FR2708601A1 - Procédé de cristallisation d'Iopamidol. - Google Patents
Procédé de cristallisation d'Iopamidol.Info
- Publication number
- FR2708601A1 FR2708601A1 FR9409238A FR9409238A FR2708601A1 FR 2708601 A1 FR2708601 A1 FR 2708601A1 FR 9409238 A FR9409238 A FR 9409238A FR 9409238 A FR9409238 A FR 9409238A FR 2708601 A1 FR2708601 A1 FR 2708601A1
- Authority
- FR
- France
- Prior art keywords
- iopamidol
- crystallization process
- pharmacopoeia
- butanol
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procédé de cristallisation d'Iopamidol utilisant un butanol comme solvant. L'Iopamidol est obtenu avec des rendements élevés, même en partant de solutions aqueuses de celui-ci, et présente des caractéristiques conformes à celles requises par la pharmacopée.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI931720A IT1257001B (it) | 1993-07-30 | 1993-07-30 | Processo per la cristalizzazione dello iopamidolo |
IT000760 IT1269339B (it) | 1994-04-20 | 1994-04-20 | Processo per la cristallizzazione dello iopamidolo |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2708601A1 true FR2708601A1 (fr) | 1995-02-10 |
FR2708601B1 FR2708601B1 (fr) | 1995-12-08 |
Family
ID=26331032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR9409238A Expired - Lifetime FR2708601B1 (fr) | 1993-07-30 | 1994-07-26 | Procédé de cristallisation d'Iopamidol. |
Country Status (29)
Country | Link |
---|---|
US (3) | US5571941A (fr) |
JP (1) | JP3299045B2 (fr) |
KR (1) | KR100355211B1 (fr) |
CN (1) | CN1035940C (fr) |
AT (1) | AT404832B (fr) |
AU (1) | AU690138B2 (fr) |
BE (1) | BE1008403A4 (fr) |
CA (1) | CA2128942C (fr) |
CH (1) | CH686783A5 (fr) |
CZ (1) | CZ289300B6 (fr) |
DE (1) | DE4426818A1 (fr) |
DK (1) | DK172074B1 (fr) |
ES (1) | ES2102312B1 (fr) |
FI (1) | FI960400A (fr) |
FR (1) | FR2708601B1 (fr) |
GB (1) | GB2280436B (fr) |
GR (1) | GR940100366A (fr) |
HU (1) | HU217023B (fr) |
IE (1) | IE80675B1 (fr) |
IL (1) | IL110391A (fr) |
NL (1) | NL194272C (fr) |
NO (1) | NO304226B1 (fr) |
NZ (1) | NZ271632A (fr) |
PT (1) | PT101554B (fr) |
RU (1) | RU2135462C1 (fr) |
SE (1) | SE9402595L (fr) |
SI (1) | SI9420046B (fr) |
WO (1) | WO1995004031A1 (fr) |
ZA (1) | ZA945472B (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL110391A (en) | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the formation of infamidol |
US6310243B1 (en) * | 1994-09-23 | 2001-10-30 | Nycomed Imaging As | Iodinated x-ray contrast media |
PT101720A (pt) * | 1995-06-08 | 1997-01-31 | Hovione Sociedade Quimica S A | Processo para a purificacao e cristalizacao de iopamidol |
AU6516196A (en) * | 1995-07-04 | 1997-02-05 | Recordati S.A. | A process for preparing iopamidol by using a c1-c5 monoalkylether of a c2-c10 alkylene-glycol |
AU708195B2 (en) * | 1995-09-08 | 1999-07-29 | Bracco International B.V. | Process for the crystallization from water of (S)-N,N'-bis{2-hydroxy-1-(hydroxymethyl)ethyl}-5-{(2-hydroxy -1-oxopropyl)amino}-2,4,6-triiodo-1,3-benzendicarboxamide |
PT101919B (pt) * | 1996-09-30 | 2000-01-31 | Hovione Sociedade Quimica Sa | Um processo para a purificacao de tohexol |
KR100758741B1 (ko) * | 1997-02-11 | 2007-09-14 | 브라코 인터내셔날 비이.브이. | 선형 또는 분지형 (c5-c6) 알콜 또는 그의 혼합물로부터 (s)-n,n'-비스[2-히드록시-1-(히드록시메틸)에틸]-5-[(2-히드록시-1-옥소프로필)아미노]-2,4,6-트리요오도-1,3-벤젠디카르복스아미드의 결정화 방법 |
GB9720969D0 (en) * | 1997-10-02 | 1997-12-03 | Nycomed Imaging As | Process |
KR20000031642A (ko) * | 1998-11-09 | 2000-06-05 | 강재헌 | 이오파미돌의 결정화 방법 |
US6265610B1 (en) | 1999-01-12 | 2001-07-24 | The University Of North Carolina At Chapel Hill | Contrast media for angiography |
US6803485B2 (en) | 1999-02-26 | 2004-10-12 | Bracco Imaging S.P.A. | Process for the preparation of iopamidol |
IT1319671B1 (it) | 2000-12-01 | 2003-10-23 | Bracco Spa | Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino) |
DE102005059191B4 (de) * | 2005-12-05 | 2008-02-07 | Bayer Schering Pharma Ag | Verfahren zur Rückgewinnung von für pharmazeutische Zwecke geeignetem Iopromid aus Mutterlaugen |
KR100976097B1 (ko) | 2008-12-05 | 2010-08-16 | 주식회사 대웅제약 | 이오프로마이드의 z 이성체를 선택적으로 결정화하는 방법 |
CA2757480A1 (fr) * | 2009-04-02 | 2010-10-07 | Allergan, Inc. | Antagonistes du recepteur de la prostaglandine e |
WO2012136813A2 (fr) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents pour un diagnostic par radar médical |
DE102012104679A1 (de) | 2011-05-30 | 2012-12-06 | Westfälische Wilhelms-Universität Münster | Biotechnologische konversion von glycerin zu 2-amino-1,3-propandiol (serinol) in rekombinanten escherichia coli |
CA2890449C (fr) | 2012-12-19 | 2020-12-29 | Ge Healthcare As | Purification d'agents de contraste pour imagerie par rayons x |
KR102128423B1 (ko) * | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1472050A (en) * | 1974-12-13 | 1977-04-27 | Savac Ag | Non-ionic x-ray contrast agents |
WO1988009328A1 (fr) * | 1987-05-22 | 1988-12-01 | Bracco Industria Chimica S.P.A. | Preparation de derives de 5-acylamino-2,4,6-triiodo- ou tribromo-acide benzoique |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1548594A (en) * | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
IT1193211B (it) * | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
DE3150916A1 (de) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel" |
US5204086A (en) * | 1982-10-01 | 1993-04-20 | Nycomed Imaging As | X-ray contrast agent |
IT1248741B (it) * | 1991-02-26 | 1995-01-26 | Bracco Spa | Processo di concentrazione e di purificazione di composti organici |
IL110391A (en) | 1993-07-30 | 1998-12-06 | Zambon Spa | Process for the formation of infamidol |
-
1994
- 1994-07-20 IL IL11039194A patent/IL110391A/en not_active IP Right Cessation
- 1994-07-22 SI SI9420046A patent/SI9420046B/sl unknown
- 1994-07-22 CN CN94192930A patent/CN1035940C/zh not_active Expired - Lifetime
- 1994-07-22 GR GR940100366A patent/GR940100366A/el unknown
- 1994-07-22 NZ NZ271632A patent/NZ271632A/en not_active IP Right Cessation
- 1994-07-22 HU HU9600191A patent/HU217023B/hu unknown
- 1994-07-22 WO PCT/EP1994/002415 patent/WO1995004031A1/fr active Application Filing
- 1994-07-22 RU RU96105070A patent/RU2135462C1/ru active
- 1994-07-22 KR KR1019960700580A patent/KR100355211B1/ko not_active IP Right Cessation
- 1994-07-22 AU AU75321/94A patent/AU690138B2/en not_active Expired
- 1994-07-25 ZA ZA945472A patent/ZA945472B/xx unknown
- 1994-07-25 GB GB9414912A patent/GB2280436B/en not_active Expired - Lifetime
- 1994-07-26 FR FR9409238A patent/FR2708601B1/fr not_active Expired - Lifetime
- 1994-07-26 CH CH02354/94A patent/CH686783A5/it not_active IP Right Cessation
- 1994-07-26 PT PT101554A patent/PT101554B/pt not_active IP Right Cessation
- 1994-07-26 NL NL9401229A patent/NL194272C/nl not_active IP Right Cessation
- 1994-07-27 CA CA002128942A patent/CA2128942C/fr not_active Expired - Lifetime
- 1994-07-28 DE DE4426818A patent/DE4426818A1/de not_active Ceased
- 1994-07-29 AT AT0150594A patent/AT404832B/de not_active IP Right Cessation
- 1994-07-29 IE IE940609A patent/IE80675B1/en not_active IP Right Cessation
- 1994-07-29 JP JP17811594A patent/JP3299045B2/ja not_active Expired - Lifetime
- 1994-07-29 DK DK089294A patent/DK172074B1/da not_active IP Right Cessation
- 1994-07-29 US US08/281,985 patent/US5571941A/en not_active Ceased
- 1994-07-29 ES ES09401679A patent/ES2102312B1/es not_active Expired - Fee Related
- 1994-07-29 BE BE9400717A patent/BE1008403A4/fr not_active IP Right Cessation
- 1994-07-29 SE SE9402595A patent/SE9402595L/xx not_active Application Discontinuation
- 1994-07-29 CZ CZ19941831A patent/CZ289300B6/cs not_active IP Right Cessation
-
1996
- 1996-01-29 NO NO960376A patent/NO304226B1/no not_active IP Right Cessation
- 1996-01-29 FI FI960400A patent/FI960400A/fi not_active Application Discontinuation
-
1997
- 1997-02-07 US US08/797,610 patent/USRE36433E/en not_active Expired - Lifetime
-
1998
- 1998-08-25 US US09/139,894 patent/US6506938B1/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1472050A (en) * | 1974-12-13 | 1977-04-27 | Savac Ag | Non-ionic x-ray contrast agents |
WO1988009328A1 (fr) * | 1987-05-22 | 1988-12-01 | Bracco Industria Chimica S.P.A. | Preparation de derives de 5-acylamino-2,4,6-triiodo- ou tribromo-acide benzoique |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property |