CY1120345T1 - Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης[ενσωματασης] toy hiv - Google Patents

Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης[ενσωματασης] toy hiv

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Publication number
CY1120345T1
CY1120345T1 CY20181100633T CY181100633T CY1120345T1 CY 1120345 T1 CY1120345 T1 CY 1120345T1 CY 20181100633 T CY20181100633 T CY 20181100633T CY 181100633 T CY181100633 T CY 181100633T CY 1120345 T1 CY1120345 T1 CY 1120345T1
Authority
CY
Cyprus
Prior art keywords
activity
rab
hiv
restrictive
polycyclic carbamoylpyridone
Prior art date
Application number
CY20181100633T
Other languages
English (en)
Inventor
Brian Alvin Johns
Takashi Kawasuji
Teruhiko Taishi
Yoshiyuki Taoda
Original Assignee
Viiv Healthcare Company
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37215098&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1120345(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Viiv Healthcare Company filed Critical Viiv Healthcare Company
Publication of CY1120345T1 publication Critical patent/CY1120345T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η παρούσα εφεύρεση πρόκειται να παράσχει καινοφανή ένωση που δείχνεται παρακάτω, που έχει την δραστηριότητα κατά του ιού, ειδικότερα δε την ανασταλτική δραστηριότητα της ιντεγκράσης του HIV, και φάρμακο που περιέχει την ίδια, ειδικότερα φάρμακο κατά του HIV, ως επίσης και διεργασία και ενδιάμεσο προϊόν εξ αυτής.
CY20181100633T 2005-04-28 2018-06-19 Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης[ενσωματασης] toy hiv CY1120345T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2005131161 2005-04-28
JP2005312076 2005-10-27
EP06758843.4A EP1874117B8 (en) 2005-04-28 2006-04-28 Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity
EP12159079.8A EP2527007B1 (en) 2005-04-28 2006-04-28 Polycyclic carbamoylpyridone derivative having HIV integrase inhibitory activity

Publications (1)

Publication Number Publication Date
CY1120345T1 true CY1120345T1 (el) 2019-07-10

Family

ID=37215098

Family Applications (7)

Application Number Title Priority Date Filing Date
CY20131101061T CY1115151T1 (el) 2005-04-28 2013-11-27 Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης [ενσωματασης] του hiv
CY20141100201T CY1116331T1 (el) 2005-04-28 2014-03-13 Παραγωγο πολυκυκλικης καρβαμοϋλοπυριδονης με ανασταλτικη ενεργοτητα της ιντεγκρασης του ηiv
CY2014024C CY2014024I1 (el) 2005-04-28 2014-06-25 Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης [ενσωματασης] του hiv
CY20181100633T CY1120345T1 (el) 2005-04-28 2018-06-19 Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης[ενσωματασης] toy hiv
CY20191100891T CY1122052T1 (el) 2005-04-28 2019-08-20 Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης [ενσωματασης] toy hiv
CY2021016C CY2021016I2 (el) 2005-04-28 2021-05-26 Παραγωγο πολυκυκλικης καρβαμοϋλοπυριδονης με ανασταλτικη ενεργοτητα της ιντεγκρασης του ηiv
CY20211100866T CY1124601T1 (el) 2005-04-28 2021-10-06 Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης [ενσωματασης] toy hiv

Family Applications Before (3)

Application Number Title Priority Date Filing Date
CY20131101061T CY1115151T1 (el) 2005-04-28 2013-11-27 Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης [ενσωματασης] του hiv
CY20141100201T CY1116331T1 (el) 2005-04-28 2014-03-13 Παραγωγο πολυκυκλικης καρβαμοϋλοπυριδονης με ανασταλτικη ενεργοτητα της ιντεγκρασης του ηiv
CY2014024C CY2014024I1 (el) 2005-04-28 2014-06-25 Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης [ενσωματασης] του hiv

Family Applications After (3)

Application Number Title Priority Date Filing Date
CY20191100891T CY1122052T1 (el) 2005-04-28 2019-08-20 Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης [ενσωματασης] toy hiv
CY2021016C CY2021016I2 (el) 2005-04-28 2021-05-26 Παραγωγο πολυκυκλικης καρβαμοϋλοπυριδονης με ανασταλτικη ενεργοτητα της ιντεγκρασης του ηiv
CY20211100866T CY1124601T1 (el) 2005-04-28 2021-10-06 Πολυκυκλικο παραγωγο καρβαμοϋλπυριδονης που εχει ανασταλτικη δραστηριοτητα ιντεγ(κ)ρασης [ενσωματασης] toy hiv

Country Status (29)

Country Link
US (22) US8129385B2 (el)
EP (9) EP1874117B8 (el)
JP (2) JP4295353B2 (el)
KR (4) KR101580310B1 (el)
AU (1) AU2006239177B8 (el)
BR (1) BRPI0610030B8 (el)
CA (1) CA2606282C (el)
CY (7) CY1115151T1 (el)
DK (6) DK3372281T3 (el)
EA (1) EA014162B1 (el)
ES (7) ES2567197T3 (el)
FI (1) FIC20210017I1 (el)
FR (1) FR14C0041I2 (el)
HK (4) HK1107227A1 (el)
HU (6) HUE037795T2 (el)
IL (4) IL186555A (el)
LT (4) LT3045206T (el)
LU (2) LU92446I2 (el)
MA (1) MA29460B1 (el)
MX (2) MX302718B (el)
NL (2) NL300676I2 (el)
NO (5) NO339525B1 (el)
NZ (1) NZ562339A (el)
PL (5) PL2465580T3 (el)
PT (5) PT3372281T (el)
SI (6) SI3045206T1 (el)
TW (1) TWI378931B (el)
VN (1) VN34404A1 (el)
WO (1) WO2006116764A1 (el)

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US11267823B2 (en) 2022-03-08
CY2014024I1 (el) 2015-12-09
NL301109I2 (nl) 2021-09-15
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US20090318421A1 (en) 2009-12-24
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EP3045206B2 (en) 2023-02-15
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DK1874117T3 (da) 2013-09-23
PT3372281T (pt) 2021-10-14
NO340111B1 (no) 2017-03-13
US8778943B2 (en) 2014-07-15
CA2606282A1 (en) 2006-11-02
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PL3284520T3 (pl) 2020-01-31
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US20190284208A1 (en) 2019-09-19
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US9051337B2 (en) 2015-06-09
LU92446I2 (fr) 2015-10-29
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WO2006116764A1 (en) 2006-11-02
EA014162B1 (ru) 2010-10-29
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NO2017010I2 (no) 2017-03-27
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US20120115875A1 (en) 2012-05-10
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US20220213121A1 (en) 2022-07-07
HUE056603T2 (hu) 2022-02-28
PL3045206T3 (pl) 2018-08-31
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AU2006239177B2 (en) 2011-10-20
US20170029438A1 (en) 2017-02-02
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US20170209454A1 (en) 2017-07-27
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US20170260203A1 (en) 2017-09-14
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US8410103B2 (en) 2013-04-02
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US20160304535A1 (en) 2016-10-20
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IL215788A0 (en) 2011-12-29
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PT2465580E (pt) 2014-02-25
HK1251191A1 (zh) 2019-01-25
DK2465580T3 (en) 2014-03-10
US20130172559A1 (en) 2013-07-04
MX302718B (es) 2012-08-27
KR20080009733A (ko) 2008-01-29
LT3372281T (lt) 2021-12-10
MX312216B (en) 2013-08-12
BRPI0610030B8 (pt) 2022-01-11
EP1874117B8 (en) 2014-03-12
JP2009079058A (ja) 2009-04-16
IL186555A (en) 2016-10-31
KR101848819B1 (ko) 2018-04-16
US20160137666A1 (en) 2016-05-19
EP3187226A1 (en) 2017-07-05
JP4295353B2 (ja) 2009-07-15
EP3187225A1 (en) 2017-07-05
LUC00210I2 (el) 2022-10-07
US20170224695A1 (en) 2017-08-10
NO339525B1 (no) 2016-12-27
NO20075165L (no) 2007-11-22
AU2006239177A1 (en) 2006-11-02
EP1874117B1 (en) 2013-08-28
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KR101363875B1 (ko) 2014-02-21
HUS2100023I1 (hu) 2021-07-28

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