ATE79368T1 - Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate. - Google Patents

Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate.

Info

Publication number
ATE79368T1
ATE79368T1 AT88904526T AT88904526T ATE79368T1 AT E79368 T1 ATE79368 T1 AT E79368T1 AT 88904526 T AT88904526 T AT 88904526T AT 88904526 T AT88904526 T AT 88904526T AT E79368 T1 ATE79368 T1 AT E79368T1
Authority
AT
Austria
Prior art keywords
tribromo
pct
triiodo
acylamino
preparation
Prior art date
Application number
AT88904526T
Other languages
English (en)
Inventor
Ernest Felder
Carlo Musu
Luciano Fumagalli
Fulvio Uggeri
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT20647/87A external-priority patent/IT1205029B/it
Priority claimed from IT8847935A external-priority patent/IT1219934B/it
Application filed by Bracco Spa filed Critical Bracco Spa
Application granted granted Critical
Publication of ATE79368T1 publication Critical patent/ATE79368T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT88904526T 1987-05-22 1988-05-20 Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate. ATE79368T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IT20647/87A IT1205029B (it) 1987-05-22 1987-05-22 Processo per la preparazione di derivati dell'acido 5-acilamino-2,4,6-triiodo o tribromo-benzoico e corrispondenti nuovi derivati dell'acido 5-acilamino-2,4,6-triioco o tribromo-benzzoico,ottenuti con tale processo
IT8847935A IT1219934B (it) 1988-05-05 1988-05-05 Processo per la preparazione di derivati dell' acido 5-acilamino-2,4,6-triiodo o tribromo-brenzoico e corrispondenti derivati dell' acido 5-acilamino-2,4,6-triiodo o tribromo-benzoico,ottenuti con tale processo
PCT/EP1988/000453 WO1988009328A1 (en) 1987-05-22 1988-05-20 Preparation of 5-acylamino-2,4,6-triiodo- or tribromo-benzoic acid derivatives
EP88904526A EP0365541B1 (de) 1987-05-22 1988-05-20 Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesäure-derivate

Publications (1)

Publication Number Publication Date
ATE79368T1 true ATE79368T1 (de) 1992-08-15

Family

ID=26327605

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88904526T ATE79368T1 (de) 1987-05-22 1988-05-20 Herstellung von 5-acylamino-2,4,6-trijodo- oder tribromo-benzoesaeure-derivate.

Country Status (13)

Country Link
US (1) US5066823A (de)
EP (1) EP0365541B1 (de)
JP (1) JP2585087B2 (de)
KR (1) KR960016747B1 (de)
AT (1) ATE79368T1 (de)
AU (1) AU618535B2 (de)
CA (1) CA1327600C (de)
DE (1) DE3873766T2 (de)
ES (1) ES2006951A6 (de)
IE (1) IE63232B1 (de)
IL (1) IL86450A (de)
NZ (1) NZ224743A (de)
WO (1) WO1988009328A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8717625D0 (en) * 1987-07-24 1987-09-03 Nycomed As Chemical compounds
WO1989008101A1 (en) * 1988-03-01 1989-09-08 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
ATE123018T1 (de) * 1988-04-06 1995-06-15 Mallinckrodt Inc Verfahren zur herstellung von 2,4,6-triiodo-5- amino-n-alkyl-isophthalsäure.
IL90326A (en) * 1988-06-02 1993-05-13 Guerbet Sa Non-ionic triiodobenzene compounds and contrast media containing them
FR2643077B1 (fr) * 1989-01-23 1991-10-31 Guerbet Sa Nouveaux composes non ioniques iodes et produits de contraste les contenant
US5614638A (en) * 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
US5075502A (en) * 1989-12-13 1991-12-24 Mallinckrodt, Inc. Nonionic x-ray contrast agents, compositions and methods
US5191120A (en) * 1989-12-13 1993-03-02 Mallinckrodt Medical, Inc. Process for preparing nonionic X-ray contrast agents
US5019371A (en) * 1990-11-21 1991-05-28 Mallinckrodt Medical, Inc. Novel x-ray contrast agents, compositions and methods
US5356613A (en) * 1991-03-18 1994-10-18 Mallinckrodt Medical, Inc. X-ray contrast agents, compositions and methods
DE4109169A1 (de) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz Wasserloesliche nicht ionische roentgenkontrastmittel sowie mittel und verfahren zu ihrer herstellung
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
IT1274027B (it) * 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
GB9419206D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
IT1271134B (it) * 1994-12-01 1997-05-26 Bracco Spa Derivati iodurati del bifenile e loro impiego diagnostico
EP0842141A1 (de) * 1995-07-04 1998-05-20 RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY Verfahren zur herstellung von iopamidol unter mitverwendung von c1-c5 monoalkylether vom c2-c10 alkylenglycol
IT1277339B1 (it) * 1995-07-25 1997-11-10 Bracco Spa Processo per la produzione di agenti contrastografici iodurati
IT1303797B1 (it) 1998-11-27 2001-02-23 Bracco Spa Processo per la preparazione di n,n'-bis(2,3-diidrossipropil)-5-((idrossiacetil)metilammino)-2,4,6-triiodo-1,3-benzendicarbossammide.
EP1186305A1 (de) * 2000-09-07 2002-03-13 Schering Aktiengesellschaft Neue bromierte Verbindungen als Kontrastmedien für Röntgenmammography
WO2002034712A1 (fr) * 2000-10-27 2002-05-02 Takeda Chemical Industries, Ltd. Procede de preparation de composes aromatiques substitues et produits intermediaires associes
JP5340281B2 (ja) * 2007-07-12 2013-11-13 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
EP2093206A1 (de) 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Verfahren zur Iodierung aromatischer Verbindungen
EP2243767A1 (de) 2009-04-21 2010-10-27 Bracco Imaging S.p.A Verfahren zur Iodierung aromatischer Verbindungen
ES2443149T3 (es) 2009-07-07 2014-02-18 Bracco Imaging Spa Proceso para la preparación de un agente de yodación
EP2394984A1 (de) 2010-06-10 2011-12-14 Bracco Imaging S.p.A Verfahren zur Iodinierung von Phenol-Derivaten
CN107253918A (zh) * 2017-07-27 2017-10-17 成都丽璟科技有限公司 一种制备碘美普尔的新方法
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법
WO2023209165A1 (en) 2022-04-29 2023-11-02 Bracco Imaging Spa Process for the preparation of 2,4,6-triiodophenol derivatives

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL34803A (en) * 1969-06-27 1975-03-13 Nyegaard & Co As N-hydroxyalkyl substituted benzamides and iodo methanesulfonamide and radiological compositions containing them
US3660464A (en) * 1970-06-19 1972-05-02 Squibb & Sons Inc Tri-iodinated diaminobenzoic acid derivatives
BE787669A (fr) * 1971-08-17 1973-02-19 Schering Ag Anilides d'acide n-methyl-dicarboxylique triiodes, et leur procede de preparation
DD104193A5 (de) * 1972-12-22 1974-03-05
CH583562A5 (de) * 1973-07-17 1977-01-14 Bracco Ind Chimica Spa
US4065553A (en) * 1974-05-31 1977-12-27 Laboratoires Andre Guerbet X-Ray contrast media
CH608189A5 (de) * 1974-12-13 1978-12-29 Savac Ag
US4321368A (en) * 1975-10-20 1982-03-23 Mallinckrodt, Inc. Glycosyl triidobenzoic acid derivatives
DE2629228C2 (de) * 1976-06-25 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung
US4191775A (en) * 1977-12-15 1980-03-04 Imperial Chemical Industries Limited Amide derivatives
DE2852094A1 (de) * 1978-11-30 1980-06-12 Schering Ag Neue roentgenkontrastmittel
IT1193211B (it) * 1979-08-09 1988-06-15 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3150916A1 (de) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-hydroxyaethylierte 2,4,6-trijodaminoisiophthalsaeure-bis- trihydroxybutylamide, deren herstellung und diese enthaltende roentgenkontrastmittel"
US4396598A (en) * 1982-01-11 1983-08-02 Mallinckrodt, Inc. Triiodoisophthalamide X-ray contrast agent
FR2541272A1 (fr) * 1983-02-23 1984-08-24 Guerbet Sa Composes bromes et produits opacifiants en contenant
DE3429949A1 (de) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue nicht -ionische 2,4,6-trijod-isophthalsaeure-bis-amide, verfahren zu ihrer herstellung und ihre verwendung als roentgenkontrastmittel
US4567034A (en) * 1984-09-07 1986-01-28 E. R. Squibb & Sons, Inc. Esters of diatrizoic acid as X-ray contrast agents

Also Published As

Publication number Publication date
CA1327600C (en) 1994-03-08
AU618535B2 (en) 1992-01-02
ES2006951A6 (es) 1989-05-16
IL86450A0 (en) 1988-11-15
KR960016747B1 (ko) 1996-12-20
US5066823A (en) 1991-11-19
AU1797888A (en) 1988-12-21
DE3873766T2 (de) 1993-02-11
JPH02503556A (ja) 1990-10-25
WO1988009328A1 (en) 1988-12-01
NZ224743A (en) 1991-07-26
JP2585087B2 (ja) 1997-02-26
EP0365541A1 (de) 1990-05-02
IE63232B1 (en) 1995-04-05
KR890701547A (ko) 1989-12-20
DE3873766D1 (de) 1992-09-17
IE881518L (en) 1988-11-22
IL86450A (en) 1994-05-30
EP0365541B1 (de) 1992-08-12

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time