NO301588B1 - Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat - Google Patents

Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat

Info

Publication number
NO301588B1
NO301588B1 NO931421A NO931421A NO301588B1 NO 301588 B1 NO301588 B1 NO 301588B1 NO 931421 A NO931421 A NO 931421A NO 931421 A NO931421 A NO 931421A NO 301588 B1 NO301588 B1 NO 301588B1
Authority
NO
Norway
Prior art keywords
cyanomethyl
dimethylethyl
dioxane
cis
dimethyl
Prior art date
Application number
NO931421A
Other languages
English (en)
Norwegian (no)
Other versions
NO931421D0 (no
NO931421L (no
Inventor
Alan Millar
Donald Eugene Butler
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO931421D0 publication Critical patent/NO931421D0/no
Publication of NO931421L publication Critical patent/NO931421L/no
Publication of NO301588B1 publication Critical patent/NO301588B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
NO931421A 1990-10-17 1993-04-16 Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat NO301588B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/599,521 US5103024A (en) 1990-10-17 1990-10-17 Process for the synthesis of (4r-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
PCT/US1991/006697 WO1992006968A1 (en) 1990-10-17 1991-09-11 Process for the synthesis of (4r-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate

Publications (3)

Publication Number Publication Date
NO931421D0 NO931421D0 (no) 1993-04-16
NO931421L NO931421L (no) 1993-06-16
NO301588B1 true NO301588B1 (no) 1997-11-17

Family

ID=24399962

Family Applications (1)

Application Number Title Priority Date Filing Date
NO931421A NO301588B1 (no) 1990-10-17 1993-04-16 Fremgangsmåte og mellomprodukt for syntese av (4R-cis)-1,1-dimetyletyl-6-cyanometyl-2,2-dimetyl-1,3-dioksan-4-acetat

Country Status (20)

Country Link
US (1) US5103024A (cs)
EP (1) EP0553213B1 (cs)
JP (1) JP3105923B2 (cs)
KR (1) KR0166385B1 (cs)
AT (1) ATE118772T1 (cs)
AU (1) AU646311B2 (cs)
CA (1) CA2092997C (cs)
CZ (5) CZ283003B6 (cs)
DE (1) DE69107622T2 (cs)
DK (1) DK0553213T3 (cs)
ES (1) ES2070519T3 (cs)
FI (1) FI108539B (cs)
HK (1) HK1005026A1 (cs)
HU (2) HU219237B (cs)
IE (1) IE62940B1 (cs)
NO (1) NO301588B1 (cs)
PT (1) PT99244B (cs)
RU (1) RU2067580C1 (cs)
SK (5) SK280938B6 (cs)
WO (1) WO1992006968A1 (cs)

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HRP960312B1 (en) 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
ES2207202T3 (es) * 1998-04-30 2004-05-16 Kaneka Corporation Procedimiento para producir derivados de acido 6-cianometil-1, 3-dioxano-4-acetico.
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SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
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GB0116212D0 (en) * 2001-07-03 2001-08-29 Avecia Ltd Process
HRP20040077A2 (en) 2001-07-30 2004-06-30 Reddys Lab Ltd Dr Crystalline forms vi and vii of atorvastatin-calcium
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WO2003018547A2 (en) * 2001-08-31 2003-03-06 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
HU227124B1 (en) * 2001-09-14 2010-07-28 Egis Gyogyszergyar Nyilvanosan Polymorphs of 1-pyrrole derivative, intermediate for the preparation of atorvastatin
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
EP1323717A1 (en) * 2001-12-27 2003-07-02 Dsm N.V. Process for the preparation of 2-(6-Substituted-1,3-Dioxane-4-yL) acetic acid derivatives
CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
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EP1375493A1 (en) * 2002-06-17 2004-01-02 Dsm N.V. Process for the preparation of an dioxane acetic acid ester
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KR100529703B1 (ko) * 2002-09-23 2005-11-17 임광민 키랄 중간체의 제조방법 및 그를 이용한 아토바스타틴의제조방법
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PL1727795T3 (pl) 2004-03-17 2012-06-29 Ranbaxy Laboratories Ltd Sposób wytwarzania soli wapniowej atorwastatyny w formie bezpostaciowej
CN1960972A (zh) * 2004-04-16 2007-05-09 辉瑞产品公司 用于形成无定形阿托伐它汀钙的方法
JP2007536373A (ja) 2004-05-05 2007-12-13 ファイザー・プロダクツ・インク アトルバスタチンの塩形態
JP5000502B2 (ja) * 2004-07-16 2012-08-15 レツク・フアーマシユーテイカルズ・デー・デー アトルバスタチンカルシウムの酸化分解生成物
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CN106008251A (zh) * 2016-05-19 2016-10-12 河南豫辰药业股份有限公司 一种2-苯甲撑-3-氧代-4-甲基-n-苯基戊酰胺的制备方法

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US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
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Also Published As

Publication number Publication date
HU9701183D0 (en) 1997-09-29
PT99244A (pt) 1992-09-30
DE69107622D1 (de) 1995-03-30
WO1992006968A1 (en) 1992-04-30
CZ209495A3 (en) 1997-12-17
ES2070519T3 (es) 1995-06-01
CZ61493A3 (en) 1994-02-16
HU219237B (en) 2001-03-28
IE913629A1 (en) 1992-04-22
SK280942B6 (sk) 2000-09-12
EP0553213A1 (en) 1993-08-04
SK280941B6 (sk) 2000-09-12
AU8848091A (en) 1992-05-20
HK1005026A1 (en) 1998-12-18
SK33993A3 (en) 1993-10-06
KR0166385B1 (en) 1999-01-15
DE69107622T2 (de) 1995-07-06
JP3105923B2 (ja) 2000-11-06
IE62940B1 (en) 1995-03-08
HU9301122D0 (en) 1993-08-30
CZ282994B6 (cs) 1997-12-17
FI931680L (fi) 1993-04-14
CZ282992B6 (cs) 1997-12-17
RU2067580C1 (ru) 1996-10-10
AU646311B2 (en) 1994-02-17
CA2092997C (en) 2002-05-14
HU213731B (en) 1997-09-29
JPH06502162A (ja) 1994-03-10
DK0553213T3 (da) 1995-07-17
FI931680A0 (fi) 1993-04-14
CZ283003B6 (cs) 1997-12-17
CZ282922B6 (cs) 1997-11-12
CZ124797A3 (en) 1997-12-17
NO931421D0 (no) 1993-04-16
SK280939B6 (sk) 2000-09-12
CZ124697A3 (en) 1997-12-17
EP0553213B1 (en) 1995-02-22
PT99244B (pt) 1999-04-30
CA2092997A1 (en) 1992-04-18
ATE118772T1 (de) 1995-03-15
US5103024A (en) 1992-04-07
SK280940B6 (sk) 2000-09-12
SK280938B6 (sk) 2000-09-12
CZ124597A3 (en) 1997-12-17
KR930702328A (ko) 1993-09-08
CZ282993B6 (cs) 1997-12-17
HUT64049A (en) 1993-11-29
NO931421L (no) 1993-06-16
FI108539B (fi) 2002-02-15

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