ATA150594A - Verfahren zur kristallisation von iopamidol - Google Patents
Verfahren zur kristallisation von iopamidolInfo
- Publication number
- ATA150594A ATA150594A AT0150594A AT150594A ATA150594A AT A150594 A ATA150594 A AT A150594A AT 0150594 A AT0150594 A AT 0150594A AT 150594 A AT150594 A AT 150594A AT A150594 A ATA150594 A AT A150594A
- Authority
- AT
- Austria
- Prior art keywords
- iopamidol
- crystallizing
- crystallizing iopamidol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI931720A IT1257001B (it) | 1993-07-30 | 1993-07-30 | Processo per la cristalizzazione dello iopamidolo |
| IT000760 IT1269339B (it) | 1994-04-20 | 1994-04-20 | Processo per la cristallizzazione dello iopamidolo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA150594A true ATA150594A (de) | 1998-07-15 |
| AT404832B AT404832B (de) | 1999-03-25 |
Family
ID=26331032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0150594A AT404832B (de) | 1993-07-30 | 1994-07-29 | Verfahren zur kristallisation von iopamidol |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US5571941A (de) |
| JP (1) | JP3299045B2 (de) |
| KR (1) | KR100355211B1 (de) |
| CN (1) | CN1035940C (de) |
| AT (1) | AT404832B (de) |
| AU (1) | AU690138B2 (de) |
| BE (1) | BE1008403A4 (de) |
| CA (1) | CA2128942C (de) |
| CH (1) | CH686783A5 (de) |
| CZ (1) | CZ289300B6 (de) |
| DE (1) | DE4426818A1 (de) |
| DK (1) | DK172074B1 (de) |
| ES (1) | ES2102312B1 (de) |
| FI (1) | FI960400A (de) |
| FR (1) | FR2708601B1 (de) |
| GB (1) | GB2280436B (de) |
| GR (1) | GR940100366A (de) |
| HU (1) | HU217023B (de) |
| IE (1) | IE80675B1 (de) |
| IL (1) | IL110391A (de) |
| NL (1) | NL194272C (de) |
| NO (1) | NO304226B1 (de) |
| NZ (1) | NZ271632A (de) |
| PT (1) | PT101554B (de) |
| RU (1) | RU2135462C1 (de) |
| SE (1) | SE9402595L (de) |
| SI (1) | SI9420046B (de) |
| WO (1) | WO1995004031A1 (de) |
| ZA (1) | ZA945472B (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL110391A (en) | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the formation of infamidol |
| US6310243B1 (en) * | 1994-09-23 | 2001-10-30 | Nycomed Imaging As | Iodinated x-ray contrast media |
| PT101720A (pt) * | 1995-06-08 | 1997-01-31 | Hovione Sociedade Quimica S A | Processo para a purificacao e cristalizacao de iopamidol |
| EP0842141A1 (de) * | 1995-07-04 | 1998-05-20 | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY | Verfahren zur herstellung von iopamidol unter mitverwendung von c1-c5 monoalkylether vom c2-c10 alkylenglycol |
| CZ288645B6 (cs) * | 1995-09-08 | 2001-08-15 | Bracco International B. V. | Způsob krystalizace Iopamidolu |
| PT101919B (pt) * | 1996-09-30 | 2000-01-31 | Hovione Sociedade Quimica Sa | Um processo para a purificacao de tohexol |
| ES2141691T3 (es) * | 1997-02-11 | 2003-05-16 | Bracco Int Bv | Procedimiento para la cristalizacion de (s)-n,n'-bis(2-hidroxi-1-(hidroximetil)etil)-5-((2-hidroxi-1-oxopropil)amino)-2,4,6-triyodo-1,3-bencenodicarboxamida en un alcohol (c5-c6) lineal o ramificado o sus mezclas. |
| GB9720969D0 (en) | 1997-10-02 | 1997-12-03 | Nycomed Imaging As | Process |
| KR20000031642A (ko) * | 1998-11-09 | 2000-06-05 | 강재헌 | 이오파미돌의 결정화 방법 |
| US6265610B1 (en) | 1999-01-12 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Contrast media for angiography |
| US6803485B2 (en) | 1999-02-26 | 2004-10-12 | Bracco Imaging S.P.A. | Process for the preparation of iopamidol |
| IT1319671B1 (it) | 2000-12-01 | 2003-10-23 | Bracco Spa | Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino) |
| DE102005059191B4 (de) * | 2005-12-05 | 2008-02-07 | Bayer Schering Pharma Ag | Verfahren zur Rückgewinnung von für pharmazeutische Zwecke geeignetem Iopromid aus Mutterlaugen |
| KR100976097B1 (ko) * | 2008-12-05 | 2010-08-16 | 주식회사 대웅제약 | 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법 |
| AU2010232556A1 (en) * | 2009-04-02 | 2011-11-03 | Allergan, Inc. | Prostaglandin E receptor antagonists |
| WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
| DE102012104679A1 (de) | 2011-05-30 | 2012-12-06 | Westfälische Wilhelms-Universität Münster | Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli |
| JP6342421B2 (ja) | 2012-12-19 | 2018-06-13 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | Ｘ線造影剤の精製 |
| KR102128423B1 (ko) * | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (de) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
| GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| IT1193211B (it) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
| DE3150916A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel" |
| US5204086A (en) * | 1982-10-01 | 1993-04-20 | Nycomed Imaging As | X-ray contrast agent |
| ES2006951A6 (es) * | 1987-05-22 | 1989-05-16 | Bracco Ind Chimica Spa | Un procedimiento para la preparacion de derivados de acido 5-acilamino-2,4,6-triyodo o tribromo-benzoico. |
| IT1248741B (it) * | 1991-02-26 | 1995-01-26 | Bracco Spa | Processo di concentrazione e di purificazione di composti organici |
| IL110391A (en) | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the formation of infamidol |
-
1994
- 1994-07-20 IL IL11039194A patent/IL110391A/en not_active IP Right Cessation
- 1994-07-22 RU RU96105070A patent/RU2135462C1/ru active
- 1994-07-22 GR GR940100366A patent/GR940100366A/el unknown
- 1994-07-22 NZ NZ271632A patent/NZ271632A/en not_active IP Right Cessation
- 1994-07-22 AU AU75321/94A patent/AU690138B2/en not_active Expired
- 1994-07-22 WO PCT/EP1994/002415 patent/WO1995004031A1/en active Application Filing
- 1994-07-22 SI SI9420046A patent/SI9420046B/sl unknown
- 1994-07-22 KR KR1019960700580A patent/KR100355211B1/ko not_active IP Right Cessation
- 1994-07-22 CN CN94192930A patent/CN1035940C/zh not_active Expired - Lifetime
- 1994-07-22 HU HU9600191A patent/HU217023B/hu unknown
- 1994-07-25 GB GB9414912A patent/GB2280436B/en not_active Expired - Lifetime
- 1994-07-25 ZA ZA945472A patent/ZA945472B/xx unknown
- 1994-07-26 NL NL9401229A patent/NL194272C/nl not_active IP Right Cessation
- 1994-07-26 PT PT101554A patent/PT101554B/pt not_active IP Right Cessation
- 1994-07-26 FR FR9409238A patent/FR2708601B1/fr not_active Expired - Lifetime
- 1994-07-26 CH CH02354/94A patent/CH686783A5/it not_active IP Right Cessation
- 1994-07-27 CA CA002128942A patent/CA2128942C/en not_active Expired - Lifetime
- 1994-07-28 DE DE4426818A patent/DE4426818A1/de not_active Ceased
- 1994-07-29 US US08/281,985 patent/US5571941A/en not_active Ceased
- 1994-07-29 CZ CZ19941831A patent/CZ289300B6/cs not_active IP Right Cessation
- 1994-07-29 ES ES09401679A patent/ES2102312B1/es not_active Expired - Fee Related
- 1994-07-29 BE BE9400717A patent/BE1008403A4/fr not_active IP Right Cessation
- 1994-07-29 JP JP17811594A patent/JP3299045B2/ja not_active Expired - Lifetime
- 1994-07-29 SE SE9402595A patent/SE9402595L/xx not_active Application Discontinuation
- 1994-07-29 AT AT0150594A patent/AT404832B/de not_active IP Right Cessation
- 1994-07-29 IE IE940609A patent/IE80675B1/en not_active IP Right Cessation
- 1994-07-29 DK DK089294A patent/DK172074B1/da not_active IP Right Cessation
-
1996
- 1996-01-29 FI FI960400A patent/FI960400A/fi not_active Application Discontinuation
- 1996-01-29 NO NO960376A patent/NO304226B1/no not_active IP Right Cessation
-
1997
- 1997-02-07 US US08/797,610 patent/USRE36433E/en not_active Expired - Lifetime
-
1998
- 1998-08-25 US US09/139,894 patent/US6506938B1/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee | ||
| MK07 | Expiry |
Effective date: 20140729 |