SI9111154B - Novi ergolinski derivati 2-propinilamina, postopek za njihovo pripravo in njihova uporaba za zdravila - Google Patents

Novi ergolinski derivati 2-propinilamina, postopek za njihovo pripravo in njihova uporaba za zdravila Download PDF

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Publication number
SI9111154B
SI9111154B SI9111154A SI9111154A SI9111154B SI 9111154 B SI9111154 B SI 9111154B SI 9111154 A SI9111154 A SI 9111154A SI 9111154 A SI9111154 A SI 9111154A SI 9111154 B SI9111154 B SI 9111154B
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Slovenia
Prior art keywords
methylergoline
didehydro
propynyl
carboxamide
general formula
Prior art date
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SI9111154A
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English (en)
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SI9111154A (en
Inventor
Rudolf Ručman
Bole-Vunduk
Magdalena Ocvirk
Bogomila Lavrič
Igor Krisch
Original Assignee
Lek
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Publication date
Application filed by Lek filed Critical Lek
Publication of SI9111154A publication Critical patent/SI9111154A/sl
Publication of SI9111154B publication Critical patent/SI9111154B/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (8)

1 SI 9111154 Patentni zahtevki 1. Ergolinski derivati 2-propinilamma s splošno formulo I
v kateri pomenijo Ri, R2 in R3 neodvisno drug od drugega atom vodika ali nerazvejeno ali razvejeno CrC6 alkilno skupino, X atom vodika ali halogena, Z karbonilno ali metilensko skupino in C9 ϋ: Cjo enojno ali dvojno vez, diastereomeme oblike in racemati in njihove kislinske adicijske soli.
2. 9,10-didehidro-N-(2'-propinil)-6-metilergolin-8 β-karboksamid.
3. 2-bromo-9,10-didehidro-N-(2'-propinil)-6-metilergolin-8 β-karboksamid.
4. 9,10-didehidro-N-metil-N-(2'-propinil)-6-metilergolin-8 β-karboksamid.
5. 2-bromo-9,10-didehidro-N-metil-N-(2'-propinil)-6-metilergolin-8 β-karboksamid.
6. δβ^είΐΙ-Ν-ιηείΐΙ-Ν-^'-ρΓορϊηί^-ό-ηιεΰΙε^οΙίη. 9
7. Farmacevtski sestavek, označen s tem, da obsega antidepresivno učinkovito količino spojine po zahtevku 1 ali njene kislinske adicijske soli skupaj s farmacevtsko sprejemljivimi nosilci.
8. Farmacevtski sestavek, označen s tem, da obsega anksiolitično učinkovito količino spojine po zahtevku 1 ali njene kislinske adicijske soli skupaj s farmacevtsko sprejemljivimi nosilci.
SI9111154A 1991-07-01 1991-07-01 Novi ergolinski derivati 2-propinilamina, postopek za njihovo pripravo in njihova uporaba za zdravila SI9111154B (sl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU115491A YU48687B (sh) 1991-07-01 1991-07-01 Novi ergolinski derivati 2-propinilamina i postupak za njihovo pripremanje

Publications (2)

Publication Number Publication Date
SI9111154A SI9111154A (en) 1995-04-30
SI9111154B true SI9111154B (sl) 1999-12-31

Family

ID=25552993

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9111154A SI9111154B (sl) 1991-07-01 1991-07-01 Novi ergolinski derivati 2-propinilamina, postopek za njihovo pripravo in njihova uporaba za zdravila

Country Status (4)

Country Link
US (1) US5288724A (sl)
JP (1) JPH06206878A (sl)
SI (1) SI9111154B (sl)
YU (1) YU48687B (sl)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3346580A (en) * 1967-10-10 Lysergic acid amides
US3228944A (en) * 1966-01-11 Lumiergoline derivatives
US4064249A (en) * 1974-05-28 1977-12-20 Richter Gedeon Vegyeszeti Gyar Rt. Compounds with ergoline skeleton

Also Published As

Publication number Publication date
SI9111154A (en) 1995-04-30
YU48687B (sh) 1999-07-28
JPH06206878A (ja) 1994-07-26
US5288724A (en) 1994-02-22
YU115491A (sh) 1994-01-20

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