EE04990B1 - HMG reduktaasi inhibiitorit sisaldavad farmatseutilised kompositsioonid, nende kasutamine ja saamismeetod - Google Patents

HMG reduktaasi inhibiitorit sisaldavad farmatseutilised kompositsioonid, nende kasutamine ja saamismeetod

Info

Publication number
EE04990B1
EE04990B1 EEP200200052A EEP200200052A EE04990B1 EE 04990 B1 EE04990 B1 EE 04990B1 EE P200200052 A EEP200200052 A EE P200200052A EE P200200052 A EEP200200052 A EE P200200052A EE 04990 B1 EE04990 B1 EE 04990B1
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
reductase inhibitor
hmg reductase
Prior art date
Application number
EEP200200052A
Other languages
English (en)
Inventor
Richard Creekmore Joseph
Alfred Wiggins Norman
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9884259&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE04990(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of EE200200052A publication Critical patent/EE200200052A/et
Publication of EE04990B1 publication Critical patent/EE04990B1/et

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2813—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200200052A 2000-01-26 2000-08-04 HMG reduktaasi inhibiitorit sisaldavad farmatseutilised kompositsioonid, nende kasutamine ja saamismeetod EE04990B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0001621.2A GB0001621D0 (en) 2000-01-26 2000-01-26 Pharmaceutical compositions
PCT/GB2000/003014 WO2001054668A1 (en) 2000-01-26 2000-08-04 Pharmaceutical compositions comprising a hmg reductase inhibitor

Publications (2)

Publication Number Publication Date
EE200200052A EE200200052A (et) 2003-04-15
EE04990B1 true EE04990B1 (et) 2008-04-15

Family

ID=9884259

Family Applications (3)

Application Number Title Priority Date Filing Date
EEP200900047A EE05586B1 (et) 2000-01-26 2000-08-04 Farmatseutiline kompositsioon, mis sisaldab (E)-7-[4-(4-fluorofenüül)-6-isopropüül-2-[metüül(metüül-sulfonüül)amino]pürimidiin-5-üül]-(3R,5S)-3,5-dihüdroksühept-6-eenhapet v?i selle farmatseutiliseltaktsepteeritavat soola, millel on valguse toime ees
EEP200200411A EE05221B1 (et) 2000-01-26 2000-08-04 HMG-CoA reduktaasi inhibiitorit sisaldavad farmatseutilised kompositsioonid, mitmevalentse katiooniga anorgaanilise soola kasutamine ja stabiliseeritud farmatseutilise kompositsiooni valmistamismeetod
EEP200200052A EE04990B1 (et) 2000-01-26 2000-08-04 HMG reduktaasi inhibiitorit sisaldavad farmatseutilised kompositsioonid, nende kasutamine ja saamismeetod

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EEP200900047A EE05586B1 (et) 2000-01-26 2000-08-04 Farmatseutiline kompositsioon, mis sisaldab (E)-7-[4-(4-fluorofenüül)-6-isopropüül-2-[metüül(metüül-sulfonüül)amino]pürimidiin-5-üül]-(3R,5S)-3,5-dihüdroksühept-6-eenhapet v?i selle farmatseutiliseltaktsepteeritavat soola, millel on valguse toime ees
EEP200200411A EE05221B1 (et) 2000-01-26 2000-08-04 HMG-CoA reduktaasi inhibiitorit sisaldavad farmatseutilised kompositsioonid, mitmevalentse katiooniga anorgaanilise soola kasutamine ja stabiliseeritud farmatseutilise kompositsiooni valmistamismeetod

Country Status (48)

Country Link
US (2) US6548513B1 (et)
EP (6) EP2133070A1 (et)
JP (3) JP4800467B2 (et)
KR (3) KR100388713B1 (et)
CN (3) CN101028268A (et)
AP (2) AP1449A (et)
AR (3) AR023624A1 (et)
AT (3) AT412063B (et)
AU (5) AU781269C (et)
BE (2) BE1013413A3 (et)
BG (4) BG65234B1 (et)
BR (2) BR0003364A (et)
CA (3) CA2639407C (et)
CH (2) CH700184B1 (et)
CL (1) CL2007001807A1 (et)
CR (3) CR6568A (et)
CZ (3) CZ298411B6 (et)
DE (3) DE60001371T2 (et)
DK (3) DK178242B1 (et)
EE (3) EE05586B1 (et)
ES (2) ES2155043B1 (et)
FI (3) FI121365B (et)
FR (2) FR2795324B1 (et)
GB (3) GB0001621D0 (et)
HK (6) HK1036934A1 (et)
HR (3) HRP20020097B1 (et)
HU (2) HU222578B1 (et)
IL (4) IL147870A (et)
IS (3) IS1940B (et)
IT (2) ITTO20000780A1 (et)
ME (4) MEP33808A (et)
MY (2) MY123650A (et)
NL (2) NL1015858C2 (et)
NO (4) NO312434B1 (et)
NZ (2) NZ531474A (et)
PL (2) PL196808B1 (et)
PT (3) PT1223918E (et)
RS (1) RS50201B (et)
RU (2) RU2264210C2 (et)
SE (2) SE523471C2 (et)
SI (1) SI1223918T1 (et)
SK (2) SK283872B6 (et)
TR (3) TR200701171T2 (et)
TW (2) TW553749B (et)
UA (2) UA51853C2 (et)
WO (2) WO2001054669A1 (et)
YU (1) YU52902A (et)
ZA (2) ZA200003997B (et)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
USRE44578E1 (en) 2000-04-10 2013-11-05 Teva Pharmaceutical Industries, Ltd. Stable pharmaceutical compositions containing 7-substituted-3,5-dihydroxyheptanoic acids or 7-substituted-3,5-dihydroxyheptenoic acids
DK1274401T4 (da) † 2000-04-10 2014-09-08 Teva Pharma Stabile farmaceutiske sammensætninger indeholdende 7-substituerede-3,5-dihydroxyheptansyrer eller 7-substituerede-3,5-dihydroxyheptensyrer
NZ535261A (en) * 2000-08-08 2004-12-24 Smithkline Beecham P A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide
GB0028429D0 (en) * 2000-11-22 2001-01-10 Astrazeneca Ab Therapy
EP1911462A3 (en) * 2001-01-26 2011-11-30 Schering Corporation Compositions comprising a sterol absorption inhibitor
US7842308B2 (en) * 2001-01-30 2010-11-30 Smithkline Beecham Limited Pharmaceutical formulation
GB0102342D0 (en) * 2001-01-30 2001-03-14 Smithkline Beecham Plc Pharmaceutical formulation
US7883721B2 (en) * 2001-01-30 2011-02-08 Smithkline Beecham Limited Pharmaceutical formulation
US20050175687A1 (en) * 2001-01-30 2005-08-11 Mcallister Stephen M. Pharmaceutical formulations
KR20040026705A (ko) * 2001-08-16 2004-03-31 테바 파마슈티컬 인더스트리즈 리미티드 스타틴의 칼슘 염 형태의 제조 방법
EP1541140A1 (en) * 2002-08-12 2005-06-15 Kyowa Hakko Kogyo Co., Ltd. Amino acid-containing chewable
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
US20080293750A1 (en) * 2002-10-17 2008-11-27 Anna Helgadottir Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
US20060019269A1 (en) * 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
SI21402A (sl) 2003-02-12 2004-08-31 LEK farmacevtska dru�ba d.d. Obloženi delci in farmacevtske oblike
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
TW200526274A (en) * 2003-07-21 2005-08-16 Smithkline Beecham Plc Pharmaceutical formulations
EP1562912A2 (en) * 2003-08-28 2005-08-17 Teva Pharmaceutical Industries Limited Process for preparation of rosuvastatin calcium
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
SG146608A1 (en) * 2003-09-12 2008-10-30 Amgen Inc Dw Us Rapid dissolution formulation of a calcium receptor-active compound
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
CA2546701C (en) * 2003-11-24 2010-07-27 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
ATE507209T1 (de) * 2003-12-02 2011-05-15 Teva Pharma Referenzstandard zur charakterisierung von rosuvastatin
US8158362B2 (en) * 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
US20100216863A1 (en) * 2004-01-30 2010-08-26 Decode Genetics Ehf. Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
TW201240679A (en) * 2004-03-12 2012-10-16 Capsugel Belgium Nv Pharmaceutical formulations
EP2455067B1 (en) * 2004-05-04 2016-10-12 Innophos, Inc. Directly compressible tricalcium phosphate
GB0411378D0 (en) * 2004-05-21 2004-06-23 Astrazeneca Ab Pharmaceutical compositions
CN1323665C (zh) * 2004-06-16 2007-07-04 鲁南制药集团股份有限公司 治疗高血脂症的组合物
WO2006017357A1 (en) * 2004-07-13 2006-02-16 Teva Pharmaceutical Industries Ltd. A process for the preparation of rosuvastatin involving a tempo-mediated oxidation step
CA2573316A1 (en) * 2004-08-06 2006-02-16 Transform Pharmaceuticals, Inc. Novel fenofibrate formulations and related methods of treatment
US20070037979A1 (en) * 2005-02-22 2007-02-15 Valerie Niddam-Hildesheim Preparation of rosuvastatin
EP1737829A2 (en) * 2005-02-22 2007-01-03 Teva Pharmaceutical Industries Ltd Preparation of rosuvastatin
US20070167625A1 (en) * 2005-02-22 2007-07-19 Anna Balanov Preparation of rosuvastatin
AU2006278444A1 (en) * 2005-08-04 2007-02-15 Transform Pharmaceuticals, Inc. Novel formulations comprising fenofibrate and a statin, and related methods of treatment
JP2008515931A (ja) * 2005-08-16 2008-05-15 テバ ファーマシューティカル インダストリーズ リミティド 結晶形ロスバスタチン中間体
PT1928409E (pt) 2005-09-12 2012-11-27 Actelion Pharmaceuticals Ltd Composição farmacêutica estável que compreende uma pirimidina-sulfamida
SI1944029T1 (sl) * 2005-10-31 2012-03-30 Kowa Co Farmacevtski pripravek ki ima odlično fotostabilnost
CA2630704C (en) * 2005-12-20 2014-08-19 Lek Pharmaceuticals D.D. Pharmaceutical composition
HU227696B1 (en) * 2006-04-13 2011-12-28 Egyt Gyogyszervegyeszeti Gyar Zinc salt of rosuvastatin, process for its preparation and pharmaceutical compositions containing it
WO2007125547A2 (en) * 2006-05-03 2007-11-08 Manne Satyanarayana Reddy Novel process for statins and its pharmaceutically acceptable salts thereof
HU227610B1 (en) * 2006-09-18 2011-09-28 Richter Gedeon Nyrt Pharmaceutical compositions containing rosuvastatin potassium
US8404841B2 (en) * 2006-10-09 2013-03-26 Msn Laboratories Limited Process for the preparation of statins and their pharmaceutically acceptable salts thereof
US20080249141A1 (en) * 2007-04-06 2008-10-09 Palepu Nageswara R Co-therapy with and combinations of statins and 1,4-dihydropyridine-3,5-dicarboxydiesters
AP2009005026A0 (en) * 2007-04-09 2009-12-31 Scidose Llc Combinations of statins and anti-obesity agent
US20080249156A1 (en) * 2007-04-09 2008-10-09 Palepu Nageswara R Combinations of statins and anti-obesity agent and glitazones
CN101336920B (zh) * 2007-07-05 2013-06-05 江苏正大天晴药业股份有限公司 一种稳定的药物组合物
US20110003837A1 (en) * 2008-01-30 2011-01-06 Lupin Limited Modified release formulations of hmg coa reductase inhibitors
WO2009112870A1 (en) * 2008-03-11 2009-09-17 Belupo-Lijekovi I Kozmetika D.D. Pharmaceutical composition comprising rosuvastatin calcium and magnesium carbonate hydroxide pentahydrate as a stabilizer
US8653265B2 (en) 2008-05-27 2014-02-18 Changzhou Pharmaceutical Factory Preparation method of rosuvastatin calcium and its intermediates
EP2320876A2 (en) * 2008-06-13 2011-05-18 Pfizer Inc. Hydroxypropyl cellulose capsule shell
EP2309992B1 (en) * 2008-06-27 2017-10-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising a statin
EP2138165A1 (en) 2008-06-27 2009-12-30 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising a statin
EA201170101A1 (ru) * 2008-06-27 2011-08-30 Абды Ибрахым Иладж Санайи Ве Тыджарет Аноным Сыркеты Фармацевтические композиции роувастатина кальция
PL386051A1 (pl) * 2008-09-09 2010-03-15 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Stabilna doustna kompozycja farmaceutyczna zawierająca farmaceutycznie dopuszczalną sól kwsu [(E)-7-[4-(4-fluorofenylo)-6-izopropylo-2-[metylo(metylosulfonylo)amino]pirymidyn-5-ylo] (3R,5S)-3,5-dihydroksyhept-6-enowego
HU230877B1 (hu) * 2008-09-30 2018-11-29 EGIS Gyógyszergyár NyR Stabil kombinációs gyógyszerkészítmény
MX344885B (es) * 2008-11-10 2017-01-10 Psicofarma S A De C V Proceso para la obtencion de una composicion de rosuvastatina calcica y producto obtenido.
EP2387561A4 (en) 2009-01-19 2012-07-25 Msn Lab Ltd IMPROVED PROCESS FOR THE PREPARATION OF HIGH-PURITY (3R, 5S) -7-β-CYCLOPROPYL-4- (4-FLUOROPHENYL) QUINOLIN-3-YL-3,5-DIHYDROXY-6 (E) -HEPTENOIC ACID, INCLUDING ITS PHARMACEUTICALLY ACCEPTABLE SALTS
TR200902077A2 (tr) 2009-03-17 2010-01-21 Sanovel İlaç San.Veti̇c.A.Ş. Stabil rosuvastatin kompozisyonları
US8470805B2 (en) * 2009-04-30 2013-06-25 Kaohsiung Medical University Processes for preparing piperazinium salts of KMUP and use thereof
TR200904341A2 (tr) 2009-06-03 2010-12-21 Bi̇lgi̇ç Mahmut Rosuvastatin kalsiyum içeren kararlı farmasötik bileşimler.
EP2464344A2 (en) 2009-08-13 2012-06-20 Synthon B.V. Pharmaceutical tablet comprising rosuvastatin calcium
WO2011086584A2 (en) 2010-01-18 2011-07-21 Msn Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof
CN101766578B (zh) * 2010-02-09 2011-06-08 鲁南贝特制药有限公司 一种含瑞舒伐他汀钙的片剂及其制备工艺
TR201009397A2 (tr) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Rosuvastatin içeren farmasötik bileşimler.
WO2011139256A2 (en) 2010-05-04 2011-11-10 Bilgic Mahmut Stable rosuvastatin formulations
WO2012027331A1 (en) 2010-08-27 2012-03-01 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
TWI462739B (zh) 2010-11-02 2014-12-01 Univ Kaohsiung Medical Ｓｉｌｄｅｎａｆｉｌ－同族物四級銨哌嗪鹽類之製備及醫療用途
EP2698159A4 (en) * 2011-04-12 2014-11-05 Sawai Seiyaku Kk PITAVASTATE-CONTAINING PREPARATION AND METHOD OF MANUFACTURING THEREOF
JP6055465B2 (ja) 2011-05-20 2016-12-27 アストラゼネカ・ユーケイ・リミテッドＡｓｔｒａＺｅｎｅｃａ ＵＫ Ｌｉｍｉｔｅｄ ロスバスタチンカルシウムの医薬組成物
RU2508109C2 (ru) * 2011-05-27 2014-02-27 Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") Фармацевтическая композиция для лечения нарушений липидного обмена
ES2903149T3 (es) * 2012-05-14 2022-03-31 Shionogi & Co Preparación que contiene derivado de 7-carbamoilmorfinano 6,7-insaturado
AR091706A1 (es) * 2012-07-11 2015-02-25 Teva Pharma Formulaciones de laquinimod sin agentes alcalinizantes
BR112015022103A2 (pt) * 2013-03-12 2017-07-18 Lg Life Sciences Ltd composição farmacêutica, método para preparar uma composição farmacêutica, uso de uma composição farmacêutica, e, método para prevenir ou tratar uma doença
RO129060B1 (ro) 2013-04-25 2014-11-28 Antibiotice S.A. Compoziţie farmaceutică stabilă cu rosuvastatină calcică amorfă
RU2547574C2 (ru) * 2013-07-09 2015-04-10 Общество с ограниченной ответственностью "Трейдсервис" Лекарственная форма гиполипидемического действия и способ ее изготовления
KR101597004B1 (ko) 2013-07-25 2016-02-23 씨제이헬스케어 주식회사 서방형 메트포르민과 속방형 HMG-CoA 환원효소 억제제를 포함하는 복합제제
CN107072997A (zh) * 2014-11-11 2017-08-18 盐野义制药株式会社 含有对光不稳定的药物的多层片剂
JP2016169198A (ja) * 2015-03-13 2016-09-23 大原薬品工業株式会社 ロスバスタチンカルシウムを含有する錠剤
JP6095176B2 (ja) * 2015-04-24 2017-03-15 大原薬品工業株式会社 ロスバスタチンカルシウムの光安定性が向上したフィルムコーティング錠剤
EP3364946A4 (en) 2015-10-23 2019-06-26 Lyndra, Inc. STOMACH DISTRIBUTION SYSTEMS FOR DELAYED RELEASE OF THERAPEUTIC ACTIVE SUBSTANCES AND METHOD FOR THEIR USE
EP3243506A1 (en) 2016-05-09 2017-11-15 Adamed sp. z o.o. Pharmaceutical composition
WO2018064630A1 (en) 2016-09-30 2018-04-05 Lyndra, Inc. Gastric residence systems for sustained delivery of adamantane-class drugs
CN107913257A (zh) * 2016-10-10 2018-04-17 北京阜康仁生物制药科技有限公司 一种包含瑞舒伐他汀钙的药物组合物及其制备方法
US10600502B2 (en) 2016-12-20 2020-03-24 Astrazeneca Uk Ltd. Systems and methods for dispensing a statin medication over the counter
JP2018027987A (ja) * 2017-11-24 2018-02-22 共和薬品工業株式会社 医薬組成物
CN112274487A (zh) * 2019-07-25 2021-01-29 北京福元医药股份有限公司 一种瑞舒伐他汀钙药物制剂
CN110638743B (zh) * 2019-10-25 2023-03-28 乐普制药科技有限公司 一种含布立西坦的组合物
US20220008519A1 (en) 2020-07-09 2022-01-13 Costa Rican Social Security Fund / Caja Costarricense de Seguro Social (CCSS) Treatment of severe acute respiratory syndrome-related coronavirus infection with klotho
GB2622822A (en) 2022-09-28 2024-04-03 Novumgen Ltd A rapidly disintegrating tablet of rosuvastatin and its process of preparation

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2262229A (en) * 1939-06-24 1941-11-11 Interchem Corp Pigment and method of preparation
GB653026A (en) 1947-07-02 1951-05-09 Merck & Co Inc Vitamin preparations
US4743450A (en) 1987-02-24 1988-05-10 Warner-Lambert Company Stabilized compositions
US4929620A (en) * 1987-12-10 1990-05-29 Warner-Lambert Company 5-pyrimidinyl-3,5-dihydroxy-6-heptenoic acid compounds useful as inhibitors of cholesterol biosynthesis
NO890521L (no) 1988-02-25 1989-08-28 Bayer Ag Substituerte pyrimidiner.
US5030447A (en) 1988-03-31 1991-07-09 E. R. Squibb & Sons, Inc. Pharmaceutical compositions having good stability
WO1990003973A1 (en) * 1988-10-06 1990-04-19 Sandoz Ag Pyrimidinyl-substituted hydroxyacids, lactones and esters and pharmaceutical compositions containing them
US5004651A (en) 1989-01-24 1991-04-02 Abbott Laboratories Stabilizing system for solid dosage forms
US5130298A (en) 1989-05-16 1992-07-14 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
ATE112491T1 (de) 1990-09-13 1994-10-15 Akzo Nobel Nv Stabilisierte feste chemische zusammensetzungen.
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
HU9203780D0 (en) * 1991-12-12 1993-03-29 Sandoz Ag Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
US5478832A (en) * 1992-05-08 1995-12-26 The Green Cross Corporation Quinoline compounds
ATE178794T1 (de) 1993-01-19 1999-04-15 Warner Lambert Co Stabilisierte, oral anzuwendende zusammensetzung enthaltend die verbindung ci-981 und verfahren
TW442301B (en) * 1995-06-07 2001-06-23 Sanofi Synthelabo Pharmaceutical compositions containing irbesartan
WO1997023200A1 (en) * 1995-12-22 1997-07-03 Kowa Company, Ltd. Pharmaceutical composition stabilized with a basic agent
ATE220543T1 (de) * 1996-04-23 2002-08-15 Janssen Pharmaceutica Nv Rasch-freisetzende ph-unabhängige feste dosisformen enthaltend cisaprid
ES2242398T3 (es) 1998-06-05 2005-11-01 Warner-Lambert Company Llc Estabilizacion de composiciones que contienen inhibidores de la enzima de conversion de la angiotensina utilizando oxido de magnesio.
SI20109A (sl) 1998-12-16 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Stabilna farmacevtska formulacija
GB9900339D0 (en) * 1999-01-09 1999-02-24 Zeneca Ltd Chemical compounds
US6150410A (en) 1999-02-04 2000-11-21 Abbott Laboratories pH independent extended release pharmaceutical formulation
GB0000710D0 (en) 1999-02-06 2000-03-08 Zeneca Ltd Drug combination
GB0001662D0 (en) * 1999-02-06 2000-03-15 Zeneca Ltd Pharmaceutical compositions
AR022462A1 (es) 1999-02-06 2002-09-04 Astrazeneca Uk Ltd Uso de un agente que disminuye el colesterol
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
EP1253921A4 (en) 2000-01-28 2004-10-13 Merck & Co Inc TREATMENT AND PROPHYLAXIS OF PROSTATE CANCER WITH COX-2 SELECTIVE INHIBITORS

Also Published As

Publication number Publication date
WO2001054669A1 (en) 2001-08-02
AU2005202392A1 (en) 2005-06-30
MEP33808A (en) 2010-10-10
RU2206324C1 (ru) 2003-06-20
CN101028268A (zh) 2007-09-05
CA2313783A1 (en) 2000-10-16
EE05221B1 (et) 2009-10-15
CH691347A5 (de) 2001-07-13
MY123650A (en) 2006-05-31
DE10038110B4 (de) 2006-06-29
NO20003967L (no) 2001-07-27
ITTO20000779A1 (it) 2002-02-04
HU222578B1 (hu) 2003-08-28
GB0019028D0 (en) 2000-09-27
BE1013413A3 (fr) 2001-12-04
PL341853A1 (en) 2001-01-29
ES2171123A1 (es) 2002-08-16
FI111806B (fi) 2003-09-30
AU781269B2 (en) 2005-05-12
AR023624A1 (es) 2002-09-04
RU2264210C2 (ru) 2005-11-20
AU5184200A (en) 2001-08-02
ZA200003997B (en) 2000-08-14
GB2358583A (en) 2001-08-01
ATA13602000A (de) 2004-02-15
NO327675B1 (no) 2009-09-07
TW553749B (en) 2003-09-21
AU738074B2 (en) 2001-09-06
AU781269C (en) 2006-11-30
EE200200411A (et) 2003-12-15
CN1282581A (zh) 2001-02-07
BG66168B1 (bg) 2011-10-31
HK1200368A1 (en) 2015-08-07
CA2315141C (en) 2009-08-18
ITTO20000780A1 (it) 2000-11-04
KR100388713B1 (ko) 2003-06-25
HUP0003110A3 (en) 2003-02-28
KR20030036492A (ko) 2003-05-09
DK1223918T3 (da) 2003-04-28
HK1047052A1 (zh) 2003-02-07
FI20001749A (fi) 2001-07-27
NO20003967D0 (no) 2000-08-04
AP1879A (en) 2008-08-14
CZ20002883A3 (cs) 2000-10-11
ES2171123B1 (es) 2003-11-16
EP1251831A1 (en) 2002-10-30
NL1015859A1 (nl) 2001-07-27
FR2795324B1 (fr) 2002-05-17
AU2005202392C1 (en) 2016-06-02
YU5202A (sh) 2004-12-31
HRP20080525A2 (en) 2008-12-31
ATA13612000A (de) 2004-02-15
EE200900047A (et) 2011-04-15
FI20001750A0 (fi) 2000-08-04
FI20001750A (fi) 2001-07-27
NO327554B1 (no) 2009-08-10
HRP20020632A2 (en) 2004-12-31
NO2010005I1 (no) 2010-05-03
BG66159B1 (bg) 2011-09-30
CZ298411B6 (cs) 2007-09-26
AP2002002591A0 (en) 2002-09-30
NO20003968L (no) 2001-07-27
AR060248A2 (es) 2008-06-04
FI121589B (fi) 2011-01-31
FR2795324A1 (fr) 2000-12-29
KR20000072135A (ko) 2000-12-05
KR100698333B1 (ko) 2007-03-23
CA2313783C (en) 2002-03-12
JP4800988B2 (ja) 2011-10-26
IS6254A (is) 2002-01-29
DE10038108A1 (de) 2001-08-02
NL1015859C2 (nl) 2001-10-16
CL2007001807A1 (es) 2008-01-18
CR6687A (es) 2005-07-18
FI20001749A0 (fi) 2000-08-04
MEP33708A (en) 2010-10-10
AU2000264559A1 (en) 2001-08-07
JP4800467B2 (ja) 2011-10-26
ME00191B (me) 2010-10-10
GB2358583B (en) 2002-02-06
US6548513B1 (en) 2003-04-15
NO312434B1 (no) 2002-05-13
HK1040936A1 (en) 2002-06-28
IS1940B (is) 2004-07-16
IL187416A0 (en) 2008-02-09
PL196808B1 (pl) 2008-02-29
HK1048950A1 (zh) 2003-04-25
AU5184100A (en) 2001-08-02
TR200701171T2 (tr) 2007-04-24
NL1015858C2 (nl) 2001-07-27
SK283872B6 (sk) 2004-03-02
CN1319396A (zh) 2001-10-31
PT1223918E (pt) 2003-06-30
IL150513A (en) 2012-12-31
NZ531474A (en) 2007-04-27
HRP20020097A2 (en) 2002-06-30
ES2155043B1 (es) 2001-12-01
CZ290167B6 (cs) 2002-06-12
SE523471C2 (sv) 2004-04-20
CA2639407A1 (en) 2001-07-26
TR200200270T2 (tr) 2002-06-21
BG110353A (en) 2009-09-30
SE0002827L (sv) 2001-07-27
ZA200003998B (en) 2000-08-14
FR2804025B1 (fr) 2002-08-23
AP2002002409A0 (en) 2002-03-31
SE0002827D0 (sv) 2000-08-04
CA2639407C (en) 2011-09-13
EP1223918A1 (en) 2002-07-24
YU52902A (sh) 2006-01-16
ITTO20000779A0 (it) 2000-08-04
HUP0003110A2 (hu) 2001-05-28
HRP20020632B1 (en) 2010-12-31
ME00202B (me) 2010-10-10
ES2155043A1 (es) 2001-04-16
CZ299105B6 (cs) 2008-04-23
HK1036934A1 (en) 2002-01-25
UA51853C2 (uk) 2002-12-16
CN100528161C (zh) 2009-08-19
JP3267960B2 (ja) 2002-03-25
HK1036935A1 (en) 2002-01-25
DE60001371D1 (de) 2003-03-13
FR2804025A1 (fr) 2001-07-27
AU2005202392B2 (en) 2008-11-20
CH700184B1 (de) 2010-07-15
NO20003968D0 (no) 2000-08-04
TR200201888T2 (tr) 2002-11-21
AT412062B (de) 2004-09-27
BR0003365A (pt) 2001-09-18
HU0003111D0 (en) 2000-10-28
CA2315141A1 (en) 2001-07-26
HU0003110D0 (en) 2000-10-28
JP2001206877A (ja) 2001-07-31
IL147870A0 (en) 2002-08-14
GB0019029D0 (en) 2000-09-27
GB2358582B (en) 2004-09-29
IS6480A (is) 2002-07-23
EE200200052A (et) 2003-04-15
AT412063B (de) 2004-09-27
ATE232088T1 (de) 2003-02-15
NO20071303L (no) 2001-07-27
RU2002122752A (ru) 2004-03-10
PT102504A (pt) 2001-07-31
IS2805B (is) 2012-09-15
SK11792000A3 (sk) 2001-12-03
SK11782000A3 (sk) 2001-12-03
FI121365B (fi) 2010-10-29
HUP0003111A2 (hu) 2002-02-28
PT102503A (pt) 2000-12-29
FI20105657A (fi) 2010-06-10
BR0003364A (pt) 2001-09-18
DK178242B1 (da) 2015-09-28
CR10114A (es) 2008-08-21
PT102503B (pt) 2004-02-27
PL341855A1 (en) 2001-07-30
IS8620A (is) 2007-03-07
HK1040936B (zh) 2010-06-11
BG65234B1 (bg) 2007-09-28
GB2358582A (en) 2001-08-01
JP2001206847A (ja) 2001-07-31
RS50201B (sr) 2009-07-15
SE523481C2 (sv) 2004-04-20
US6316460B1 (en) 2001-11-13
WO2001054668A1 (en) 2001-08-02
CZ20002884A3 (cs) 2001-09-12
IL147870A (en) 2003-10-31
CN1149997C (zh) 2004-05-19
EP1223918B1 (en) 2003-02-05
DK200001170A (da) 2001-01-27
DE10038110A1 (de) 2001-08-23
AR025055A1 (es) 2002-11-06
MY122707A (en) 2006-04-29
EP2018853A1 (en) 2009-01-28
CR6568A (es) 2004-03-05
EP2133070A1 (en) 2009-12-16
AU6580000A (en) 2001-08-07
DK200001171A (da) 2001-07-27
AP1449A (en) 2005-07-28
HUP0003111A3 (en) 2003-03-28
BG106393A (en) 2002-07-31
EP2774609A1 (en) 2014-09-10
SE0002826D0 (sv) 2000-08-04
KR20010077840A (ko) 2001-08-20
UA77156C2 (en) 2006-11-15
JP2007182452A (ja) 2007-07-19
SI1223918T1 (en) 2003-06-30
IL150513A0 (en) 2003-02-12
BG106926A (bg) 2003-04-30
HRP20020097B1 (en) 2010-12-31
BE1013414A5 (fr) 2001-12-04
EE05586B1 (et) 2012-10-15
NZ519774A (en) 2004-04-30
SE0002826L (sv) 2001-07-27
TWI228050B (en) 2005-02-21
EP2266540A1 (en) 2010-12-29
GB0001621D0 (en) 2000-03-15
DE60001371T2 (de) 2004-01-22

Similar Documents

Publication Publication Date Title
EE04990B1 (et) HMG reduktaasi inhibiitorit sisaldavad farmatseutilised kompositsioonid, nende kasutamine ja saamismeetod
EE200300207A (et) Heterotsüklüülalküülpiperidiini derivaadid, nendevalmistamismeetodid ja farmatseutiline kompositsioon
AU2002363236A1 (en) Compounds, pharmaceutical compositions and methods of use therefor
HUP0303644A3 (en) Pyridazinone-derivatives aldose reductase inhibitors, their use and pharmaceutical compositions containing them
HUP0302412A3 (en) Betha-carboline derivatives useful as inhibitors of phosphodiesterase and pharmaceutical compositions containing the same
EE200300145A (et) Asa- ja polüasanaftalenüülkarboksamiidid ja farmatseutiline kompositsioon
HUP0400194A3 (en) Imidazolidindion derivatives as metalloproteinase inhibitors, their use and pharmaceutical compositions containing them
EE200300054A (et) Kinaasi inhibiitoritena toimivad bitsüklopürasoolid, nende valmistamismeetod, kasutamine ja neid sisaldavad farmatseutilised kompositsioonid
IL192937A0 (en) Pharmaceutical compositions containing beta-lapachone or derivatives or analogs thereof, and methods of using same
EE200200486A (et) Farmatseutilised kompositsioonid, mis sisaldavad 3-aminoasetidiini derivaate, uued derivaadid ja nende valmistamismeetodid
ATE293970T1 (de) Lipasehemmer enthaltende pharmazeutische zusammensetzungen
EE200300475A (et) Türosiini kinaasi inhibiitorid, neid sisaldavad ravimkoostised ja nimetatud ühendid kasutamiseks haiguste ravis
EE200200328A (et) Multši kompositsioon ja meetod
NO20024528L (no) Proteaseinhibitor, farmasoytisk sammensetning og anvendelse av forbindelsen
MA26882A1 (fr) COMPOSITIONS PHARMACEUTIQUES D'INHIBITEURS ET GLYCOGèNE-PHOSPHORYLASE
HUP0400193A3 (en) Imidazolindion derivatives as metalloproteinase inhibitors, their use and pharmaceutical compositions containing them
DE60225014D1 (de) Pharmazeutische zusammensetzungen von amlodipin und atorvastatin
EE05020B1 (et) Glburiidi ravimkoostis
HUP0105160A3 (en) Complex of ras-farnesyltransferase inhibitor and sulfobutylether-7-betha-cyclodextrin or 2-hydroxypropyl-betha-cyclodextrin and method for its preparation and pharmaceutical compositions containing them
EE200100653A (et) Indolüülpiperidiinühendid, nende valmistamismeetod, kompositsioon ja nende kasutamine
HUP0303731A3 (en) Sulfonylguanidines and their use for preparation of pharmaceutical compositions
AU2001247196A1 (en) Methods and compositions for detection of disease
EP1274460A4 (en) Aqueous PRODRUG COMPOUND WITH A PART OF PACLITAXEL OR ITS DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF
AU2003252493A1 (en) Pharmaceutical composition containing decoy and method of using the same
EE200300468A (et) Pravastatiini stabiilne farmatseutiline kompositsioon

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231