AR038618A1 - Forma poliformica cristalina de clorhidratos de irinotecan - Google Patents

Forma poliformica cristalina de clorhidratos de irinotecan

Info

Publication number
AR038618A1
AR038618A1 ARP030100656A ARP030100656A AR038618A1 AR 038618 A1 AR038618 A1 AR 038618A1 AR P030100656 A ARP030100656 A AR P030100656A AR P030100656 A ARP030100656 A AR P030100656A AR 038618 A1 AR038618 A1 AR 038618A1
Authority
AR
Argentina
Prior art keywords
polyform
irinotecan
hydraulic
approximately
chloride
Prior art date
Application number
ARP030100656A
Other languages
English (en)
Inventor
Romualdo Forino
Natale Barbugian
Massimo Zampieri
Attilio Tomasi
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Publication of AR038618A1 publication Critical patent/AR038618A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

Reivindicación 1: Una forma polimórfica de clorhidrato de irinotecan cristalino de fórmula (1), caracterizada porque brinda un patrón de difracción de rayos X de polvo que comprende valores de ángulo 2 tetha de aproximadamente 9,15; aproximadamente 10,00; aproximadamente 11,80; aproximadamente 12,20; aproximadamente 13,00 y aproximadamente 13,40. Un procedimiento para preparar esta forma polimórfica, composiciones farmacéuticas que la contienen como ingrediente activo, y el empleo de la misma y de sus composiciones farmacéuticas como agente terapéutico.
ARP030100656A 2002-03-01 2003-02-28 Forma poliformica cristalina de clorhidratos de irinotecan AR038618A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36068402P 2002-03-01 2002-03-01

Publications (1)

Publication Number Publication Date
AR038618A1 true AR038618A1 (es) 2005-01-19

Family

ID=27789001

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030100656A AR038618A1 (es) 2002-03-01 2003-02-28 Forma poliformica cristalina de clorhidratos de irinotecan

Country Status (24)

Country Link
EP (1) EP1487840B1 (es)
JP (1) JP2005525367A (es)
KR (1) KR20040091083A (es)
CN (1) CN1276923C (es)
AR (1) AR038618A1 (es)
AT (1) ATE364610T1 (es)
AU (1) AU2003215594A1 (es)
BR (1) BR0308133A (es)
CA (1) CA2477926A1 (es)
DE (1) DE60314378T2 (es)
DK (1) DK1487840T3 (es)
ES (1) ES2287495T3 (es)
HK (1) HK1075044A1 (es)
IL (1) IL163820A0 (es)
MX (1) MXPA04008484A (es)
NO (1) NO20044138L (es)
NZ (1) NZ534999A (es)
PE (1) PE20030923A1 (es)
PL (1) PL372318A1 (es)
PT (1) PT1487840E (es)
RU (1) RU2300535C2 (es)
TW (1) TWI270374B (es)
WO (1) WO2003074527A1 (es)
ZA (1) ZA200406927B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4566128B2 (ja) * 2003-02-25 2010-10-20 株式会社ヤクルト本社 イリノテカン塩酸塩の結晶多形の製造方法
ES2245891B1 (es) * 2004-07-09 2006-11-16 Clinmet S.L. "metodo para la obtencion de un excipiente universal para la administracion oral de principios activos farmaceuticos y composiciones de excipientes resultantes del metodo".
PT1828196E (pt) 2004-12-21 2012-11-19 Sigma Tau Ind Farmaceuti Processo estereo-selectivo e formas cristalinas de uma camptotecina
PL1846412T3 (pl) 2005-02-07 2010-03-31 Fermion Oy Sposób wytwarzania 7-etylo-10-hydroksykamptotecyny
CA2591074C (en) * 2005-02-08 2015-01-20 Fermion Oy Preparation method
US7662964B2 (en) 2005-02-08 2010-02-16 Fermion Oy Process for producing [1,4′] bipiperidinyl-1′-carbonyl chloride or hydrochloride thereof
ATE460162T1 (de) * 2005-09-20 2010-03-15 Scinopharm Singapore Pte Ltd Neue kristallformen von irinotecan-hydrochlorid
CN101318964B (zh) * 2007-06-07 2010-12-15 上海迪赛诺医药发展有限公司 盐酸伊立替康新晶型及其制备方法
FR2918279B1 (fr) * 2007-07-05 2010-10-22 Aventis Pharma Sa Combinaisons antitumorales contenant un agent inhibiteur de vegf et de l'irinotecan
IT1391757B1 (it) * 2008-11-11 2012-01-27 Antibioticos Spa Irinotecan cloridrato cristallino e metodi per la sua preparazione
CN101659667B (zh) * 2009-09-07 2011-11-02 重庆泰濠制药有限公司 一种盐酸伊立替康的纯化方法
US8546573B2 (en) 2009-11-18 2013-10-01 Cadila Healthcare Limited Process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperdino] carbonyloxy-camptothecin hydrochloride trihydrate
JO3283B1 (ar) 2011-04-26 2018-09-16 Sanofi Sa تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI)
CN102866126B (zh) * 2011-07-05 2016-03-23 重庆华邦制药有限公司 一种定量测定化合物中晶型比例的方法
CN102311443B (zh) * 2011-08-24 2014-07-16 上海北卡医药技术有限公司 盐酸伊立替康的新晶型及其制备方法
RU2529831C2 (ru) * 2012-11-30 2014-09-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) Способ лечения рака толстой кишки
EP3170005B1 (en) 2014-07-18 2019-04-10 Sanofi Method for predicting the outcome of a treatment with aflibercept of a patient suspected to suffer from a cancer
KR102293907B1 (ko) * 2015-06-30 2021-08-26 한미약품 주식회사 이리노테칸 함유 경구용 고형제제 및 그 제조방법
KR102066402B1 (ko) * 2017-12-22 2020-01-15 대화제약 주식회사 이리노테칸 또는 그의 약제학적으로 허용가능한 염을 포함하는 경구투여용 약제학적 조성물
US10919905B2 (en) 2019-05-16 2021-02-16 Scinopharm Taiwan, Ltd. Polymorphism for irinotecan free base

Also Published As

Publication number Publication date
TWI270374B (en) 2007-01-11
KR20040091083A (ko) 2004-10-27
HK1075044A1 (en) 2005-12-02
EP1487840A1 (en) 2004-12-22
CN1276923C (zh) 2006-09-27
WO2003074527A1 (en) 2003-09-12
BR0308133A (pt) 2005-01-04
MXPA04008484A (es) 2004-12-06
RU2300535C2 (ru) 2007-06-10
NZ534999A (en) 2007-03-30
PE20030923A1 (es) 2003-10-29
EP1487840B1 (en) 2007-06-13
ATE364610T1 (de) 2007-07-15
NO20044138L (no) 2004-11-29
RU2004129307A (ru) 2005-04-10
CN1642958A (zh) 2005-07-20
IL163820A0 (en) 2005-12-18
DK1487840T3 (da) 2007-07-16
DE60314378T2 (de) 2008-02-28
CA2477926A1 (en) 2003-09-12
ZA200406927B (en) 2006-06-28
AU2003215594A1 (en) 2003-09-16
PT1487840E (pt) 2007-09-11
ES2287495T3 (es) 2007-12-16
JP2005525367A (ja) 2005-08-25
PL372318A1 (en) 2005-07-11
DE60314378D1 (en) 2007-07-26
TW200303753A (en) 2003-09-16

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