ZA927793B - Process for the synthesis of (5R)-1,1-dimethylethyl 6-cyano-hydroxy-3-oxo-hexanoate - Google Patents

Process for the synthesis of (5R)-1,1-dimethylethyl 6-cyano-hydroxy-3-oxo-hexanoate

Info

Publication number
ZA927793B
ZA927793B ZA927793A ZA927793A ZA927793B ZA 927793 B ZA927793 B ZA 927793B ZA 927793 A ZA927793 A ZA 927793A ZA 927793 A ZA927793 A ZA 927793A ZA 927793 B ZA927793 B ZA 927793B
Authority
ZA
South Africa
Prior art keywords
hexanoate
dimethylethyl
oxo
cyano
hydroxy
Prior art date
Application number
ZA927793A
Other languages
English (en)
Inventor
Donald Eugene Butler
Tung Van Le
Alan Millar
Thomas Norman Nanninga
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of ZA927793B publication Critical patent/ZA927793B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ZA927793A 1991-10-11 1992-10-09 Process for the synthesis of (5R)-1,1-dimethylethyl 6-cyano-hydroxy-3-oxo-hexanoate ZA927793B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/775,162 US5155251A (en) 1991-10-11 1991-10-11 Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate

Publications (1)

Publication Number Publication Date
ZA927793B true ZA927793B (en) 1994-04-11

Family

ID=25103514

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA927793A ZA927793B (en) 1991-10-11 1992-10-09 Process for the synthesis of (5R)-1,1-dimethylethyl 6-cyano-hydroxy-3-oxo-hexanoate

Country Status (16)

Country Link
US (1) US5155251A (xx)
EP (1) EP0643689B1 (xx)
JP (2) JP3241723B2 (xx)
AT (1) ATE175190T1 (xx)
AU (1) AU667320B2 (xx)
CA (1) CA2116973C (xx)
DE (1) DE69228073T2 (xx)
DK (1) DK0643689T3 (xx)
ES (1) ES2129457T3 (xx)
FI (1) FI941632A (xx)
MX (1) MX9205824A (xx)
NO (1) NO300208B1 (xx)
PT (1) PT100943B (xx)
SG (1) SG46599A1 (xx)
WO (1) WO1993007115A1 (xx)
ZA (1) ZA927793B (xx)

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CN101250133B (zh) * 2000-05-31 2010-06-09 中国医学科学院药物研究所 (±)对氟-2-(2-甲基-丙酰基)-4-氧-n，3-二苯基-苯丁酰胺的合成方法以及其中的中间体
EP1724256A3 (en) 2001-01-09 2007-03-21 Warner-Lambert Company LLC Novel process for the synthesis of 5-(4-fluorphenyl)-1-2(2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl)-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
US6476235B2 (en) 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
WO2002057229A1 (en) * 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
CZ20033478A3 (cs) 2001-06-29 2004-10-13 Warner@Lambertácompanyállc Krystalické formy vápenaté soli }@�B [R@}RgŹRgB]@}@fluorofenylB@betaŹ@delta@dihydroxy@Q@}�@methylethylB@fenyl[}fenylaminoBkarbonyl]@�H@pyrrol@�@heptanové kyseliny }atorvastatinB
DE60235365D1 (de) 2001-07-06 2010-04-01 Basf Se Verfahren zur herstellung von 7-amino-syn-3,5-dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung
US7199261B2 (en) * 2001-07-06 2007-04-03 Teva Pharmaceutical Industries Ltd Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
US7420078B2 (en) 2001-07-06 2008-09-02 Ciba Specialty Chemicals Corp. Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof
JP4765217B2 (ja) * 2001-07-30 2011-09-07 住友化学株式会社 （ｒ）−４−シアノ−３−ヒドロキシブタン酸エステルの製造法
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US7563911B2 (en) * 2001-08-31 2009-07-21 Morepen Laboratories Ltd. Process for the preparation of amorphous atorvastin calcium salt (2:1)
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
KR100849880B1 (ko) * 2001-12-20 2008-08-01 주식회사 중외제약 광학활성 2-[6-(치환된 알킬)-1,3-디옥산-4-일]아세트산유도체의 신규 제조 방법
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DE10212492B4 (de) * 2002-03-21 2012-02-02 Daimler Ag Kolbenpumpe
PL375415A1 (en) * 2002-08-06 2005-11-28 Warner-Lambert Company Llc Process for preparing 5-(4-fluorophenyl)-1-[2-((2r,4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
BR0305767A (pt) * 2002-08-09 2005-05-24 Codexis Inc Métodos e composições para a preparação de derivados de ácido 4-substituìdo 3-hidroxibutìrico
WO2004022053A1 (en) * 2002-09-03 2004-03-18 Morepen Laboratories Limited Atorvastatin calcium form vi or hydrates thereof
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AU2003272080A1 (en) * 2003-09-18 2005-04-06 Biocon Limited Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
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KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
SI2614057T1 (sl) 2010-09-09 2016-03-31 Dsm Sinochem Pharmaceuticals Netherlands B.V. Soli estrov 7-amino-3,5-dihidroksi heptanojske kisline
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CN103145584B (zh) * 2013-03-05 2015-08-26 复旦大学 一种合成(3r,5r)-3,5-二羟基-6-氰基己酸酯的方法
CN106397241A (zh) * 2016-08-23 2017-02-15 杨锋 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

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Also Published As

Publication number Publication date
AU2764192A (en) 1993-05-03
ATE175190T1 (de) 1999-01-15
MX9205824A (es) 1993-04-01
US5155251A (en) 1992-10-13
FI941632A0 (fi) 1994-04-08
EP0643689B1 (en) 1998-12-30
EP0643689A1 (en) 1995-03-22
WO1993007115A1 (en) 1993-04-15
DK0643689T3 (da) 1999-08-30
JP2002030060A (ja) 2002-01-29
PT100943A (pt) 1993-10-29
PT100943B (pt) 1999-07-30
DE69228073T2 (de) 1999-06-10
SG46599A1 (en) 1998-02-20
NO941280D0 (no) 1994-04-08
ES2129457T3 (es) 1999-06-16
DE69228073D1 (de) 1999-02-11
CA2116973C (en) 2004-09-21
NO300208B1 (no) 1997-04-28
AU667320B2 (en) 1996-03-21
JP3429500B2 (ja) 2003-07-22
JPH07500105A (ja) 1995-01-05
NO941280L (no) 1994-04-08
JP3241723B2 (ja) 2001-12-25
FI941632A (fi) 1994-04-08
CA2116973A1 (en) 1993-04-15

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