NO2017010I2 - Dolutegravir eller et farmasøytisk akseptabelt salt eller solvat derav - Google Patents

Dolutegravir eller et farmasøytisk akseptabelt salt eller solvat derav

Info

Publication number
NO2017010I2
NO2017010I2 NO2017010C NO2017010C NO2017010I2 NO 2017010 I2 NO2017010 I2 NO 2017010I2 NO 2017010 C NO2017010 C NO 2017010C NO 2017010 C NO2017010 C NO 2017010C NO 2017010 I2 NO2017010 I2 NO 2017010I2
Authority
NO
Norway
Prior art keywords
dolutegravir
solvate
pharmaceutically acceptable
acceptable salt
salt
Prior art date
Application number
NO2017010C
Other languages
English (en)
Other versions
NO2017010I1 (no
Original Assignee
Shionogi & Co
Viiv Healthcare Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37215098&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2017010(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shionogi & Co, Viiv Healthcare Co filed Critical Shionogi & Co
Publication of NO2017010I2 publication Critical patent/NO2017010I2/no
Publication of NO2017010I1 publication Critical patent/NO2017010I1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO2017010C 2005-04-28 2017-03-27 (4R,9aS)-5-hydroksy-4-metyl-6,10-diokso-3,4,6,9,9a,10-heksahydro-2H-1-oksa-4a, 8a-diazaantracen-7-karboksylsyre 2,4,-difluor-benzylamid eller et farmaceutisk akseptabelt salt eller solvat derav NO2017010I1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2005131161 2005-04-28
JP2005312076 2005-10-27
PCT/US2006/016604 WO2006116764A1 (en) 2005-04-28 2006-04-28 Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity

Publications (2)

Publication Number Publication Date
NO2017010I2 true NO2017010I2 (no) 2017-03-27
NO2017010I1 NO2017010I1 (no) 2017-03-27

Family

ID=37215098

Family Applications (5)

Application Number Title Priority Date Filing Date
NO20075165A NO339525B1 (no) 2005-04-28 2007-10-10 Polycyklisk karbamoylderivat, farmasøytisk sammensetning omfattende denne samt denne forbindelsen og sammensetningener omfattende denne for behandling av sykdom.
NO20161315A NO340111B1 (no) 2005-04-28 2016-08-18 Polysyklisk karbamoylderivat, farmasøytisk sammensetning omfattende samme samt slike forbindelser for anvendelse i medisinsk terapi
NO2017010C NO2017010I1 (no) 2005-04-28 2017-03-27 (4R,9aS)-5-hydroksy-4-metyl-6,10-diokso-3,4,6,9,9a,10-heksahydro-2H-1-oksa-4a, 8a-diazaantracen-7-karboksylsyre 2,4,-difluor-benzylamid eller et farmaceutisk akseptabelt salt eller solvat derav
NO2021018C NO2021018I1 (no) 2005-04-28 2021-05-10 kabotegravir eller et farmasøytisk akseptabelt salt eller solvat derav
NO2023042C NO2023042I1 (no) 2005-04-28 2023-11-08 Dolutegravir

Family Applications Before (2)

Application Number Title Priority Date Filing Date
NO20075165A NO339525B1 (no) 2005-04-28 2007-10-10 Polycyklisk karbamoylderivat, farmasøytisk sammensetning omfattende denne samt denne forbindelsen og sammensetningener omfattende denne for behandling av sykdom.
NO20161315A NO340111B1 (no) 2005-04-28 2016-08-18 Polysyklisk karbamoylderivat, farmasøytisk sammensetning omfattende samme samt slike forbindelser for anvendelse i medisinsk terapi

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO2021018C NO2021018I1 (no) 2005-04-28 2021-05-10 kabotegravir eller et farmasøytisk akseptabelt salt eller solvat derav
NO2023042C NO2023042I1 (no) 2005-04-28 2023-11-08 Dolutegravir

Country Status (29)

Country Link
US (21) US8129385B2 (no)
EP (9) EP3187226A1 (no)
JP (2) JP4295353B2 (no)
KR (4) KR101363875B1 (no)
AU (1) AU2006239177B8 (no)
BR (1) BRPI0610030B8 (no)
CA (1) CA2606282C (no)
CY (6) CY1115151T1 (no)
DK (6) DK3284520T3 (no)
EA (1) EA014162B1 (no)
ES (7) ES2667868T5 (no)
FI (1) FIC20210017I1 (no)
FR (1) FR14C0041I2 (no)
HK (4) HK1107227A1 (no)
HU (6) HUE037795T2 (no)
IL (4) IL186555A (no)
LT (4) LT3372281T (no)
LU (2) LU92446I2 (no)
MA (1) MA29460B1 (no)
MX (2) MX302718B (no)
NL (2) NL300676I2 (no)
NO (5) NO339525B1 (no)
NZ (1) NZ562339A (no)
PL (5) PL3372281T3 (no)
PT (5) PT3372281T (no)
SI (6) SI3045206T1 (no)
TW (1) TWI378931B (no)
VN (1) VN34404A1 (no)
WO (1) WO2006116764A1 (no)

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JP2009079058A (ja) 2009-04-16
ES2906792T3 (es) 2022-04-20
ES2892304T3 (es) 2022-02-03
PL1874117T3 (pl) 2014-01-31
KR20140097438A (ko) 2014-08-06
CY1116331T1 (el) 2017-02-08
EP3045206B1 (en) 2018-03-28
KR20130133061A (ko) 2013-12-05
PT2465580E (pt) 2014-02-25
HUS1400039I1 (hu) 2016-08-29
EP2465580A1 (en) 2012-06-20
EP3372281B1 (en) 2021-07-07
PT3372281T (pt) 2021-10-14
EP3187225A1 (en) 2017-07-05
US20220213121A1 (en) 2022-07-07
US20170209454A1 (en) 2017-07-27
HK1172282A1 (en) 2013-04-19
US20170224695A1 (en) 2017-08-10
EP1874117A4 (en) 2009-12-30
BRPI0610030B8 (pt) 2022-01-11
EA014162B1 (ru) 2010-10-29
US20090318421A1 (en) 2009-12-24
ES2743531T3 (es) 2020-02-19
US20200339598A1 (en) 2020-10-29
KR20160003889A (ko) 2016-01-11
HK1251191A1 (zh) 2019-01-25
EP3284520B1 (en) 2019-06-05
US9273065B2 (en) 2016-03-01
NO339525B1 (no) 2016-12-27
US20170029438A1 (en) 2017-02-02
MX2007013351A (es) 2008-01-21
US10927129B2 (en) 2021-02-23
US20170369509A1 (en) 2017-12-28
US20120115875A1 (en) 2012-05-10
FR14C0041I2 (fr) 2015-11-13
NO2017010I1 (no) 2017-03-27
KR101504998B1 (ko) 2015-03-23
CA2606282C (en) 2016-04-26

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