ATE97930T1 - Biologisch abbaubare poly-(hydroxyalkyl)aminodicarbons|ure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe. - Google Patents

Biologisch abbaubare poly-(hydroxyalkyl)aminodicarbons|ure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe.

Info

Publication number
ATE97930T1
ATE97930T1 AT87119291T AT87119291T ATE97930T1 AT E97930 T1 ATE97930 T1 AT E97930T1 AT 87119291 T AT87119291 T AT 87119291T AT 87119291 T AT87119291 T AT 87119291T AT E97930 T1 ATE97930 T1 AT E97930T1
Authority
AT
Austria
Prior art keywords
hydroxyalkyl
derivatives
aminodicarbons
ure
processes
Prior art date
Application number
AT87119291T
Other languages
English (en)
Inventor
Hubert Dr Bader
Diether Dr Rueppel
Axel Dr Walch
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of ATE97930T1 publication Critical patent/ATE97930T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/2045—Polyamides; Polyaminoacids, e.g. polylysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyamides (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT87119291T 1987-01-03 1987-12-29 Biologisch abbaubare poly-(hydroxyalkyl)aminodicarbons|ure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe. ATE97930T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873700128 DE3700128A1 (de) 1987-01-03 1987-01-03 Biologisch abbaubare poly- (hydroxyalkyl)- aminodicarbonsaeure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
EP87119291A EP0274127B1 (de) 1987-01-03 1987-12-29 Biologisch abbaubare Poly-(hydroxyalkyl)-Aminodicarbonsäure-Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben für Depotzubereitungen mit kontrollierter Wirkstoffabgabe

Publications (1)

Publication Number Publication Date
ATE97930T1 true ATE97930T1 (de) 1993-12-15

Family

ID=6318447

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87119291T ATE97930T1 (de) 1987-01-03 1987-12-29 Biologisch abbaubare poly-(hydroxyalkyl)aminodicarbons|ure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe.

Country Status (5)

Country Link
US (2) US4906473A (de)
EP (1) EP0274127B1 (de)
JP (1) JPH0825909B2 (de)
AT (1) ATE97930T1 (de)
DE (2) DE3700128A1 (de)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5237016A (en) * 1989-01-05 1993-08-17 Siska Diagnostics, Inc. End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
DE3921912A1 (de) * 1989-07-04 1991-01-17 Roehm Gmbh Polyasparaginsaeurederivate als ueberzugsmittel fuer arzneiformen und lebensmittel
DE4002736A1 (de) * 1990-01-31 1991-08-01 Hoechst Ag Biologisch abbaubare polymere, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe
US5205287A (en) * 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) * 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5629020A (en) * 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US6099856A (en) 1992-06-15 2000-08-08 Emisphere Technologies, Inc. Active agent transport systems
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
DK0548794T3 (da) * 1991-12-20 1999-12-06 Aventis Res & Tech Gmbh & Co Polyaspartamidderivater som adsorptionsmidler for galdesyrer, polyaspartamidderivater ladet med galdesyrer, fremgangsmåder
US5792451A (en) * 1994-03-02 1998-08-11 Emisphere Technologies, Inc. Oral drug delivery compositions and methods
US5811127A (en) * 1992-06-15 1998-09-22 Emisphere Technologies, Inc. Desferrioxamine oral delivery system
EP0601417A3 (de) * 1992-12-11 1998-07-01 Hoechst Aktiengesellschaft Physiologisch verträglicher und physiologisch abbaubarer, Kohlenhydratrezeptorblocker auf Polymerbasis, ein Verfahren zu seiner Herstellung und seine Verwendung
US5709861A (en) * 1993-04-22 1998-01-20 Emisphere Technologies, Inc. Compositions for the delivery of antigens
ATE298561T1 (de) * 1993-04-22 2005-07-15 Emisphere Tech Inc Orale dareichungsform
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6090958A (en) 1995-03-31 2000-07-18 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
BR9604880A (pt) 1995-03-31 1998-05-19 Emisphere Tech Inc Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
DE19528782A1 (de) * 1995-08-04 1997-02-06 Bayer Ag Verwendung von Polyasparaginsäureamiden als Lederhilfsmittel
DE19681560T1 (de) 1995-09-11 1998-08-20 Emisphere Tech Inc Verfahren zur Herstellung von omega-Aminoalkansäure-Derivaten aus Cycloalkanonen
CA2258264A1 (en) 1996-06-14 1997-12-18 Emisphere Technologies, Inc. Microencapsulated fragrances and method for preparation
US5750070A (en) * 1996-07-19 1998-05-12 Nalco Chemical Company Use of biodegradable polymers in preventing corrosion and scale build-up
US5776875A (en) * 1996-07-16 1998-07-07 Nalco Chemical Company Use of biodegradable polymers in preventing scale build-up
US5876623A (en) * 1996-09-20 1999-03-02 Nalco Chemical Company Biodegradable aspartic acid polymers for preventing scale formation in boilers
DE19635061A1 (de) * 1996-08-30 1998-03-05 Bayer Ag Mittel zum Färben oder Bedrucken von Textilmaterialien
US5876710A (en) 1997-02-07 1999-03-02 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
US5990166A (en) 1997-02-07 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6060513A (en) 1997-02-07 2000-05-09 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5879681A (en) 1997-02-07 1999-03-09 Emisphere Technolgies Inc. Compounds and compositions for delivering active agents
US5804688A (en) 1997-02-07 1998-09-08 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5939381A (en) 1997-02-07 1999-08-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5863944A (en) 1997-04-30 1999-01-26 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5962710A (en) 1997-05-09 1999-10-05 Emisphere Technologies, Inc. Method of preparing salicyloylamino acids
DE19809359A1 (de) * 1998-03-05 1999-09-09 Bayer Ag Gleichzeitiges Waschen und Bleichen nativer Fasern und textiler Erzeugnisse daraus
DE19822603A1 (de) 1998-05-20 1999-11-25 Goldschmidt Ag Th Pigmentpasten enthaltend hydrophob modifizierte Polyasparaginsäurederivate
DE10342926A1 (de) * 2003-09-17 2005-04-14 Bayer Chemicals Ag Polyethermodifizierte Polymere als Lederhilfsmittel
US20100036093A1 (en) * 2006-05-09 2010-02-11 Osaka University Cholesterolamine-introduced poly-gamma-glutamic acid derivative
WO2010132879A2 (en) 2009-05-15 2010-11-18 The Johns Hopkins University Multicomponent degradable cationic polymers
WO2011019942A2 (en) * 2009-08-12 2011-02-17 University Of Kansas Synthetic cholesterylamine-linker derivatives for agent delivery into cells
US20200086616A1 (en) 2016-12-16 2020-03-19 Basf Se Multi-layered film , method for the production and use thereof
WO2018108687A1 (de) 2016-12-16 2018-06-21 Basf Se Verfahren zur herstellung funktioneller wasserlöslicher folien
US20190316061A1 (en) 2016-12-16 2019-10-17 Basf Se Washing and cleaning multi-layer films, method for the production and use thereof
WO2019048474A1 (en) 2017-09-06 2019-03-14 Basf Se ACTIVE WASHING AND CLEANING POLYMER FILMS, METHOD FOR PRODUCING THE SAME, AND USE THEREOF
WO2019238730A1 (en) 2018-06-14 2019-12-19 Basf Se Process for producing water-soluble containers for dosing detergent
WO2019238761A1 (en) 2018-06-15 2019-12-19 Basf Se Water soluble multilayer films containing wash active chemicals and enzymes
EP3837340A1 (de) 2018-08-16 2021-06-23 Basf Se Wasserlösliche polymerfilme aus ethylenoxid-homo- oder -copolymeren, verfahren zur herstellung davon und verwendung davon
WO2020224962A1 (en) 2019-05-03 2020-11-12 Basf Se Water-soluble films with three-dimensional topography
WO2021191175A1 (en) 2020-03-24 2021-09-30 Basf Se Detergent formulation in form of a three dimensional body

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3371069A (en) * 1963-03-20 1968-02-27 Ajinomoto Kk Filaments and surgical sutures of polyl-glutamic acid partly esterified with lower alkanols and process therefor
US3297033A (en) * 1963-10-31 1967-01-10 American Cyanamid Co Surgical sutures
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4069307A (en) * 1970-10-01 1978-01-17 Alza Corporation Drug-delivery device comprising certain polymeric materials for controlled release of drug
US4180646A (en) * 1975-01-28 1979-12-25 Alza Corporation Novel orthoester polymers and orthocarbonate polymers
US4093709A (en) * 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4356166A (en) * 1978-12-08 1982-10-26 University Of Utah Time-release chemical delivery system
US4304767A (en) * 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
DE3045135A1 (de) * 1980-11-29 1982-06-09 Sandoz-Patent-GmbH, 7850 Lörrach Pharmazeutische kompositionen enthaltende bioabbaubare polymere
US4652443A (en) * 1983-06-07 1987-03-24 Japan Atomic Energy Research Institute Slow-release composite and process for producing the same
JPS60501759A (ja) * 1983-07-01 1985-10-17 バテル　メモリアル　インステイチユ−ト 生物分解性ポリペプチド及び薬剤の緩慢な放出のためのその使用
ATE60340T1 (de) * 1984-10-19 1991-02-15 Battelle Memorial Institute Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten.
CS254355B1 (en) * 1985-04-10 1988-01-15 Vladimir Saudek Soluble and biodegradatable copolymeres activated for bond of biologicaly active substances
US4668506A (en) * 1985-08-16 1987-05-26 Bausch & Lomb Incorporated Sustained-release formulation containing and amino acid polymer
CH667874A5 (fr) * 1985-12-19 1988-11-15 Battelle Memorial Institute Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments.

Also Published As

Publication number Publication date
JPH0825909B2 (ja) 1996-03-13
US4906473A (en) 1990-03-06
DE3700128A1 (de) 1988-07-14
EP0274127A2 (de) 1988-07-13
US5041291A (en) 1991-08-20
JPS63174937A (ja) 1988-07-19
EP0274127A3 (en) 1990-06-27
DE3788344D1 (de) 1994-01-13
EP0274127B1 (de) 1993-12-01

Similar Documents

Publication Publication Date Title
ATE97930T1 (de) Biologisch abbaubare poly-(hydroxyalkyl)aminodicarbons|ure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe.
DE69310204D1 (de) Salpetersäureester mit pharmazeutischer wirkung und verfahren zu deren herstellung
DE19775011I2 (de) Chinolinderivate Verfahren zu ihrer Herstellung und ihre Verwendung zur Bekaempfung unerwuenschten Planzenwuchses
JPS6429362A (en) 3-demethylmevalonic acid derivative
ATE90345T1 (de) Bis-naphthalimide, ihre herstellung und verwendung.
ATE110369T1 (de) Pyrimidin-4,6-dicarbonsäurediamide, verfahren zu deren herstellung sowie verwendung derselben sowie arzneimittel auf basis dieser verbindungen.
EP0387821A3 (de) 2-Alkyl-4-arylmethylaminochinoline, ihre Verwendung und daraus hergestellte Arzneimittel
DE3164474D1 (en) N-benzoyl n' phenylureas, preparation and use thereof as insecticides
PT76473B (de) Salicylsaeurederivate verfahren zu ihrer herstellung pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
EP0331092A3 (en) Alpha-amino-carboxylic-acid derivatives, their preparation and use
DE59004518D1 (de) Biologisch abbaubare Polymere, Verfahren zu ihrer Herstellung und Verwendung derselben für Depotzubereitungen mit kontrollierter Wirkstoffabgabe.
KR960004860B1 (en) Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof and medicaments
ATE66610T1 (de) Primycin enthaltendes kolloidales grundgel, verfahren zu dessen herstellung, dieses grundgel enthaltende pharmazeutische und pharmako- kosmetische kompositionen.
ATE59035T1 (de) Basisch substituierte benzofurancarbonsaeureamide, verfahren zu ihrer herstellung und sie enthaltende therapeutische mittel.
ATE113598T1 (de) Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
IL65936A (en) Chloroacetic acid cyclohexylamides,their preparation and their use as herbicides
DE69112432D1 (de) Derivate von methylpiperazinoazepin, verfahren zu ihrer herstellung und verwendung.
DE69116423D1 (de) 3'-Deamino-4'-deoxy-4'-amino-8-fluoranthracycline und Verfahren zu ihrer Herstellung
EP0317913A3 (en) Di(meth)acrylates, process for their preparation and their use
ATE107311T1 (de) Modifizierte splenopentine, verfahren zu ihrer herstellung und ihre verwendung.
DE58902264D1 (de) Beta-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als und in arzneimitteln.
ATE89563T1 (de) Oxiran-pseudooligosaccharide, verfahren zu deren herstellung, deren verwendung und pharmazeutische praeparate.
ATE62688T1 (de) Benzylaminoaryl-dihydropyridinelactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln.
DE59105948D1 (de) 2-Amino-(fluoralkoxy-pyrimidine) und Verfahren zu ihrer Herstellung.
ATE111903T1 (de) Substituierte 1.2.3.4-oxatriazolium-5-olate, verfahren zu ihrer herstellung und ihre verwendung.

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee