FI941632A - Parannettu menetelmä (5R)-1,1-dimetyylietyyli-6-syano-5-hydroksi-3-oksoheksanoaatin valmistamiseksi - Google Patents

Parannettu menetelmä (5R)-1,1-dimetyylietyyli-6-syano-5-hydroksi-3-oksoheksanoaatin valmistamiseksi Download PDF

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Publication number
FI941632A
FI941632A FI941632A FI941632A FI941632A FI 941632 A FI941632 A FI 941632A FI 941632 A FI941632 A FI 941632A FI 941632 A FI941632 A FI 941632A FI 941632 A FI941632 A FI 941632A
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FI
Finland
Prior art keywords
dimethylethyl
cyano
hydroxy
preparation
improved process
Prior art date
Application number
FI941632A
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English (en)
Swedish (sv)
Other versions
FI941632A0 (fi
Inventor
Donald Eugene Butler
Tung Van Le
Alan Millar
Thomas Norman Nanninga
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI941632A0 publication Critical patent/FI941632A0/fi
Publication of FI941632A publication Critical patent/FI941632A/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
FI941632A 1991-10-11 1994-04-08 Parannettu menetelmä (5R)-1,1-dimetyylietyyli-6-syano-5-hydroksi-3-oksoheksanoaatin valmistamiseksi FI941632A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/775,162 US5155251A (en) 1991-10-11 1991-10-11 Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
PCT/US1992/008441 WO1993007115A1 (en) 1991-10-11 1992-10-05 Improved process for the synthesis of (5r)-1,1-dimethylethyl 6-cyano-5-hydroxy-3-oxo-hexanoate

Publications (2)

Publication Number Publication Date
FI941632A0 FI941632A0 (fi) 1994-04-08
FI941632A true FI941632A (fi) 1994-04-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
FI941632A FI941632A (fi) 1991-10-11 1994-04-08 Parannettu menetelmä (5R)-1,1-dimetyylietyyli-6-syano-5-hydroksi-3-oksoheksanoaatin valmistamiseksi

Country Status (16)

Country Link
US (1) US5155251A (fi)
EP (1) EP0643689B1 (fi)
JP (2) JP3241723B2 (fi)
AT (1) ATE175190T1 (fi)
AU (1) AU667320B2 (fi)
CA (1) CA2116973C (fi)
DE (1) DE69228073T2 (fi)
DK (1) DK0643689T3 (fi)
ES (1) ES2129457T3 (fi)
FI (1) FI941632A (fi)
MX (1) MX9205824A (fi)
NO (1) NO300208B1 (fi)
PT (1) PT100943B (fi)
SG (1) SG46599A1 (fi)
WO (1) WO1993007115A1 (fi)
ZA (1) ZA927793B (fi)

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JP4659309B2 (ja) * 1999-06-04 2011-03-30 株式会社カネカ ５−ヒドロキシ−３−オキソペンタン酸誘導体の製造法
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CN101250133B (zh) * 2000-05-31 2010-06-09 中国医学科学院药物研究所 (±)对氟-2-(2-甲基-丙酰基)-4-氧-n，3-二苯基-苯丁酰胺的合成方法以及其中的中间体
US6476235B2 (en) 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
EP1724256A3 (en) 2001-01-09 2007-03-21 Warner-Lambert Company LLC Novel process for the synthesis of 5-(4-fluorphenyl)-1-2(2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl)-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
WO2002057229A1 (en) * 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
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EA005317B1 (ru) 2001-06-29 2004-12-30 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1h-пиррол-1-гептановой кислоты кальциевой соли (2:1) (аторвастатин)
US7199261B2 (en) * 2001-07-06 2007-04-03 Teva Pharmaceutical Industries Ltd Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
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US7563911B2 (en) * 2001-08-31 2009-07-21 Morepen Laboratories Ltd. Process for the preparation of amorphous atorvastin calcium salt (2:1)
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KR100849880B1 (ko) * 2001-12-20 2008-08-01 주식회사 중외제약 광학활성 2-[6-(치환된 알킬)-1,3-디옥산-4-일]아세트산유도체의 신규 제조 방법
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CN101528917B (zh) 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
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GB2474687A (en) * 2009-10-23 2011-04-27 Phoenix Chemicals Ltd A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives)
KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
CN103153976B (zh) * 2010-09-09 2015-07-08 中化帝斯曼制药有限公司荷兰公司 7-氨基-3,5-二羟基庚酸酯的盐
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CN102766072B (zh) * 2012-08-07 2013-12-25 浙江宏元药业有限公司 一种制备阿托伐他汀钙手性侧链的方法
CN103145584B (zh) * 2013-03-05 2015-08-26 复旦大学 一种合成(3r,5r)-3,5-二羟基-6-氰基己酸酯的方法
CN106397241A (zh) * 2016-08-23 2017-02-15 杨锋 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

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Also Published As

Publication number Publication date
FI941632A0 (fi) 1994-04-08
CA2116973C (en) 2004-09-21
ES2129457T3 (es) 1999-06-16
NO300208B1 (no) 1997-04-28
NO941280L (no) 1994-04-08
WO1993007115A1 (en) 1993-04-15
CA2116973A1 (en) 1993-04-15
JP3429500B2 (ja) 2003-07-22
NO941280D0 (no) 1994-04-08
EP0643689A1 (en) 1995-03-22
MX9205824A (es) 1993-04-01
JP3241723B2 (ja) 2001-12-25
DE69228073T2 (de) 1999-06-10
JP2002030060A (ja) 2002-01-29
US5155251A (en) 1992-10-13
JPH07500105A (ja) 1995-01-05
PT100943A (pt) 1993-10-29
DK0643689T3 (da) 1999-08-30
EP0643689B1 (en) 1998-12-30
AU2764192A (en) 1993-05-03
PT100943B (pt) 1999-07-30
ZA927793B (en) 1994-04-11
DE69228073D1 (de) 1999-02-11
ATE175190T1 (de) 1999-01-15
AU667320B2 (en) 1996-03-21
SG46599A1 (en) 1998-02-20

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