DE60336324D1 - Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate - Google Patents

Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate

Info

Publication number
DE60336324D1
DE60336324D1 DE60336324T DE60336324T DE60336324D1 DE 60336324 D1 DE60336324 D1 DE 60336324D1 DE 60336324 T DE60336324 T DE 60336324T DE 60336324 T DE60336324 T DE 60336324T DE 60336324 D1 DE60336324 D1 DE 60336324D1
Authority
DE
Germany
Prior art keywords
acid derivatives
substituted
preparation
enzymatic procedures
hydroxybutylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60336324T
Other languages
English (en)
Inventor
Christopher S Davis
John H Grate
David R Gray
John M Gruber
Gjalt W Huisman
Steven K Ma
Lisa M Newman
Roger Sheldon
Li A Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Codexis Inc
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Application granted granted Critical
Publication of DE60336324D1 publication Critical patent/DE60336324D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
DE60336324T 2002-08-09 2003-08-11 Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate Expired - Lifetime DE60336324D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40243602P 2002-08-09 2002-08-09
PCT/US2003/025263 WO2004015132A2 (en) 2002-08-09 2003-08-11 Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives

Publications (1)

Publication Number Publication Date
DE60336324D1 true DE60336324D1 (de) 2011-04-21

Family

ID=31715856

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60336324T Expired - Lifetime DE60336324D1 (de) 2002-08-09 2003-08-11 Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate

Country Status (12)

Country Link
US (1) US7125693B2 (de)
EP (1) EP1537222B1 (de)
JP (2) JP4578240B2 (de)
AT (1) ATE501264T1 (de)
AU (1) AU2003258187A1 (de)
BR (1) BR0305767A (de)
CA (1) CA2493941A1 (de)
DE (1) DE60336324D1 (de)
HK (1) HK1074059A1 (de)
MX (1) MXPA05001537A (de)
NO (1) NO20041379L (de)
WO (1) WO2004015132A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05001537A (es) 2002-08-09 2005-11-17 Codexis Inc Procesos enzimaticos para la produccion de derivados de acido 4-sustituido 3-hidroxibutirico.
EP1654354A1 (de) 2003-08-11 2006-05-10 Codexis, Inc. Verbesserte ketoreduktase polypeptide und entsprechende polynukleotide
CA2535147A1 (en) 2003-08-11 2005-05-19 Codexis, Inc. Improved glucose dehydrogenase polypeptides and related polynucleotides
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
JP2007502123A (ja) 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改善されたハロヒドリンデハロゲナーゼおよび関連するポリヌクレオチド
US7588928B2 (en) 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
EP1660669A4 (de) * 2003-08-11 2008-10-01 Codexis Inc Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate und von mit vicinalem cyano, hydroxy substituierten carbonsäureestern
JP2008537477A (ja) * 2005-02-23 2008-09-18 コデクシス， インコーポレイテッド 改良されたハロヒドリンデハロゲナーゼおよび関連のポリヌクレオチド
ITMI20051971A1 (it) * 2005-10-18 2007-04-19 Dipharma Spa Procedimento per la preparazione di - modafinil
EP2137315B1 (de) 2007-03-16 2014-09-03 Genomatica, Inc. Zusammensetzungen und verfahren zur biosynthese von 1,4-butandiol und seinen vorstufen
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
EP3514242A3 (de) 2008-09-10 2019-08-28 Genomatica, Inc. Mikroorganismen zur herstellung von 1,4-butandiol
EP2379713A4 (de) 2008-12-18 2013-07-10 Codexis Inc Rekombinante halohydrin-dehalogenase-polypeptide
SI3199511T1 (sl) 2009-06-04 2020-07-31 Genomatica, Inc. Proces separacije komponent fermentacijske brozge
VN29801A1 (de) 2009-06-04 2012-05-25
WO2011005527A2 (en) 2009-06-22 2011-01-13 Codexis, Inc. Ketoreductase-mediated stereoselective route to alpha chloroalcohols
KR20120083908A (ko) * 2009-10-13 2012-07-26 게노마티카 인코포레이티드 1,4-부탄다이올, 4-하이드록시부탄알, 4-하이드록시부티릴-ｃｏａ, 푸트레신 및 관련 화합물의 제조를 위한 미생물 및 관련 방법
WO2011066076A1 (en) 2009-11-25 2011-06-03 Genomatica, Inc. Microorganisms and methods for the coproduction of 1,4-butanediol and gamma-butyrolactone
WO2011100265A2 (en) 2010-02-10 2011-08-18 Codexis, Inc. Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
WO2012003299A2 (en) 2010-06-30 2012-01-05 Codexis, Inc. Highly stable beta-class carbonic anhydrases useful in carbon capture systems
CN102168117B (zh) * 2011-01-12 2014-05-07 江苏阿尔法药业有限公司 一种制备(r)-4-氰基-3-羟基丁酸乙酯的方法
JP5705580B2 (ja) 2011-02-21 2015-04-22 公益財団法人微生物化学研究会 チオアミド化合物、チオアミド化合物の製造方法、［（４ｒ，６ｒ）−６−アミノエチル−１，３−ジオキサン−４−イル］アセテート誘導体の製造方法、及びアトルバスタチンの製造方法
CN102676597A (zh) * 2011-03-16 2012-09-19 苏州国镝医药科技有限公司 生物酶手性合成立普妥中间体ats-5
WO2013184602A2 (en) 2012-06-04 2013-12-12 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
CN103695486A (zh) * 2014-01-03 2014-04-02 黄冈华阳药业有限公司 一种(3r,5r)-6-氰基-3,5-二羟基己酸叔丁酯的生物制备方法
CN105368886A (zh) * 2015-12-11 2016-03-02 江苏万年长药业有限公司 一种树脂固定卤醇脱卤酶催化合成(r)-4-氰基-3-羟基丁酸乙酯的工艺
CN109439700A (zh) * 2018-11-09 2019-03-08 浙江宏元药业股份有限公司 一种脱卤酶高效催化合成他汀类药物中间体的方法
CN111876448A (zh) * 2020-08-03 2020-11-03 连云港宏业化工有限公司 4-氰基-3-羟基丁酸乙酯合成方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3019450A1 (de) * 1980-05-21 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gewinnung von glucosedehydrogenase und hierfuer geeigneter mikroorganismus
IE56322B1 (en) * 1982-12-06 1991-06-19 Sigma Tau Ind Farmaceuti Process for preparing l-carnitine and chemical intermediates employed therein
US4542098A (en) * 1983-05-06 1985-09-17 Institut Francais Du Petrole Production of glucose dehydrogenase and use of the resultant enzyme in the enzymatic synthesis of L-carnitine
US4710468A (en) * 1983-10-24 1987-12-01 Sigma-Tau Industrie Pharmaceutiche Riunite S.P.A. Process for preparing L-carnitine and chemical intermediates employed therein
US4877733A (en) * 1986-05-02 1989-10-31 Toyo Jozo Kabushiki Kaisha Glucose dehydrogenase and its production
US5250415A (en) * 1987-04-08 1993-10-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Process for the preparation of glucose dehydrogenase from Bacillus megaterium
DE3711881A1 (de) * 1987-04-08 1988-10-27 Merck Patent Gmbh Verfahren zur herstellung von glucosedehydrogenase aus bacillus megaterium
JPH0286779A (ja) * 1988-09-22 1990-03-27 Amano Pharmaceut Co Ltd 改良型組換えｄｎａ、それを含む形質転換体及びそれを用いた耐熱性グルコースデヒドロゲナーゼの製造法
JP2742281B2 (ja) * 1988-12-29 1998-04-22 旭化成工業株式会社 グルコース―６―リン酸デヒドロゲナーゼ遺伝子
US5210031A (en) * 1989-07-20 1993-05-11 Nitto Chemical Industry Co., Ltd. Process for the production of R(-)-4-halo-3-hydroxybutyronitrile
JP2840722B2 (ja) * 1989-07-20 1998-12-24 日東化学工業株式会社 ４‐ハロ‐３‐ヒドロキシブチロニトリルの製造法
JP2850515B2 (ja) * 1990-09-25 1999-01-27 東洋紡績株式会社 グルコースデヒドロゲナーゼおよびその製造法
US5244796A (en) * 1990-10-12 1993-09-14 Syracuse University Cloned leuconostoc mesenteroides glucose-6-phosphate dehydrogenase genes and method of making glucose-6-phospate dehydrogenase
US5155251A (en) * 1991-10-11 1992-10-13 Warner-Lambert Company Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
US5385833A (en) * 1992-02-26 1995-01-31 The Scripps Research Institute Pseudomonas sp. ATCC No. 49794 alcohol dehydrogenase
DK0630402T3 (da) * 1992-03-13 1997-12-22 Forschungszentrum Juelich Gmbh Ny ketoesterreduktase, fremstilling deraf og anvendelse deraf til enzymatiske redoxreaktioner
US5413921A (en) * 1992-05-28 1995-05-09 Ajinomoto Co., Ltd. Method of the production of (s)-gamma-halogenated-γ-hydroxybutyric acid esters
JP3171931B2 (ja) * 1992-06-02 2001-06-04 高砂香料工業株式会社 （Ｒ）−（−）−４−シアノ−３−ヒドロキシ酪酸ｔ−ブチルエステル及びその製造方法
JP3155107B2 (ja) * 1993-01-12 2001-04-09 ダイセル化学工業株式会社 光学活性４−ハロ−３−ヒドロキシ酪酸エステルの製造方法
JPH08336393A (ja) * 1995-04-13 1996-12-24 Mitsubishi Chem Corp 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法
GB9512837D0 (en) * 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
US5891685A (en) * 1996-06-03 1999-04-06 Mitsubishi Chemical Corporation Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid
US5908953A (en) * 1996-12-18 1999-06-01 Mitsubishi Chemical Corporation Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester
IL131241A0 (en) 1997-02-07 2001-01-28 Kaneka Corp Novel carbonyl reductase gene coding same and method for using such reductase and gene
US6531308B2 (en) * 1997-11-04 2003-03-11 Eli Lilly And Company Ketoreductase gene and protein from yeast
JPH11171850A (ja) 1997-12-12 1999-06-29 Kanegafuchi Chem Ind Co Ltd 酪酸エステル誘導体の製造方法
KR100668575B1 (ko) * 1997-12-19 2007-01-17 워너-램버트 익스포트 리미티드 1,3-디올의 합성방법
JPH11187869A (ja) * 1997-12-25 1999-07-13 Daicel Chem Ind Ltd 新規な４−ハロアセト酢酸エステル還元酵素、該酵素の製造方法、及び該酵素を利用したアルコールの製造方法
JP4012299B2 (ja) * 1998-02-25 2007-11-21 ダイセル化学工業株式会社 ハロゲン置換を含む光学活性アルコールの製造方法
EP1077212B1 (de) * 1998-04-30 2003-08-20 Kaneka Corporation Verfahren zur herstellung von derivaten der 6-cyanomethyl-1,3-dioxan-4-essigsäure
CA2305564C (en) * 1998-08-05 2008-06-17 Kaneka Corporation Process for the preparation of optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives
JP2000236883A (ja) * 1998-12-21 2000-09-05 Daicel Chem Ind Ltd 新規なカルボニル還元酵素、該酵素の製造方法、該酵素をコードするｄｎａおよびこれを利用したアルコールの製造方法
KR100313668B1 (ko) * 1999-02-03 2001-11-26 박영구 (ｒ)-4-시아노-3-히드록시부티르산 에스테르의 제조방법
WO2001004336A1 (de) * 1999-07-09 2001-01-18 Forschungszentrum Jülich GmbH Verfahren zur reduktion von keto-carbonsäuren und deren estern
HUP0105331A3 (en) * 1999-12-03 2005-10-28 Kaneka Corp Novel carbonyl reductase, gene thereof and method of using the same
EP1158054A1 (de) * 2000-05-25 2001-11-28 Rijksuniversiteit te Groningen Enzymatische Umwandlung von Epoxiden
JP2001335554A (ja) * 2000-05-30 2001-12-04 Mitsubishi Chemicals Corp （ｒ）−４−シアノ−３−ヒドロキシ酪酸低級アルキルエステルの製造方法
US6781009B2 (en) * 2000-10-31 2004-08-24 Sumitomo Chemical Company, Limited Method for producing 4-cyano-3-oxobutanoate and 4-ctano-3-hydroxybutanoate
JP2002201169A (ja) * 2000-10-31 2002-07-16 Sumitomo Chem Co Ltd ４−シアノ−３−オキソブタン酸エステルの製造法
JP4603171B2 (ja) * 2001-01-22 2010-12-22 ダイセル化学工業株式会社 （ｓ）−４−ハロ−３−ヒドロキシ酪酸エステルの製造に有用な酵素をコードする遺伝子、その取得方法、およびこれを利用した光学活性アルコールの製造方法
EP1416050A4 (de) 2001-07-02 2004-12-22 Kaneka Corp Verfahren zur enzymmodifikation und oxidoreduktase-variante
MXPA05001537A (es) 2002-08-09 2005-11-17 Codexis Inc Procesos enzimaticos para la produccion de derivados de acido 4-sustituido 3-hidroxibutirico.
JP2007502123A (ja) 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド 改善されたハロヒドリンデハロゲナーゼおよび関連するポリヌクレオチド
CA2535147A1 (en) * 2003-08-11 2005-05-19 Codexis, Inc. Improved glucose dehydrogenase polypeptides and related polynucleotides
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
EP1660669A4 (de) 2003-08-11 2008-10-01 Codexis Inc Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate und von mit vicinalem cyano, hydroxy substituierten carbonsäureestern
EP1654354A1 (de) 2003-08-11 2006-05-10 Codexis, Inc. Verbesserte ketoreduktase polypeptide und entsprechende polynukleotide

Also Published As

Publication number Publication date
JP2005535330A (ja) 2005-11-24
AU2003258187A8 (en) 2004-02-25
JP2010172348A (ja) 2010-08-12
WO2004015132A3 (en) 2005-04-14
US7125693B2 (en) 2006-10-24
WO2004015132A2 (en) 2004-02-19
NO20041379L (no) 2004-06-01
EP1537222A4 (de) 2008-10-01
HK1074059A1 (en) 2005-10-28
BR0305767A (pt) 2005-05-24
CA2493941A1 (en) 2004-02-19
ATE501264T1 (de) 2011-03-15
EP1537222B1 (de) 2011-03-09
US20040137585A1 (en) 2004-07-15
AU2003258187A1 (en) 2004-02-25
EP1537222A2 (de) 2005-06-08
JP4578240B2 (ja) 2010-11-10
MXPA05001537A (es) 2005-11-17

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