ES2069221T3 - Preparacion de liberacion prolongada y polimeros para dicha preparacion. - Google Patents

Preparacion de liberacion prolongada y polimeros para dicha preparacion.

Info

Publication number
ES2069221T3
ES2069221T3 ES91309490T ES91309490T ES2069221T3 ES 2069221 T3 ES2069221 T3 ES 2069221T3 ES 91309490 T ES91309490 T ES 91309490T ES 91309490 T ES91309490 T ES 91309490T ES 2069221 T3 ES2069221 T3 ES 2069221T3
Authority
ES
Spain
Prior art keywords
preparation
prolonged release
polymers
drug
release period
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91309490T
Other languages
English (en)
Inventor
Minoru Yamada
Seiko Ishiguro
Yasuaki Ogawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2069221T3 publication Critical patent/ES2069221T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/745—Polymers of hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

1. UN POLIMERO PARA UNA PREPARACION DE LIBERACION PROLONGADA QUE INCLUYE (A) UN ACIDO POLILACTICO Y (B) UN POLIMERO DE ACIDO GLICOLICO Y UN ACIDO HIDROXICARBOXILICO DE FORMULA GENERAL EN DONDE R REPRESENTA UN GRUPO ALQUILO TENIENDO DE 2 A 8 ATOMOS DE CARBONO , Y EN DONDE LA RAZON DE PESO DE (A) Y (B) ESTA EN EL RANGO DE 10/90 A 90/10. LA DROGA ES LIBERADA A RAZON CONSTANTE A PARTIR DE LA PREPARACION SOBRE EL PERIODO DE LIBERACION TOTAL SIN GRAN REBOSAMIENTO EN LA ETAPA INICIAL. ADEMAS EL PERIODO DE LIBERACION DE 1 DROGA DE LA PREPARACION PUEDE SER LIBREMENTE CONTROLADO MEDIANTE LA VARIACION DE LA RAZON DE LA MEZCLA DE (A) Y (B).
ES91309490T 1990-10-16 1991-10-15 Preparacion de liberacion prolongada y polimeros para dicha preparacion. Expired - Lifetime ES2069221T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27803790 1990-10-16
JP21704591 1991-08-28

Publications (1)

Publication Number Publication Date
ES2069221T3 true ES2069221T3 (es) 1995-05-01

Family

ID=26521778

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91309490T Expired - Lifetime ES2069221T3 (es) 1990-10-16 1991-10-15 Preparacion de liberacion prolongada y polimeros para dicha preparacion.

Country Status (24)

Country Link
US (1) US5304377A (es)
EP (1) EP0481732B1 (es)
JP (1) JP3196035B2 (es)
KR (1) KR100199119B1 (es)
CN (2) CN1043189C (es)
AT (1) ATE119035T1 (es)
AU (1) AU644019B2 (es)
CA (1) CA2053468C (es)
DE (1) DE69107773T2 (es)
DK (1) DK0481732T3 (es)
EE (1) EE02958B1 (es)
ES (1) ES2069221T3 (es)
FI (1) FI101454B1 (es)
GE (1) GEP19981287B (es)
IE (1) IE66705B1 (es)
LT (1) LT3277B (es)
LV (1) LV10055B (es)
MX (1) MX9101595A (es)
NO (1) NO302481B1 (es)
NZ (1) NZ240214A (es)
PT (1) PT99236B (es)
RU (1) RU2103005C1 (es)
UA (1) UA27707C2 (es)
ZA (1) ZA918168B (es)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US6005067A (en) * 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
US6005068A (en) 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
JP3447289B2 (ja) * 1992-10-02 2003-09-16 カーギル， インコーポレイテッド 溶融安定性ラクチドポリマー繊維及びその製造方法
DE69322155T2 (de) * 1992-10-02 1999-08-19 Cargill Inc Papier mit einer beschichtung aus schmelzstabilem polymer und dessen verfahren zur herstellung
UA61046C2 (en) 1992-12-07 2003-11-17 Takeda Chemical Industries Ltd Sustained-release preparation and method for its manufacture
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
EP2226085B1 (en) 1993-07-19 2013-11-27 Angiotech Pharmaceuticals, Inc. Anti-angiogenic compositions and methods of use
US5994341A (en) * 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US5424289A (en) * 1993-07-30 1995-06-13 Alza Corporation Solid formulations of therapeutic proteins for gastrointestinal delivery
CA2143044C (en) * 1994-02-21 2005-04-12 Yasutaka Igari Matrix for sustained-release preparation
FR2718642B1 (fr) * 1994-04-15 1996-07-12 Pf Medicament Microsphères biodégradables à libération contrôlée et leur procédé de préparation.
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
JP2987064B2 (ja) * 1994-09-12 1999-12-06 グンゼ株式会社 人工硬膜
US6117455A (en) 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
DE69615763T2 (de) * 1995-07-13 2002-08-08 Mitsubishi Gas Chemical Co Polymermischungen aliphatischer Polyester auf Basis von Polylactiden, Verfahren zu deren Herstellung und Verfahren zum Formen diese Mischungen
EP0765660A3 (en) * 1995-09-28 1998-09-23 Takeda Chemical Industries, Ltd. Microcapsules comprising 2-piperazinone-1-acetic acid compounds
US5637085A (en) * 1995-11-20 1997-06-10 Cardinale; Robert M. Method of cancer tumor treatment by slow release delivery of 1,2,4-benzotriazine oxides to tumor site
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
FR2744367B1 (fr) * 1996-02-02 1999-07-09 Emperaire Jean Claude Medicaments pour le declenchement de l'ovulation
DE69717263T2 (de) * 1996-03-28 2003-07-24 Takeda Chemical Industries Ltd Zubereitung mit verzögerter freisetzung und deren herstellung
WO1997045105A1 (en) 1996-05-24 1997-12-04 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating or preventing diseases of body passageways
JP4317599B2 (ja) * 1996-06-26 2009-08-19 武田薬品工業株式会社 徐放性製剤
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US7235524B2 (en) * 1997-01-31 2007-06-26 Applied Research System Ars Holding N.V. Medicaments for initiating ovulation
US5945126A (en) * 1997-02-13 1999-08-31 Oakwood Laboratories L.L.C. Continuous microsphere process
EP0973818B1 (en) 1997-04-03 2004-10-13 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly(phosphate) polymers, compositions, articles, and methods for making and using the same
US6051558A (en) * 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
ZA987019B (en) * 1997-08-06 1999-06-04 Focal Inc Hemostatic tissue sealants
KR19990065921A (ko) * 1998-01-19 1999-08-16 김충섭 항생제의서방성제제
US6099859A (en) * 1998-03-20 2000-08-08 Andrx Pharmaceuticals, Inc. Controlled release oral tablet having a unitary core
US6419709B1 (en) 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US6153212A (en) * 1998-10-02 2000-11-28 Guilford Pharmaceuticals Inc. Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same
US6270802B1 (en) 1998-10-28 2001-08-07 Oakwood Laboratories L.L.C. Method and apparatus for formulating microspheres and microcapsules
GB2344287A (en) * 1998-12-03 2000-06-07 Ferring Bv Controlled release pharmaceutical formulation
AU1970900A (en) * 1998-12-15 2000-07-03 Wolff Walsrode Ag Biodegradable, thermoplastic shaped bodies exhibiting an improved stability withregard to hydrolysis and an improved resistance to stress cracking
US6350464B1 (en) * 1999-01-11 2002-02-26 Guilford Pharmaceuticals, Inc. Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same
US6537585B1 (en) 1999-03-26 2003-03-25 Guilford Pharmaceuticals, Inc. Methods and compositions for treating solid tumors
ATE361057T1 (de) 2000-12-21 2007-05-15 Alrise Biosystems Gmbh Verfahren umfassend einen induzierten phasenübergang zur herstellung von hydrophobe wirkstoffe enthaltenden mikropartikeln
CN1098883C (zh) * 2000-12-28 2003-01-15 武汉大学 分散度均匀的聚乳酸微球制备新方法
JP2004535431A (ja) 2001-06-22 2004-11-25 サザン バイオシステムズ， インコーポレイテッド ゼロ次長期放出同軸インプラント
JP4490095B2 (ja) 2001-06-29 2010-06-23 メドグラフト マイクロテック インコーポレイテッド 生体分解性の注入可能な移植物およびそれに関連する製造方法ならびに使用方法
JP2003192773A (ja) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc 生体吸収性ポリヒドロキシカルボン酸及びその製造法
CA2471521C (en) * 2001-12-26 2010-11-02 Takeda Chemical Industries, Ltd. Novel microsphere and method for production thereof
US20040197301A1 (en) * 2003-02-18 2004-10-07 Zhong Zhao Hybrid polymers and methods of making the same
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US20080286359A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US7645459B2 (en) 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
US20080287400A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US7645460B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of risedronate
US20090275730A1 (en) * 2004-10-20 2009-11-05 Hiroyuki Oku Temperature responsive depsipeptide polymer
CN1923281B (zh) * 2005-08-30 2010-05-05 孔庆忠 一种含植物生物碱的抗癌缓释注射剂
WO2007084418A2 (en) * 2006-01-13 2007-07-26 Surmodics, Inc. Microparticle containing matrices for drug delivery
ES2575933T3 (es) * 2006-05-31 2016-07-04 Baxter International Inc. Colágeno para su uso en la prevención de la formación de fibrosis epidural después de cirugía espinal
TWI436793B (zh) * 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
KR100845009B1 (ko) * 2007-08-07 2008-07-08 한국생명공학연구원 전하를 띠는 물질이 고착된 다공성 고분자 입자 및 그제조방법
TWI461227B (zh) 2007-10-30 2014-11-21 Baxter Int 再生生物功能性膠原生物基質用來治療內臟或體壁缺陷的用途
EP2259803B2 (en) 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US9039783B2 (en) * 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
PT2442835E (pt) * 2009-06-16 2015-03-23 Baxter Healthcare Sa Esponja hemostática
JPWO2011024944A1 (ja) * 2009-08-31 2013-01-31 国立大学法人豊橋技術科学大学 ステレオコンプレックスポリエステル及びその製造方法
KR101811070B1 (ko) * 2009-12-16 2017-12-20 백스터 인터내셔널 인코포레이티드 지혈 스폰지
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
JP5973997B2 (ja) 2010-06-01 2016-08-23 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 乾燥した安定な止血用組成物を作製するためのプロセス
CN103037845B (zh) 2010-06-01 2015-11-25 巴克斯特国际公司 用于制备干燥、稳定的止血组合物的方法
KR101865427B1 (ko) 2010-06-01 2018-06-07 백스터 인터내셔널 인코포레이티드 건성의 안정된 지혈 조성물의 제조 방법
CA2806351C (en) 2010-07-26 2017-12-12 Universite De Geneve Compositions comprising polymers prepared from 2-hydroxyalkyl acids
WO2013053755A2 (en) 2011-10-11 2013-04-18 Baxter International Inc. Hemostatic compositions
EP2766059B1 (en) 2011-10-11 2022-11-23 Baxter International Inc. Hemostatic compositions
AR088531A1 (es) 2011-10-27 2014-06-18 Baxter Int Composiciones hemostaticas
JP6241624B2 (ja) 2012-03-06 2017-12-06 フェロサン メディカル デバイシーズ エイ／エス 止血ペーストを収容する加圧容器
EP2825216B1 (en) 2012-06-12 2015-08-19 Ferrosan Medical Devices A/S Dry haemostatic composition
WO2014202760A2 (en) 2013-06-21 2014-12-24 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
EP3470094B1 (en) 2013-12-11 2020-07-22 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
JP6726852B2 (ja) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー／エス 止血および創傷治癒に使用するための乾燥組成物
AU2015371184B2 (en) 2014-12-24 2020-06-25 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
CA2986981A1 (en) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
JP6148701B2 (ja) * 2015-07-31 2017-06-14 ユニベルシテ ドゥ ジュネーブ ２−ヒドロキシアルキル酸から調製されたポリマーを含む組成物
CN105111417A (zh) * 2015-08-25 2015-12-02 杭州铭众生物科技有限公司 一种羟基乙酸-羟基丙酸无规共聚物的制备方法
EP4321182A2 (en) 2018-05-09 2024-02-14 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US368702A (en) 1887-08-23 bischoff
US467719A (en) 1892-01-26 Dust-guard for car-axle journals
US329526A (en) 1885-11-03 Coal-mining machine
NO139560C (no) 1972-04-29 1979-04-04 Takeda Chemical Industries Ltd Analogifremgangsmaate til fremstilling av terapeutisk virksomme nonapeptidamid-derivater
JPS528375B2 (es) 1973-07-02 1977-03-09
FR2238700B1 (es) 1973-07-24 1977-10-14 Takeda Chemical Industries Ltd
CS180644B2 (en) 1973-09-29 1978-01-31 Takeda Chemical Industries Ltd Process for preparing nonapeptides
JPS5726506B2 (es) 1974-03-08 1982-06-04
FR2329293A1 (fr) 1975-10-29 1977-05-27 Parke Davis & Co Nouveaux nonapeptides et procedes pour leur production
US4087390A (en) 1977-02-02 1978-05-02 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4093574A (en) 1977-02-02 1978-06-06 Eli Lilly And Company Somatostatin analogs and intermediates thereto
JPS5944308B2 (ja) 1976-03-23 1984-10-29 武田薬品工業株式会社 ペプタイド
US4121577A (en) 1977-01-03 1978-10-24 Binder Timothy A Method and apparatus for aiding conditioning of an erect spinal column and advantageous muscle control
US4100117A (en) 1977-04-21 1978-07-11 Eli Lilly And Company Somatostatin analogs and intermediates thereto
US4253998A (en) 1979-03-09 1981-03-03 American Home Products Corporation Peptides related to somatostatin
US4277394A (en) 1979-04-23 1981-07-07 Takeda Chemical Industries, Ltd Tetrapeptidehydrazide derivatives
US4317815A (en) 1979-06-13 1982-03-02 Coy David Howard LH-RH Antagonists
US4622244A (en) * 1979-09-04 1986-11-11 The Washington University Process for preparation of microcapsules
US4253997A (en) 1979-12-17 1981-03-03 American Home Products Corporation Anti-ovulatory decapeptides
JPS5692846A (en) 1979-12-27 1981-07-27 Takeda Chem Ind Ltd Tetrapeptide derivative and its preparation
US4675189A (en) * 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
PH19942A (en) * 1980-11-18 1986-08-14 Sintex Inc Microencapsulation of water soluble polypeptides
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
DE3218151A1 (de) * 1982-05-14 1983-11-17 Akzo Gmbh, 5600 Wuppertal Mikroporoese, pulverfoermige polylactide und verfahren zu deren herstellung
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production
JPH0678425B2 (ja) 1984-07-06 1994-10-05 和光純薬工業株式会社 重合体の新規製造法
DE3678308D1 (de) * 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
US4962091A (en) * 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
JP2526589B2 (ja) * 1986-08-08 1996-08-21 武田薬品工業株式会社 ペプチド含有マイクロカプセルおよびその製造法
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
AU606383B2 (en) * 1987-03-06 1991-02-07 Research Triangle Institute Polymer blends for selective biodegradability
JPH0613602B2 (ja) * 1987-07-14 1994-02-23 三井東圧化学株式会社 ｄ▲ｌ▼−乳酸−グリコール酸共重合物の製造方法
US4897811A (en) 1988-01-19 1990-01-30 Nestor, Inc. N-dimensional coulomb neural network which provides for cumulative learning of internal representations
JP2827287B2 (ja) * 1988-07-05 1998-11-25 武田薬品工業株式会社 水溶性薬物含有徐放型マイクロカプセル
ES2099064T3 (es) 1988-09-01 1997-05-16 Takeda Chemical Industries Ltd Derivados de fumagillol.
EP0357061B1 (en) 1988-09-01 1994-06-08 Takeda Chemical Industries, Ltd. Angiogenesis inhibitory agent
JPH02212436A (ja) * 1989-02-14 1990-08-23 Japan Atom Energy Res Inst 徐放性基剤
EP0415294A3 (en) 1989-08-31 1991-06-12 Takeda Chemical Industries, Ltd. Cyclohexanol derivatives, production and use thereof
CN2891061Y (zh) 2006-03-15 2007-04-18 鸿富锦精密工业（深圳）有限公司 一体式液晶电脑及其电脑主机

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CN1043189C (zh) 1999-05-05
EP0481732B1 (en) 1995-03-01
NO302481B1 (no) 1998-03-09
LV10055A (lv) 1994-05-10
EP0481732A1 (en) 1992-04-22
MX9101595A (es) 1992-06-05
NO914032L (no) 1992-04-21
NZ240214A (en) 1993-02-25
KR100199119B1 (ko) 1999-06-15
FI914865A0 (fi) 1991-10-15
RU2103005C1 (ru) 1998-01-27
IE66705B1 (en) 1996-01-24
CN1116212A (zh) 1996-02-07
CA2053468A1 (en) 1992-04-17
CN1057670C (zh) 2000-10-25
DE69107773D1 (de) 1995-04-06
LTIP442A (en) 1994-11-25
FI101454B (fi) 1998-06-30
FI101454B1 (fi) 1998-06-30
LT3277B (en) 1995-05-25
PT99236B (pt) 1999-04-30
PT99236A (pt) 1992-09-30
ATE119035T1 (de) 1995-03-15
KR920007632A (ko) 1992-05-27
CA2053468C (en) 2002-07-09
EE02958B1 (et) 1997-02-17
GEP19981287B (en) 1998-09-01
LV10055B (en) 1995-02-20
FI914865A (fi) 1992-04-17
DE69107773T2 (de) 1995-06-29
AU8586491A (en) 1992-04-30
NO914032D0 (no) 1991-10-14
IE913624A1 (en) 1992-04-22
ZA918168B (en) 1993-04-14
DK0481732T3 (da) 1995-05-22
JP3196035B2 (ja) 2001-08-06
JPH05112468A (ja) 1993-05-07
AU644019B2 (en) 1993-12-02
CN1060851A (zh) 1992-05-06
US5304377A (en) 1994-04-19
UA27707C2 (uk) 2000-10-16

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