YU115491A - Novi ergolinski derivati 2-propihilamina i postupak za njihovo pripremanje - Google Patents

Novi ergolinski derivati 2-propihilamina i postupak za njihovo pripremanje

Info

Publication number
YU115491A
YU115491A YU115491A YU115491A YU115491A YU 115491 A YU115491 A YU 115491A YU 115491 A YU115491 A YU 115491A YU 115491 A YU115491 A YU 115491A YU 115491 A YU115491 A YU 115491A
Authority
YU
Yugoslavia
Prior art keywords
preparation
propychylamine
procedure
new
compounds
Prior art date
Application number
YU115491A
Other languages
English (en)
Other versions
YU48687B (sh
Inventor
R. Ručman
V. Bole
M. Ocvirk
B. Lavrič
I. Krisch
Original Assignee
Lek Tovarna Farmacevtskih In Kemičnih Izdelkov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Tovarna Farmacevtskih In Kemičnih Izdelkov filed Critical Lek Tovarna Farmacevtskih In Kemičnih Izdelkov
Priority to SI9111154A priority Critical patent/SI9111154B/sl
Priority to YU115491A priority patent/YU48687B/sh
Priority to US07/901,983 priority patent/US5288724A/en
Priority to JP4174003A priority patent/JPH06206878A/ja
Priority to US08/160,271 priority patent/US5480885A/en
Publication of YU115491A publication Critical patent/YU115491A/sh
Publication of YU48687B publication Critical patent/YU48687B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Opisani so novi ergolinski derivati 2-propinilamina s formulo I v kateri pomenijo R1, R2 in R3 neodvisno drug od drugega atom vodika ali nerazvejeno ali razvejeno C1-C6-alkilno akupino, X atom vodika ali halogena, Z karbonilno ali metilensko skupino in C9-C10 enojno ali dvojno vez, in njihove kislinske adicijske soli, diastereoizomerne oblike in racemati. Opisan je tudi postopek za pripravo spojin s splošno for-mulo I in farmacevtski pripravek, kijih vsebuje. Spojine s splošno formulo I so v farmacevtski industriji uporabne kot učinkovine za pripravo zdravil, uporabnih pri zdravljenju hiper-tenzije, migrene, anksioznih stanj, mentalne depresije, debelosti, itd.
YU115491A 1991-07-01 1991-07-01 Novi ergolinski derivati 2-propinilamina i postupak za njihovo pripremanje YU48687B (sh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
SI9111154A SI9111154B (sl) 1991-07-01 1991-07-01 Novi ergolinski derivati 2-propinilamina, postopek za njihovo pripravo in njihova uporaba za zdravila
YU115491A YU48687B (sh) 1991-07-01 1991-07-01 Novi ergolinski derivati 2-propinilamina i postupak za njihovo pripremanje
US07/901,983 US5288724A (en) 1991-07-01 1992-06-22 Ergoline derivatives of 2-propinylamine, a process for the manufacture thereof and the use thereof for medicaments
JP4174003A JPH06206878A (ja) 1991-07-01 1992-07-01 ２−プロピニルアミンの新規エルゴリン誘導体、その製造方法及びこれを含有する医薬組成物。
US08/160,271 US5480885A (en) 1991-07-01 1993-12-02 Ergoline derivatives of 1-propinylamine, a process for the manufacture thereof and the use thereof for medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU115491A YU48687B (sh) 1991-07-01 1991-07-01 Novi ergolinski derivati 2-propinilamina i postupak za njihovo pripremanje

Publications (2)

Publication Number Publication Date
YU115491A true YU115491A (sh) 1994-01-20
YU48687B YU48687B (sh) 1999-07-28

Family

ID=25552993

Family Applications (1)

Application Number Title Priority Date Filing Date
YU115491A YU48687B (sh) 1991-07-01 1991-07-01 Novi ergolinski derivati 2-propinilamina i postupak za njihovo pripremanje

Country Status (4)

Country Link
US (1) US5288724A (sh)
JP (1) JPH06206878A (sh)
SI (1) SI9111154B (sh)
YU (1) YU48687B (sh)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228944A (en) * 1966-01-11 Lumiergoline derivatives
US3346580A (en) * 1967-10-10 Lysergic acid amides
US4064249A (en) * 1974-05-28 1977-12-20 Richter Gedeon Vegyeszeti Gyar Rt. Compounds with ergoline skeleton

Also Published As

Publication number Publication date
SI9111154A (en) 1995-04-30
SI9111154B (sl) 1999-12-31
YU48687B (sh) 1999-07-28
JPH06206878A (ja) 1994-07-26
US5288724A (en) 1994-02-22

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