MX9101595A - Preparacion para liberar en forma prolongada un medicamento y polimero su obtencion - Google Patents

Preparacion para liberar en forma prolongada un medicamento y polimero su obtencion

Info

Publication number
MX9101595A
MX9101595A MX9101595A MX9101595A MX9101595A MX 9101595 A MX9101595 A MX 9101595A MX 9101595 A MX9101595 A MX 9101595A MX 9101595 A MX9101595 A MX 9101595A MX 9101595 A MX9101595 A MX 9101595A
Authority
MX
Mexico
Prior art keywords
preparation
polymer
release
obtaining
medicinal product
Prior art date
Application number
MX9101595A
Other languages
English (en)
Inventor
Minoru Yamada
Seiko Ishiguro
Yasuaki Ogawa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of MX9101595A publication Critical patent/MX9101595A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/745—Polymers of hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
MX9101595A 1990-10-16 1991-10-15 Preparacion para liberar en forma prolongada un medicamento y polimero su obtencion MX9101595A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27803790 1990-10-16
JP21704591 1991-08-28

Publications (1)

Publication Number Publication Date
MX9101595A true MX9101595A (es) 1992-06-05

Family

ID=26521778

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9101595A MX9101595A (es) 1990-10-16 1991-10-15 Preparacion para liberar en forma prolongada un medicamento y polimero su obtencion

Country Status (24)

Country Link
US (1) US5304377A (es)
EP (1) EP0481732B1 (es)
JP (1) JP3196035B2 (es)
KR (1) KR100199119B1 (es)
CN (2) CN1043189C (es)
AT (1) ATE119035T1 (es)
AU (1) AU644019B2 (es)
CA (1) CA2053468C (es)
DE (1) DE69107773T2 (es)
DK (1) DK0481732T3 (es)
EE (1) EE02958B1 (es)
ES (1) ES2069221T3 (es)
FI (1) FI101454B (es)
GE (1) GEP19981287B (es)
IE (1) IE66705B1 (es)
LT (1) LT3277B (es)
LV (1) LV10055B (es)
MX (1) MX9101595A (es)
NO (1) NO302481B1 (es)
NZ (1) NZ240214A (es)
PT (1) PT99236B (es)
RU (1) RU2103005C1 (es)
UA (1) UA27707C2 (es)
ZA (1) ZA918168B (es)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US6005067A (en) * 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6005068A (en) * 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
EP0624212B1 (en) * 1992-10-02 1998-11-18 Cargill, Incorporated Paper having a melt-stable lactide polymer coating and process for manufacture thereof
BR9305661A (pt) * 1992-10-02 1996-11-26 Cargill Inc Pano de polímero de lactideo estável em fusao e processo para a sua fabricaçao
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
UA61046C2 (en) * 1992-12-07 2003-11-17 Takeda Chemical Industries Ltd Sustained-release preparation and method for its manufacture
US5886026A (en) * 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
CA2468375A1 (en) 1993-07-19 1995-02-02 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions, uses and methods
US5424289A (en) * 1993-07-30 1995-06-13 Alza Corporation Solid formulations of therapeutic proteins for gastrointestinal delivery
ATE178789T1 (de) * 1994-02-21 1999-04-15 Takeda Chemical Industries Ltd Polyester matrix für eine pharmazeutische zusammensetzung mit verzögerter freigabe
FR2718642B1 (fr) * 1994-04-15 1996-07-12 Pf Medicament Microsphères biodégradables à libération contrôlée et leur procédé de préparation.
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
JP2987064B2 (ja) * 1994-09-12 1999-12-06 グンゼ株式会社 人工硬膜
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
EP0753539B1 (en) * 1995-07-13 2001-10-10 Mitsubishi Gas Chemical Company, Inc. Aliphatic polyester polymer blends based on poly(lactic acid), methods for manufacturing the same, and methods for molding the same
EP0765660A3 (en) * 1995-09-28 1998-09-23 Takeda Chemical Industries, Ltd. Microcapsules comprising 2-piperazinone-1-acetic acid compounds
US5637085A (en) * 1995-11-20 1997-06-10 Cardinale; Robert M. Method of cancer tumor treatment by slow release delivery of 1,2,4-benzotriazine oxides to tumor site
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
FR2744367B1 (fr) * 1996-02-02 1999-07-09 Emperaire Jean Claude Medicaments pour le declenchement de l'ovulation
DK0889722T3 (da) * 1996-03-28 2003-02-10 Takeda Chemical Industries Ltd Præparat med forsinket frigivelse og fremstilling deraf
CA2255891C (en) 1996-05-24 2007-12-04 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing diseases of body passageways
JP4317599B2 (ja) * 1996-06-26 2009-08-19 武田薬品工業株式会社 徐放性製剤
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US7235524B2 (en) * 1997-01-31 2007-06-26 Applied Research System Ars Holding N.V. Medicaments for initiating ovulation
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
ATE279461T1 (de) 1997-04-03 2004-10-15 Guilford Pharm Inc Bioabbaubare terephthalat polyester-polyphosphat polymere, zusammensetzungen, gegenstände und verfahren für ihre herstellung und verwendung
US6051558A (en) * 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
US6162241A (en) * 1997-08-06 2000-12-19 Focal, Inc. Hemostatic tissue sealants
KR19990065921A (ko) * 1998-01-19 1999-08-16 김충섭 항생제의서방성제제
US6099859A (en) 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US6153212A (en) * 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
US6419709B1 (en) 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
GB2344287A (en) * 1998-12-03 2000-06-07 Ferring Bv Controlled release pharmaceutical formulation
JP2002532603A (ja) * 1998-12-15 2002-10-02 ヴオルフ・ヴアルスロデ・アクチエンゲゼルシヤフト 改良された加水分解安定性と改良された耐応力亀裂性を示す生分解性で熱可塑性の成形体
US6350464B1 (en) 1999-01-11 2002-02-26 Guilford Pharmaceuticals, Inc. Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
US6537585B1 (en) 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
JP2004516262A (ja) 2000-12-21 2004-06-03 ネクター セラピューティクス 親水性活性剤を含有するマイクロ粒子の製造のための誘発相転移法
CN1098883C (zh) * 2000-12-28 2003-01-15 武汉大学 分散度均匀的聚乳酸微球制备新方法
WO2003000156A1 (en) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
EP1411861B1 (en) 2001-06-29 2012-04-04 Medgraft Microtech, Inc. Biodegradable injectable implants and related methods of manufacture and use
JP2003192773A (ja) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc 生体吸収性ポリヒドロキシカルボン酸及びその製造法
AU2002367105A1 (en) * 2001-12-26 2003-07-15 Takeda Chemical Industries, Ltd. Novel microsphere and method for production thereof
US20040197301A1 (en) * 2003-02-18 2004-10-07 Zhong Zhao Hybrid polymers and methods of making the same
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US7645460B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of risedronate
US20080287400A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US20080286359A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US7645459B2 (en) 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
JP4599567B2 (ja) * 2004-10-20 2010-12-15 国立大学法人群馬大学 温度応答性デプシペプチドポリマー
CN1923281B (zh) * 2005-08-30 2010-05-05 孔庆忠 一种含植物生物碱的抗癌缓释注射剂
US8663674B2 (en) * 2006-01-13 2014-03-04 Surmodics, Inc. Microparticle containing matrices for drug delivery
EP2021045B1 (en) * 2006-05-31 2016-03-16 Baxter International Inc. Collagen for use in prevention of peridural fibrosis formation after spinal surgery
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
KR100845009B1 (ko) * 2007-08-07 2008-07-08 한국생명공학연구원 전하를 띠는 물질이 고착된 다공성 고분자 입자 및 그제조방법
CL2008003219A1 (es) 2007-10-30 2009-10-09 Baxter Int Uso de una biomatriz de colageno biofuncional, multicapas y no porosa, que dirige el crecimiento celular dentro de los intersticios de la biomatriz de colageno, para tratar un defecto de una membrana visceral o parietal; y biomatriz utilizada.
EP2259803B2 (en) 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
DK2442835T3 (en) * 2009-06-16 2015-03-16 Baxter Int Styptic sponge
JPWO2011024944A1 (ja) * 2009-08-31 2013-01-31 国立大学法人豊橋技術科学大学 ステレオコンプレックスポリエステル及びその製造方法
BR112012014773A2 (pt) * 2009-12-16 2015-11-03 Baxter Healthcare Sa esponja de compósito hemostática, método para fabricar uma esponja de compósito hemostática, e, uso da referida esponja
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
EP2575776B1 (en) 2010-06-01 2018-05-30 Baxter International Inc Process for making dry and stable hemostatic compositions
JP5973997B2 (ja) 2010-06-01 2016-08-23 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 乾燥した安定な止血用組成物を作製するためのプロセス
JP5968308B2 (ja) 2010-06-01 2016-08-10 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 乾燥した安定な止血用組成物を作成するためのプロセス
JP6147664B2 (ja) * 2010-07-26 2017-06-14 ユニベルシテ ドゥ ジュネーブ ２−ヒドロキシアルキル酸から調製されたポリマーを含む組成物
ES2938568T3 (es) 2011-10-11 2023-04-12 Baxter Int Composiciones hemostaticas
CN103957948B (zh) 2011-10-11 2016-10-26 巴克斯特国际公司 止血组合物
CN103889447B (zh) 2011-10-27 2015-11-25 巴克斯特国际公司 止血组合物
IN2014DN08122A (es) 2012-03-06 2015-05-01 Ferrosan Medical Devices As
EP2977066A3 (en) 2012-06-12 2016-07-27 Ferrosan Medical Devices A/S Dry haemostatic composition
BR112015030612B1 (pt) 2013-06-21 2020-07-21 Ferrosan Medical Devices A/S método para preparar uma composição seca
EP3079731B1 (en) 2013-12-11 2018-08-08 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
US11046818B2 (en) 2014-10-13 2021-06-29 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
CN107206165B (zh) 2014-12-24 2020-10-23 弗罗桑医疗设备公司 用于保持并混合第一和第二物质的注射器
US10918796B2 (en) 2015-07-03 2021-02-16 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
JP6148701B2 (ja) * 2015-07-31 2017-06-14 ユニベルシテ ドゥ ジュネーブ ２−ヒドロキシアルキル酸から調製されたポリマーを含む組成物
CN105111417A (zh) * 2015-08-25 2015-12-02 杭州铭众生物科技有限公司 一种羟基乙酸-羟基丙酸无规共聚物的制备方法
KR20210008479A (ko) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 지혈 조성물을 제조하는 방법

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US329526A (en) 1885-11-03 Coal-mining machine
US467719A (en) 1892-01-26 Dust-guard for car-axle journals
US368702A (en) 1887-08-23 bischoff
NO139560C (no) 1972-04-29 1979-04-04 Takeda Chemical Industries Ltd Analogifremgangsmaate til fremstilling av terapeutisk virksomme nonapeptidamid-derivater
JPS528375B2 (es) 1973-07-02 1977-03-09
FR2238700B1 (es) 1973-07-24 1977-10-14 Takeda Chemical Industries Ltd
AT347054B (de) 1973-09-29 1978-12-11 Takeda Chemical Industries Ltd Verfahren zur herstellung von neuen nonapeptidamid-derivaten
JPS5726506B2 (es) 1974-03-08 1982-06-04
BE847762A (fr) 1975-10-29 1977-02-14 Nouveaux nonapeptides et procedes pour les preparer,
US4093574A (en) 1977-02-02 1978-06-06 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4087390A (en) 1977-02-02 1978-05-02 Eli Lilly And Company Somatostatin analogs and intermediates thereto
JPS5944308B2 (ja) 1976-03-23 1984-10-29 武田薬品工業株式会社 ペプタイド
US4121577A (en) 1977-01-03 1978-10-24 Binder Timothy A Method and apparatus for aiding conditioning of an erect spinal column and advantageous muscle control
US4100117A (en) 1977-04-21 1978-07-11 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4253998A (en) 1979-03-09 1981-03-03 American Home Products Corporation Peptides related to somatostatin
US4277394A (en) 1979-04-23 1981-07-07 Takeda Chemical Industries, Ltd Tetrapeptidehydrazide derivatives
US4317815A (en) 1979-06-13 1982-03-02 Coy David Howard LH-RH Antagonists
US4622244A (en) * 1979-09-04 1986-11-11 The Washington University Process for preparation of microcapsules
US4253997A (en) 1979-12-17 1981-03-03 American Home Products Corporation Anti-ovulatory decapeptides
JPS5692846A (en) 1979-12-27 1981-07-27 Takeda Chem Ind Ltd Tetrapeptide derivative and its preparation
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3218151A1 (de) * 1982-05-14 1983-11-17 Akzo Gmbh, 5600 Wuppertal Mikroporoese, pulverfoermige polylactide und verfahren zu deren herstellung
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production
JPH0678425B2 (ja) 1984-07-06 1994-10-05 和光純薬工業株式会社 重合体の新規製造法
ATE61935T1 (de) * 1985-02-07 1991-04-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
JP2526589B2 (ja) * 1986-08-08 1996-08-21 武田薬品工業株式会社 ペプチド含有マイクロカプセルおよびその製造法
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
AU606383B2 (en) * 1987-03-06 1991-02-07 Research Triangle Institute Polymer blends for selective biodegradability
JPH0613602B2 (ja) * 1987-07-14 1994-02-23 三井東圧化学株式会社 ｄ▲ｌ▼−乳酸−グリコール酸共重合物の製造方法
US4897811A (en) 1988-01-19 1990-01-30 Nestor, Inc. N-dimensional coulomb neural network which provides for cumulative learning of internal representations
JP2827287B2 (ja) * 1988-07-05 1998-11-25 武田薬品工業株式会社 水溶性薬物含有徐放型マイクロカプセル
EP0359036B1 (en) 1988-09-01 1997-03-26 Takeda Chemical Industries, Ltd. Fumagillol derivatives
KR0141692B1 (ko) 1988-09-01 1998-06-01 우메모또 요시마사 맥관 형성 억제제
JPH02212436A (ja) * 1989-02-14 1990-08-23 Japan Atom Energy Res Inst 徐放性基剤
EP0415294A3 (en) 1989-08-31 1991-06-12 Takeda Chemical Industries, Ltd. Cyclohexanol derivatives, production and use thereof
CN2891061Y (zh) 2006-03-15 2007-04-18 鸿富锦精密工业（深圳）有限公司 一体式液晶电脑及其电脑主机

Also Published As

Publication number Publication date
DK0481732T3 (da) 1995-05-22
NO302481B1 (no) 1998-03-09
ES2069221T3 (es) 1995-05-01
NZ240214A (en) 1993-02-25
NO914032L (no) 1992-04-21
US5304377A (en) 1994-04-19
FI101454B1 (fi) 1998-06-30
FI914865A (fi) 1992-04-17
IE66705B1 (en) 1996-01-24
EE02958B1 (et) 1997-02-17
DE69107773D1 (de) 1995-04-06
IE913624A1 (en) 1992-04-22
CN1116212A (zh) 1996-02-07
CN1043189C (zh) 1999-05-05
JPH05112468A (ja) 1993-05-07
CA2053468A1 (en) 1992-04-17
FI101454B (fi) 1998-06-30
FI914865A0 (fi) 1991-10-15
AU8586491A (en) 1992-04-30
LV10055A (lv) 1994-05-10
PT99236B (pt) 1999-04-30
PT99236A (pt) 1992-09-30
RU2103005C1 (ru) 1998-01-27
JP3196035B2 (ja) 2001-08-06
ZA918168B (en) 1993-04-14
LTIP442A (en) 1994-11-25
LT3277B (en) 1995-05-25
KR100199119B1 (ko) 1999-06-15
KR920007632A (ko) 1992-05-27
CN1060851A (zh) 1992-05-06
DE69107773T2 (de) 1995-06-29
AU644019B2 (en) 1993-12-02
CN1057670C (zh) 2000-10-25
UA27707C2 (uk) 2000-10-16
EP0481732B1 (en) 1995-03-01
LV10055B (en) 1995-02-20
CA2053468C (en) 2002-07-09
GEP19981287B (en) 1998-09-01
EP0481732A1 (en) 1992-04-22
ATE119035T1 (de) 1995-03-15
NO914032D0 (no) 1991-10-14

Similar Documents

Publication Publication Date Title
MX9101595A (es) Preparacion para liberar en forma prolongada un medicamento y polimero su obtencion
IL111647A (en) Pharmaceutical compositions comprising microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles and their preparation
EP1207155A4 (en) DRUG COMPOSITIONS HAVING AGONIST THROMBOPOIETINE ACTIVITY
GB9930610D0 (en) Tricyclic vascular damaging agents
IE871733L (en) Amides
HUT50627A (en) Process for producing pharmaceutical compositions with controlled release
DE69200290D1 (de) Thienopyridin -Derivative und diese enthaltende Arzneimittel.
FI894899A0 (fi) Menetelmä dispergoituvan kiinteän lääkeainekoostumuksen valmistamiseksi
IL147417A0 (en) Sustained release compositions, methods for producing the same and uses thereof
ES2174930T3 (es) Composiciones de metronidazol de liberacion modificada y metodos para preparar y utilizar las mismas.
HUT61763A (en) Process for producing xanthine derivatives and pharmaceutical compositions comprising same as active ingredient, against disorders of cerebration
IE44030L (en) Ó-amino-ketones.
FI905814A0 (fi) Farmaceutiska produkter.
FR2677546B1 (fr) Composition therapeutique pour liberation prolonge de magnesium.
CA2416706A1 (en) Dementia remedies containing 2-aryl-8-oxodihydropurine derivatives as the active ingredient
FR2655042B1 (fr) Nouvelles benzothiazolinones substituees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
RU96123569A (ru) Лекарственный препарат
UA84678C2 (ru) Фармацевтической композиции модифицированного высвобождения соли производного манделовой кислоты и ее применение для лечения сердечнососудистых нарушений
SI9111154B (sl) Novi ergolinski derivati 2-propinilamina, postopek za njihovo pripravo in njihova uporaba za zdravila
IE40082B1 (en) O-pyrazolopyrimidine-thiono-phosphoric acid ester-amides, a praocess for their preparation and their use as insecticides and acaricides

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees