NO941280D0 - Forbedret fremgangsmåte for syntese av (5R)-1,1-dimetyletyl, 6-cyano-5-hydroksy-3-okso-heksanoat - Google Patents

Forbedret fremgangsmåte for syntese av (5R)-1,1-dimetyletyl, 6-cyano-5-hydroksy-3-okso-heksanoat

Info

Publication number
NO941280D0
NO941280D0 NO941280A NO941280A NO941280D0 NO 941280 D0 NO941280 D0 NO 941280D0 NO 941280 A NO941280 A NO 941280A NO 941280 A NO941280 A NO 941280A NO 941280 D0 NO941280 D0 NO 941280D0
Authority
NO
Norway
Prior art keywords
dimethylethyl
cyano
hydroxy
improved process
oxohexanoate
Prior art date
Application number
NO941280A
Other languages
English (en)
Other versions
NO941280L (no
NO300208B1 (no
Inventor
Donald Eugene Butler
Alan Millar
Tung Van Le
Thomas Norman Nanninga
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO941280L publication Critical patent/NO941280L/no
Publication of NO941280D0 publication Critical patent/NO941280D0/no
Publication of NO300208B1 publication Critical patent/NO300208B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
NO941280A 1991-10-11 1994-04-08 Forbedret fremgangsmåte for syntese av (5R)-1,1-dimetyletyl, 6-cyano-5-hydroksy-3-okso-heksanoat NO300208B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/775,162 US5155251A (en) 1991-10-11 1991-10-11 Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
PCT/US1992/008441 WO1993007115A1 (en) 1991-10-11 1992-10-05 Improved process for the synthesis of (5r)-1,1-dimethylethyl 6-cyano-5-hydroxy-3-oxo-hexanoate

Publications (3)

Publication Number Publication Date
NO941280L NO941280L (no) 1994-04-08
NO941280D0 true NO941280D0 (no) 1994-04-08
NO300208B1 NO300208B1 (no) 1997-04-28

Family

ID=25103514

Family Applications (1)

Application Number Title Priority Date Filing Date
NO941280A NO300208B1 (no) 1991-10-11 1994-04-08 Forbedret fremgangsmåte for syntese av (5R)-1,1-dimetyletyl, 6-cyano-5-hydroksy-3-okso-heksanoat

Country Status (16)

Country Link
US (1) US5155251A (no)
EP (1) EP0643689B1 (no)
JP (2) JP3241723B2 (no)
AT (1) ATE175190T1 (no)
AU (1) AU667320B2 (no)
CA (1) CA2116973C (no)
DE (1) DE69228073T2 (no)
DK (1) DK0643689T3 (no)
ES (1) ES2129457T3 (no)
FI (1) FI941632A (no)
MX (1) MX9205824A (no)
NO (1) NO300208B1 (no)
PT (1) PT100943B (no)
SG (1) SG46599A1 (no)
WO (1) WO1993007115A1 (no)
ZA (1) ZA927793B (no)

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* Cited by examiner, † Cited by third party
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JP3171931B2 (ja) * 1992-06-02 2001-06-04 高砂香料工業株式会社 (R)−(−)−4−シアノ−3−ヒドロキシ酪酸t−ブチルエステル及びその製造方法
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HRP960312B1 (en) 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
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CN101250133B (zh) * 2000-05-31 2010-06-09 中国医学科学院药物研究所 (±)对氟-2-(2-甲基-丙酰基)-4-氧-n,3-二苯基-苯丁酰胺的合成方法以及其中的中间体
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EP1724256A3 (en) 2001-01-09 2007-03-21 Warner-Lambert Company LLC Novel process for the synthesis of 5-(4-fluorphenyl)-1-2(2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl)-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
WO2002057229A1 (en) * 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
CN1524073A (zh) * 2001-06-29 2004-08-25 ����-�����ع�˾ ′R-(R*,R*)-2-(4-氟苯基)-β,δ-二羟基-5-(1-甲基乙基)-3-苯基-4-(苯基氨基)羰基-1H-吡咯-1-庚酸钙盐(2∶1)(阿托伐他汀)
EP1406860A1 (en) * 2001-07-06 2004-04-14 Teva Pharmaceutical Industries Limited Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
HUP0401145A3 (en) 2001-07-06 2008-08-28 Ciba Sc Holding Ag Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof
CZ2004158A3 (cs) 2001-07-06 2005-01-12 Teva Pharmaceutical Industries Ltd. Syntéza a meziprodukty derivátů 3,5-dihydroxyheptanové kyseliny
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JP4765217B2 (ja) * 2001-07-30 2011-09-07 住友化学株式会社 (r)−4−シアノ−3−ヒドロキシブタン酸エステルの製造法
US20030114497A1 (en) * 2001-07-31 2003-06-19 Laman Alani Pharmaceutical compositions of amlodipine and atorvastatin
AU2001284385A1 (en) * 2001-08-31 2003-03-10 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
KR100849880B1 (ko) * 2001-12-20 2008-08-01 주식회사 중외제약 광학활성 2-[6-(치환된 알킬)-1,3-디옥산-4-일]아세트산유도체의 신규 제조 방법
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CN1852894A (zh) * 2003-09-17 2006-10-25 沃尼尔·朗伯有限责任公司 [R-(R*, R*)]-2-(4-氟苯基) -β,δ-二羟基-5-(1-甲基乙基) -3-苯基-4-[(苯基氨基)羰基] -1 H-吡咯-1-庚酸的结晶形式
US7557238B2 (en) * 2003-09-18 2009-07-07 Biocon Limited Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
US7943786B2 (en) * 2003-12-29 2011-05-17 Ljubomir Antoncic Process for preparing amorphous (4R-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid
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CN101528917B (zh) * 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
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ES2523404T3 (es) * 2007-08-03 2014-11-25 Pfizer Products Inc. Procedimiento de preparación de compuestos quirales
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GB2474687A (en) * 2009-10-23 2011-04-27 Phoenix Chemicals Ltd A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives)
KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
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CN102766072B (zh) * 2012-08-07 2013-12-25 浙江宏元药业有限公司 一种制备阿托伐他汀钙手性侧链的方法
CN103145584B (zh) * 2013-03-05 2015-08-26 复旦大学 一种合成(3r,5r)-3,5-二羟基-6-氰基己酸酯的方法
CN106397241A (zh) * 2016-08-23 2017-02-15 杨锋 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

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Also Published As

Publication number Publication date
FI941632A0 (fi) 1994-04-08
NO941280L (no) 1994-04-08
AU2764192A (en) 1993-05-03
NO300208B1 (no) 1997-04-28
FI941632A (fi) 1994-04-08
JPH07500105A (ja) 1995-01-05
CA2116973A1 (en) 1993-04-15
ZA927793B (en) 1994-04-11
DE69228073T2 (de) 1999-06-10
ATE175190T1 (de) 1999-01-15
AU667320B2 (en) 1996-03-21
CA2116973C (en) 2004-09-21
JP2002030060A (ja) 2002-01-29
SG46599A1 (en) 1998-02-20
JP3429500B2 (ja) 2003-07-22
PT100943B (pt) 1999-07-30
DE69228073D1 (de) 1999-02-11
PT100943A (pt) 1993-10-29
JP3241723B2 (ja) 2001-12-25
US5155251A (en) 1992-10-13
DK0643689T3 (da) 1999-08-30
ES2129457T3 (es) 1999-06-16
EP0643689B1 (en) 1998-12-30
MX9205824A (es) 1993-04-01
EP0643689A1 (en) 1995-03-22
WO1993007115A1 (en) 1993-04-15

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