BR112017009521A2 - comprimido de múltiplas camadas que contém um fármaco instável à luz - Google Patents
comprimido de múltiplas camadas que contém um fármaco instável à luzInfo
- Publication number
- BR112017009521A2 BR112017009521A2 BR112017009521A BR112017009521A BR112017009521A2 BR 112017009521 A2 BR112017009521 A2 BR 112017009521A2 BR 112017009521 A BR112017009521 A BR 112017009521A BR 112017009521 A BR112017009521 A BR 112017009521A BR 112017009521 A2 BR112017009521 A2 BR 112017009521A2
- Authority
- BR
- Brazil
- Prior art keywords
- light
- tablet containing
- multilayer tablet
- unstable drug
- stable
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
a presente invenção refere-se a um comprimido que se desintegra oralmente que contém a rosuvastatina ou um sal da mesma e é estável à luz. um comprimido que se desintegra oralmente estável à luz, à temperatura e à umidade pode ser provido mediante a preparação de um comprimido de múltiplas camadas que contém a rosuvastatina ou um sal farmaceuticamente aceitável da mesma como um ingrediente ativo, um estabilizante de luz, e um sal inorgânico ou um óxido básico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014228516 | 2014-11-11 | ||
PCT/JP2015/081526 WO2016076280A1 (ja) | 2014-11-11 | 2015-11-10 | 光に対して不安定な薬物を含有する多層錠剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112017009521A2 true BR112017009521A2 (pt) | 2017-12-19 |
Family
ID=55954364
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017009521A BR112017009521A2 (pt) | 2014-11-11 | 2015-11-10 | comprimido de múltiplas camadas que contém um fármaco instável à luz |
Country Status (9)
Country | Link |
---|---|
US (1) | US10398694B2 (pt) |
EP (1) | EP3219318A4 (pt) |
JP (1) | JP6075818B2 (pt) |
KR (1) | KR20170083071A (pt) |
CN (1) | CN107072997A (pt) |
BR (1) | BR112017009521A2 (pt) |
CL (1) | CL2017001186A1 (pt) |
CO (1) | CO2017005544A2 (pt) |
WO (1) | WO2016076280A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017204215A1 (ja) * | 2016-05-27 | 2017-11-30 | 日本化薬株式会社 | ラパマイシン又はその誘導体を含有する医薬組成物 |
CN109528665A (zh) * | 2017-09-21 | 2019-03-29 | 浙江京新药业股份有限公司 | 一种治疗迟发型运动障碍的药物的口崩片及其制备方法 |
CN108245516B (zh) * | 2017-11-09 | 2019-04-12 | 浙江京新药业股份有限公司 | 一种含瑞舒伐他汀钙的药物组合物及其制备方法 |
CN111135149B (zh) * | 2018-11-04 | 2021-05-11 | 张家港市中医医院 | 一种瑞舒伐他汀钙片及其制备方法 |
JP2021120357A (ja) * | 2020-01-30 | 2021-08-19 | サンノーバ株式会社 | 錠剤 |
CA3216359A1 (en) | 2021-04-07 | 2022-10-13 | Battelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
GB2622822A (en) * | 2022-09-28 | 2024-04-03 | Novumgen Ltd | A rapidly disintegrating tablet of rosuvastatin and its process of preparation |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU9203780D0 (en) | 1991-12-12 | 1993-03-29 | Sandoz Ag | Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them |
GB0001621D0 (en) * | 2000-01-26 | 2000-03-15 | Astrazeneca Ab | Pharmaceutical compositions |
JP3815301B2 (ja) | 2001-11-09 | 2006-08-30 | 田辺製薬株式会社 | 成型製剤及びその製法 |
ITFI20010230A1 (it) | 2001-11-29 | 2003-05-29 | Menarini Int Operations Lu Sa | Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii |
JP2005255617A (ja) * | 2004-03-11 | 2005-09-22 | Asahi Kasei Chemicals Corp | 微粒子状活性成分および多孔質セルロース凝集体含有固形製剤組成物 |
RU2007133601A (ru) * | 2005-02-10 | 2009-03-20 | Лайфсайкл Фарма А/С (Dk) | УСТОЙЧИВАЯ ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ФИКСИРОВАННУЮ ДОЗУ КОМБИНАЦИИ ФЕНОФИБРАТА И ИНГИБИТОРА HMG-CoA-РЕДУКТАЗЫ |
CA2618977C (en) | 2005-08-10 | 2014-10-21 | Shionogi & Co., Ltd. | Orally disintegratable tablet |
EP1905424A3 (en) * | 2006-02-02 | 2008-04-30 | Ranbaxy Laboratories Limited | Process for the preparation of a pharmaceutical composition comprising stabilized statin particles |
JP5497435B2 (ja) | 2006-08-04 | 2014-05-21 | エチファーム | 多層口腔内崩壊錠剤 |
HU227610B1 (en) | 2006-09-18 | 2011-09-28 | Richter Gedeon Nyrt | Pharmaceutical compositions containing rosuvastatin potassium |
MX2010013834A (es) | 2008-06-27 | 2011-02-21 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | Composiciones farmaceuticas de calcio de rosuvastatina. |
PL386051A1 (pl) | 2008-09-09 | 2010-03-15 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Stabilna doustna kompozycja farmaceutyczna zawierająca farmaceutycznie dopuszczalną sól kwsu [(E)-7-[4-(4-fluorofenylo)-6-izopropylo-2-[metylo(metylosulfonylo)amino]pirymidyn-5-ylo] (3R,5S)-3,5-dihydroksyhept-6-enowego |
CN102300563A (zh) * | 2009-01-29 | 2011-12-28 | 大日本住友制药株式会社 | 具有内核的口腔崩解片剂 |
EP2433652B1 (en) | 2009-05-20 | 2016-11-09 | Sumitomo Dainippon Pharma Co., Ltd. | Dry-coated orally-disintegrating tablet |
JP2012001460A (ja) * | 2010-06-15 | 2012-01-05 | Ohara Yakuhin Kogyo Kk | 光過敏性薬物の安定化法 |
JP2012144564A (ja) | 2010-10-25 | 2012-08-02 | Kowa Co | 医薬組成物 |
WO2012056509A1 (ja) * | 2010-10-25 | 2012-05-03 | 興和株式会社 | 医薬組成物 |
PE20140005A1 (es) | 2010-12-03 | 2014-01-23 | Takeda Pharmaceutical | Tableta oralmente desintegradora |
EP2709592B1 (en) * | 2011-05-20 | 2017-08-16 | AstraZeneca UK Limited | Pharmaceutical composition of rosuvastatin calcium |
JP5844573B2 (ja) * | 2011-08-10 | 2016-01-20 | 共和薬品工業株式会社 | ピタバスタチンを含有する錠剤 |
JP2013133291A (ja) | 2011-12-26 | 2013-07-08 | Novartis Ag | 錠剤 |
JP6122098B2 (ja) * | 2012-03-30 | 2017-04-26 | デウン ファーマシューティカル カンパニー リミテッド | オルメサルタンメドキソミルとロスバスタチンまたはその塩とを含む医薬組成物 |
JP2013216701A (ja) | 2013-07-29 | 2013-10-24 | Ssp Co Ltd | 経口投与用製剤 |
-
2015
- 2015-11-10 WO PCT/JP2015/081526 patent/WO2016076280A1/ja active Application Filing
- 2015-11-10 CN CN201580060779.9A patent/CN107072997A/zh active Pending
- 2015-11-10 JP JP2016550875A patent/JP6075818B2/ja active Active
- 2015-11-10 EP EP15858595.0A patent/EP3219318A4/en not_active Withdrawn
- 2015-11-10 KR KR1020177015106A patent/KR20170083071A/ko unknown
- 2015-11-10 BR BR112017009521A patent/BR112017009521A2/pt not_active Application Discontinuation
-
2017
- 2017-05-03 US US15/585,903 patent/US10398694B2/en not_active Expired - Fee Related
- 2017-05-10 CL CL2017001186A patent/CL2017001186A1/es unknown
- 2017-06-02 CO CONC2017/0005544A patent/CO2017005544A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
KR20170083071A (ko) | 2017-07-17 |
US20170231989A1 (en) | 2017-08-17 |
US10398694B2 (en) | 2019-09-03 |
CO2017005544A2 (es) | 2017-08-10 |
CL2017001186A1 (es) | 2018-01-05 |
JPWO2016076280A1 (ja) | 2017-04-27 |
CN107072997A (zh) | 2017-08-18 |
JP6075818B2 (ja) | 2017-02-08 |
WO2016076280A1 (ja) | 2016-05-19 |
EP3219318A1 (en) | 2017-09-20 |
EP3219318A4 (en) | 2018-07-11 |
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Legal Events
Date | Code | Title | Description |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |