HRP20130114T4 - Farmaceutski oblik s brzim oslobađanjem sinakalcet hci - Google Patents
Farmaceutski oblik s brzim oslobađanjem sinakalcet hci Download PDFInfo
- Publication number
- HRP20130114T4 HRP20130114T4 HRP20130114TT HRP20130114T HRP20130114T4 HR P20130114 T4 HRP20130114 T4 HR P20130114T4 HR P20130114T T HRP20130114T T HR P20130114TT HR P20130114 T HRP20130114 T HR P20130114T HR P20130114 T4 HRP20130114 T4 HR P20130114T4
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- Croatia
- Prior art keywords
- mixture
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- total mass
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Links
- 239000000203 mixture Substances 0.000 title claims 35
- VDHAWDNDOKGFTD-MRXNPFEDSA-N cinacalcet Chemical compound N([C@H](C)C=1C2=CC=CC=C2C=CC=1)CCCC1=CC=CC(C(F)(F)F)=C1 VDHAWDNDOKGFTD-MRXNPFEDSA-N 0.000 title 1
- 229960003315 cinacalcet Drugs 0.000 title 1
- 238000004090 dissolution Methods 0.000 title 1
- 238000009472 formulation Methods 0.000 title 1
- QANQWUQOEJZMLL-PKLMIRHRSA-N cinacalcet hydrochloride Chemical compound Cl.N([C@H](C)C=1C2=CC=CC=C2C=CC=1)CCCC1=CC=CC(C(F)(F)F)=C1 QANQWUQOEJZMLL-PKLMIRHRSA-N 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical group C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 5
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 239000000314 lubricant Substances 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 3
- 229940069328 povidone Drugs 0.000 claims 3
- 208000037147 Hypercalcaemia Diseases 0.000 claims 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- MWKXCSMICWVRGW-UHFFFAOYSA-N calcium;phosphane Chemical compound P.[Ca] MWKXCSMICWVRGW-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 229960000913 crospovidone Drugs 0.000 claims 2
- 239000007884 disintegrant Substances 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 230000000148 hypercalcaemia Effects 0.000 claims 2
- 208000030915 hypercalcemia disease Diseases 0.000 claims 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 2
- 239000008108 microcrystalline cellulose Substances 0.000 claims 2
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 2
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 2
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- 239000008107 starch Substances 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 206010020707 Hyperparathyroidism primary Diseases 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 201000000981 Primary Hyperparathyroidism Diseases 0.000 claims 1
- 208000005770 Secondary Hyperparathyroidism Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 238000005029 sieve analysis Methods 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (24)
1. Farmaceutska smjesa koja sadrži
(a) od 10% do 40% težinski sinakalcet HCl;
(b) od 45% do 85% težinski barem jednog punila; i
(c) od 1% do 5% težinski barem jednog veziva;
gdje se težinski postotak odnosi na ukupnu masu smjese,
pri čemu je najmanje jedno vezivo izabrano između povidona, hidroksipropil metilceluloze, dihidroksi propilceluloze,i natrijeve karboksil metilceluloze, i
pri čemu je najmanje jedan razrjeđivač mješavina mikrokristalne celuloze i škroba, a pri čemu je mikrokristalna celuloza je prisutna u količini od 40 do 75 masenih%, a škrob je prisutan u količini od 5% do 10% po težini, u odnosu na ukupnu masu smjese.
2. Smjesa prema zahtjevu 1 koja dalje sadrži od 1% do 10% težinski barem jednog sredstva za raspadanje, gdje se težinski postotak odnosi na ukupnu masu smjese.
3. Smjesa prema zahtjevu 1 koja dalje sadrži od 0.05% do 5% barem jednog aditiva izabranog između sredstava za klizenje, lubrikanta i sredstva za prianjanje, gdje se težinski postotak odnosi na ukupnu masu smjese.
4. Smjesa prema zahtjevu 1 koja sadrži od 0.05% do 1.5% težinski barem jednog sredstva za klizenje.
5. Smjesa prema zahtjevu 1 koja sadrži od 0.05% do 1.5% težinski sredstva za prianjanje.
6. Smjesa prema zahtjevu 1 koja dalje sadrži barem jedan sastojak izabran između lubrikanta i bezbojnih i obojenih materijala za oblaganje.
7. Smjesa prema zahtjevu 1, gdje je sinakalcet HCl u obliku izbranom između amorfnih prašaka, kristalnih čestica, matriks čestica i bilo kakvih njihovih mješavina.
8. Smjesa prema zahtjevu 1, gdje je sinakalcet HCl u obliku izbranom između čestica u obliku igala, čestica u obliku štapića, čestica u obliku pločica i bilo kakvih njihovih mješavina.
9. Smjesa prema zahtjevu 8, gdje je D50 čestica sinakalcet HCl manji ili jednak 50 µm.
10. Smjesa prema zahtjevu 1, gdje je smjesa u obliku granula.
11. Smjesa prema zahtjevu 1, gdje je smjesa u obliku izbranom između tableta, kapsula i praška.
12. Smjesa prema zahtjevu 10, gdje granule imaju D50 izmjeren pomoću analize sitom u rasponu od 50 µm do 150 µm, poželjno od 80 µm do 130 µm.
13. Smjesa prema zahtjevu 1, gdje je sinakalcet HCl prisutan u količini u rasponu od 15% do 20%, težinski u odnosu na ukupnu masu smjese.
14. Smjesa prema zahtjevu 1, gdje je barem jedno vezivno sredstvo povidon.
15. Smjesa prema zahtjevu 14, gdje je povidon prisutan u količini u rasponu od 1% do 5% težinski u odnosu na ukupnu masu smjese.
16. Smjesa prema zahtjevu 1, gdje je barem jedno sredstvo za raspadanje krospovidon.
17. Smjesa prema zahtjevu 16, gdje je krospovidon prisutan intergranularno, intragranularno, ili u kombinaciji istih.
18. Smjesa prema zahtjevu 1, nadalje sadrži od 1% do 6% po težini barem jednog pokrivnog materijala odabranih između prozirnih i obojanih pokrivnih materijala u odnosu na ukupnu težinu smjese.
19. Smjesa prema zahtjevu 1, pri čemu je cinakalcet HCl prisutan u terapeutski učinkovitoj količini ili učinkovitoj dozi za liječenje barem jednog od hiperparatireoidizma, hiperfosfonije, hiperkalcemije, i povišen produkt kalcijevog fosfora.
20. Smjesa prema zahtjevu 19, pri čemu je hiperparatiroidizam odabran između primarnog hiperparatireoidizma i sekundarnog hiperparatiroidizma.
21. Smjesa prema zahtjevu 1 pri čemu efektivna količina doze ili terapeutski učinkovita količina cinakalceta HCl kreće se od 1 mg do 360 mg, poželjno od 5 mg do 240 mg, poželjnije od 20 mg do 100 mg, ili se bira između 5 mg, 15 mg, 30 mg , 50 mg, 60 mg, 75 mg, 90 mg, 120 mg, 150 mg, 180 mg, 210 mg, 240 mg, 300 mg i 360 mg.
22. Uporaba učinkovite dozirajuće količine pripravka u skladu s patentnim zahtjevom 1, za dobivanje lijeka za liječenje pacijenta koji pati od najmanje jedne bolesti izabrane od hiperparatiroidizma, hiperfosfonije, hiperkalcemije i povišenog proizvoda kalcijevog fosfora.
23. Uporaba u skladu s patentnim zahtjevom 22, naznačena time što je pacijent čovjek.
24. Upotreba u skladu s patentnim zahtjevom 22, naznačena time što je učinkovita dozirajuća količina farmaceutskog pripravka odabrana između 5 mg, 15 mg, 30 mg, 50 mg, 60 mg, 75 mg, 90 mg, 120 mg, 150 mg, 180 mg, 210 mg, 240 mg, 300 mg, 360 mg.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50221903P | 2003-09-12 | 2003-09-12 | |
| EP04781429.8A EP1663182B2 (en) | 2003-09-12 | 2004-09-10 | RAPID DISSOLUTION FORMULATION OF CINACALCET HCl |
| PCT/US2004/026732 WO2005034928A1 (en) | 2003-09-12 | 2004-09-10 | Rapid dissolution formulation of a calcium receptor-active compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20130114T1 HRP20130114T1 (en) | 2013-03-31 |
| HRP20130114T4 true HRP20130114T4 (hr) | 2019-12-27 |
Family
ID=34434844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20130114TT HRP20130114T4 (hr) | 2003-09-12 | 2013-02-08 | Farmaceutski oblik s brzim oslobađanjem sinakalcet hci |
Country Status (30)
| Country | Link |
|---|---|
| US (7) | US7829595B2 (hr) |
| EP (8) | EP3395338B1 (hr) |
| JP (3) | JP5026077B2 (hr) |
| KR (1) | KR101332058B1 (hr) |
| CN (1) | CN1946382B (hr) |
| AR (1) | AR045637A1 (hr) |
| AU (1) | AU2004279318C1 (hr) |
| BR (2) | BR122018013029B1 (hr) |
| CA (1) | CA2536487C (hr) |
| CY (5) | CY1119609T1 (hr) |
| DE (1) | DE19164145T1 (hr) |
| DK (6) | DK3260117T3 (hr) |
| EA (1) | EA013425B1 (hr) |
| ES (7) | ES2735226T3 (hr) |
| HR (1) | HRP20130114T4 (hr) |
| HU (5) | HUE045411T2 (hr) |
| IL (1) | IL173737A (hr) |
| IS (1) | IS3027B (hr) |
| MX (1) | MXPA06002616A (hr) |
| MY (1) | MY142046A (hr) |
| NO (1) | NO335739B1 (hr) |
| NZ (1) | NZ545498A (hr) |
| PL (6) | PL1663182T5 (hr) |
| PT (6) | PT2821067T (hr) |
| SG (1) | SG146608A1 (hr) |
| SI (6) | SI3395340T1 (hr) |
| TR (4) | TR201910447T4 (hr) |
| TW (1) | TWI344363B (hr) |
| WO (1) | WO2005034928A1 (hr) |
| ZA (1) | ZA200602710B (hr) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100074949A1 (en) * | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| DK3260117T3 (da) | 2003-09-12 | 2019-07-01 | Amgen Inc | Hurtigt opløsende formulering, der omfatter cinacalcet-hcl |
| CN101006076B (zh) | 2004-06-24 | 2010-09-29 | 沃泰克斯药物股份有限公司 | Atp-结合弹夹转运蛋白的调控剂 |
| ATE443038T1 (de) * | 2005-05-16 | 2009-10-15 | Teva Pharma | Verfahren zur herstellung von cinacalcet hydrochlorid |
| JP2008507565A (ja) * | 2005-05-23 | 2008-03-13 | テバ ファーマシューティカル インダストリーズ リミティド | シナカルセトの精製 |
| KR20080007376A (ko) * | 2005-05-23 | 2008-01-18 | 테바 파마슈티컬 인더스트리즈 리미티드 | 무정형 시나칼셋 염산염 및 이의 제조 |
| BRPI0611409B8 (pt) | 2005-05-26 | 2021-05-25 | Dainippon Sumitomo Pharma Co | preparação oral compreendendo lurasidona |
| JP5244597B2 (ja) * | 2005-09-02 | 2013-07-24 | アムジエン・インコーポレーテツド | カルシリティック化合物またはカルシウム模倣性化合物を用いて腸液バランスを調節する方法 |
| WO2007062147A1 (en) * | 2005-11-22 | 2007-05-31 | Teva Pharmaceutical Industries Ltd. | Crystal forms of cinacalcet hci and processes for their preparation |
| JP5409010B2 (ja) | 2005-12-28 | 2014-02-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ｎ−［２，４−ビス（１，１−ジメチルエチル）−５−ヒドロキシフェニル］−１，４−ジヒドロ−４−オキソキノリン−３−カルボキサミドの固体形態 |
| US8426391B2 (en) | 2006-02-03 | 2013-04-23 | Proventiv Therapeutics, Llc | Treating vitamin D insufficiency and deficiency with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 |
| EP2001832A1 (en) * | 2006-03-23 | 2008-12-17 | Amgen Inc. | Methods and compositions for making and using polymorphs of cinacalcet |
| KR20080011320A (ko) * | 2006-04-27 | 2008-02-01 | 테바 파마슈티컬 인더스트리즈 리미티드 | 시나칼셋 염기의 제조 방법 |
| CA2649616A1 (en) * | 2006-04-27 | 2007-11-08 | Teva Pharmaceutical Industries Ltd. | Process for the preparation of cinacalcet base |
| SI2679228T1 (en) | 2006-06-21 | 2018-06-29 | Opko Ireland Global Holdings, Ltd. | THERAPY WITH THE USE OF VITAMIN D ADDITIONAL FIBER AND HORMON RESISTANCE OF VITAMIN D |
| US20090258949A1 (en) * | 2006-06-27 | 2009-10-15 | Johannes Ludescher | Amorphous form of cinacalcet |
| US20080181959A1 (en) * | 2006-09-01 | 2008-07-31 | Ilan Zalit | Solid composites of a calcium receptor-active compound |
| US20080146845A1 (en) * | 2006-11-20 | 2008-06-19 | Boaz Gome | Process for preparing Cinacalcet |
| WO2008064202A2 (en) * | 2006-11-20 | 2008-05-29 | Dr. Reddy's Labortories, Ltd. | Modified-release formulations of calcium receptor-active compounds |
| TWI573802B (zh) | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
| CA2701638A1 (en) * | 2007-04-02 | 2008-10-09 | Concert Pharmaceuticals Inc. | Pharmaceutical calcimimetics |
| ES2403107T3 (es) | 2007-04-25 | 2013-05-14 | Cytochroma Inc. | Método de tratamiento de insuficiencia y deficiencia de vitamina D |
| DK3342405T3 (da) | 2007-04-25 | 2019-11-11 | Opko Ireland Global Holdings Ltd | Kontrolleret frigivelse af 25-hydroxyvitamin d |
| EP2170805B1 (en) | 2007-06-21 | 2016-03-16 | Amgen Inc. | Methods of synthesizing cinacalcet and salts thereof |
| WO2009025792A2 (en) * | 2007-08-16 | 2009-02-26 | Teva Pharmaceutical Industries Ltd. | Crystalline forms cinacalcet fumarate and cinacalcet succinate and processes for preparation thereof |
| EP2300415A2 (en) * | 2008-05-05 | 2011-03-30 | Medichem, S.A. | Process for controlling the particle size of a 3-(trifluoromethyl)phenyl¨-1-aminopropane derivative |
| US20100256184A1 (en) * | 2008-08-13 | 2010-10-07 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| JP2012503613A (ja) * | 2008-09-25 | 2012-02-09 | ラシオファルム ゲーエムベーハー | コンパクト化シナカルセット |
| WO2010086129A1 (en) | 2009-01-27 | 2010-08-05 | Rathiopharm Gmbh | Inclusion complex comprising cinacalcet and cyclodextrin |
| EP2821400B1 (en) | 2009-03-20 | 2017-09-27 | Vertex Pharmaceuticals Incorporated | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
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