ES2174930T3 - Composiciones de metronidazol de liberacion modificada y metodos para preparar y utilizar las mismas. - Google Patents

Composiciones de metronidazol de liberacion modificada y metodos para preparar y utilizar las mismas.

Info

Publication number
ES2174930T3
ES2174930T3 ES95907963T ES95907963T ES2174930T3 ES 2174930 T3 ES2174930 T3 ES 2174930T3 ES 95907963 T ES95907963 T ES 95907963T ES 95907963 T ES95907963 T ES 95907963T ES 2174930 T3 ES2174930 T3 ES 2174930T3
Authority
ES
Spain
Prior art keywords
metronidazole
aqueous
compositions
methods
aqueous soluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95907963T
Other languages
English (en)
Inventor
Subhash Desai
Alan Mark Mancini
Steven Charles Schumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2174930T3 publication Critical patent/ES2174930T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBEN COMPOSICIONES FARMACEUTICAS CON UN PERFIL DE LIBERACION MODIFICADO PARA LA ADMINISTRACION UNA VEZ/DIA DE METRONIDAZOL, LOS METODOS PARA PREPARAR LAS COMPOSICIONES FARMACEUTICAS Y LOS METODOS PARA TRATAR UNA INFECCION MICROBIANA CON LA ADMINISTRACION 1 VEZ/DIA DE LAS COMPOSICIONES FARMACEUTICAS. LAS COMPOSICIONES ADMINISTRADAS UNA VEZ/DIA SON BIOEQUIVALENTES AL METRONIDAZOL DE LIBERACION INMEDIATA ADMINISTRADO 3 VECES/DIA. LAS COMPOSICIONES DE LA INVENCION CONTIENEN: (A) UNA PRIMERA PARTE DE METRONIDAZOL, ENTRE 59 Y 79% POR PESO, APROXIMADAMENTE; (B) APROXIMADAMENTE 1,5 A 3,0% POR PESO DE UN COPOLIMERO ESTERIFICADO DE POLIMETACRILATO, INSOLUBLE EN AGUA, PERMEABLE AL AGUA, EXPANSIBLE EN AGUA E INDEPENDIENTE DE PH; (C) APROXIMADAMENTE 0,1 A 2,0 % POR PESO DE UN DESVISCOSIFICADOR; (D) 0 A APROXIMADAMENTE 23% POR PESO DE UN DILUYENTE FARMACEUTICO SOLUBLE EN AGUA; (E) 0 A APROXIMADAMENTE 23% POR PESO DE UN SEGUNDO DILUYENTE SOLUBLE EN AGUA, ADECUADO PARA FORMAR UN COMPRIMIDO FARMACEUTICO AL COMPRIMIRSE CON GRANULOS DE (A), Y DISTINTO O IGUAL AL PRIMER DILUYENTE SOLUBLE EN AGUA; (F) 0 A APROXIMADAMENTE 20% POR PESO DE UNA SEGUNDA PARTE DE METRONIDAZOL; (G) 0 A APROXIMADAMENTE 0,2% POR PESO DE GLIDANTE Y (H) 0 A APROXIMADAMENTE 2% POR PESO DE LUBRICANTE. LA COMPOSICION CONTIENE GRANULOS DE METRONIDAZOL COMPUESTOS POR (A), (B), (C), Y (D). LA SUMA DE LOS PORCENTAJES POR PESO DE METRONIDAZOL COMPUESTOS POR (A) Y (F) ES ENTRE 70 Y 79% POR PESO, APROXIMADAMENTE Y LA SUMA DE LOS PORCENTAJES POR PESO DE DILUYENTE SOLUBLE EN AGUA COMPUESTO POR (D) Y (E) ES ENTRE 16 Y 23% POR PESO, APROXIMADAMENTE.
ES95907963T 1994-01-27 1995-01-04 Composiciones de metronidazol de liberacion modificada y metodos para preparar y utilizar las mismas. Expired - Lifetime ES2174930T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/187,568 US6103262A (en) 1994-01-27 1994-01-27 Modified-release metronidazole compositions and methods for making and using same

Publications (1)

Publication Number Publication Date
ES2174930T3 true ES2174930T3 (es) 2002-11-16

Family

ID=22689500

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95907963T Expired - Lifetime ES2174930T3 (es) 1994-01-27 1995-01-04 Composiciones de metronidazol de liberacion modificada y metodos para preparar y utilizar las mismas.

Country Status (16)

Country Link
US (2) US6103262A (es)
EP (1) EP0744947B1 (es)
JP (1) JPH09508381A (es)
KR (1) KR100368769B1 (es)
CN (1) CN1095665C (es)
AT (1) ATE216236T1 (es)
AU (1) AU682248B2 (es)
BR (1) BR9506662A (es)
CA (1) CA2181985C (es)
DE (1) DE69526434T2 (es)
DK (1) DK0744947T3 (es)
ES (1) ES2174930T3 (es)
MX (1) MX9602951A (es)
NZ (1) NZ279368A (es)
PT (1) PT744947E (es)
WO (1) WO1995020383A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999004829A1 (en) 1997-07-28 1999-02-04 Redmond Mary L Composition and process for the treatment of epidermal traumas such as decubitus ulcers
US20010055613A1 (en) 1998-10-21 2001-12-27 Beth A. Burnside Oral pulsed dose drug delivery system
DE19850445A1 (de) * 1998-11-02 2000-05-04 Falk Pharma Gmbh Arzneimittel zur topischen Behandlung entzündlicher Darmerkrankungen
ECSP003851A (es) * 1999-12-22 2002-05-23 Pharmacia Corp Composicon de liberacion doble de un inhibidor ciclooxigenasa-2
US6423707B1 (en) 2000-08-28 2002-07-23 California Pacific Medical Center Nitroimidazole ester analogues and therapeutic applications
US8846100B2 (en) * 2006-05-12 2014-09-30 Shire Llc Controlled dose drug delivery system
WO2012075015A2 (en) 2010-11-29 2012-06-07 Dr. Reddy's Laboratories Ltd. Oral metronidazole pharmaceutical compositions
IN2012DE00193A (es) * 2012-01-23 2015-06-12 Ranbaxy Lab Ltd
CA2959414C (en) 2014-09-05 2023-03-14 Symbiomix Therapeutics, Llc Secnidazole for use in the treatment of bacterial vaginosis
WO2016196653A1 (en) * 2015-06-01 2016-12-08 Symbiomix Therapeutics, Llc Novel nitroimidazole formulations and uses thereof
WO2017027528A1 (en) * 2015-08-10 2017-02-16 Purdue Research Foundation Methods and systems for depositing active ingredients on substrates
GR1008992B (el) 2015-12-17 2017-03-23 Verisfield (Uk) Ltd, Υποκαταστημα Ελλαδας, Εμπορια Φαρμακων Φαρμακευτικη συνθεση σε μορφη κοκκιων για χορηγηση απο το στομα που περιεχει μετρονιδαζολη ή παραγωγα αυτης και εναν παραγοντα καλυψης της γευσης
CN112007002B (zh) * 2020-08-05 2022-08-12 河北君临药业有限公司 一种质量稳定的甲硝唑片剂组合物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2944061A (en) * 1957-09-20 1960-07-05 Acyl derivatives and process
FI63335B (fi) * 1979-02-02 1983-02-28 Orion Yhtymae Oy Foerfarande foer framstaellning av tabletter med foerdroejd loslighet av effektaemne
JPS6056122B2 (ja) * 1980-05-21 1985-12-09 塩野義製薬株式会社 徐放性製剤
GB8707416D0 (en) * 1987-03-27 1987-04-29 Wellcome Found Pharmaceutical formulations
US4927639A (en) * 1989-02-02 1990-05-22 Warner-Lambert Company Modified release gemfibrozil composition
DE4125048A1 (de) * 1991-07-29 1993-02-04 Peggy Albrecht Arzneimittel mit verzoegerter freisetzung zur behandlung von periodontitis
CA2093282C (en) * 1992-05-04 1999-01-12 Tibor Sipos Intraoral medicament-releasing device

Also Published As

Publication number Publication date
CN1095665C (zh) 2002-12-11
US5618559A (en) 1997-04-08
EP0744947A1 (en) 1996-12-04
AU1596795A (en) 1995-08-15
WO1995020383A1 (en) 1995-08-03
DE69526434D1 (de) 2002-05-23
US6103262A (en) 2000-08-15
DK0744947T3 (da) 2002-07-29
CA2181985A1 (en) 1995-08-03
NZ279368A (en) 1998-04-27
DE69526434T2 (de) 2002-10-31
CA2181985C (en) 2000-12-05
ATE216236T1 (de) 2002-05-15
AU682248B2 (en) 1997-09-25
EP0744947B1 (en) 2002-04-17
CN1139382A (zh) 1997-01-01
BR9506662A (pt) 1997-11-18
MX9602951A (es) 1997-06-28
JPH09508381A (ja) 1997-08-26
PT744947E (pt) 2002-08-30
KR100368769B1 (ko) 2003-05-16

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