ES2129457T3 - Proceso mejorado de sintesis de (5r)-1,1-dimetiletil 6-ciano-5-oxo-hexanoato. - Google Patents

Proceso mejorado de sintesis de (5r)-1,1-dimetiletil 6-ciano-5-oxo-hexanoato.

Info

Publication number
ES2129457T3
ES2129457T3 ES92921435T ES92921435T ES2129457T3 ES 2129457 T3 ES2129457 T3 ES 2129457T3 ES 92921435 T ES92921435 T ES 92921435T ES 92921435 T ES92921435 T ES 92921435T ES 2129457 T3 ES2129457 T3 ES 2129457T3
Authority
ES
Spain
Prior art keywords
ciano
oxo
dimetiletil
hexanoato
synthesis process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921435T
Other languages
English (en)
Inventor
Donald Eugene Butler
Tung Van Le
Alan Millar
Thomas Norman Nanninga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2129457T3 publication Critical patent/ES2129457T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/21Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton the carbon skeleton being further substituted by doubly-bound oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

SE DESCRIBE UN PROCESO MEJORADO PARA LA PREPARACION DE (5R) -1,1-6DIMELETILO-CIANO-5-HIDROXI-3-OXO EN DONDE UN HIDROXIESTER ASES EN EL PRODUCTO DESEADO
ES92921435T 1991-10-11 1992-10-05 Proceso mejorado de sintesis de (5r)-1,1-dimetiletil 6-ciano-5-oxo-hexanoato. Expired - Lifetime ES2129457T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/775,162 US5155251A (en) 1991-10-11 1991-10-11 Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate

Publications (1)

Publication Number Publication Date
ES2129457T3 true ES2129457T3 (es) 1999-06-16

Family

ID=25103514

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921435T Expired - Lifetime ES2129457T3 (es) 1991-10-11 1992-10-05 Proceso mejorado de sintesis de (5r)-1,1-dimetiletil 6-ciano-5-oxo-hexanoato.

Country Status (16)

Country Link
US (1) US5155251A (es)
EP (1) EP0643689B1 (es)
JP (2) JP3241723B2 (es)
AT (1) ATE175190T1 (es)
AU (1) AU667320B2 (es)
CA (1) CA2116973C (es)
DE (1) DE69228073T2 (es)
DK (1) DK0643689T3 (es)
ES (1) ES2129457T3 (es)
FI (1) FI941632A7 (es)
MX (1) MX9205824A (es)
NO (1) NO300208B1 (es)
PT (1) PT100943B (es)
SG (1) SG46599A1 (es)
WO (1) WO1993007115A1 (es)
ZA (1) ZA927793B (es)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5245047A (en) * 1988-02-22 1993-09-14 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
JP3171931B2 (ja) * 1992-06-02 2001-06-04 高砂香料工業株式会社 (R)−(−)−4−シアノ−3−ヒドロキシ酪酸t−ブチルエステル及びその製造方法
US5298627A (en) * 1993-03-03 1994-03-29 Warner-Lambert Company Process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
HRP960312B1 (en) 1995-07-17 2001-10-31 Warner Lambert Co NOVEL PROCESS FOR THE PRODUCTION OF AMORPHOUS /R-(R*, R*)/-2-(4-FLUOROPHENYL)-"beta", "delta"-DIHYDROXY-5-PHENYL-4-/(PHENYLAMINO)CARBONYL/-1H-PYRROLE -1-HEPTANOIC ACID CALCIUM SALT (2 : 1)
US6087511A (en) * 1996-07-16 2000-07-11 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl )-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid) calcium salt (2:1)
US5908953A (en) * 1996-12-18 1999-06-01 Mitsubishi Chemical Corporation Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester
JPH11171850A (ja) * 1997-12-12 1999-06-29 Kanegafuchi Chem Ind Co Ltd 酪酸エステル誘導体の製造方法
IL135562A (en) 1997-12-19 2005-08-31 Warner Lambert Exp Ltd Process for the synthesis of cis-1,3-diols and a synergistic combination of trialkylborane and dialkylalkoxyborane for such synthesis
ES2207202T3 (es) * 1998-04-30 2004-05-16 Kaneka Corporation Procedimiento para producir derivados de acido 6-cianometil-1, 3-dioxano-4-acetico.
CN1162422C (zh) 1998-08-05 2004-08-18 钟渊化学工业株式会社 制备光学活性的2-[6-(羟甲基)-1,3-二噁烷-4-基]乙酸衍生物的方法
KR100313668B1 (ko) * 1999-02-03 2001-11-26 박영구 (r)-4-시아노-3-히드록시부티르산 에스테르의 제조방법
HU227840B1 (en) * 1999-05-06 2012-05-02 Egis Gyogyszergyar Nyilvanosan M Kod Ruszvunytarsasag Intermediates of atorvastatin synthesis and process for producing them
JP4659309B2 (ja) * 1999-06-04 2011-03-30 株式会社カネカ 5−ヒドロキシ−3−オキソペンタン酸誘導体の製造法
US20040063969A1 (en) * 1999-10-18 2004-04-01 Egis Gyogyszergyar Rt. Process for the preparation of amorphous atorvastatin calcium
ES2252088T3 (es) 1999-12-17 2006-05-16 Pfizer Science And Technology Ireland Limited Procedimiento de produccion a escala industrial de la hemisal de calcio de la atorvastatina trihidrato cristalina.
CA2391357C (en) 1999-12-17 2009-01-06 Warner Lambert Research And Development Ireland Limited A process for producing crystalline atorvastatin calcium
CN100368386C (zh) * 2000-05-31 2008-02-13 中国医学科学院药物研究所 (±)对氟-2-(2-甲基-丙酰基)-4-氧-n,3-二苯基-苯丁酰胺的合成方法以及其中的中间体
CN101250133B (zh) * 2000-05-31 2010-06-09 中国医学科学院药物研究所 (±)对氟-2-(2-甲基-丙酰基)-4-氧-n,3-二苯基-苯丁酰胺的合成方法以及其中的中间体
US6476235B2 (en) 2001-01-09 2002-11-05 Warner-Lambert Company Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
EP1734034A3 (en) 2001-01-09 2007-01-03 Warner-Lambert Company LLC Carboxylic acid salts of beta-alanine esters or -amides
WO2002057229A1 (en) * 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
SI20814A (sl) * 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
HUP0400381A2 (hu) * 2001-06-29 2004-09-28 Warner-Lambert Company Llc [R-(R*,R*)]-2-(4fluorfenil)-béta, delta-dihidroxi-5-(1-metiletil)-3-fenil-4-[(fenilamino)karbonil]-1H-pirrol-1-heptánsav 2:1 arányú kalciumsójának (atorvasztatin) kristályos formái
US7420078B2 (en) 2001-07-06 2008-09-02 Ciba Specialty Chemicals Corp. Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof
US7317123B2 (en) 2001-07-06 2008-01-08 Teva Pharmaceutical Industries, Ltd Process for preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation
CA2451159A1 (en) * 2001-07-06 2003-01-16 Teva Pharmaceutical Industries Ltd. Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives
JP4765217B2 (ja) * 2001-07-30 2011-09-07 住友化学株式会社 (r)−4−シアノ−3−ヒドロキシブタン酸エステルの製造法
EE200400048A (et) 2001-07-30 2004-04-15 Dr. Reddy's Laboratories Ltd. Atorvastatiinkaltsiumi kristalsed vormid VI ja VII
PE20030324A1 (es) * 2001-07-31 2003-04-03 Warner Lambert Co Composiciones farmaceuticas de amlodipina y atorvastatina
AU2001284385A1 (en) * 2001-08-31 2003-03-10 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
UA77990C2 (en) * 2001-12-12 2007-02-15 Crystalline calcium salt of (2:1) [r-(r*,r*)]-2-(4-fluorophenyl)-?,?-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrroleheptanic acid
KR100849880B1 (ko) * 2001-12-20 2008-08-01 주식회사 중외제약 광학활성 2-[6-(치환된 알킬)-1,3-디옥산-4-일]아세트산유도체의 신규 제조 방법
CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
DE10212492B4 (de) * 2002-03-21 2012-02-02 Daimler Ag Kolbenpumpe
CN100357289C (zh) * 2002-08-06 2007-12-26 沃尼尔·朗伯有限责任公司 制备5-(4-氟苯基)-1-[2-((2r,4r)-4-羟基-6-氧代-四氢-吡喃-2-基)乙基]-2-异丙基-4-苯基-1h-吡咯-3-羧酸苯基酰胺的方法
DE60336324D1 (de) * 2002-08-09 2011-04-21 Codexis Inc Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate
AU2002330735A1 (en) * 2002-09-03 2004-03-29 Morepen Laboratories Limited Atorvastatin calcium form vi or hydrates thereof
HRP20020885B1 (en) * 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
RS20050760A (sr) * 2003-04-14 2008-04-04 Warner-Lambert Company Llc., Postupak za izradu fenilamida 5-(4- fluorofenil)-1-(2-((2r, 4r)-4-hidroksi- 6-okso-tetrahidro-piran-2-il)etil)-2- izopropil-4-fenil-1h-pirol-3- karboksilne kiseline
US20050182125A1 (en) * 2003-05-16 2005-08-18 Ambit Biosciences Corporation Pyrrole compounds and uses thereof
US20040248972A1 (en) * 2003-05-16 2004-12-09 Ambit Biosciences Corporation Compounds and uses thereof
EP1626713A2 (en) * 2003-05-16 2006-02-22 Ambit Biosciences Corporation Heterocyclic compounds and uses thereof
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
US7655692B2 (en) * 2003-06-12 2010-02-02 Pfizer Inc. Process for forming amorphous atorvastatin
US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
US20070276027A1 (en) * 2003-09-17 2007-11-29 Warner-Lambert Company Llc Crystalline Forms of [R-(R* ,R*)]-2-(4-Fluorophenyl)-Beta, -Dihydroxy-5-(1-Methylethyl)-3-Phenyl-4-[(Phenylamino)Carbonyl]-1H-Pyrrole-1-Heptanoic Acid
AU2003272080A1 (en) * 2003-09-18 2005-04-06 Biocon Limited Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
US7943786B2 (en) * 2003-12-29 2011-05-17 Ljubomir Antoncic Process for preparing amorphous (4R-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid
CA2456430A1 (en) * 2004-01-28 2005-07-28 Brantford Chemicals Inc. Improved process for the preparation of amorphous atorvastatin calcium
CA2666359A1 (en) 2004-03-17 2005-10-06 Yatendra Kumar Process for the production of atorvastatin calcium in amorphous form
AU2005232959A1 (en) * 2004-04-16 2005-10-27 Pfizer Products Inc. Process for forming amorphous atorvastatin calcium
US7875731B2 (en) 2004-05-05 2011-01-25 Pfizer Inc. Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)Carbonyl]-1H-pyrrole-1-heptanoic acid
AU2005263550C1 (en) * 2004-07-16 2013-01-17 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
CA2672554C (en) 2004-07-20 2012-01-03 Warner-Lambert Company Llc Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl).beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1)
WO2006021969A1 (en) * 2004-08-27 2006-03-02 Biocon Limited Process for atorvastatin calcium amorphous
EP1807055A1 (en) * 2004-10-28 2007-07-18 Warner-Lambert Company LLC Process for forming amorphous atorvastatin
AU2005305460B2 (en) 2004-11-22 2011-04-21 Dexcel Pharma Technologies Ltd. Stable atorvastatin formulations
JP2008521878A (ja) * 2004-12-02 2008-06-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 非晶質アトルバスタチンの医薬組成物及びその製造のための方法
WO2007029217A1 (en) * 2005-09-09 2007-03-15 Pfizer Science And Technology Ireland Limited Preparation of an atorvastatin intermediate
EP1922315B1 (en) * 2005-09-09 2009-05-27 Pfizer Science and Technology Ireland Limited Preparation of an atorvastatin intermediate
US20090216029A1 (en) * 2005-09-16 2009-08-27 Yatendra Kumar Process for the production of atorvastatin calcium in amorphous form
CA2547216A1 (en) 2005-09-21 2007-03-21 Renuka D. Reddy Process for annealing amorphous atorvastatin
DK1957452T3 (da) 2005-11-21 2010-07-26 Warner Lambert Co Nye former af [R-(R*,R*)]-2-(4-fluorphenyl)-B,B-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-heptansyre- magnesium
EP1810667A1 (en) 2006-01-20 2007-07-25 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising amorphous atorvastatin
US7879585B2 (en) 2006-10-02 2011-02-01 Codexis, Inc. Ketoreductase enzymes and uses thereof
US20100113802A1 (en) * 2006-11-02 2010-05-06 Cadila Pharmaceuticals Limited Process for preparing amorphous atorvastatin hemi calcium salt and its itermediate
WO2008059366A2 (en) * 2006-11-17 2008-05-22 Pfizer Products Inc. Process for the preparation of cis-1, 3-diols from the corresponding beta-hydroxy ketones employing microbial ketone reductases
US7834195B2 (en) * 2007-01-24 2010-11-16 Apotex Pharmachem Inc. Atorvastatin calcium propylene glycol solvates
WO2009013633A2 (en) * 2007-07-20 2009-01-29 Actavis Group Ptc Ehf Amorphous coprecipitates of atorvastatin pharmaceutically acceptable salts
CA2918498A1 (en) 2007-08-03 2009-02-12 Pfizer Products Inc. 2-[2-(4,6-dihydroxy-tetrahydro-pyran-2-yl)ethyl]-isoindole-1,3-dione and related compounds
EP2075246A1 (en) 2007-12-27 2009-07-01 M. J. Institute of Research A process for preparation of amorphous form of atorvastatin hemi-calcium salt
US8115015B2 (en) * 2009-01-26 2012-02-14 Cadila Healthcare Limited Process for the preparation of amorphous atorvastatin calcium
GB2474687A (en) * 2009-10-23 2011-04-27 Phoenix Chemicals Ltd A continuous process for the production of (R)-6-cyano-5-hydroxy-3-oxo-hexanoic acid tert-butyl ester (and derivatives)
KR20120011249A (ko) 2010-07-28 2012-02-07 주식회사 경보제약 아토바스타틴 헤미칼슘염의 신규한 결정형, 이의 수화물, 및 그의 제조방법
SI2614057T1 (sl) 2010-09-09 2016-03-31 Dsm Sinochem Pharmaceuticals Netherlands B.V. Soli estrov 7-amino-3,5-dihidroksi heptanojske kisline
WO2013004591A1 (en) 2011-07-01 2013-01-10 Dsm Sinochem Pharmaceuticals Netherlands B.V. Micronized crystals of atorvastatin hemicalcium
CN102766072B (zh) * 2012-08-07 2013-12-25 浙江宏元药业有限公司 一种制备阿托伐他汀钙手性侧链的方法
CN103145584B (zh) * 2013-03-05 2015-08-26 复旦大学 一种合成(3r,5r)-3,5-二羟基-6-氰基己酸酯的方法
CN106397241A (zh) * 2016-08-23 2017-02-15 杨锋 一种4‑甲基‑3‑氧代‑n‑苯基戊酰胺的绿色环保后处理方法
CN108033899B (zh) * 2017-12-06 2020-04-10 浙江科技学院 一种(r)-6-氰基-5-羟基-3-羰基己酸叔丁酯的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647576A (en) * 1984-09-24 1987-03-03 Warner-Lambert Company Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis
US4611067A (en) * 1985-01-31 1986-09-09 Merck & Co., Inc. Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein
US4681893A (en) * 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
DE3741509A1 (de) * 1987-12-08 1989-06-22 Hoechst Ag Verfahren zur herstellung optisch aktiver 3-desmethylmevalonsaeurederivate sowie zwischenprodukte
US5003080A (en) * 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis

Also Published As

Publication number Publication date
FI941632L (fi) 1994-04-08
JPH07500105A (ja) 1995-01-05
DE69228073T2 (de) 1999-06-10
NO941280L (no) 1994-04-08
WO1993007115A1 (en) 1993-04-15
EP0643689B1 (en) 1998-12-30
AU667320B2 (en) 1996-03-21
FI941632A0 (fi) 1994-04-08
DE69228073D1 (de) 1999-02-11
PT100943A (pt) 1993-10-29
MX9205824A (es) 1993-04-01
US5155251A (en) 1992-10-13
ATE175190T1 (de) 1999-01-15
JP3429500B2 (ja) 2003-07-22
CA2116973C (en) 2004-09-21
DK0643689T3 (da) 1999-08-30
JP3241723B2 (ja) 2001-12-25
NO941280D0 (no) 1994-04-08
ZA927793B (en) 1994-04-11
CA2116973A1 (en) 1993-04-15
EP0643689A1 (en) 1995-03-22
JP2002030060A (ja) 2002-01-29
PT100943B (pt) 1999-07-30
FI941632A7 (fi) 1994-04-08
NO300208B1 (no) 1997-04-28
AU2764192A (en) 1993-05-03
SG46599A1 (en) 1998-02-20

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