AU5722486A - Compositions for the preparation of microparticles permitting a prolonged release of a biologically active substance - Google Patents
Compositions for the preparation of microparticles permitting a prolonged release of a biologically active substanceInfo
- Publication number
- AU5722486A AU5722486A AU57224/86A AU5722486A AU5722486A AU 5722486 A AU5722486 A AU 5722486A AU 57224/86 A AU57224/86 A AU 57224/86A AU 5722486 A AU5722486 A AU 5722486A AU 5722486 A AU5722486 A AU 5722486A
- Authority
- AU
- Australia
- Prior art keywords
- active substance
- biologically active
- microparticles
- permitting
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Peptides Or Proteins (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Abstract
1. A composition for the preparation by extrusion of microparticles permitting a prolonged release of a biologically active substance, which composition consists of a biologically active substance, one or more non-hydrophilic polymers and from 10 to 40% by weight either of a mixture of at least two lipid excipients one of which has the property of dissolving or gelling the polymer or polymers and the other has lubricating properties or of a lipid excipient having both the property of dissolving or gelling the polymer or polymers and lubricating properties, and, if appropriate, one or more additives chosen from diluents and antistatic agents.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8507013 | 1985-05-09 | ||
FR8507013A FR2581541B1 (en) | 1985-05-09 | 1985-05-09 | NOVEL PHARMACEUTICAL COMPOSITIONS FOR THE EXTENDED RELEASE OF AN ACTIVE INGREDIENT AND THEIR PREPARATION METHOD |
Publications (2)
Publication Number | Publication Date |
---|---|
AU5722486A true AU5722486A (en) | 1986-11-13 |
AU579012B2 AU579012B2 (en) | 1988-11-10 |
Family
ID=9319093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU57224/86A Ceased AU579012B2 (en) | 1985-05-09 | 1986-05-07 | Compositions for the preparation of microparticles permitting a prolonged release of a biologically active substance |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0204596B1 (en) |
JP (1) | JPS61260029A (en) |
KR (1) | KR860008774A (en) |
AT (1) | ATE45283T1 (en) |
AU (1) | AU579012B2 (en) |
CA (1) | CA1266841A (en) |
DE (1) | DE3664867D1 (en) |
DK (1) | DK217286A (en) |
ES (1) | ES8802206A1 (en) |
FI (1) | FI861923A (en) |
FR (1) | FR2581541B1 (en) |
MA (1) | MA20670A1 (en) |
NZ (1) | NZ216082A (en) |
ZA (1) | ZA863431B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5700410A (en) * | 1992-10-16 | 1997-12-23 | Nippon Shinyaku Co., Ltd. | Method of manufacturing wax matrices |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5198226A (en) * | 1986-01-30 | 1993-03-30 | Syntex (U.S.A.) Inc. | Long acting nicardipine hydrochloride formulation |
US4940556A (en) * | 1986-01-30 | 1990-07-10 | Syntex (U.S.A.) Inc. | Method of preparing long acting formulation |
IL81419A0 (en) * | 1986-01-30 | 1987-08-31 | Syntex Inc | Long acting sustained release pharmaceutical compositions containing dihydropyridines and their preparation |
SE457326B (en) * | 1986-02-14 | 1988-12-19 | Lejus Medical Ab | PROCEDURES FOR PREPARING A QUICK SUBSTANTIAL CANDLES CONTAINING BLA MICROCRISTALLIN CELLULOSA |
DE3612212A1 (en) * | 1986-04-11 | 1987-10-15 | Basf Ag | METHOD FOR PRODUCING SOLID PHARMACEUTICAL FORMS |
HU202753B (en) * | 1986-06-21 | 1991-04-29 | Sandoz Ag | Process for producing retard pharmaceutical compositions containing cetotiphene |
FR2634376B1 (en) | 1988-07-21 | 1992-04-17 | Farmalyoc | NOVEL SOLID AND POROUS UNIT FORM COMPRISING MICROPARTICLES AND / OR NANOPARTICLES, AS WELL AS ITS PREPARATION |
FR2663818B1 (en) * | 1990-06-29 | 1993-07-09 | Rhone Poulenc Nutrition Animale | PROCESS FOR THE PREPARATION OF GRANULES OF ACTIVE PRINCIPLES BY EXTRUSION. |
DE4021678C2 (en) * | 1990-07-07 | 1994-07-07 | Merz & Co Gmbh & Co | Process for the preparation of small-sized shaped articles with a high etofibrate content and controlled release of active ingredient, their use and existing orally administrable administration forms |
DE4031881C2 (en) * | 1990-10-08 | 1994-02-24 | Sanol Arznei Schwarz Gmbh | Solvent-free, oral sustained-release pharmaceutical preparation and process for its preparation |
WO1993007859A1 (en) * | 1991-10-23 | 1993-04-29 | Warner-Lambert Company | Novel pharmaceutical pellets and process for their production |
US5792474A (en) * | 1992-05-22 | 1998-08-11 | Goedecke Aktiengesellschaft | Process for the production of retarded pharmaceutical compositions |
ES2061394B1 (en) * | 1993-02-05 | 1995-06-16 | Robert S A Lab | MANUFACTURING PROCEDURE OF A POTASSIC CITRATE GRANULATE WITH DELAYED ASSIGNMENT. |
US5843347A (en) * | 1993-03-23 | 1998-12-01 | Laboratoire L. Lafon | Extrusion and freeze-drying method for preparing particles containing an active ingredient |
FR2702968B1 (en) * | 1993-03-23 | 1995-06-23 | Lafon Labor | Process for the preparation of particles containing an active ingredient by extrusion and lyophilization. |
BE1006990A5 (en) * | 1993-04-22 | 1995-02-07 | Univ Gent | METHOD AND COMPOSITION TO MAKE AN ACTIVE INGREDIENT IN A solid dosage form. |
FR2710500B1 (en) * | 1993-09-27 | 1995-12-01 | Virbac Laboratoires | Composition and system for oral administration for animals, their preparation process and their applications. |
DE4422881A1 (en) * | 1993-10-25 | 1995-04-27 | Bayer Ag | Colloidally dispersible drug formulations |
CA2182282C (en) * | 1994-02-16 | 2006-04-18 | Jacqueline E. Briskin | Process for preparing fine particle pharmaceutical formulations |
DE4413350A1 (en) * | 1994-04-18 | 1995-10-19 | Basf Ag | Retard matrix pellets and process for their production |
GB9422154D0 (en) * | 1994-11-03 | 1994-12-21 | Euro Celtique Sa | Pharmaceutical compositions and method of producing the same |
US5965161A (en) | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
DE29502547U1 (en) * | 1995-02-16 | 1995-03-30 | Röhm GmbH, 64293 Darmstadt | Thermoplastic coating and binding agent for pharmaceutical forms |
DE19531277A1 (en) * | 1995-08-25 | 1997-02-27 | Basf Ag | Use of lipids as an aid in the production of solid dosage forms by the melt extrusion process |
DE19539363A1 (en) * | 1995-10-23 | 1997-04-24 | Basf Ag | Process for the production of solid dosage forms |
GB2344520A (en) * | 1998-12-08 | 2000-06-14 | Phares Pharm Res Nv | Pharmaceutical carriers comprising lipids and polymers |
DE10029201A1 (en) | 2000-06-19 | 2001-12-20 | Basf Ag | Retarded release oral dosage form, obtained by granulating mixture containing active agent and polyvinyl acetate-polyvinyl pyrrolidone mixture below the melting temperature |
BR0112782A (en) | 2000-08-03 | 2003-07-01 | Procter & Gamble | Methods and apparatus for the production of granular compositions |
WO2018140941A1 (en) * | 2017-01-30 | 2018-08-02 | Case Western Reserve University | Polymer constructs for controlled release of guest agents |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3146167A (en) * | 1961-10-05 | 1964-08-25 | Smith Kline French Lab | Method of preparing sustained release pellets and products thereof |
US3247065A (en) * | 1963-10-14 | 1966-04-19 | Hoffmann La Roche | Free-flowing coated ascorbic acid |
US3965256A (en) * | 1972-05-16 | 1976-06-22 | Synergistics | Slow release pharmaceutical compositions |
DE3024416C2 (en) * | 1980-06-28 | 1982-04-15 | Gödecke AG, 1000 Berlin | Process for the production of medicaments with sustained release of active substances |
FR2515035A1 (en) * | 1981-10-26 | 1983-04-29 | Rhone Poulenc Sante | NEW SOLID GALENIC FORM FOR ORAL ADMINISTRATION AND METHOD OF MANUFACTURING THE SAME |
IT1200217B (en) * | 1986-09-30 | 1989-01-05 | Valducci Roberto | MEMBRANE FOR PHARMACEUTICAL AND INDUSTRIAL USE |
-
1985
- 1985-05-09 FR FR8507013A patent/FR2581541B1/en not_active Expired
-
1986
- 1986-04-30 MA MA20895A patent/MA20670A1/en unknown
- 1986-05-07 AU AU57224/86A patent/AU579012B2/en not_active Ceased
- 1986-05-07 ZA ZA863431A patent/ZA863431B/en unknown
- 1986-05-07 NZ NZ216082A patent/NZ216082A/en unknown
- 1986-05-08 JP JP61103953A patent/JPS61260029A/en active Pending
- 1986-05-08 FI FI861923A patent/FI861923A/en not_active Application Discontinuation
- 1986-05-08 CA CA000508680A patent/CA1266841A/en not_active Expired - Lifetime
- 1986-05-08 KR KR1019860003576A patent/KR860008774A/en not_active Application Discontinuation
- 1986-05-09 AT AT86400996T patent/ATE45283T1/en not_active IP Right Cessation
- 1986-05-09 DK DK217286A patent/DK217286A/en not_active Application Discontinuation
- 1986-05-09 EP EP86400996A patent/EP0204596B1/en not_active Expired
- 1986-05-09 ES ES554821A patent/ES8802206A1/en not_active Expired
- 1986-05-09 DE DE8686400996T patent/DE3664867D1/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5700410A (en) * | 1992-10-16 | 1997-12-23 | Nippon Shinyaku Co., Ltd. | Method of manufacturing wax matrices |
Also Published As
Publication number | Publication date |
---|---|
FI861923A0 (en) | 1986-05-08 |
MA20670A1 (en) | 1986-12-31 |
FR2581541B1 (en) | 1988-05-20 |
EP0204596B1 (en) | 1989-08-09 |
KR860008774A (en) | 1986-12-18 |
ES8802206A1 (en) | 1988-04-16 |
FR2581541A1 (en) | 1986-11-14 |
FI861923A (en) | 1986-11-10 |
AU579012B2 (en) | 1988-11-10 |
DK217286A (en) | 1986-11-10 |
DE3664867D1 (en) | 1989-09-14 |
ES554821A0 (en) | 1988-04-16 |
CA1266841A (en) | 1990-03-20 |
JPS61260029A (en) | 1986-11-18 |
ATE45283T1 (en) | 1989-08-15 |
DK217286D0 (en) | 1986-05-09 |
ZA863431B (en) | 1986-12-30 |
NZ216082A (en) | 1989-01-06 |
EP0204596A1 (en) | 1986-12-10 |
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