NO304226B1 - FremgangsmÕte for krystallisering av iopamidol, samt anvendelse av butanoler ved krystalliseringen - Google Patents

FremgangsmÕte for krystallisering av iopamidol, samt anvendelse av butanoler ved krystalliseringen

Info

Publication number
NO304226B1
NO304226B1 NO960376A NO960376A NO304226B1 NO 304226 B1 NO304226 B1 NO 304226B1 NO 960376 A NO960376 A NO 960376A NO 960376 A NO960376 A NO 960376A NO 304226 B1 NO304226 B1 NO 304226B1
Authority
NO
Norway
Prior art keywords
crystallization
iopamidol
butanols
Prior art date
Application number
NO960376A
Other languages
English (en)
Norwegian (no)
Other versions
NO960376D0 (no
NO960376L (no
Inventor
Marco Villa
Maurizio Paiocchi
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI931720A external-priority patent/IT1257001B/it
Priority claimed from IT000760 external-priority patent/IT1269339B/it
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of NO960376D0 publication Critical patent/NO960376D0/no
Publication of NO960376L publication Critical patent/NO960376L/no
Publication of NO304226B1 publication Critical patent/NO304226B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO960376A 1993-07-30 1996-01-29 FremgangsmÕte for krystallisering av iopamidol, samt anvendelse av butanoler ved krystalliseringen NO304226B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI931720A IT1257001B (it) 1993-07-30 1993-07-30 Processo per la cristalizzazione dello iopamidolo
IT000760 IT1269339B (it) 1994-04-20 1994-04-20 Processo per la cristallizzazione dello iopamidolo
PCT/EP1994/002415 WO1995004031A1 (en) 1993-07-30 1994-07-22 Process for the crystallization of iopamidol

Publications (3)

Publication Number Publication Date
NO960376D0 NO960376D0 (no) 1996-01-29
NO960376L NO960376L (no) 1996-01-29
NO304226B1 true NO304226B1 (no) 1998-11-16

Family

ID=26331032

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960376A NO304226B1 (no) 1993-07-30 1996-01-29 FremgangsmÕte for krystallisering av iopamidol, samt anvendelse av butanoler ved krystalliseringen

Country Status (29)

Country Link
US (3) US5571941A (ko)
JP (1) JP3299045B2 (ko)
KR (1) KR100355211B1 (ko)
CN (1) CN1035940C (ko)
AT (1) AT404832B (ko)
AU (1) AU690138B2 (ko)
BE (1) BE1008403A4 (ko)
CA (1) CA2128942C (ko)
CH (1) CH686783A5 (ko)
CZ (1) CZ289300B6 (ko)
DE (1) DE4426818A1 (ko)
DK (1) DK172074B1 (ko)
ES (1) ES2102312B1 (ko)
FI (1) FI960400A0 (ko)
FR (1) FR2708601B1 (ko)
GB (1) GB2280436B (ko)
GR (1) GR940100366A (ko)
HU (1) HU217023B (ko)
IE (1) IE80675B1 (ko)
IL (1) IL110391A (ko)
NL (1) NL194272C (ko)
NO (1) NO304226B1 (ko)
NZ (1) NZ271632A (ko)
PT (1) PT101554B (ko)
RU (1) RU2135462C1 (ko)
SE (1) SE9402595L (ko)
SI (1) SI9420046B (ko)
WO (1) WO1995004031A1 (ko)
ZA (1) ZA945472B (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
AU6516196A (en) * 1995-07-04 1997-02-05 Recordati S.A. A process for preparing iopamidol by using a c1-c5 monoalkylether of a c2-c10 alkylene-glycol
BR9606624A (pt) * 1995-09-08 1997-11-11 Bracco Int Bv Processo para a cristalização de (s)-n,n'-bisÚ2-hidróxi-1-(hidroximetil)etil¾-5-Ú(2-hidróxi-1-oxopropil)amino¾-2,4,6-triiodo-1,3-benzonodicar-boxamida a partir de água
PT101919B (pt) * 1996-09-30 2000-01-31 Hovione Sociedade Quimica Sa Um processo para a purificacao de tohexol
CZ299420B6 (cs) * 1997-02-11 2008-07-23 Bracco International B. V. Zpusob krystalizace iopamidolu
GB9720969D0 (en) 1997-10-02 1997-12-03 Nycomed Imaging As Process
KR20000031642A (ko) * 1998-11-09 2000-06-05 강재헌 이오파미돌의 결정화 방법
US6265610B1 (en) 1999-01-12 2001-07-24 The University Of North Carolina At Chapel Hill Contrast media for angiography
US6803485B2 (en) 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
IT1319671B1 (it) 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
DE102005059191B4 (de) * 2005-12-05 2008-02-07 Bayer Schering Pharma Ag Verfahren zur Rückgewinnung von für pharmazeutische Zwecke geeignetem Iopromid aus Mutterlaugen
KR100976097B1 (ko) * 2008-12-05 2010-08-16 주식회사 대웅제약 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법
AU2010232556A1 (en) * 2009-04-02 2011-11-03 Allergan, Inc. Prostaglandin E receptor antagonists
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
DE102012104679A1 (de) 2011-05-30 2012-12-06 Westfälische Wilhelms-Universität Münster Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli
SG11201504201RA (en) 2012-12-19 2015-07-30 Ge Healthcare As Purification of x-ray contrast agents
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (ko) * 1974-12-13 1978-12-29 Savac Ag
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
KR960016747B1 (ko) * 1987-05-22 1996-12-20 브라코 인터내셔날 비. 브이 5-아실아미노-2,4,6-트리요오도-또는 트리브로모-벤조산 유도체의 제조 방법
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol

Also Published As

Publication number Publication date
CA2128942A1 (en) 1995-01-31
ATA150594A (de) 1998-07-15
USRE36433E (en) 1999-12-07
ES2102312A1 (es) 1997-07-16
NL194272C (nl) 2001-11-05
GB9414912D0 (en) 1994-09-14
GR940100366A (en) 1996-03-31
CZ183194A3 (en) 1995-02-15
IE940609A1 (en) 1995-02-08
HU217023B (hu) 1999-11-29
SI9420046B (sl) 2003-10-31
FI960400A (fi) 1996-01-29
ZA945472B (en) 1995-03-03
FI960400A0 (fi) 1996-01-29
DK89294A (da) 1995-01-31
SE9402595D0 (sv) 1994-07-29
GB2280436B (en) 1997-08-13
NL194272B (nl) 2001-07-02
CA2128942C (en) 2003-07-15
SI9420046A (en) 1996-10-31
IL110391A0 (en) 1994-10-21
WO1995004031A1 (en) 1995-02-09
ES2102312B1 (es) 1998-04-01
AU7532194A (en) 1995-02-28
SE9402595L (sv) 1995-01-31
KR960703842A (ko) 1996-08-31
HU9600191D0 (en) 1996-11-28
JP3299045B2 (ja) 2002-07-08
AT404832B (de) 1999-03-25
CN1128020A (zh) 1996-07-31
US5571941A (en) 1996-11-05
PT101554A (pt) 1995-05-04
NL9401229A (nl) 1995-02-16
IE80675B1 (en) 1998-11-18
JPH07145125A (ja) 1995-06-06
FR2708601B1 (fr) 1995-12-08
AU690138B2 (en) 1998-04-23
CH686783A5 (it) 1996-06-28
RU2135462C1 (ru) 1999-08-27
IL110391A (en) 1998-12-06
DE4426818A1 (de) 1995-02-02
KR100355211B1 (ko) 2003-04-10
CN1035940C (zh) 1997-09-24
US6506938B1 (en) 2003-01-14
FR2708601A1 (fr) 1995-02-10
NO960376D0 (no) 1996-01-29
GB2280436A (en) 1995-02-01
PT101554B (pt) 2000-01-31
CZ289300B6 (cs) 2001-12-12
DK172074B1 (da) 1997-10-13
HUP9774567A2 (en) 1997-01-28
NZ271632A (en) 1997-07-27
BE1008403A4 (fr) 1996-05-07
NO960376L (no) 1996-01-29

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