PT101554A - Processo para a cristalizacao de iopamidol utilizando um butanol como solvente, iopamidol cristalino assim obtido e agentes de contraste radiograficos que o contem - Google Patents

Processo para a cristalizacao de iopamidol utilizando um butanol como solvente, iopamidol cristalino assim obtido e agentes de contraste radiograficos que o contem

Info

Publication number
PT101554A
PT101554A PT101554A PT10155494A PT101554A PT 101554 A PT101554 A PT 101554A PT 101554 A PT101554 A PT 101554A PT 10155494 A PT10155494 A PT 10155494A PT 101554 A PT101554 A PT 101554A
Authority
PT
Portugal
Prior art keywords
iopamidol
crystalization
butanol
solvent
contrast agents
Prior art date
Application number
PT101554A
Other languages
English (en)
Other versions
PT101554B (pt
Inventor
Maurizio Paiocchi
Marco Villa
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI931720A external-priority patent/IT1257001B/it
Priority claimed from IT000760 external-priority patent/IT1269339B/it
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of PT101554A publication Critical patent/PT101554A/pt
Publication of PT101554B publication Critical patent/PT101554B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PT101554A 1993-07-30 1994-07-26 Processo para a cristalizacao de iopamidol utilizando um butanol como solvente, iopamidol cristalino assim obtido e agentes de contraste radiograficos que o contem PT101554B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI931720A IT1257001B (it) 1993-07-30 1993-07-30 Processo per la cristalizzazione dello iopamidolo
IT000760 IT1269339B (it) 1994-04-20 1994-04-20 Processo per la cristallizzazione dello iopamidolo

Publications (2)

Publication Number Publication Date
PT101554A true PT101554A (pt) 1995-05-04
PT101554B PT101554B (pt) 2000-01-31

Family

ID=26331032

Family Applications (1)

Application Number Title Priority Date Filing Date
PT101554A PT101554B (pt) 1993-07-30 1994-07-26 Processo para a cristalizacao de iopamidol utilizando um butanol como solvente, iopamidol cristalino assim obtido e agentes de contraste radiograficos que o contem

Country Status (29)

Country Link
US (3) US5571941A (pt)
JP (1) JP3299045B2 (pt)
KR (1) KR100355211B1 (pt)
CN (1) CN1035940C (pt)
AT (1) AT404832B (pt)
AU (1) AU690138B2 (pt)
BE (1) BE1008403A4 (pt)
CA (1) CA2128942C (pt)
CH (1) CH686783A5 (pt)
CZ (1) CZ289300B6 (pt)
DE (1) DE4426818A1 (pt)
DK (1) DK172074B1 (pt)
ES (1) ES2102312B1 (pt)
FI (1) FI960400A7 (pt)
FR (1) FR2708601B1 (pt)
GB (1) GB2280436B (pt)
GR (1) GR940100366A (pt)
HU (1) HU217023B (pt)
IE (1) IE80675B1 (pt)
IL (1) IL110391A (pt)
NL (1) NL194272C (pt)
NO (1) NO304226B1 (pt)
NZ (1) NZ271632A (pt)
PT (1) PT101554B (pt)
RU (1) RU2135462C1 (pt)
SE (1) SE9402595L (pt)
SI (1) SI9420046B (pt)
WO (1) WO1995004031A1 (pt)
ZA (1) ZA945472B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the crystallization of iopamidol
US6310243B1 (en) * 1994-09-23 2001-10-30 Nycomed Imaging As Iodinated x-ray contrast media
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol
WO1997002235A1 (en) * 1995-07-04 1997-01-23 Recordati S.A. Chemical And Pharmaceutical Company A process for preparing iopamidol by using a c1-c5 monoalkylether of a c2-c10 alkylen-glycol
CA2204734C (en) * 1995-09-08 2009-12-29 Marina Mauro Process for the crystallization from water of (s)-n,n'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzendicarboxamide
PT101919B (pt) * 1996-09-30 2000-01-31 Hovione Sociedade Quimica Sa Um processo para a purificacao de tohexol
DE966428T1 (de) * 1997-02-11 2000-06-29 Bracco International B.V., Amsterdam Verfahren zur kritallisation von (s)-n-n'-bis [2-hydroxy-1-(hydroxymethyl) ethyl]-5-[(2-hydroxy-1-xopropyl) amino]-2,4,6-trirodo-1,3-benzoldicarboxamid aus linearem oder verzweigtem (c5-c6) alkohol oder gemischen davon
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
KR20000031642A (ko) * 1998-11-09 2000-06-05 강재헌 이오파미돌의 결정화 방법
US6265610B1 (en) 1999-01-12 2001-07-24 The University Of North Carolina At Chapel Hill Contrast media for angiography
US6803485B2 (en) 1999-02-26 2004-10-12 Bracco Imaging S.P.A. Process for the preparation of iopamidol
IT1319671B1 (it) 2000-12-01 2003-10-23 Bracco Spa Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
NO20043305D0 (no) * 2004-08-09 2004-08-09 Amersham Health As Preparation of lodixanol
DE102005059191B4 (de) * 2005-12-05 2008-02-07 Bayer Schering Pharma Ag Verfahren zur Rückgewinnung von für pharmazeutische Zwecke geeignetem Iopromid aus Mutterlaugen
KR100976097B1 (ko) 2008-12-05 2010-08-16 주식회사 대웅제약 이오프로마이드의 ｚ 이성체를 선택적으로 결정화하는 방법
KR20120028867A (ko) * 2009-04-02 2012-03-23 알러간, 인코포레이티드 프로스타글란딘 ｅ 수용체 길항제
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
DE102012104679A1 (de) 2011-05-30 2012-12-06 Westfälische Wilhelms-Universität Münster Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli
CN104854080B (zh) 2012-12-19 2018-07-03 通用电气医疗集团股份有限公司 X-射线造影剂的纯化
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608189A5 (pt) * 1974-12-13 1978-12-29 Savac Ag
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
DE3873766T2 (de) * 1987-05-22 1993-02-11 Bracco Ind Chimica Spa Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate.
IT1248741B (it) * 1991-02-26 1995-01-26 Bracco Spa Processo di concentrazione e di purificazione di composti organici
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the crystallization of iopamidol

Also Published As

Publication number Publication date
DK89294A (da) 1995-01-31
IL110391A (en) 1998-12-06
AT404832B (de) 1999-03-25
IE80675B1 (en) 1998-11-18
FR2708601B1 (fr) 1995-12-08
KR100355211B1 (ko) 2003-04-10
NZ271632A (en) 1997-07-27
HU9600191D0 (en) 1996-11-28
GB2280436A (en) 1995-02-01
NL194272C (nl) 2001-11-05
ATA150594A (de) 1998-07-15
CZ289300B6 (cs) 2001-12-12
CA2128942A1 (en) 1995-01-31
FI960400L (fi) 1996-01-29
NL9401229A (nl) 1995-02-16
USRE36433E (en) 1999-12-07
FR2708601A1 (fr) 1995-02-10
CN1128020A (zh) 1996-07-31
RU2135462C1 (ru) 1999-08-27
NO304226B1 (no) 1998-11-16
GB2280436B (en) 1997-08-13
JPH07145125A (ja) 1995-06-06
WO1995004031A1 (en) 1995-02-09
CZ183194A3 (en) 1995-02-15
KR960703842A (ko) 1996-08-31
NO960376D0 (no) 1996-01-29
SI9420046A (en) 1996-10-31
SE9402595L (sv) 1995-01-31
NL194272B (nl) 2001-07-02
HU217023B (hu) 1999-11-29
NO960376L (no) 1996-01-29
CN1035940C (zh) 1997-09-24
ES2102312A1 (es) 1997-07-16
IL110391A0 (en) 1994-10-21
SE9402595D0 (sv) 1994-07-29
CA2128942C (en) 2003-07-15
DE4426818A1 (de) 1995-02-02
DK172074B1 (da) 1997-10-13
HUP9774567A2 (en) 1997-01-28
GR940100366A (en) 1996-03-31
US5571941A (en) 1996-11-05
AU690138B2 (en) 1998-04-23
FI960400A0 (fi) 1996-01-29
PT101554B (pt) 2000-01-31
FI960400A7 (fi) 1996-01-29
AU7532194A (en) 1995-02-28
IE940609A1 (en) 1995-02-08
BE1008403A4 (fr) 1996-05-07
US6506938B1 (en) 2003-01-14
CH686783A5 (it) 1996-06-28
ES2102312B1 (es) 1998-04-01
SI9420046B (sl) 2003-10-31
ZA945472B (en) 1995-03-03
JP3299045B2 (ja) 2002-07-08
GB9414912D0 (en) 1994-09-14

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