SG46599A1 - Improved process for the synthesis of (5R)-1, 1- dimethylethyl 6-cyano 5-hydroxy-3-oxo-hexanoate - Google Patents

Improved process for the synthesis of (5R)-1, 1- dimethylethyl 6-cyano 5-hydroxy-3-oxo-hexanoate

Info

Publication number
SG46599A1
SG46599A1 SG1996006497A SG1996006497A SG46599A1 SG 46599 A1 SG46599 A1 SG 46599A1 SG 1996006497 A SG1996006497 A SG 1996006497A SG 1996006497 A SG1996006497 A SG 1996006497A SG 46599 A1 SG46599 A1 SG 46599A1
Authority
SG
Singapore
Prior art keywords
hexanoate
dimethylethyl
oxo
cyano
hydroxy
Prior art date
Application number
SG1996006497A
Other languages
English (en)
Inventor
Donald Eugene Butler
Van Tung Le
Alan Millar
Thomas Norman Nanninga
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of SG46599A1 publication Critical patent/SG46599A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
SG1996006497A 1991-10-11 1992-10-05 Improved process for the synthesis of (5R)-1, 1- dimethylethyl 6-cyano 5-hydroxy-3-oxo-hexanoate SG46599A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/775,162 US5155251A (en) 1991-10-11 1991-10-11 Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate

Publications (1)

Publication Number Publication Date
SG46599A1 true SG46599A1 (en) 1998-02-20

Family

ID=25103514

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996006497A SG46599A1 (en) 1991-10-11 1992-10-05 Improved process for the synthesis of (5R)-1, 1- dimethylethyl 6-cyano 5-hydroxy-3-oxo-hexanoate

Country Status (16)

Country Link
US (1) US5155251A (pt)
EP (1) EP0643689B1 (pt)
JP (2) JP3241723B2 (pt)
AT (1) ATE175190T1 (pt)
AU (1) AU667320B2 (pt)
CA (1) CA2116973C (pt)
DE (1) DE69228073T2 (pt)
DK (1) DK0643689T3 (pt)
ES (1) ES2129457T3 (pt)
FI (1) FI941632A (pt)
MX (1) MX9205824A (pt)
NO (1) NO300208B1 (pt)
PT (1) PT100943B (pt)
SG (1) SG46599A1 (pt)
WO (1) WO1993007115A1 (pt)
ZA (1) ZA927793B (pt)

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CN101250133B (zh) * 2000-05-31 2010-06-09 中国医学科学院药物研究所 (±)对氟-2-(2-甲基-丙酰基)-4-氧-n，3-二苯基-苯丁酰胺的合成方法以及其中的中间体
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EP1724256A3 (en) 2001-01-09 2007-03-21 Warner-Lambert Company LLC Novel process for the synthesis of 5-(4-fluorphenyl)-1-2(2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl)-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
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SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
CN1524073A (zh) * 2001-06-29 2004-08-25 ����-�����ع�˾ ′R-(R*,R*)-2-(4-氟苯基)-β,δ-二羟基-5-(1-甲基乙基)-3-苯基-4-(苯基氨基）羰基-1H-吡咯-1-庚酸钙盐（2∶1）（阿托伐他汀）
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UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
KR100849880B1 (ko) * 2001-12-20 2008-08-01 주식회사 중외제약 광학활성 2-[6-(치환된 알킬)-1,3-디옥산-4-일]아세트산유도체의 신규 제조 방법
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US7557238B2 (en) * 2003-09-18 2009-07-07 Biocon Limited Process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
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KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
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CN103145584B (zh) * 2013-03-05 2015-08-26 复旦大学 一种合成(3r,5r)-3,5-二羟基-6-氰基己酸酯的方法
CN106397241A (zh) * 2016-08-23 2017-02-15 杨锋 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

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Also Published As

Publication number Publication date
FI941632A0 (fi) 1994-04-08
NO941280L (no) 1994-04-08
AU2764192A (en) 1993-05-03
NO300208B1 (no) 1997-04-28
FI941632A (fi) 1994-04-08
JPH07500105A (ja) 1995-01-05
CA2116973A1 (en) 1993-04-15
ZA927793B (en) 1994-04-11
DE69228073T2 (de) 1999-06-10
NO941280D0 (no) 1994-04-08
ATE175190T1 (de) 1999-01-15
AU667320B2 (en) 1996-03-21
CA2116973C (en) 2004-09-21
JP2002030060A (ja) 2002-01-29
JP3429500B2 (ja) 2003-07-22
PT100943B (pt) 1999-07-30
DE69228073D1 (de) 1999-02-11
PT100943A (pt) 1993-10-29
JP3241723B2 (ja) 2001-12-25
US5155251A (en) 1992-10-13
DK0643689T3 (da) 1999-08-30
ES2129457T3 (es) 1999-06-16
EP0643689B1 (en) 1998-12-30
MX9205824A (es) 1993-04-01
EP0643689A1 (en) 1995-03-22
WO1993007115A1 (en) 1993-04-15

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