IT1248741B - Processo di concentrazione e di purificazione di composti organici - Google Patents

Processo di concentrazione e di purificazione di composti organici

Info

Publication number
IT1248741B
IT1248741B ITMI910493A ITMI910493A IT1248741B IT 1248741 B IT1248741 B IT 1248741B IT MI910493 A ITMI910493 A IT MI910493A IT MI910493 A ITMI910493 A IT MI910493A IT 1248741 B IT1248741 B IT 1248741B
Authority
IT
Italy
Prior art keywords
concentration
organic compounds
purification process
water
solutions
Prior art date
Application number
ITMI910493A
Other languages
English (en)
Inventor
Carlo Viscardi
Rodolfo Piva
Original Assignee
Bracco Spa
Tecnofarmaci
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa, Tecnofarmaci filed Critical Bracco Spa
Publication of ITMI910493A0 publication Critical patent/ITMI910493A0/it
Priority to ITMI910493A priority Critical patent/IT1248741B/it
Priority to ES92905017T priority patent/ES2057988T3/es
Priority to EP92905017A priority patent/EP0575360B1/en
Priority to US08/107,799 priority patent/US5447635A/en
Priority to KR1019930702498A priority patent/KR100198407B1/ko
Priority to DK92905017.7T priority patent/DK0575360T3/da
Priority to PCT/EP1992/000341 priority patent/WO1992014539A1/en
Priority to AT92905017T priority patent/ATE109678T1/de
Priority to HK98106787.7A priority patent/HK1007532B/en
Priority to DE69200322T priority patent/DE69200322T2/de
Priority to JP50489692A priority patent/JP3304972B2/ja
Priority to IE920549A priority patent/IE74957B1/en
Publication of ITMI910493A1 publication Critical patent/ITMI910493A1/it
Priority to NO932974A priority patent/NO180774C/no
Application granted granted Critical
Publication of IT1248741B publication Critical patent/IT1248741B/it

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/027—Nanofiltration
    • B01D61/0271—Nanofiltration comprising multiple nanofiltration steps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B01D61/146—Ultrafiltration comprising multiple ultrafiltration steps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Water Supply & Treatment (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Paper (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Si descrive un processo di concentrazione e purificazione di composti organici iodurati non ionici idrosolubili dalle loro soluzioni acquose, contenenti fra l'altro sali inorganici, reagenti organici in eccesso, solventi idrosolubili, potendo queste impurezze essere presenti singolarmente o in miscela, caratterizzato dal fatto che viene realizzato tramite filtrazione tangenziale di dette soluzioni su membrane da ultrafiltrazione o da nanofiltrazione.
ITMI910493A 1991-02-26 1991-02-26 Processo di concentrazione e di purificazione di composti organici IT1248741B (it)

Priority Applications (13)

Application Number Priority Date Filing Date Title
ITMI910493A IT1248741B (it) 1991-02-26 1991-02-26 Processo di concentrazione e di purificazione di composti organici
PCT/EP1992/000341 WO1992014539A1 (en) 1991-02-26 1992-02-19 Process of concentration and purification of organic compounds
HK98106787.7A HK1007532B (en) 1991-02-26 1992-02-19 Process of concentration and purification of organic compounds
US08/107,799 US5447635A (en) 1991-02-26 1992-02-19 Process of concentration and purification of organic compounds
KR1019930702498A KR100198407B1 (ko) 1991-02-26 1992-02-19 유기 화합물의 농축 및 정제방법
DK92905017.7T DK0575360T3 (da) 1991-02-26 1992-02-19 Fremgangsmåde til koncentrering og oprensning af organiske forbindelser
ES92905017T ES2057988T3 (es) 1991-02-26 1992-02-19 Procedimiento para la concentracion y purificacion de compuestos organicos.
AT92905017T ATE109678T1 (de) 1991-02-26 1992-02-19 Verfahren zum konzentrieren und reinigen von organischen verbindungen.
EP92905017A EP0575360B1 (en) 1991-02-26 1992-02-19 Process of concentration and purification of organic compounds
DE69200322T DE69200322T2 (de) 1991-02-26 1992-02-19 Verfahren zum konzentrieren und reinigen von organischen verbindungen.
JP50489692A JP3304972B2 (ja) 1991-02-26 1992-02-19 有機化合物の濃縮ならびに精製法
IE920549A IE74957B1 (en) 1991-02-26 1992-02-21 Process of concentration and purification of organic compounds
NO932974A NO180774C (no) 1991-02-26 1993-08-20 Fremgangsmåte ved konsentrasjon og rensing av ikke-ioniske, vannopplöselige joderte kontrastökende organiske forbindelser fra sine vandige opplösninger, samt totrinns tangentiell filteranordning for anvendelse ved fremgangsmåten

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI910493A IT1248741B (it) 1991-02-26 1991-02-26 Processo di concentrazione e di purificazione di composti organici

Publications (3)

Publication Number Publication Date
ITMI910493A0 ITMI910493A0 (it) 1991-02-26
ITMI910493A1 ITMI910493A1 (it) 1992-08-26
IT1248741B true IT1248741B (it) 1995-01-26

Family

ID=11358746

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI910493A IT1248741B (it) 1991-02-26 1991-02-26 Processo di concentrazione e di purificazione di composti organici

Country Status (11)

Country Link
EP (1) EP0575360B1 (it)
JP (1) JP3304972B2 (it)
KR (1) KR100198407B1 (it)
AT (1) ATE109678T1 (it)
DE (1) DE69200322T2 (it)
DK (1) DK0575360T3 (it)
ES (1) ES2057988T3 (it)
IE (1) IE74957B1 (it)
IT (1) IT1248741B (it)
NO (1) NO180774C (it)
WO (1) WO1992014539A1 (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5210300A (en) * 1991-09-25 1993-05-11 Malinckrodt Medical, Inc. Purification of crude ioversol using continuous deionization
US5160437A (en) * 1991-12-03 1992-11-03 Mallinckrodt Medical, Inc. Purification of crude Ioversol using reverse osmosis
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the crystallization of iopamidol
BE1007425A3 (nl) * 1993-08-30 1995-06-13 Holland Sweetener Co Werkwijze en inrichting voor de terugwinning van grondstoffen in het aspartaambereidingsproces.
IT1274027B (it) * 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
IT1282674B1 (it) * 1996-02-23 1998-03-31 Bracco Spa Processo per la purificazione di agenti contrastografici opacizzanti
US5538641A (en) * 1994-12-29 1996-07-23 Global Environmental Solutions, Inc. Process for recycling laden fluids
IT1275427B (it) * 1995-05-16 1997-08-07 Bracco Spa Processo per la depirogenazione di soluzioni farmaceutiche iniettabili
IT1283319B1 (it) * 1996-03-29 1998-04-16 Zambon Spa Processo per la preparazione di un intermedio utile nella sintesi di mezzi di contrasto iodurati
FR2748130B1 (fr) * 1996-04-29 2004-04-09 Kodak Pathe Procede et dispositif pour l'extraction selective des ions halogenures des bains photographiques
IT1292127B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la dissalazione di sostanze instabili a ph acidi
DE19736472C1 (de) * 1997-08-21 1999-04-22 Bernhard Dr Sixt Verfahren zum Herstellen von weitgehend nebenwirkungsfreien Kontrastmitteln
IT1302200B1 (it) * 1998-09-11 2000-07-31 Dibra Spa PROCESSO PER LA PREPARAZIONE DELLA S-N,N'-BIS°2-IDROSSI-1-(IDROSSIMETIL)ETILé-5-°(2-IDROSSI-1-
US6803485B2 (en) 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
KR100528651B1 (ko) * 2001-08-29 2005-11-15 이원바이오텍주식회사 집단 주거 및 취사 시설의 음식물 쓰레기를 발생 현장에서처리하는 방법
KR100781566B1 (ko) 2006-11-08 2007-12-03 (주)비룡 요오드화칼륨 폐용액의 재생처리 장치 및 방법
EP2216088A1 (en) * 2009-02-04 2010-08-11 Lonza Ltd. Recovery of product losses from ED waste streams
US20110021828A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Recovering unreacted intermediate from desalinated and desolventized dimerisation reaction mixture by ultrafiltration
AU2013364113B2 (en) * 2012-12-19 2018-01-18 Ge Healthcare As Purification of X-ray contrast agents
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US524806A (en) * 1894-08-21 moore
US3836457A (en) * 1973-03-19 1974-09-17 Westinghouse Electric Corp System for concentrating solutions by low pressure recycling
US4000065A (en) * 1974-11-18 1976-12-28 Basf Wyandotte Corporation Method and apparatus for purifying aqueous streams contaminated with organic materials
CH608189A5 (it) * 1974-12-13 1978-12-29 Savac Ag
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
JPH02261801A (ja) * 1989-04-03 1990-10-24 Tetsuo Suami 低粘度ヨード化ヒドロキシエチル澱粉およびその製法

Also Published As

Publication number Publication date
EP0575360A1 (en) 1993-12-29
IE920549A1 (en) 1992-08-26
JP3304972B2 (ja) 2002-07-22
NO932974D0 (no) 1993-08-20
JPH06506142A (ja) 1994-07-14
ITMI910493A1 (it) 1992-08-26
KR100198407B1 (ko) 1999-06-15
IE74957B1 (en) 1997-08-13
DK0575360T3 (da) 1995-04-24
DE69200322T2 (de) 1994-12-01
EP0575360B1 (en) 1994-08-10
ATE109678T1 (de) 1994-08-15
HK1007532A1 (en) 1999-04-16
NO180774B (no) 1997-03-10
KR930703061A (ko) 1993-11-29
WO1992014539A1 (en) 1992-09-03
NO932974L (no) 1993-08-20
ITMI910493A0 (it) 1991-02-26
DE69200322D1 (de) 1994-09-15
ES2057988T3 (es) 1994-10-16
NO180774C (no) 1997-06-18

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970226