DK0643689T3 - Forbedret fremgangsmåde til syntese af (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoat - Google Patents

Forbedret fremgangsmåde til syntese af (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoat

Info

Publication number
DK0643689T3
DK0643689T3 DK92921435T DK92921435T DK0643689T3 DK 0643689 T3 DK0643689 T3 DK 0643689T3 DK 92921435 T DK92921435 T DK 92921435T DK 92921435 T DK92921435 T DK 92921435T DK 0643689 T3 DK0643689 T3 DK 0643689T3
Authority
DK
Denmark
Prior art keywords
hexanoate
dimethylethyl
oxo
cyano
hydroxy
Prior art date
Application number
DK92921435T
Other languages
Danish (da)
English (en)
Inventor
Tung Van Le
Donald Eugene Butler
Alan Millar
Thomas Norman Nanninga
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of DK0643689T3 publication Critical patent/DK0643689T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
DK92921435T 1991-10-11 1992-10-05 Forbedret fremgangsmåde til syntese af (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoat DK0643689T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/775,162 US5155251A (en) 1991-10-11 1991-10-11 Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
PCT/US1992/008441 WO1993007115A1 (en) 1991-10-11 1992-10-05 Improved process for the synthesis of (5r)-1,1-dimethylethyl 6-cyano-5-hydroxy-3-oxo-hexanoate

Publications (1)

Publication Number Publication Date
DK0643689T3 true DK0643689T3 (da) 1999-08-30

Family

ID=25103514

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92921435T DK0643689T3 (da) 1991-10-11 1992-10-05 Forbedret fremgangsmåde til syntese af (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoat

Country Status (16)

Country Link
US (1) US5155251A (xx)
EP (1) EP0643689B1 (xx)
JP (2) JP3241723B2 (xx)
AT (1) ATE175190T1 (xx)
AU (1) AU667320B2 (xx)
CA (1) CA2116973C (xx)
DE (1) DE69228073T2 (xx)
DK (1) DK0643689T3 (xx)
ES (1) ES2129457T3 (xx)
FI (1) FI941632A (xx)
MX (1) MX9205824A (xx)
NO (1) NO300208B1 (xx)
PT (1) PT100943B (xx)
SG (1) SG46599A1 (xx)
WO (1) WO1993007115A1 (xx)
ZA (1) ZA927793B (xx)

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CN101250133B (zh) * 2000-05-31 2010-06-09 中国医学科学院药物研究所 (±)对氟-2-(2-甲基-丙酰基)-4-氧-n，3-二苯基-苯丁酰胺的合成方法以及其中的中间体
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EP1724256A3 (en) 2001-01-09 2007-03-21 Warner-Lambert Company LLC Novel process for the synthesis of 5-(4-fluorphenyl)-1-2(2-((2r,4r)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl)-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
WO2002057229A1 (en) * 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
CN1524073A (zh) * 2001-06-29 2004-08-25 ����-�����ع�˾ ′R-(R*,R*)-2-(4-氟苯基)-β,δ-二羟基-5-(1-甲基乙基)-3-苯基-4-(苯基氨基）羰基-1H-吡咯-1-庚酸钙盐（2∶1）（阿托伐他汀）
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UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
KR100849880B1 (ko) * 2001-12-20 2008-08-01 주식회사 중외제약 광학활성 2-[6-(치환된 알킬)-1,3-디옥산-4-일]아세트산유도체의 신규 제조 방법
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CN103145584B (zh) * 2013-03-05 2015-08-26 复旦大学 一种合成(3r,5r)-3,5-二羟基-6-氰基己酸酯的方法
CN106397241A (zh) * 2016-08-23 2017-02-15 杨锋 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

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Also Published As

Publication number Publication date
FI941632A0 (fi) 1994-04-08
NO941280L (no) 1994-04-08
AU2764192A (en) 1993-05-03
NO300208B1 (no) 1997-04-28
FI941632A (fi) 1994-04-08
JPH07500105A (ja) 1995-01-05
CA2116973A1 (en) 1993-04-15
ZA927793B (en) 1994-04-11
DE69228073T2 (de) 1999-06-10
NO941280D0 (no) 1994-04-08
ATE175190T1 (de) 1999-01-15
AU667320B2 (en) 1996-03-21
CA2116973C (en) 2004-09-21
JP2002030060A (ja) 2002-01-29
SG46599A1 (en) 1998-02-20
JP3429500B2 (ja) 2003-07-22
PT100943B (pt) 1999-07-30
DE69228073D1 (de) 1999-02-11
PT100943A (pt) 1993-10-29
JP3241723B2 (ja) 2001-12-25
US5155251A (en) 1992-10-13
ES2129457T3 (es) 1999-06-16
EP0643689B1 (en) 1998-12-30
MX9205824A (es) 1993-04-01
EP0643689A1 (en) 1995-03-22
WO1993007115A1 (en) 1993-04-15

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