NL194272C - Werkwijze voor de kristallisatie van iopamidol. - Google Patents

Werkwijze voor de kristallisatie van iopamidol. Download PDF

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Publication number
NL194272C
NL194272C NL9401229A NL9401229A NL194272C NL 194272 C NL194272 C NL 194272C NL 9401229 A NL9401229 A NL 9401229A NL 9401229 A NL9401229 A NL 9401229A NL 194272 C NL194272 C NL 194272C
Authority
NL
Netherlands
Prior art keywords
iopamidol
butanol
water
sec
mixture
Prior art date
Application number
NL9401229A
Other languages
English (en)
Dutch (nl)
Other versions
NL194272B (nl
NL9401229A (nl
Inventor
Maurizio Paiocchi
Marco Villa
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI931720A external-priority patent/IT1257001B/it
Priority claimed from ITMI940760 external-priority patent/IT1269339B/it
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of NL9401229A publication Critical patent/NL9401229A/nl
Publication of NL194272B publication Critical patent/NL194272B/xx
Application granted granted Critical
Publication of NL194272C publication Critical patent/NL194272C/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NL9401229A 1993-07-30 1994-07-26 Werkwijze voor de kristallisatie van iopamidol. NL194272C (nl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ITMI931720A IT1257001B (it) 1993-07-30 1993-07-30 Processo per la cristalizzazione dello iopamidolo
ITMI931720 1993-07-30
ITMI940760 1994-04-20
ITMI940760 IT1269339B (it) 1994-04-20 1994-04-20 Processo per la cristallizzazione dello iopamidolo

Publications (3)

Publication Number Publication Date
NL9401229A NL9401229A (nl) 1995-02-16
NL194272B NL194272B (nl) 2001-07-02
NL194272C true NL194272C (nl) 2001-11-05

Family

ID=26331032

Family Applications (1)

Application Number Title Priority Date Filing Date
NL9401229A NL194272C (nl) 1993-07-30 1994-07-26 Werkwijze voor de kristallisatie van iopamidol.

Country Status (29)

Country Link
US (3) US5571941A (ko)
JP (1) JP3299045B2 (ko)
KR (1) KR100355211B1 (ko)
CN (1) CN1035940C (ko)
AT (1) AT404832B (ko)
AU (1) AU690138B2 (ko)
BE (1) BE1008403A4 (ko)
CA (1) CA2128942C (ko)
CH (1) CH686783A5 (ko)
CZ (1) CZ289300B6 (ko)
DE (1) DE4426818A1 (ko)
DK (1) DK172074B1 (ko)
ES (1) ES2102312B1 (ko)
FI (1) FI960400A (ko)
FR (1) FR2708601B1 (ko)
GB (1) GB2280436B (ko)
GR (1) GR940100366A (ko)
HU (1) HU217023B (ko)
IE (1) IE80675B1 (ko)
IL (1) IL110391A (ko)
NL (1) NL194272C (ko)
NO (1) NO304226B1 (ko)
NZ (1) NZ271632A (ko)
PT (1) PT101554B (ko)
RU (1) RU2135462C1 (ko)
SE (1) SE9402595L (ko)
SI (1) SI9420046B (ko)
WO (1) WO1995004031A1 (ko)
ZA (1) ZA945472B (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
EP0842141A1 (en) * 1995-07-04 1998-05-20 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY A process for preparing iopamidol by using a c1-c5 monoalkylether of a c2-c10 alkylen-glycol
JP4070235B2 (ja) * 1995-09-08 2008-04-02 ブラッコ・インテルナツィオナル・ベーヴェー （ｓ）−ｎ，ｎ’−ビス［２−ヒドロキシ−１−（ヒドロキシメチル）エチル］−５−［（２−ヒドロキシ−１−オキソプロピル）アミノ］−２，４，６−トリヨード−１，３−ベンゼンジカルボキサアミドの、水からの結晶化方法
PT101919B (pt) * 1996-09-30 2000-01-31 Hovione Sociedade Quimica Sa Um processo para a purificacao de tohexol
ES2141691T3 (es) * 1997-02-11 2003-05-16 Bracco Int Bv Procedimiento para la cristalizacion de (s)-n,n'-bis(2-hidroxi-1-(hidroximetil)etil)-5-((2-hidroxi-1-oxopropil)amino)-2,4,6-triyodo-1,3-bencenodicarboxamida en un alcohol (c5-c6) lineal o ramificado o sus mezclas.
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
KR20000031642A (ko) * 1998-11-09 2000-06-05 강재헌 이오파미돌의 결정화 방법
US6265610B1 (en) 1999-01-12 2001-07-24 The University Of North Carolina At Chapel Hill Contrast media for angiography
US6803485B2 (en) 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
IT1319671B1 (it) 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
DE102005059191B4 (de) * 2005-12-05 2008-02-07 Bayer Schering Pharma Ag Verfahren zur Rückgewinnung von für pharmazeutische Zwecke geeignetem Iopromid aus Mutterlaugen
KR100976097B1 (ko) 2008-12-05 2010-08-16 주식회사 대웅제약 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법
AU2010232556A1 (en) * 2009-04-02 2011-11-03 Allergan, Inc. Prostaglandin E receptor antagonists
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
DE102012104679A1 (de) 2011-05-30 2012-12-06 Westfälische Wilhelms-Universität Münster Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli
AU2013364113B2 (en) 2012-12-19 2018-01-18 Ge Healthcare As Purification of X-ray contrast agents
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (ko) * 1974-12-13 1978-12-29 Savac Ag
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
ATE79368T1 (de) * 1987-05-22 1992-08-15 Bracco Spa Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate.
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol

Also Published As

Publication number Publication date
NL194272B (nl) 2001-07-02
GB9414912D0 (en) 1994-09-14
SE9402595L (sv) 1995-01-31
NO960376L (no) 1996-01-29
AU690138B2 (en) 1998-04-23
CN1128020A (zh) 1996-07-31
ATA150594A (de) 1998-07-15
SE9402595D0 (sv) 1994-07-29
HUP9774567A2 (en) 1997-01-28
NO960376D0 (no) 1996-01-29
NL9401229A (nl) 1995-02-16
PT101554B (pt) 2000-01-31
HU9600191D0 (en) 1996-11-28
FR2708601A1 (fr) 1995-02-10
JPH07145125A (ja) 1995-06-06
ES2102312B1 (es) 1998-04-01
IE80675B1 (en) 1998-11-18
FR2708601B1 (fr) 1995-12-08
CA2128942A1 (en) 1995-01-31
NO304226B1 (no) 1998-11-16
AU7532194A (en) 1995-02-28
DK89294A (da) 1995-01-31
GR940100366A (en) 1996-03-31
FI960400A0 (fi) 1996-01-29
CA2128942C (en) 2003-07-15
DK172074B1 (da) 1997-10-13
FI960400A (fi) 1996-01-29
SI9420046B (sl) 2003-10-31
CN1035940C (zh) 1997-09-24
RU2135462C1 (ru) 1999-08-27
HU217023B (hu) 1999-11-29
ES2102312A1 (es) 1997-07-16
US6506938B1 (en) 2003-01-14
KR100355211B1 (ko) 2003-04-10
NZ271632A (en) 1997-07-27
IL110391A0 (en) 1994-10-21
ZA945472B (en) 1995-03-03
IL110391A (en) 1998-12-06
IE940609A1 (en) 1995-02-08
GB2280436A (en) 1995-02-01
GB2280436B (en) 1997-08-13
US5571941A (en) 1996-11-05
JP3299045B2 (ja) 2002-07-08
PT101554A (pt) 1995-05-04
AT404832B (de) 1999-03-25
WO1995004031A1 (en) 1995-02-09
CZ289300B6 (cs) 2001-12-12
KR960703842A (ko) 1996-08-31
CH686783A5 (it) 1996-06-28
DE4426818A1 (de) 1995-02-02
BE1008403A4 (fr) 1996-05-07
CZ183194A3 (en) 1995-02-15
SI9420046A (en) 1996-10-31
USRE36433E (en) 1999-12-07

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Legal Events

Date Code Title Description
BB A search report has been drawn up
BC A request for examination has been filed
CNR Transfer of rights (patent application after its laying open for public inspection)

Free format text: BRACCO INTERNATIONAL B.V.

SNR Assignments of patents or rights arising from examined patent applications

Owner name: BRACCO IMAGING S.P.A.

V4 Discontinued because of reaching the maximum lifetime of a patent

Effective date: 20140726