HUP0003110A2 - (4-Fluor-fenil)-pirimidin-származékokat tartalmazó gyógyászati készítmények és eljárás előállításukra - Google Patents

(4-Fluor-fenil)-pirimidin-származékokat tartalmazó gyógyászati készítmények és eljárás előállításukra

Info

Publication number
HUP0003110A2
HUP0003110A2 HU0003110A HUP0003110A HUP0003110A2 HU P0003110 A2 HUP0003110 A2 HU P0003110A2 HU 0003110 A HU0003110 A HU 0003110A HU P0003110 A HUP0003110 A HU P0003110A HU P0003110 A2 HUP0003110 A2 HU P0003110A2
Authority
HU
Hungary
Prior art keywords
fluorophenyl
producing
pharmaceutical compositions
compositions containing
pyrimidine derivatives
Prior art date
Application number
HU0003110A
Other languages
English (en)
Inventor
Joseph Richard Creekmore
Norman Alfred Wiggins
Original Assignee
Astrazeneca Ab.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9884259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0003110(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab. filed Critical Astrazeneca Ab.
Publication of HU0003110D0 publication Critical patent/HU0003110D0/hu
Publication of HUP0003110A2 publication Critical patent/HUP0003110A2/hu
Publication of HUP0003110A3 publication Critical patent/HUP0003110A3/hu
Publication of HU222578B1 publication Critical patent/HU222578B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

A találmány hatóanyagként (E)-7-[4-(4-fluor-fenil)-6-izo-propil-2-(metil-/metil-szulfonil/-amino)-pirimidin-5-il]-(3R,5S)-3,5-dihidroxi-hept-6-én-karbonsavat vagy gyógyászatilag alkalmazható sójáttartalmazó, stabilizált gyógyászati készítményekre vonatkozik. Astabilizálószer többvegyértékű kationt tartalmazó tribázikusfoszfátsó. A hatóanyag a túlzott koleszterinszint, a túlzott lipid- ésproteinszint és az érelmeszesedés kezelésére alkalmas. Ó
HU0003110A 2000-01-26 2000-08-04 Pirimidin-5-il-hepténsav-származékot és tribázikus foszfátsót tartalmazó gyógyászati készítmények és eljárás előállításukra HU222578B1 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0001621.2A GB0001621D0 (en) 2000-01-26 2000-01-26 Pharmaceutical compositions

Publications (4)

Publication Number Publication Date
HU0003110D0 HU0003110D0 (en) 2000-10-28
HUP0003110A2 true HUP0003110A2 (hu) 2001-05-28
HUP0003110A3 HUP0003110A3 (en) 2003-02-28
HU222578B1 HU222578B1 (hu) 2003-08-28

Family

ID=9884259

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0003111A HUP0003111A3 (en) 2000-01-26 2000-08-04 Pharmaceutical compositions containing methylsulfonylamino pyrimidin derivative and process for their preparation
HU0003110A HU222578B1 (hu) 2000-01-26 2000-08-04 Pirimidin-5-il-hepténsav-származékot és tribázikus foszfátsót tartalmazó gyógyászati készítmények és eljárás előállításukra

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0003111A HUP0003111A3 (en) 2000-01-26 2000-08-04 Pharmaceutical compositions containing methylsulfonylamino pyrimidin derivative and process for their preparation

Country Status (48)

Country Link
US (2) US6548513B1 (hu)
EP (6) EP2018853A1 (hu)
JP (3) JP3267960B2 (hu)
KR (3) KR100388713B1 (hu)
CN (3) CN101028268A (hu)
AP (2) AP1879A (hu)
AR (3) AR023624A1 (hu)
AT (3) AT412062B (hu)
AU (5) AU6580000A (hu)
BE (2) BE1013413A3 (hu)
BG (4) BG65234B1 (hu)
BR (2) BR0003364A (hu)
CA (3) CA2313783C (hu)
CH (2) CH700184B1 (hu)
CL (1) CL2007001807A1 (hu)
CR (3) CR6568A (hu)
CZ (3) CZ298411B6 (hu)
DE (3) DE10038108A1 (hu)
DK (3) DK200001170A (hu)
EE (3) EE04990B1 (hu)
ES (2) ES2171123B1 (hu)
FI (3) FI121365B (hu)
FR (2) FR2804025B1 (hu)
GB (3) GB0001621D0 (hu)
HK (6) HK1036935A1 (hu)
HR (3) HRP20020097B1 (hu)
HU (2) HUP0003111A3 (hu)
IL (4) IL147870A (hu)
IS (3) IS1940B (hu)
IT (2) ITTO20000780A1 (hu)
ME (4) MEP33808A (hu)
MY (2) MY123650A (hu)
NL (2) NL1015858C2 (hu)
NO (4) NO312434B1 (hu)
NZ (2) NZ519774A (hu)
PL (2) PL341855A1 (hu)
PT (3) PT102503B (hu)
RS (1) RS50201B (hu)
RU (2) RU2206324C1 (hu)
SE (2) SE523481C2 (hu)
SI (1) SI1223918T1 (hu)
SK (2) SK283872B6 (hu)
TR (3) TR200200270T2 (hu)
TW (2) TWI228050B (hu)
UA (2) UA51853C2 (hu)
WO (2) WO2001054669A1 (hu)
YU (1) YU52902A (hu)
ZA (2) ZA200003998B (hu)

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