PT100943A - Processo aperfeicoado para a sintese de (5r)-6-ciano-5-hidroxi-3-oxo-hexanoato de 1,1-dimetiletilo - Google Patents

Processo aperfeicoado para a sintese de (5r)-6-ciano-5-hidroxi-3-oxo-hexanoato de 1,1-dimetiletilo

Info

Publication number
PT100943A
PT100943A PT100943A PT10094392A PT100943A PT 100943 A PT100943 A PT 100943A PT 100943 A PT100943 A PT 100943A PT 10094392 A PT10094392 A PT 10094392A PT 100943 A PT100943 A PT 100943A
Authority
PT
Portugal
Prior art keywords
hexanoate
oxo
cyano
hydroxy
dimethylthyl
Prior art date
Application number
PT100943A
Other languages
English (en)
Other versions
PT100943B (pt
Inventor
Alan Millar
Donald Engene Butler
Thomas Norman Nanninga
Turgan Van Le
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PT100943A publication Critical patent/PT100943A/pt
Publication of PT100943B publication Critical patent/PT100943B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
PT100943A 1991-10-11 1992-10-09 Processo aperfeicoado para a sintese de (5r)-6-ciano-5-hidroxi-3-oxo-hexanoato de 1,1-dimetiletilo PT100943B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/775,162 US5155251A (en) 1991-10-11 1991-10-11 Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate

Publications (2)

Publication Number Publication Date
PT100943A true PT100943A (pt) 1993-10-29
PT100943B PT100943B (pt) 1999-07-30

Family

ID=25103514

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100943A PT100943B (pt) 1991-10-11 1992-10-09 Processo aperfeicoado para a sintese de (5r)-6-ciano-5-hidroxi-3-oxo-hexanoato de 1,1-dimetiletilo

Country Status (16)

Country Link
US (1) US5155251A (pt)
EP (1) EP0643689B1 (pt)
JP (2) JP3241723B2 (pt)
AT (1) ATE175190T1 (pt)
AU (1) AU667320B2 (pt)
CA (1) CA2116973C (pt)
DE (1) DE69228073T2 (pt)
DK (1) DK0643689T3 (pt)
ES (1) ES2129457T3 (pt)
FI (1) FI941632A (pt)
MX (1) MX9205824A (pt)
NO (1) NO300208B1 (pt)
PT (1) PT100943B (pt)
SG (1) SG46599A1 (pt)
WO (1) WO1993007115A1 (pt)
ZA (1) ZA927793B (pt)

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CN101250133B (zh) * 2000-05-31 2010-06-09 中国医学科学院药物研究所 (±)对氟-2-(2-甲基-丙酰基)-4-氧-n，3-二苯基-苯丁酰胺的合成方法以及其中的中间体
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EA005317B1 (ru) 2001-06-29 2004-12-30 УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си Кристаллические формы [r-(r*,r*)]-2-(4-фторфенил)-бета, дельта-дигидрокси-5-(1-метилэтил)-3-фенил-4-[(фениламино)карбонил]-1h-пиррол-1-гептановой кислоты кальциевой соли (2:1) (аторвастатин)
US7199261B2 (en) * 2001-07-06 2007-04-03 Teva Pharmaceutical Industries Ltd Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
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US7563911B2 (en) * 2001-08-31 2009-07-21 Morepen Laboratories Ltd. Process for the preparation of amorphous atorvastin calcium salt (2:1)
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US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
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CN101528917B (zh) 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
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US20110142883A1 (en) * 2007-07-20 2011-06-16 Actavis Group Ptc Ehf Amorphous Coprecipitates of Atorvastatin Pharmaceutically Acceptable Salts
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KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
CN103153976B (zh) * 2010-09-09 2015-07-08 中化帝斯曼制药有限公司荷兰公司 7-氨基-3,5-二羟基庚酸酯的盐
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CN102766072B (zh) * 2012-08-07 2013-12-25 浙江宏元药业有限公司 一种制备阿托伐他汀钙手性侧链的方法
CN103145584B (zh) * 2013-03-05 2015-08-26 复旦大学 一种合成(3r,5r)-3,5-二羟基-6-氰基己酸酯的方法
CN106397241A (zh) * 2016-08-23 2017-02-15 杨锋 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

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Also Published As

Publication number Publication date
FI941632A0 (fi) 1994-04-08
CA2116973C (en) 2004-09-21
ES2129457T3 (es) 1999-06-16
NO300208B1 (no) 1997-04-28
NO941280L (no) 1994-04-08
WO1993007115A1 (en) 1993-04-15
CA2116973A1 (en) 1993-04-15
JP3429500B2 (ja) 2003-07-22
NO941280D0 (no) 1994-04-08
EP0643689A1 (en) 1995-03-22
MX9205824A (es) 1993-04-01
JP3241723B2 (ja) 2001-12-25
DE69228073T2 (de) 1999-06-10
JP2002030060A (ja) 2002-01-29
US5155251A (en) 1992-10-13
JPH07500105A (ja) 1995-01-05
DK0643689T3 (da) 1999-08-30
EP0643689B1 (en) 1998-12-30
AU2764192A (en) 1993-05-03
FI941632A (fi) 1994-04-08
PT100943B (pt) 1999-07-30
ZA927793B (en) 1994-04-11
DE69228073D1 (de) 1999-02-11
ATE175190T1 (de) 1999-01-15
AU667320B2 (en) 1996-03-21
SG46599A1 (en) 1998-02-20

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