A patent/SG146608A1/en unknown
- 2004-09-10 SI SI200432475T patent/SI3395338T1/sl unknown
- 2004-09-10 AR ARP040103266A patent/AR045637A1/es unknown
- 2004-09-10 DK DK18175499.5T patent/DK3395340T3/da active
- 2004-09-10 ES ES14163366.9T patent/ES2655435T3/es active Active
- 2004-09-10 PL PL14163366T patent/PL2821067T3/pl unknown
- 2004-09-10 SI SI200432472T patent/SI3260117T1/sl unknown
- 2004-09-10 AU AU2004279318A patent/AU2004279318C1/en active Active
- 2004-09-10 TR TR2019/10180T patent/TR201910180T4/tr unknown
- 2004-09-10 TW TW093127508A patent/TWI344363B/zh active
- 2004-09-10 DK DK18175497.9T patent/DK3395339T3/da active
- 2004-09-10 CN CN2004800327959A patent/CN1946382B/zh active Active
- 2004-09-10 EP EP18175497.9A patent/EP3395339B8/en not_active Revoked
- 2004-09-10 SI SI200432473T patent/SI3395339T1/sl unknown
- 2004-09-10 EP EP17185704.8A patent/EP3260117B8/en active Active
- 2004-09-10 TR TR2019/09267T patent/TR201909267T4/tr unknown
- 2004-09-10 BR BRPI0414254A patent/BRPI0414254B8/pt active IP Right Grant
- 2004-09-10 HU HUE17185704A patent/HUE043958T2/hu unknown
- 2004-09-10 HU HUE18175499 patent/HUE044822T2/hu unknown
- 2004-09-10 PT PT18175499T patent/PT3395340T/pt unknown
- 2004-09-10 PL PL18175497T patent/PL3395339T3/pl unknown
- 2004-09-10 DK DK14163366.9T patent/DK2821067T3/en active
- 2004-09-10 EP EP10014567A patent/EP2316442A1/en not_active Withdrawn
- 2004-09-10 ES ES19164145T patent/ES2812198T1/es active Pending
-
2006
- 2006-02-14 IL IL173737A patent/IL173737A/en active IP Right Grant
- 2006-02-23 IS IS8324A patent/IS3027B/is unknown
- 2006-04-03 ZA ZA200602710A patent/ZA200602710B/en unknown
- 2006-04-11 NO NO20061640A patent/NO335739B1/no unknown
-
2010
- 2010-11-09 US US12/942,646 patent/US9375405B2/en active Active
-
2012
- 2012-05-14 JP JP2012110758A patent/JP5849015B2/ja active Active
-
2013
- 2013-02-08 HR HRP20130114TT patent/HRP20130114T4/hr unknown
-
2014
- 2014-08-15 JP JP2014165378A patent/JP5940120B2/ja active Active
-
2016
- 2016-05-24 US US15/163,356 patent/US20160338975A1/en not_active Abandoned
-
2017
- 2017-11-20 CY CY20171101211T patent/CY1119609T1/el unknown
-
2018
- 2018-04-30 US US15/966,812 patent/US20180243238A1/en not_active Abandoned
- 2018-12-20 US US16/227,882 patent/US20190117592A1/en not_active Abandoned
-
2019
- 2019-06-28 CY CY20191100682T patent/CY1122259T1/el unknown
- 2019-07-10 CY CY20191100734T patent/CY1121812T1/el unknown
- 2019-07-10 CY CY20191100735T patent/CY1121814T1/el unknown
- 2019-07-18 CY CY20191100767T patent/CY1121820T1/el unknown
-
2020
- 2020-03-27 US US16/832,087 patent/US20200222340A1/en not_active Abandoned
- 2020-11-06 US US17/091,798 patent/US20210052518A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR201910177T4 (tr) | Bir sinakalset HCl içeren hızlı çözünme formülasyonu. | |
PL372809A1 (en) | Substituted 1,3-diphenylprop-2-en-1-one derivatives and preparation and uses thereof | |
BRPI0413393A (pt) | fexofenadina, composição farmaceuticamente aceitável, método de tratamento antihistamìnico, composição, processo para preparar fexofenadina e uso de fexofenadina | |
ATE355829T1 (de) | Einen lipophilen wirkstoff enthaltende feste pharmazeutische zusammensetzung sowie deren herstellung | |
ATE505203T1 (de) | Pharmazeutische kombination aus aliskiren und valsartan | |
ZA200806778B (en) | N-Hydroxyacrylamide compounds | |
BRPI0517032A (pt) | compostos, processo para a sua manufatura, composições farmacêuticas que os compreendem, método para o tratamento e/ou prevenção de enfermidades e utilização desses compostos | |
AR038618A1 (es) | Forma poliformica cristalina de clorhidratos de irinotecan | |
BR0315462A (pt) | Composto, composição farmacêutica, uso de um composto, método para o tratamento de um sujeito que sofre de uma condição patológica ou de doença susceptìvel de alìvio por antagonismo de receptores de ltd4 e produto de combinação | |
SE0102440D0 (sv) | New compound | |
DOP2003000621A (es) | Inhibidores triariloxiariloxipirimidin-2,4,6-triona de metaloproteinasa | |
AR039162A1 (es) | Formulaciones de venlafaxina de liberacion extendida | |
BRPI0507985A (pt) | derivados de piperazina uréia para o tratamento de endometriose | |
MXPA01009032A (es) | Composicion farmaceutica para la prevencion o el tratamiento de una enfermedad asociada con un exceso se la produccion de il-12. | |
CY1113703T1 (el) | Ταχειας διαλυσης φαρμακοτεχνικη μορφη της σινακαλσετης hci | |
DE60102084D1 (de) | Propanolaminotetraline, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende pharmazeutische zusammensetzungen | |
DE50202121D1 (de) | Metallsalze als antimykotika | |
CR7754A (es) | Derivados de 4-piridil-metil-ftalazina para la fabricacion de un medicamento para el tratamiento de sindromes mielodisplasticos | |
BRPI0414423A (pt) | inibidores de pace4, suas composições farmacêuticas e respectivos usos | |
GR1004660B (el) | Βελτιωμενες φαρμακευτικες συνθεσεις του τριυδρικου αλενδρονικου νατριου και μεθοδοι παρασκευης τους | |
RU2004107084A (ru) | Способ лечения рецидивирующего птеригиума | |
CY1110563T1 (el) | Παραγωγο του ισοξαζολικου οξεος για την ανακουφιση νευροπαθητικου πονου | |
UY27599A1 (es) | Formulaciones de acitromicina directamente compresibles |