DE69332738D1 - Verfahren zur kristallisation von n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoracetyl-l-lysyl-l-prolin - Google Patents

Verfahren zur kristallisation von n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoracetyl-l-lysyl-l-prolin

Info

Publication number
DE69332738D1
DE69332738D1 DE69332738T DE69332738T DE69332738D1 DE 69332738 D1 DE69332738 D1 DE 69332738D1 DE 69332738 T DE69332738 T DE 69332738T DE 69332738 T DE69332738 T DE 69332738T DE 69332738 D1 DE69332738 D1 DE 69332738D1
Authority
DE
Germany
Prior art keywords
trifluoracetyl
prolin
lysyl
phenylpropyl
crystallizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69332738T
Other languages
English (en)
Other versions
DE69332738T2 (de
Inventor
Yasuyoshi Ueda
Hajime Manabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Publication of DE69332738D1 publication Critical patent/DE69332738D1/de
Application granted granted Critical
Publication of DE69332738T2 publication Critical patent/DE69332738T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
DE69332738T 1993-01-08 1993-12-27 Verfahren zur kristallisation von n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoracetyl-l-lysyl-l-prolin Expired - Fee Related DE69332738T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP204493 1993-01-08
PCT/JP1993/001909 WO1994015957A1 (en) 1993-01-08 1993-12-27 Method of crystallizing n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoroacetyl-l-lysyl-l-proline

Publications (2)

Publication Number Publication Date
DE69332738D1 true DE69332738D1 (de) 2003-04-10
DE69332738T2 DE69332738T2 (de) 2003-10-02

Family

ID=11518332

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69332738T Expired - Fee Related DE69332738T2 (de) 1993-01-08 1993-12-27 Verfahren zur kristallisation von n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoracetyl-l-lysyl-l-prolin
DE69333521T Expired - Fee Related DE69333521T2 (de) 1993-01-08 1993-12-27 Verfahren zur Kristallisierung von N2-((S)-1-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysyl-L-prolin

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69333521T Expired - Fee Related DE69333521T2 (de) 1993-01-08 1993-12-27 Verfahren zur Kristallisierung von N2-((S)-1-ethoxycarbonyl-3-phenylpropyl)-N6-trifluoroacetyl-L-lysyl-L-prolin

Country Status (5)

Country Link
US (2) US5519146A (de)
EP (2) EP1243594B1 (de)
JP (1) JP3511519B2 (de)
DE (2) DE69332738T2 (de)
WO (1) WO1994015957A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69332738T2 (de) * 1993-01-08 2003-10-02 Kanegafuchi Kagaku Kogyo K.K., Osaka Verfahren zur kristallisation von n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoracetyl-l-lysyl-l-prolin
DE4331540A1 (de) * 1993-09-17 1995-03-23 Degussa Verfahren zur Reinigung von 1-[N·2·-((S)-Ethoxycarbonyl)-3-phenylpropyl)-N·6·-trifluoracetyl]-L-lysyl-L-prolin (Lisinopril(Tfa)ethylester)
US5962696A (en) * 1997-06-23 1999-10-05 Degussa Aktiengesellschaft Process for the preparation of 1-(N 2-(S)-ethoxycarbonyl)--3 phenylpropyl-N6-trifluoracetyl))-L-lysyl-L-prolin (Lisinopril(Tfa) ethylester, LPE))
US5907044A (en) * 1997-07-30 1999-05-25 Degussa Aktiengellschaft Method of isolating 1- N2 -((S)-ethoxycarbonyl)-3-phenylpropyl)-N6 -trifluoroacetyl!-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE)
DE69934084T2 (de) * 1998-09-22 2007-04-05 Kaneka Corp. Verfahren zur herstellung von n2-(1(s)-carboxy-3-phenylpropyl)-l-lysyl-l-prolin
ATE540924T1 (de) * 2003-06-24 2012-01-15 Servier Lab Neue kristalline formen von perindopril erbumine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0168769A3 (de) * 1984-07-16 1989-02-08 Merck & Co. Inc. Verfahren zur Herstellung von Carboxyalkyldipeptiden
JPS6248696A (ja) * 1985-08-27 1987-03-03 Kanegafuchi Chem Ind Co Ltd Ｎ−〔１（ｓ）−エトキシカルボニル−３−フエニルプロピル〕−ｌ−アラニル−ｌ−プロリンの製造法
JPH0653757B2 (ja) * 1985-12-06 1994-07-20 味の素株式会社 プロリン誘導体の芳香族スルホン酸塩
US4687840A (en) * 1986-02-11 1987-08-18 Texas Tech University Health Sciences Center Hypotensive active peptides
JPS6485994A (en) * 1987-05-29 1989-03-30 Hamari Yakuhin Kogyo Kk Nepsilon-trifluoroacetyl-l-lysyl-l-proline-d-10-camphor sulfonic acid salt and production thereof
JPH01254651A (ja) * 1988-04-04 1989-10-11 Kanegafuchi Chem Ind Co Ltd Ｎ↑２−（１−カルボキシ−３−フエニルプロピル）−ｌ−リジン誘導体及び該化合物を用いるリジノプリルの製造法
US5227497A (en) * 1988-04-04 1993-07-13 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Process for preparing N2 -(1-carboxy-3-phenylpropyl)-L-lysine derivative
DE4123248C2 (de) * 1991-07-13 1996-03-07 Degussa Verfahren zur Herstellung von N-substituierten alpha-Aminosäuren und alpha-Aminosäure-Derivaten
SI9200213A (en) * 1992-09-16 1994-03-31 Krka Process for preparing alkyl-l-alanil-l-proline derivates
DE69332738T2 (de) * 1993-01-08 2003-10-02 Kanegafuchi Kagaku Kogyo K.K., Osaka Verfahren zur kristallisation von n2-((s)-1-ethoxycarbonyl-3-phenylpropyl)-n6-trifluoracetyl-l-lysyl-l-prolin
DE4331540A1 (de) * 1993-09-17 1995-03-23 Degussa Verfahren zur Reinigung von 1-[N·2·-((S)-Ethoxycarbonyl)-3-phenylpropyl)-N·6·-trifluoracetyl]-L-lysyl-L-prolin (Lisinopril(Tfa)ethylester)

Also Published As

Publication number Publication date
EP0645398A1 (de) 1995-03-29
EP1243594A1 (de) 2002-09-25
EP1243594B1 (de) 2004-05-12
US5801251A (en) 1998-09-01
EP0645398A4 (de) 1998-01-07
DE69332738T2 (de) 2003-10-02
US5519146A (en) 1996-05-21
DE69333521D1 (de) 2004-06-17
WO1994015957A1 (en) 1994-07-21
EP0645398B1 (de) 2003-03-05
JP3511519B2 (ja) 2004-03-29
DE69333521T2 (de) 2004-09-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee