DE69603255D1 - Verfahren zur modifizierung von oberflächen - Google Patents

Verfahren zur modifizierung von oberflächen

Info

Publication number
DE69603255D1
DE69603255D1 DE69603255T DE69603255T DE69603255D1 DE 69603255 D1 DE69603255 D1 DE 69603255D1 DE 69603255 T DE69603255 T DE 69603255T DE 69603255 T DE69603255 T DE 69603255T DE 69603255 D1 DE69603255 D1 DE 69603255D1
Authority
DE
Germany
Prior art keywords
modifying surfaces
modifying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69603255T
Other languages
English (en)
Other versions
DE69603255T2 (de
Inventor
Lary Sirvio
Barbara Swenson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Terumo Cardiovascular Systems Corp
Original Assignee
Minnesota Mining and Manufacturing Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minnesota Mining and Manufacturing Co filed Critical Minnesota Mining and Manufacturing Co
Publication of DE69603255D1 publication Critical patent/DE69603255D1/de
Application granted granted Critical
Publication of DE69603255T2 publication Critical patent/DE69603255T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0094—Physical treatment, e.g. plasma treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/0427—Coating with only one layer of a composition containing a polymer binder
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/04—Coating
    • C08J7/043—Improving the adhesiveness of the coatings per se, e.g. forming primers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2479/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen, or carbon only, not provided for in groups C08J2461/00 - C08J2477/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Materials Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Materials For Medical Uses (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
DE69603255T 1995-02-01 1996-01-16 Verfahren zur modifizierung von oberflächen Expired - Lifetime DE69603255T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/381,754 US5532311A (en) 1995-02-01 1995-02-01 Process for modifying surfaces
PCT/US1996/000436 WO1996023835A1 (en) 1995-02-01 1996-01-16 Process for modifying surfaces

Publications (2)

Publication Number Publication Date
DE69603255D1 true DE69603255D1 (de) 1999-08-19
DE69603255T2 DE69603255T2 (de) 2000-04-06

Family

ID=23506233

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69603255T Expired - Lifetime DE69603255T2 (de) 1995-02-01 1996-01-16 Verfahren zur modifizierung von oberflächen

Country Status (7)

Country Link
US (1) US5532311A (de)
EP (1) EP0807141B1 (de)
JP (1) JPH10513074A (de)
AU (1) AU4698396A (de)
CA (1) CA2210921A1 (de)
DE (1) DE69603255T2 (de)
WO (1) WO1996023835A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5679659A (en) * 1995-08-22 1997-10-21 Medtronic, Inc. Method for making heparinized biomaterials
AU724068B2 (en) * 1996-05-02 2000-09-14 Commonwealth Scientific And Industrial Research Organisation Surface modification of polymers
FR2758990B1 (fr) 1996-09-19 1999-05-28 Hospal Ind Appareil pour le traitement du sang par circulation extracorporelle et procede de fabrication
NL1004538C2 (nl) * 1996-11-14 1998-05-25 Cordis Europ Matrixmateriaal met meerdere biologisch actieve stoffen.
US5997818A (en) * 1997-02-27 1999-12-07 Minnesota Mining And Manufacturing Company Cassette for tonometric calibration
US6197289B1 (en) 1997-07-01 2001-03-06 Terumo Cardiovascular Systems Corporation Removal of biologically active agents
US6146771A (en) 1997-07-01 2000-11-14 Terumo Cardiovascular Systems Corporation Process for modifying surfaces using the reaction product of a water-insoluble polymer and a polyalkylene imine
US6159232A (en) 1997-12-16 2000-12-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US6478808B2 (en) 1997-12-17 2002-11-12 Closys Corporation Clotting cascade initiating apparatus and methods of use and methods of closing wounds
US20030069601A1 (en) * 1998-12-15 2003-04-10 Closys Corporation Clotting cascade initiating apparatus and methods of use
US6340465B1 (en) 1999-04-12 2002-01-22 Edwards Lifesciences Corp. Lubricious coatings for medical devices
US6409883B1 (en) 1999-04-16 2002-06-25 Kimberly-Clark Worldwide, Inc. Methods of making fiber bundles and fibrous structures
AU5311700A (en) 1999-06-01 2000-12-28 Closys Corporation Clotting cascade initiating apparatus and methods of use
US6309660B1 (en) 1999-07-28 2001-10-30 Edwards Lifesciences Corp. Universal biocompatible coating platform for medical devices
US6929944B2 (en) * 2001-08-31 2005-08-16 Beckman Coulter, Inc. Analysis using a distributed sample
US8142844B2 (en) 2003-09-17 2012-03-27 Gambro Lundia Ab Separating material
US8496953B2 (en) * 2006-05-12 2013-07-30 W. L. Gore & Associates, Inc. Immobilized biologically active entities having a high degree of biological activity following sterilization
US8021677B2 (en) * 2006-05-12 2011-09-20 Gore Enterprise Holdings, Inc. Immobilized biologically active entities having a high degree of biological activity
US9114194B2 (en) * 2006-05-12 2015-08-25 W. L. Gore & Associates, Inc. Immobilized biologically active entities having high biological activity following mechanical manipulation
US20080279909A1 (en) * 2006-05-12 2008-11-13 Cleek Robert L Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization
US8986713B2 (en) * 2006-05-12 2015-03-24 W. L. Gore & Associates, Inc. Medical device capable of being compacted and expanded having anti-thrombin III binding activity
AU2012203521B2 (en) * 2007-11-09 2014-12-18 W. L. Gore & Associates, Inc. Immobilized biologically active entities having a high degree of biological activity
US8591932B2 (en) * 2009-09-17 2013-11-26 W. L. Gore & Associates, Inc. Heparin entities and methods of use
EP2542889B1 (de) * 2010-03-03 2015-03-25 3M Innovative Properties Company Ligandenfunktionalisierte guanidinyl-polymere
US10231721B2 (en) 2010-06-24 2019-03-19 St. Croix Surgical Systems, Llc Failsafe percutaneous wound barrier
EP2585541B1 (de) 2010-06-25 2016-06-08 3M Innovative Properties Company Semiinterpenetrierendes polymernetzwerk
KR101819873B1 (ko) 2010-07-30 2018-01-17 노파르티스 아게 가교된 친수성 코팅을 갖는 실리콘 히드로겔 렌즈
EP3375462B1 (de) 2011-03-11 2023-06-07 W. L. Gore & Associates, Inc. Verbesserungen an immobilisierten biologischen einheiten
MY164605A (en) 2011-10-12 2018-01-30 Novartis Ag Method for making uv-absorbing ophthalmic lenses
EP2932314B1 (de) 2012-12-17 2017-02-01 Novartis AG Verfahren zur herstellung von uv-licht-absorbierenden brillengläsern
WO2015009431A1 (en) * 2013-07-19 2015-01-22 Rarecyte, Inc. Solution and method for adhering suspension components to a substrate
KR101851960B1 (ko) 2013-11-28 2018-04-25 도레이 카부시키가이샤 항혈전성 재료
EP3083216B1 (de) 2013-12-17 2018-01-31 Novartis AG Silikonhydrogellinse mit vernetzter hydrophiler beschichtung
SG10201901379TA (en) 2014-08-26 2019-03-28 Novartis Ag Method for applying stable coating on silicone hydrogel contact lenses
WO2016089966A1 (en) * 2014-12-02 2016-06-09 Rarecyte, Inc. Solution and method for adhering suspension components to a substrate
MY184638A (en) 2015-12-15 2021-04-13 Alcon Inc Method for applying stable coating on silicone hydrogel contact lenses
EP4233989A3 (de) 2017-06-07 2023-10-11 Shifamed Holdings, LLC Intravaskuläre fluidbewegungsvorrichtungen, systeme und verwendungsverfahren
WO2019094963A1 (en) 2017-11-13 2019-05-16 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
US11256003B2 (en) 2017-12-13 2022-02-22 Alcon Inc. Weekly and monthly disposable water gradient contact lenses
CN117959583A (zh) 2018-02-01 2024-05-03 施菲姆德控股有限责任公司 血管内血泵以及使用和制造方法
US20220062513A1 (en) 2019-01-30 2022-03-03 Toray Industries, Inc. Medical base material for indwelling cardiovascular device
JP2022540616A (ja) 2019-07-12 2022-09-16 シファメド・ホールディングス・エルエルシー 血管内血液ポンプならびに製造および使用の方法
WO2021016372A1 (en) 2019-07-22 2021-01-28 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US11724089B2 (en) 2019-09-25 2023-08-15 Shifamed Holdings, Llc Intravascular blood pump systems and methods of use and control thereof
CN116333426B (zh) * 2022-12-22 2024-01-09 广州敬信高聚物科技有限公司 一种充电桩电缆用防水低介电热塑性弹性体绝缘料及其制备方法

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2016962A (en) * 1932-09-27 1935-10-08 Du Pont Process for producing glucamines and related products
US2918462A (en) * 1956-01-20 1959-12-22 Ciba Pharm Prod Inc Process for the preparation of amino-aldehydes
US3096602A (en) * 1962-01-05 1963-07-09 Dow Chemical Co Packaging method
SE306597B (de) * 1964-12-17 1968-12-02 Incentive Ab
US3453194A (en) * 1966-08-03 1969-07-01 Dow Corning Anticoagulant surfaces produced by radiation grafting heparin to a silicone substrate
US3617344A (en) * 1966-08-05 1971-11-02 Us Health Education & Welfare Nonthrombogenic plastic surfaces and preparation thereof
US3475358A (en) * 1967-10-31 1969-10-28 Amicon Corp Anti-thrombogenic material
US3639141A (en) * 1968-09-16 1972-02-01 Cordis Corp Heparinization of plastic
US3616935A (en) * 1970-02-05 1971-11-02 Dow Chemical Co Preparation of antithrombogenic surfaces
US3796634A (en) * 1970-03-19 1974-03-12 Us Health Education & Welfare Insolubilized biologically active enzymes
FR2087506A5 (de) * 1970-05-21 1971-12-31 Rhone Poulenc Sa
US3846353A (en) * 1970-06-08 1974-11-05 Department Of Health Education Nonthrombogenic plastic material and method for making the same
US3853804A (en) * 1970-08-14 1974-12-10 California Inst Of Techn Ionic block elastomeric polymers
US3673612A (en) * 1970-08-28 1972-07-04 Massachusetts Inst Technology Non-thrombogenic materials and methods for their preparation
DE2148011C3 (de) * 1970-10-05 1978-11-09 Aminkemi Ab Verfahren zum Herstellen nichtthrombogener Kunststoffoberflächen
US4265827A (en) * 1971-03-08 1981-05-05 Monsanto Company Catalytic asymmetric hydrogenation
US3826678A (en) * 1972-06-06 1974-07-30 Atomic Energy Commission Method for preparation of biocompatible and biofunctional materials and product thereof
US3947352A (en) * 1974-05-31 1976-03-30 Pedro Cuatrecasas Polysaccharide matrices for use as adsorbents in affinity chromatography techniques
GB1495746A (en) * 1974-07-05 1977-12-21 Ciba Geigy Ag Polymerisation of unsaturated amides
US4001583A (en) * 1974-10-04 1977-01-04 Barrett M James Covalently bound biological substances to plastic materials and use in radioassay
SE400173B (sv) * 1975-03-20 1978-03-20 Aminkemi Ab Forfarande vid stabilisering av en hepariniserad yta innehallande vid blodkontakt utlosbart heparin
US4102746A (en) * 1975-08-29 1978-07-25 Amerace Corporation Immobilized proteins
FR2324664A1 (fr) * 1975-09-22 1977-04-15 Rhone Poulenc Ind Polyurethanes pour objets a usage medical
CA1083508A (fr) * 1975-11-13 1980-08-12 Jacques Grange Supports porteurs de chaines laterales, procedes d'obtention de ces supports, procedes de fixation de composes organiques comportant un residu glucidique sur lesdits supports, produits et reactifs resultant de ladite fixation chimique
US4048064A (en) * 1976-04-23 1977-09-13 Clark Iii William T Biocompatible hemoperfusion system
US4349467A (en) * 1977-01-31 1982-09-14 Williams Joel L Nonthrombogenic articles and method of preparation
US4116898A (en) * 1977-01-31 1978-09-26 Becton, Dickinson And Company Non-thrombogenic articles
JPS5413694A (en) * 1977-07-01 1979-02-01 Sumitomo Electric Industries Composite blood vessel prosthesis and method of producing same
SE425372B (sv) * 1977-07-18 1982-09-27 Ird Biomaterial Ab Sett att heparinisera en elektriskt laddad yta pa en medecinsk artikel avsedd att komma i kontakt med blod och medel for utforande av settet
US4239664A (en) * 1978-10-31 1980-12-16 Research Corporation Anti-thrombogenic PVP-heparin polymer
US4238813A (en) * 1979-05-21 1980-12-09 The Bendix Corporation Compensated dual injector driver
US4301067A (en) * 1979-06-05 1981-11-17 Kureha Kagaku Kogyo Kabushiki Kaisha Chitin containing poly-ion complex
US4329383A (en) * 1979-07-24 1982-05-11 Nippon Zeon Co., Ltd. Non-thrombogenic material comprising substrate which has been reacted with heparin
US4268423A (en) * 1979-11-16 1981-05-19 Uop Inc. Support matrices for immobilized enzymes
US4331697A (en) * 1980-09-02 1982-05-25 Teijin Limited Novel heparin derivative, method for production thereof, and method for rendering biomedical materials antithrombotic by use of the novel heparin derivative
CA1160548A (en) * 1980-09-24 1984-01-17 Rolf L. Larsson Method for detecting proteolytic enzymes in blood
US4326532A (en) * 1980-10-06 1982-04-27 Minnesota Mining And Manufacturing Company Antithrombogenic articles
US4424346A (en) * 1981-06-04 1984-01-03 Canadian Patents And Development Ltd. Derivatives of chitins, chitosans and other polysaccharides
US4350806A (en) * 1981-09-28 1982-09-21 Akzona Incorporated Biocompatible copolymers
US4526714A (en) * 1982-12-13 1985-07-02 Cordis Europa N.V. Conjugates of anticoagulant and protein
SE8200751L (sv) * 1982-02-09 1983-08-10 Olle Larm Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter
SE456347B (sv) * 1982-02-09 1988-09-26 Ird Biomaterial Ab Ytmodifierat fast substrat samt forfarande for framstellning derav
US5258041A (en) * 1982-09-29 1993-11-02 Bio-Metric Systems, Inc. Method of biomolecule attachment to hydrophobic surfaces
US5217492A (en) * 1982-09-29 1993-06-08 Bio-Metric Systems, Inc. Biomolecule attachment to hydrophobic surfaces
US4613517A (en) * 1983-04-27 1986-09-23 Becton, Dickinson And Company Heparinization of plasma treated surfaces
EP0124676A1 (de) * 1983-05-04 1984-11-14 IRD-Biomaterial AB Oberflächlich modifiziertes festes Substrat und Verfahren zu dessen Herstellung
US4521564A (en) * 1984-02-10 1985-06-04 Warner-Lambert Company Covalent bonded antithrombogenic polyurethane material
DE3582754D1 (de) * 1984-06-04 1991-06-13 Terumo Corp Medizinisches werkzeug und verfahren zur herstellung.
US4642242A (en) * 1985-04-01 1987-02-10 Becton, Dickinson And Company Permanently bonded antithrombogenic polyurethane surface
US4600652A (en) * 1985-04-01 1986-07-15 Warner-Lambert Company Permanently bonded antithrombogenic polyurethane surface
DE3519011A1 (de) * 1985-05-25 1986-11-27 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines materials zur affinitaetschromatographie
CH665954A5 (fr) * 1985-07-08 1988-06-30 Battelle Memorial Institute Substrat dont la surface presente une activite antithrombogenique.
JPS6238172A (ja) * 1985-08-12 1987-02-19 株式会社　高研 抗血栓性医用材料の製造方法
IT1213023B (it) * 1986-01-16 1989-12-07 Rolando Barbucci Materiale capace di adsorbire stabilmente elevate quantita' di eparina, e suo procedimento di preparazione.
US4786556A (en) * 1986-03-24 1988-11-22 Becton, Dickinson And Company Polymeric articles having enhanced antithrombogenic activity
US4720512A (en) * 1986-03-24 1988-01-19 Becton, Dickinson And Company Polymeric articles having enhanced antithrombogenic activity
AU615637B2 (en) * 1986-10-17 1991-10-10 Surmodics, Inc. Improvement of the biocompatibility of solid surfaces
NL8701337A (nl) * 1987-06-09 1989-01-02 Sentron V O F Substraat voorzien van een bloedcompatibel oppervlak, verkregen door koppeling aan het oppervlak van een fysiologisch aktieve stof met remmende invloed op de vorming van bloedstolsels en/of in staat om gevormde bloedstolsels af te breken, alsmede werkwijze ter vervaardiging van het substraat.
GB8714214D0 (en) * 1987-06-17 1987-07-22 Jack Flooring Co Ltd Floor panel support system
DD276814A1 (de) * 1987-06-29 1990-03-14 Dummerstorf Rostock Tierprod Verfahren zur herstellung einer affinitaetsmatrix fuer die trennung biologischer substanzen
US5047020A (en) * 1987-09-14 1991-09-10 Baxter International Inc. Ionic heparin coating
JP2561309B2 (ja) * 1988-03-28 1996-12-04 テルモ株式会社 医療用材料およびその製造方法
US5013717A (en) * 1988-04-18 1991-05-07 Becton, Dickinson And Company Blood compatible, lubricious article and composition and method therefor
US5182317A (en) * 1988-06-08 1993-01-26 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US4865870A (en) * 1988-07-07 1989-09-12 Becton, Dickinson And Company Method for rendering a substrate surface antithrombogenic
US5053048A (en) * 1988-09-22 1991-10-01 Cordis Corporation Thromboresistant coating
US5049403A (en) * 1989-10-12 1991-09-17 Horsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5213898A (en) * 1989-10-12 1993-05-25 Norsk Hydro A.S. Process for the preparation of surface modified solid substrates
US5219926A (en) * 1989-12-29 1993-06-15 Berol Nobel Ab Method of covalently bonding biopolymer to a solid hydrophilic organic polymer
GB9009570D0 (en) * 1990-04-27 1990-06-20 Biocompatibles Ltd Antithrombogenic polymers
ATE168269T1 (de) * 1990-07-12 1998-08-15 Sts Biopolymers Inc Antithrombogene und/oder antimikrobielle zusammensetzung
SE466754B (sv) * 1990-09-13 1992-03-30 Berol Nobel Ab Saett att kovalent binda biopolymerer till hydrofila ytor
SE467309B (sv) * 1990-10-22 1992-06-29 Berol Nobel Ab Hydrofiliserad fast yta, foerfarande foer dess framstaellning samt medel daerfoer
SE467308B (sv) * 1990-10-22 1992-06-29 Berol Nobel Ab Fast yta belagd med ett hydrofilt ytterskikt med kovalent bundna biopolymerer, saett att framstaella en saadan yta och ett konjugat daerfoer
US5132108A (en) * 1990-11-08 1992-07-21 Cordis Corporation Radiofrequency plasma treated polymeric surfaces having immobilized anti-thrombogenic agents
US5159050A (en) * 1991-05-09 1992-10-27 Becton, Dickinson And Company Polyurethane and medical article therefrom
WO1993005825A1 (en) * 1991-09-20 1993-04-01 Baxter International Inc. Processes for reducing the thrombogenicity of biomaterials
SE470006B (sv) * 1991-09-26 1993-10-25 Corline Systems Ab Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet
US5145956A (en) * 1991-12-11 1992-09-08 Glycomed Incorporated Method for separation of anionic oligosaccharides
US5308641A (en) * 1993-01-19 1994-05-03 Medtronic, Inc. Biocompatibility of solid surfaces

Also Published As

Publication number Publication date
EP0807141B1 (de) 1999-07-14
AU4698396A (en) 1996-08-21
JPH10513074A (ja) 1998-12-15
EP0807141A1 (de) 1997-11-19
CA2210921A1 (en) 1996-08-08
MX9705643A (es) 1997-10-31
WO1996023835A1 (en) 1996-08-08
US5532311A (en) 1996-07-02
DE69603255T2 (de) 2000-04-06

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