LTIP442A - Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof - Google Patents

Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof

Info

Publication number
LTIP442A
LTIP442A LTIP442A LTIP442A LTIP442A LT IP442 A LTIP442 A LT IP442A LT IP442 A LTIP442 A LT IP442A LT IP442 A LTIP442 A LT IP442A LT IP442 A LTIP442 A LT IP442A
Authority
LT
Lithuania
Prior art keywords
prolonged release
preparing
base
preparation
pharmaceutical preparation
Prior art date
Application number
LTIP442A
Inventor
Minoru Yamada
Seiko Ishiguro
Yasuaki Ogawa
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of LTIP442A publication Critical patent/LTIP442A/en
Publication of LT3277B publication Critical patent/LT3277B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/745—Polymers of hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

1. A polymer for a prolonged release preparation which comprises (A) a polylactic acid and (B) a copolymer of glycolic acid and a hydroxycarboxylic acid of general formula <CHEM> wherein R stands for an alkyl group having 2 to 8 carbons, and wherein the weight ratio of (A) and (B) is in the range of 10/90 to 90/10. The drug is released at a constant rate from the preparation over the total release period without a large burst at the initial stage. Furthermore, the drug release period of the preparation can be freely controlled by varying the blending ratio of (A) and (B).
LTIP442A 1990-10-16 1993-03-19 Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof LT3277B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27803790 1990-10-16
JP21704591 1991-08-28

Publications (2)

Publication Number Publication Date
LTIP442A true LTIP442A (en) 1994-11-25
LT3277B LT3277B (en) 1995-05-25

Family

ID=26521778

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP442A LT3277B (en) 1990-10-16 1993-03-19 Prolonged release pharmaceutical preparation, polymeric composition as base for it and process for preparing thereof

Country Status (24)

Country Link
US (1) US5304377A (en)
EP (1) EP0481732B1 (en)
JP (1) JP3196035B2 (en)
KR (1) KR100199119B1 (en)
CN (2) CN1043189C (en)
AT (1) ATE119035T1 (en)
AU (1) AU644019B2 (en)
CA (1) CA2053468C (en)
DE (1) DE69107773T2 (en)
DK (1) DK0481732T3 (en)
EE (1) EE02958B1 (en)
ES (1) ES2069221T3 (en)
FI (1) FI101454B (en)
GE (1) GEP19981287B (en)
IE (1) IE66705B1 (en)
LT (1) LT3277B (en)
LV (1) LV10055B (en)
MX (1) MX9101595A (en)
NO (1) NO302481B1 (en)
NZ (1) NZ240214A (en)
PT (1) PT99236B (en)
RU (1) RU2103005C1 (en)
UA (1) UA27707C2 (en)
ZA (1) ZA918168B (en)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6005067A (en) * 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US6005068A (en) 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
WO1994008090A1 (en) * 1992-10-02 1994-04-14 Cargill, Incorporated Paper having a melt-stable lactide polymer coating and process for manufacture thereof
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
EP0615555B1 (en) 1992-10-02 2001-03-21 Cargill, Incorporated A melt-stable lactide polymer fabric and process for manufacture thereof
UA61046C2 (en) * 1992-12-07 2003-11-17 Takeda Chemical Industries Ltd Sustained-release preparation and method for its manufacture
RU2128055C1 (en) * 1992-12-07 1999-03-27 Такеда Кемикал Индастриз Лтд. Pharmaceutical composition of the delayed agent releasing and a method of its preparing
TW333456B (en) 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
CN1502331A (en) 1993-07-19 2004-06-09 Ѫ�ܼ���ҩ�﹫˾ Antiangiogenic compositions and methods of use
US5716981A (en) * 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US5424289A (en) * 1993-07-30 1995-06-13 Alza Corporation Solid formulations of therapeutic proteins for gastrointestinal delivery
US5594091A (en) * 1994-02-21 1997-01-14 Takeda Chemical Industries, Ltd. Matrix for sustained-release preparation
FR2718642B1 (en) * 1994-04-15 1996-07-12 Pf Medicament Biodegradable controlled release microspheres and their preparation process.
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
JP2987064B2 (en) * 1994-09-12 1999-12-06 グンゼ株式会社 Artificial dura
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
DE69615763T2 (en) * 1995-07-13 2002-08-08 Mitsubishi Gas Chemical Co., Inc. Polymer mixtures of aliphatic polyesters based on polylactides, processes for their preparation and processes for molding these mixtures
EP0765660A3 (en) * 1995-09-28 1998-09-23 Takeda Chemical Industries, Ltd. Microcapsules comprising 2-piperazinone-1-acetic acid compounds
US5637085A (en) * 1995-11-20 1997-06-10 Cardinale; Robert M. Method of cancer tumor treatment by slow release delivery of 1,2,4-benzotriazine oxides to tumor site
DE19545257A1 (en) 1995-11-24 1997-06-19 Schering Ag Process for the production of morphologically uniform microcapsules and microcapsules produced by this process
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
FR2744367B1 (en) * 1996-02-02 1999-07-09 Emperaire Jean Claude MEDICATIONS FOR OVULATION TRIGGERING
EP0889722B1 (en) * 1996-03-28 2002-11-20 Takeda Chemical Industries, Ltd. Sustained-release preparation and its production
ES2248847T3 (en) * 1996-05-24 2006-03-16 Angiotech Pharmaceuticals, Inc. COMPOSITIONS AND METHODS TO TREAT OR PREVENT DISEASES OF THE BODY DRIVING ROADS.
JP4317599B2 (en) * 1996-06-26 2009-08-19 武田薬品工業株式会社 Sustained release formulation
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7235524B2 (en) * 1997-01-31 2007-06-26 Applied Research System Ars Holding N.V. Medicaments for initiating ovulation
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
KR20010006026A (en) 1997-04-03 2001-01-15 존스 홉킨스 유니버시티 스쿨 오브 메디슨 Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, articles, and methods for making and using the same
US6051558A (en) * 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
US6162241A (en) * 1997-08-06 2000-12-19 Focal, Inc. Hemostatic tissue sealants
KR19990065921A (en) * 1998-01-19 1999-08-16 김충섭 Antimicrobial sustained-release drugs
FR2774591B1 (en) * 1998-02-12 2000-05-05 Lipha PHARMACEUTICAL COMPOSITION COMPRISING THE ASSOCIATION OF METFORMIN AND FIBRATE AND THE USE THEREOF FOR THE PREPARATION OF MEDICINES FOR REDUCING HYPERGLYCEMIA
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US6419709B1 (en) 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US6153212A (en) 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
GB2344287A (en) * 1998-12-03 2000-06-07 Ferring Bv Controlled release pharmaceutical formulation
WO2000036014A2 (en) * 1998-12-15 2000-06-22 Wolff Walsrode Ag Biodegradable, thermoplastic shaped bodies exhibiting an improved stability with regard to hydrolysis and an improved resistance to stress cracking
US6350464B1 (en) 1999-01-11 2002-02-26 Guilford Pharmaceuticals, Inc. Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
US6537585B1 (en) 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
RU2168986C1 (en) * 2000-08-03 2001-06-20 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Pharmaceutical composition showing antituberculosis effect
US7252842B2 (en) 2000-12-21 2007-08-07 Alrise Biosystems Gmbh Induced phase transition method for the production of microparticles containing hydrophilic active agents
CN1098883C (en) * 2000-12-28 2003-01-15 武汉大学 Preparation of uniformly dispersed polyactic acid microsphere
CA2451187C (en) 2001-06-22 2012-08-14 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
JP4490095B2 (en) 2001-06-29 2010-06-23 メドグラフト マイクロテック インコーポレイテッド Biodegradable injectable implants and related methods of manufacture and use
RU2191573C1 (en) * 2001-11-14 2002-10-27 Нестерук Владимир Викторович Method of doxycycline-base antibacterial agent preparing
US20050064039A1 (en) * 2001-12-26 2005-03-24 Tomomichi Futo Novel microsphere and method for production thereof
JP2003192773A (en) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc Bioabsorptive polyhydroxy carboxylic acid and its production method
US20040197301A1 (en) * 2003-02-18 2004-10-07 Zhong Zhao Hybrid polymers and methods of making the same
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US20080287400A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US7645460B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of risedronate
US20080286359A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US7645459B2 (en) 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
US20090275730A1 (en) * 2004-10-20 2009-11-05 Hiroyuki Oku Temperature responsive depsipeptide polymer
CN1923281B (en) * 2005-08-30 2010-05-05 孔庆忠 Anti-cancer slow release injection comprising plant alkaloid
WO2007084418A2 (en) * 2006-01-13 2007-07-26 Surmodics, Inc. Microparticle containing matrices for drug delivery
BRPI0712088B8 (en) * 2006-05-31 2021-06-22 Baxter Healthcare Sa use of a non-porous, fluid-tight, multi-layered, microscopic collagen lamina biomatrix
TWI436793B (en) 2006-08-02 2014-05-11 巴克斯特國際公司 Quick acting dry sealant and use and manufacturing method thereof
KR100845009B1 (en) * 2007-08-07 2008-07-08 한국생명공학연구원 Porous polymer particles to which charge-carrying material is fixed and a method of manufacturing the same
AR069109A1 (en) 2007-10-30 2009-12-30 Baxter Int USE OF A REGENERATIVE BIOFUNCTIONAL COLOGEN BIOMATRIZ TO TREAT VISCERAL OR PARIETAL DEFECTS
WO2009109194A2 (en) 2008-02-29 2009-09-11 Ferrosan A/S Device for promotion of hemostasis and/or wound healing
US9039783B2 (en) * 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
DK2442835T3 (en) 2009-06-16 2015-03-16 Baxter Int Styptic sponge
WO2011024944A1 (en) * 2009-08-31 2011-03-03 国立大学法人豊橋技術科学大学 Polyester stereocomplex and preparation method therefor
BR112012014773A2 (en) 2009-12-16 2015-11-03 Baxter Healthcare Sa hemostatic composite sponge, method for making a hemostatic composite sponge, and use of said sponge
SA111320355B1 (en) 2010-04-07 2015-01-08 Baxter Heathcare S A Hemostatic sponge
MX352875B (en) 2010-06-01 2017-12-13 Baxter Healthcare Sa Process for making dry and stable hemostatic compositions.
CA2801118C (en) 2010-06-01 2016-01-05 Baxter International Inc. Process for making dry and stable hemostatic compositions
AU2011260258B2 (en) 2010-06-01 2015-07-09 Baxter Healthcare S.A. Process for making dry and stable hemostatic compositions
EP2598553B1 (en) * 2010-07-26 2016-04-27 Université de Genève Compositions comprising polymers prepared from 2-hydroxyalkyl acids
CA2851321C (en) 2011-10-11 2020-07-07 Baxter International Inc. Hemostatic compositions
HK1201212A1 (en) 2011-10-11 2015-08-28 Baxter International Inc Hemostatic compositions
ES2553702T3 (en) 2011-10-27 2015-12-11 Baxter International Inc Hemostatic compositions
JP6241624B2 (en) 2012-03-06 2017-12-06 フェロサン メディカル デバイシーズ エイ／エス Pressurized container containing hemostatic paste
CN104349797B (en) 2012-06-12 2017-10-27 弗罗桑医疗设备公司 Dry hemostatic composition
EP3010419B1 (en) 2013-06-21 2020-05-20 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
EP3079731B1 (en) 2013-12-11 2018-08-08 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
JP6726852B2 (en) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー／エス Dry composition for use in hemostasis and wound healing
RU2705905C2 (en) 2014-12-24 2019-11-12 Ферросан Медикал Дивайсиз А/С Syringe for holding and mixing first and second substances
AU2016290433B2 (en) 2015-07-03 2018-05-24 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
JP6148701B2 (en) * 2015-07-31 2017-06-14 ユニベルシテ ドゥ ジュネーブ Compositions comprising polymers prepared from 2-hydroxyalkyl acids
CN105111417A (en) * 2015-08-25 2015-12-02 杭州铭众生物科技有限公司 Preparing method for glycolic acid-hydracrylic acid random copolymer
CN112368028A (en) 2018-05-09 2021-02-12 弗罗桑医疗设备公司 Method for preparing a hemostatic composition

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US368702A (en) 1887-08-23 bischoff
US467719A (en) 1892-01-26 Dust-guard for car-axle journals
US329526A (en) 1885-11-03 Coal-mining machine
NO139560C (en) 1972-04-29 1979-04-04 Takeda Chemical Industries Ltd ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY EFFECTIVE NONAPEPTIDAMIDE DERIVATIVES
JPS528375B2 (en) 1973-07-02 1977-03-09
FR2238700B1 (en) 1973-07-24 1977-10-14 Takeda Chemical Industries Ltd
AT347054B (en) 1973-09-29 1978-12-11 Takeda Chemical Industries Ltd PROCESS FOR THE PRODUCTION OF NEW NONAPEPTIDAMIDE DERIVATIVES
JPS5726506B2 (en) 1974-03-08 1982-06-04
GB1542703A (en) 1975-10-29 1979-03-21 Parke Davis & Co Nonapeptides and methods for their production
US4087390A (en) 1977-02-02 1978-05-02 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4093574A (en) 1977-02-02 1978-06-06 Eli Lilly And Company Somatostatin analogs and intermediates thereto
JPS5944308B2 (en) 1976-03-23 1984-10-29 武田薬品工業株式会社 peptide
US4121577A (en) 1977-01-03 1978-10-24 Binder Timothy A Method and apparatus for aiding conditioning of an erect spinal column and advantageous muscle control
US4100117A (en) 1977-04-21 1978-07-11 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4253998A (en) 1979-03-09 1981-03-03 American Home Products Corporation Peptides related to somatostatin
US4277394A (en) 1979-04-23 1981-07-07 Takeda Chemical Industries, Ltd Tetrapeptidehydrazide derivatives
US4317815A (en) 1979-06-13 1982-03-02 Coy David Howard LH-RH Antagonists
US4622244A (en) * 1979-09-04 1986-11-11 The Washington University Process for preparation of microcapsules
US4253997A (en) 1979-12-17 1981-03-03 American Home Products Corporation Anti-ovulatory decapeptides
JPS5692846A (en) 1979-12-27 1981-07-27 Takeda Chem Ind Ltd Tetrapeptide derivative and its preparation
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3218151A1 (en) * 1982-05-14 1983-11-17 Akzo Gmbh, 5600 Wuppertal MICROPOROUS, POWDER-SHAPED POLYLACTIDES AND METHOD FOR THE PRODUCTION THEREOF
JPS60100516A (en) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production
JPH0678425B2 (en) 1984-07-06 1994-10-05 和光純薬工業株式会社 New polymer manufacturing method
EP0190833B1 (en) * 1985-02-07 1991-03-27 Takeda Chemical Industries, Ltd. Method for producing microcapsule
JP2551756B2 (en) * 1985-05-07 1996-11-06 武田薬品工業株式会社 Polyoxycarboxylic acid ester and method for producing the same
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
JP2526589B2 (en) * 1986-08-08 1996-08-21 武田薬品工業株式会社 Peptide-containing microcapsule and method for producing the same
JPH0725689B2 (en) * 1986-10-07 1995-03-22 中外製薬株式会社 Sustained-release preparation containing granulocyte colony-stimulating factor
AU606383B2 (en) * 1987-03-06 1991-02-07 Research Triangle Institute Polymer blends for selective biodegradability
JPH0613602B2 (en) * 1987-07-14 1994-02-23 三井東圧化学株式会社 Method for producing d-l-lactic acid-glycolic acid copolymer
US4897811A (en) 1988-01-19 1990-01-30 Nestor, Inc. N-dimensional coulomb neural network which provides for cumulative learning of internal representations
JP2827287B2 (en) * 1988-07-05 1998-11-25 武田薬品工業株式会社 Sustained release microcapsules containing water-soluble drugs
ES2099064T3 (en) 1988-09-01 1997-05-16 Takeda Chemical Industries Ltd DERIVATIVES OF FUMAGILLOL.
KR0141692B1 (en) 1988-09-01 1998-06-01 우메모또 요시마사 Angiogenesis inhibitory agent
JPH02212436A (en) * 1989-02-14 1990-08-23 Japan Atom Energy Res Inst Sustained release base
EP0415294A3 (en) 1989-08-31 1991-06-12 Takeda Chemical Industries, Ltd. Cyclohexanol derivatives, production and use thereof
CN2891061Y (en) 2006-03-15 2007-04-18 鸿富锦精密工业（深圳）有限公司 Integrated liquid crystal computer and its computer mainframe

Also Published As

Publication number Publication date
IE66705B1 (en) 1996-01-24
MX9101595A (en) 1992-06-05
EP0481732A1 (en) 1992-04-22
CA2053468A1 (en) 1992-04-17
FI101454B1 (en) 1998-06-30
JPH05112468A (en) 1993-05-07
DE69107773T2 (en) 1995-06-29
EE02958B1 (en) 1997-02-17
ZA918168B (en) 1993-04-14
PT99236A (en) 1992-09-30
CN1057670C (en) 2000-10-25
LT3277B (en) 1995-05-25
NZ240214A (en) 1993-02-25
LV10055A (en) 1994-05-10
AU8586491A (en) 1992-04-30
KR100199119B1 (en) 1999-06-15
UA27707C2 (en) 2000-10-16
PT99236B (en) 1999-04-30
CN1043189C (en) 1999-05-05
KR920007632A (en) 1992-05-27
NO302481B1 (en) 1998-03-09
CN1060851A (en) 1992-05-06
AU644019B2 (en) 1993-12-02
LV10055B (en) 1995-02-20
ATE119035T1 (en) 1995-03-15
FI914865A0 (en) 1991-10-15
US5304377A (en) 1994-04-19
ES2069221T3 (en) 1995-05-01
DK0481732T3 (en) 1995-05-22
FI101454B (en) 1998-06-30
CA2053468C (en) 2002-07-09
NO914032D0 (en) 1991-10-14
JP3196035B2 (en) 2001-08-06
DE69107773D1 (en) 1995-04-06
EP0481732B1 (en) 1995-03-01
IE913624A1 (en) 1992-04-22
RU2103005C1 (en) 1998-01-27
GEP19981287B (en) 1998-09-01
FI914865L (en) 1992-04-17
NO914032L (en) 1992-04-21
CN1116212A (en) 1996-02-07

Similar Documents

Publication Publication Date Title
ZA918168B (en) Prolonged release preparation and polymers thereof.
US5035884A (en) Methylene pyrrolidone copolymers for contact lens and pharmaceutical preparations
US4851545A (en) N-substituted-3-alkylene-2-pyrrolidone compounds
NZ224024A (en) Acrivastine sustained release compositions
HUT62262A (en) Process for producing amide composition and pharmaceutical compositions comprising same as active ingredient
AU6630596A (en) Tablets containing anion exchange resin
IL147417A0 (en) Sustained release compositions, methods for producing the same and uses thereof
FI894899A0 (en) Process for preparing a dispersible solid drug composition
HU900656D0 (en) Process for producing anti-phlogistic aryl compounds
HUT49808A (en) Process for producing retarde pharmaceutical compositions containing aselastine
US4857313A (en) Transdermal drug delivery device comprising copolymers of N-morpholinoethyl methacrylate and 2-hydroxylmethacrylate
NZ248437A (en) Phenoxymethyloxirane and its preparation
ZA909557B (en) Substituted benzothiazolinones,process for preparing these and pharmaceutical compositions containing them
RU96123569A (en) MEDICINAL PRODUCT
CS267935B1 (en) Medicinal product containing theophylline
SI9111154B (en) Novel ergolin derivatives of 2-propinylamine, process for preparing them and their use for medicaments

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 20010319