BRPI0513396A - produtos de degradação oxidativa de atorvastatina de cálcio - Google Patents

produtos de degradação oxidativa de atorvastatina de cálcio

Info

Publication number
BRPI0513396A
BRPI0513396A BRPI0513396-3A BRPI0513396A BRPI0513396A BR PI0513396 A BRPI0513396 A BR PI0513396A BR PI0513396 A BRPI0513396 A BR PI0513396A BR PI0513396 A BRPI0513396 A BR PI0513396A
Authority
BR
Brazil
Prior art keywords
degradation products
oxidative degradation
atorvastatin calcium
atorvastatin
calcium
Prior art date
Application number
BRPI0513396-3A
Other languages
English (en)
Inventor
Rok Grahek
Darko Kocjan
Andrej Bastarda
Andrej Kocijan
Matjaz Kracun
Original Assignee
Lek Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35457712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0513396(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals
Publication of BRPI0513396A publication Critical patent/BRPI0513396A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

PRODUTOS DE DEGRADAçãO OXIDATIVA DE ATORVASTATINA DE CáLCIO. A presente invenção refere-se aos produtos de degradação oxidativa de atorvastatina de cálcio e o processo da preparação. A presente invenção da mesma forma refere-se a atorvastatina de cálcio substancialmente livre de produtos de degradação oxidativos e as composições farmacêuticas contendo tal atorvastatina de cálcio.
BRPI0513396-3A 2004-07-16 2005-07-15 produtos de degradação oxidativa de atorvastatina de cálcio BRPI0513396A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SI200400209 2004-07-16
SI200400348 2004-12-24
PCT/EP2005/007739 WO2006008091A2 (en) 2004-07-16 2005-07-15 Oxidative degradation products of atorvastatin calcium

Publications (1)

Publication Number Publication Date
BRPI0513396A true BRPI0513396A (pt) 2008-05-06

Family

ID=35457712

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0513396-3A BRPI0513396A (pt) 2004-07-16 2005-07-15 produtos de degradação oxidativa de atorvastatina de cálcio

Country Status (14)

Country Link
US (4) US8044086B2 (pt)
EP (1) EP1771455B1 (pt)
JP (1) JP5000502B2 (pt)
CN (1) CN1997651B (pt)
AU (1) AU2005263550C1 (pt)
BR (1) BRPI0513396A (pt)
CA (2) CA2833770A1 (pt)
ES (1) ES2586561T3 (pt)
HU (1) HUE029911T2 (pt)
MX (1) MX2007000582A (pt)
PL (1) PL1771455T3 (pt)
RU (1) RU2412191C2 (pt)
SI (1) SI1771455T1 (pt)
WO (1) WO2006008091A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI321132B (en) 2004-09-28 2010-03-01 Teva Pharma Process for preparing forms of atorvastatin calcium substantially free of impurities
ES2304335T3 (es) 2005-11-21 2010-05-19 Warner-Lambert Company Llc Formas nuevas del acido (r-(r*,r*))-2-(4-fluorofenil)-b,b-dihidroxi-5-(1-metiletil)-3-fenil-4-((fenilamino)carbonil)1h-pirrol-1-heptanoico, de magnesio.
US20070265456A1 (en) * 2006-05-09 2007-11-15 Judith Aronhime Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
IS8607A (is) * 2007-02-09 2008-08-10 Actavis Group Hf. Stöðugar atorvastatin samsetningar
WO2011077843A1 (ja) 2009-12-25 2011-06-30 沢井製薬株式会社 アトルバスタチン含有被覆製剤
CN110646550B (zh) * 2018-06-26 2022-12-02 北京伟林恒昌医药科技有限公司 一种阿托伐他汀钙中有关物质的检测方法
CN115754025A (zh) * 2021-09-02 2023-03-07 上虞京新药业有限公司 一种匹伐他汀钙中基因毒性杂质gt1的检测方法

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KR100668575B1 (ko) * 1997-12-19 2007-01-17 워너-램버트 익스포트 리미티드 1,3-디올의 합성방법
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Also Published As

Publication number Publication date
CA2573969C (en) 2014-02-04
US8044086B2 (en) 2011-10-25
US20070208071A1 (en) 2007-09-06
RU2412191C2 (ru) 2011-02-20
RU2007105689A (ru) 2008-08-27
US20100219063A1 (en) 2010-09-02
JP2008506655A (ja) 2008-03-06
CA2573969A1 (en) 2006-01-26
PL1771455T3 (pl) 2016-11-30
CA2833770A1 (en) 2006-01-26
ES2586561T3 (es) 2016-10-17
AU2005263550B2 (en) 2011-11-03
JP5000502B2 (ja) 2012-08-15
EP1771455B1 (en) 2016-05-11
US9453030B2 (en) 2016-09-27
MX2007000582A (es) 2007-03-30
CN1997651A (zh) 2007-07-11
CN1997651B (zh) 2012-06-06
HUE029911T2 (en) 2017-04-28
AU2005263550C1 (en) 2013-01-17
WO2006008091A2 (en) 2006-01-26
WO2006008091A3 (en) 2006-09-08
US20100056605A1 (en) 2010-03-04
EP1771455A2 (en) 2007-04-11
AU2005263550A1 (en) 2006-01-26
US20150105551A1 (en) 2015-04-16
SI1771455T1 (sl) 2016-09-30

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