NO941280D0 - Forbedret fremgangsmåte for syntese av (5R)-1,1-dimetyletyl, 6-cyano-5-hydroksy-3-okso-heksanoat - Google Patents

Forbedret fremgangsmåte for syntese av (5R)-1,1-dimetyletyl, 6-cyano-5-hydroksy-3-okso-heksanoat

Info

Publication number
NO941280D0
NO941280D0 NO941280A NO941280A NO941280D0 NO 941280 D0 NO941280 D0 NO 941280D0 NO 941280 A NO941280 A NO 941280A NO 941280 A NO941280 A NO 941280A NO 941280 D0 NO941280 D0 NO 941280D0
Authority
NO
Norway
Prior art keywords
dimethylethyl
cyano
hydroxy
improved process
oxohexanoate
Prior art date
Application number
NO941280A
Other languages
English (en)
Other versions
NO941280L (no
NO300208B1 (no
Inventor
Donald Eugene Butler
Alan Millar
Tung Van Le
Thomas Norman Nanninga
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO941280L publication Critical patent/NO941280L/no
Publication of NO941280D0 publication Critical patent/NO941280D0/no
Publication of NO300208B1 publication Critical patent/NO300208B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
NO941280A 1991-10-11 1994-04-08 Forbedret fremgangsmåte for syntese av (5R)-1,1-dimetyletyl, 6-cyano-5-hydroksy-3-okso-heksanoat NO300208B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/775,162 US5155251A (en) 1991-10-11 1991-10-11 Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
PCT/US1992/008441 WO1993007115A1 (en) 1991-10-11 1992-10-05 Improved process for the synthesis of (5r)-1,1-dimethylethyl 6-cyano-5-hydroxy-3-oxo-hexanoate

Publications (3)

Publication Number Publication Date
NO941280L NO941280L (no) 1994-04-08
NO941280D0 true NO941280D0 (no) 1994-04-08
NO300208B1 NO300208B1 (no) 1997-04-28

Family

ID=25103514

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941280A NO300208B1 (no) 1991-10-11 1994-04-08 Forbedret fremgangsmåte for syntese av (5R)-1,1-dimetyletyl, 6-cyano-5-hydroksy-3-okso-heksanoat

Country Status (16)

Country Link
US (1) US5155251A (no)
EP (1) EP0643689B1 (no)
JP (2) JP3241723B2 (no)
AT (1) ATE175190T1 (no)
AU (1) AU667320B2 (no)
CA (1) CA2116973C (no)
DE (1) DE69228073T2 (no)
DK (1) DK0643689T3 (no)
ES (1) ES2129457T3 (no)
FI (1) FI941632A0 (no)
MX (1) MX9205824A (no)
NO (1) NO300208B1 (no)
PT (1) PT100943B (no)
SG (1) SG46599A1 (no)
WO (1) WO1993007115A1 (no)
ZA (1) ZA927793B (no)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5245047A (en) * 1988-02-22 1993-09-14 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
JP3171931B2 (ja) * 1992-06-02 2001-06-04 高砂香料工業株式会社 （Ｒ）−（−）−４−シアノ−３−ヒドロキシ酪酸ｔ−ブチルエステル及びその製造方法
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
HRP960312B1 (en) 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
US5908953A (en) * 1996-12-18 1999-06-01 Mitsubishi Chemical Corporation Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester
JPH11171850A (ja) * 1997-12-12 1999-06-29 Kanegafuchi Chem Ind Co Ltd 酪酸エステル誘導体の製造方法
IL135562A (en) * 1997-12-19 2005-08-31 Warner Lambert Exp Ltd Process for the synthesis of cis-1,3-diols and a synergistic combination of trialkylborane and dialkylalkoxyborane for such synthesis
DE69910562T2 (de) * 1998-04-30 2004-06-17 Kaneka Corp. Verfahren zur herstellung von derivaten der 6-cyanomethyl-1,3-dioxan-4-essigsäure
ES2294236T3 (es) 1998-08-05 2008-04-01 Kaneka Corporation Procedimiento para la preparacion de esteres sustituidos con 3,5-dihidroxi como intermedios para producir derivados de acido 2-(6-hiximetil)-1,3-dioxan-4-il) acetico opticamente activos.
KR100313668B1 (ko) 1999-02-03 2001-11-26 박영구 (ｒ)-4-시아노-3-히드록시부티르산 에스테르의 제조방법
HU227840B1 (en) * 1999-05-06 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag Intermediates of atorvastatin synthesis and process for producing them
HUP0103788A3 (en) * 1999-06-04 2003-05-28 Kaneka Corp Processes for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives
US20040063969A1 (en) * 1999-10-18 2004-04-01 Egis Gyogyszergyar Rt. Process for the preparation of amorphous atorvastatin calcium
HUP0203708A3 (en) 1999-12-17 2003-11-28 Warner Lambert Res & Dev Ie A factory scale process for producing crystalline atorvastatin trihydrate hemi calcium salt
CA2391357C (en) * 1999-12-17 2009-01-06 Warner Lambert Research And Development Ireland Limited A process for producing crystalline atorvastatin calcium
CN101250133B (zh) * 2000-05-31 2010-06-09 中国医学科学院药物研究所 (±)对氟-2-(2-甲基-丙酰基)-4-氧-n，3-二苯基-苯丁酰胺的合成方法以及其中的中间体
CN100368386C (zh) * 2000-05-31 2008-02-13 中国医学科学院药物研究所 （±）对氟-2-（2-甲基-丙酰基）-4-氧-n，3-二苯基-苯丁酰胺的合成方法以及其中的中间体
US6476235B2 (en) 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
EP1724256A3 (en) 2001-01-09 2007-03-21 Warner-Lambert Company LLC Novel process for the synthesis of 5-(4-fluorphenyl)-1-2(2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl)-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
WO2002057229A1 (en) * 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
PL367943A1 (en) 2001-06-29 2005-03-07 Warner-Lambert Company Llc Crystalline forms of 'r-(r*,r*)!-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-'phenylamino)carbonyl!-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin)
JP2004533481A (ja) 2001-07-06 2004-11-04 テバ ファーマシューティカル インダストリーズ リミティド ７−アミノｓｙｎ３，５−ジヒドロキシヘプタン酸誘導体の製造方法、それらの中間体及び中間体の製造方法
US7199261B2 (en) 2001-07-06 2007-04-03 Teva Pharmaceutical Industries Ltd Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
CA2448917A1 (en) 2001-07-06 2003-01-16 Reinhold Ohrlein Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof
JP4765217B2 (ja) * 2001-07-30 2011-09-07 住友化学株式会社 （ｒ）−４−シアノ−３−ヒドロキシブタン酸エステルの製造法
CA2454500C (en) 2001-07-30 2009-11-10 Dr. Reddy's Laboratories Ltd. Crystalline forms vi and vii of atorvastatin calcium
US20030114497A1 (en) * 2001-07-31 2003-06-19 Laman Alani Pharmaceutical compositions of amlodipine and atorvastatin
CA2456095C (en) * 2001-08-31 2010-05-11 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
KR100849880B1 (ko) * 2001-12-20 2008-08-01 주식회사 중외제약 광학활성 2-[6-(치환된 알킬)-1,3-디옥산-4-일]아세트산유도체의 신규 제조 방법
CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
DE10212492B4 (de) * 2002-03-21 2012-02-02 Daimler Ag Kolbenpumpe
PL375415A1 (en) * 2002-08-06 2005-11-28 Warner-Lambert Company Llc Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
JP4578240B2 (ja) * 2002-08-09 2010-11-10 コデクシス， インコーポレイテッド ４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス
JP2006503024A (ja) * 2002-09-03 2006-01-26 モレペン、ラボラトリーズ、リミテッド Ｖｉ型アトルバスタチンカルシウムまたはその水和物
HRP20020885B1 (en) * 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
RS20050760A (sr) * 2003-04-14 2008-04-04 Warner-Lambert Company Llc., Postupak za izradu fenilamida 5-(4- fluorofenil)-1-(2-((2r, 4r)-4-hidroksi- 6-okso-tetrahidro-piran-2-il)etil)-2- izopropil-4-fenil-1h-pirol-3- karboksilne kiseline
EP1636183A1 (en) * 2003-05-16 2006-03-22 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
US20050182125A1 (en) * 2003-05-16 2005-08-18 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
US20040248972A1 (en) * 2003-05-16 2004-12-09 Ambit Biosciences Corporation Compounds and uses thereof
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20050271717A1 (en) 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
WO2005026116A1 (en) * 2003-09-17 2005-03-24 Warner-Lambert Company Llc Crystalline forms of `r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-`(phenylamino)carbonyl!-1h-pyrrole-1-heptanoic acid
AU2003272080A1 (en) * 2003-09-18 2005-04-06 Biocon Limited Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
EP1711489B1 (en) * 2003-12-29 2012-12-26 LEK Pharmaceuticals d.d. Process for preparing amorphous (4r-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methyl)-pyrrol-1-yl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
CN1942439B (zh) 2004-03-17 2011-12-21 兰贝克赛实验室有限公司 无定形形式的阿托伐他汀钙的制备方法
CN1960972A (zh) * 2004-04-16 2007-05-09 辉瑞产品公司 用于形成无定形阿托伐它汀钙的方法
JP2007536373A (ja) 2004-05-05 2007-12-13 ファイザー・プロダクツ・インク アトルバスタチンの塩形態
WO2006008091A2 (en) * 2004-07-16 2006-01-26 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
EP1771412A2 (en) * 2004-07-20 2007-04-11 Warner-Lambert Company LLC Crystalline forms of [r-(r*)]-2-(4-fluorophenyl)-bet a,gamma-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-hept anoic acid calcium salt (2:1)
EP1784389A4 (en) * 2004-08-27 2009-03-25 Biocon Ltd PROCESS FOR THE PREPARATION OF AMORPHIC ATORVASTATIN CALCIUM
EP1807055A1 (en) * 2004-10-28 2007-07-18 Warner-Lambert Company LLC Process for forming amorphous atorvastatin
AU2005305460B2 (en) * 2004-11-22 2011-04-21 Dexcel Pharma Technologies Ltd. Stable atorvastatin formulations
JP2008521878A (ja) * 2004-12-02 2008-06-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 非晶質アトルバスタチンの医薬組成物及びその製造のための方法
DE602005014686D1 (de) * 2005-09-09 2009-07-09 Pfizer Science & Tech Ltd Herstellung eines atorvastatin-zwischenprodukts
US20090221852A1 (en) * 2005-09-09 2009-09-03 Pfizer Inc. Preparation of an Atorvastatin Intermediate
US20090216029A1 (en) * 2005-09-16 2009-08-27 Yatendra Kumar Process for the production of atorvastatin calcium in amorphous form
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
US8084488B2 (en) 2005-11-21 2011-12-27 Pfizer Inc. Forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid magnesium
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
EP2066788B1 (en) 2006-10-02 2014-07-23 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
US20100113802A1 (en) * 2006-11-02 2010-05-06 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its itermediate
WO2008059366A2 (en) * 2006-11-17 2008-05-22 Pfizer Products Inc. Process for the preparation of cis-1, 3-diols from the corresponding beta-hydroxy ketones employing microbial ketone reductases
US7834195B2 (en) * 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
WO2009013633A2 (en) * 2007-07-20 2009-01-29 Actavis Group Ptc Ehf Amorphous coprecipitates of atorvastatin pharmaceutically acceptable salts
ES2523404T3 (es) * 2007-08-03 2014-11-25 Pfizer Products Inc. Procedimiento de preparación de compuestos quirales
EP2075246A1 (en) 2007-12-27 2009-07-01 M. J. Institute of Research A process for preparation of amorphous form of atorvastatin hemi-calcium salt
US8115015B2 (en) * 2009-01-26 2012-02-14 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
GB2474687A (en) * 2009-10-23 2011-04-27 Phoenix Chemicals Ltd A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives)
KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
MX2013002674A (es) 2010-09-09 2013-06-13 Dsm Sinochem Pharm Bv Sales de esteres de acido 7-amino-3,5-dihidroxiheptanoico.
CN103702982A (zh) 2011-07-01 2014-04-02 中化帝斯曼制药有限公司荷兰公司 阿托伐他汀半钙的超细晶体
CN102766072B (zh) * 2012-08-07 2013-12-25 浙江宏元药业有限公司 一种制备阿托伐他汀钙手性侧链的方法
CN103145584B (zh) * 2013-03-05 2015-08-26 复旦大学 一种合成(3r,5r)-3,5-二羟基-6-氰基己酸酯的方法
CN106397241A (zh) * 2016-08-23 2017-02-15 杨锋 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4611067A (en) * 1985-01-31 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis

Also Published As

Publication number Publication date
NO941280L (no) 1994-04-08
MX9205824A (es) 1993-04-01
ATE175190T1 (de) 1999-01-15
DE69228073D1 (de) 1999-02-11
FI941632A (fi) 1994-04-08
ES2129457T3 (es) 1999-06-16
CA2116973C (en) 2004-09-21
EP0643689A1 (en) 1995-03-22
DE69228073T2 (de) 1999-06-10
DK0643689T3 (da) 1999-08-30
FI941632A0 (fi) 1994-04-08
AU2764192A (en) 1993-05-03
CA2116973A1 (en) 1993-04-15
NO300208B1 (no) 1997-04-28
PT100943A (pt) 1993-10-29
PT100943B (pt) 1999-07-30
US5155251A (en) 1992-10-13
EP0643689B1 (en) 1998-12-30
AU667320B2 (en) 1996-03-21
JP2002030060A (ja) 2002-01-29
SG46599A1 (en) 1998-02-20
JP3241723B2 (ja) 2001-12-25
JPH07500105A (ja) 1995-01-05
ZA927793B (en) 1994-04-11
JP3429500B2 (ja) 2003-07-22
WO1993007115A1 (en) 1993-04-15

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