ZA863431B - Compositions for the preparation of microparticles permitting a prolonged release of a biologically active substance - Google Patents

Compositions for the preparation of microparticles permitting a prolonged release of a biologically active substance

Info

Publication number
ZA863431B
ZA863431B ZA863431A ZA863431A ZA863431B ZA 863431 B ZA863431 B ZA 863431B ZA 863431 A ZA863431 A ZA 863431A ZA 863431 A ZA863431 A ZA 863431A ZA 863431 B ZA863431 B ZA 863431B
Authority
ZA
South Africa
Prior art keywords
active substance
biologically active
microparticles
permitting
preparation
Prior art date
Application number
ZA863431A
Inventor
Jehan-Yves Drouin
Michel Veillard
Original Assignee
Rhone Poulenc Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante
Publication of ZA863431B publication Critical patent/ZA863431B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

1. A composition for the preparation by extrusion of microparticles permitting a prolonged release of a biologically active substance, which composition consists of a biologically active substance, one or more non-hydrophilic polymers and from 10 to 40% by weight either of a mixture of at least two lipid excipients one of which has the property of dissolving or gelling the polymer or polymers and the other has lubricating properties or of a lipid excipient having both the property of dissolving or gelling the polymer or polymers and lubricating properties, and, if appropriate, one or more additives chosen from diluents and antistatic agents.
ZA863431A 1985-05-09 1986-05-07 Compositions for the preparation of microparticles permitting a prolonged release of a biologically active substance ZA863431B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8507013A FR2581541B1 (en) 1985-05-09 1985-05-09 NOVEL PHARMACEUTICAL COMPOSITIONS FOR THE EXTENDED RELEASE OF AN ACTIVE INGREDIENT AND THEIR PREPARATION METHOD

Publications (1)

Publication Number Publication Date
ZA863431B true ZA863431B (en) 1986-12-30

Family

ID=9319093

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA863431A ZA863431B (en) 1985-05-09 1986-05-07 Compositions for the preparation of microparticles permitting a prolonged release of a biologically active substance

Country Status (14)

Country Link
EP (1) EP0204596B1 (en)
JP (1) JPS61260029A (en)
KR (1) KR860008774A (en)
AT (1) ATE45283T1 (en)
AU (1) AU579012B2 (en)
CA (1) CA1266841A (en)
DE (1) DE3664867D1 (en)
DK (1) DK217286A (en)
ES (1) ES8802206A1 (en)
FI (1) FI861923A (en)
FR (1) FR2581541B1 (en)
MA (1) MA20670A1 (en)
NZ (1) NZ216082A (en)
ZA (1) ZA863431B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198226A (en) * 1986-01-30 1993-03-30 Syntex (U.S.A.) Inc. Long acting nicardipine hydrochloride formulation
US4940556A (en) * 1986-01-30 1990-07-10 Syntex (U.S.A.) Inc. Method of preparing long acting formulation
IL81419A0 (en) * 1986-01-30 1987-08-31 Syntex Inc Long acting sustained release pharmaceutical compositions containing dihydropyridines and their preparation
SE457326B (en) * 1986-02-14 1988-12-19 Lejus Medical Ab PROCEDURES FOR PREPARING A QUICK SUBSTANTIAL CANDLES CONTAINING BLA MICROCRISTALLIN CELLULOSA
DE3612212A1 (en) * 1986-04-11 1987-10-15 Basf Ag METHOD FOR PRODUCING SOLID PHARMACEUTICAL FORMS
HU202753B (en) * 1986-06-21 1991-04-29 Sandoz Ag Process for producing retard pharmaceutical compositions containing cetotiphene
FR2634376B1 (en) 1988-07-21 1992-04-17 Farmalyoc NOVEL SOLID AND POROUS UNIT FORM COMPRISING MICROPARTICLES AND / OR NANOPARTICLES, AS WELL AS ITS PREPARATION
FR2663818B1 (en) * 1990-06-29 1993-07-09 Rhone Poulenc Nutrition Animale PROCESS FOR THE PREPARATION OF GRANULES OF ACTIVE PRINCIPLES BY EXTRUSION.
DE4021678C2 (en) * 1990-07-07 1994-07-07 Merz & Co Gmbh & Co Process for the preparation of small-sized shaped articles with a high etofibrate content and controlled release of active ingredient, their use and existing orally administrable administration forms
DE4031881C2 (en) * 1990-10-08 1994-02-24 Sanol Arznei Schwarz Gmbh Solvent-free, oral sustained-release pharmaceutical preparation and process for its preparation
WO1993007859A1 (en) * 1991-10-23 1993-04-29 Warner-Lambert Company Novel pharmaceutical pellets and process for their production
AU4316393A (en) * 1992-05-22 1993-12-30 Godecke Aktiengesellschaft Process for preparing delayed-action medicinal compositions
JP2616252B2 (en) * 1992-10-16 1997-06-04 日本新薬株式会社 Preparation of wax matrix
ES2061394B1 (en) * 1993-02-05 1995-06-16 Robert S A Lab MANUFACTURING PROCEDURE OF A POTASSIC CITRATE GRANULATE WITH DELAYED ASSIGNMENT.
FR2702968B1 (en) * 1993-03-23 1995-06-23 Lafon Labor Process for the preparation of particles containing an active ingredient by extrusion and lyophilization.
US5843347A (en) * 1993-03-23 1998-12-01 Laboratoire L. Lafon Extrusion and freeze-drying method for preparing particles containing an active ingredient
BE1006990A5 (en) * 1993-04-22 1995-02-07 Univ Gent METHOD AND COMPOSITION TO MAKE AN ACTIVE INGREDIENT IN A solid dosage form.
FR2710500B1 (en) * 1993-09-27 1995-12-01 Virbac Laboratoires Composition and system for oral administration for animals, their preparation process and their applications.
DE4422881A1 (en) * 1993-10-25 1995-04-27 Bayer Ag Colloidally dispersible drug formulations
MX9603480A (en) * 1994-02-16 1997-12-31 Abbott Lab Process for preparing fine particle pharmaceutical formulations.
DE4413350A1 (en) * 1994-04-18 1995-10-19 Basf Ag Retard matrix pellets and process for their production
GB9422154D0 (en) * 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
DE29502547U1 (en) * 1995-02-16 1995-03-30 Röhm GmbH, 64293 Darmstadt Thermoplastic coating and binding agent for pharmaceutical forms
DE19531277A1 (en) * 1995-08-25 1997-02-27 Basf Ag Use of lipids as an aid in the production of solid dosage forms by the melt extrusion process
DE19539363A1 (en) * 1995-10-23 1997-04-24 Basf Ag Process for the production of solid dosage forms
GB2344520A (en) * 1998-12-08 2000-06-14 Phares Pharm Res Nv Pharmaceutical carriers comprising lipids and polymers
DE10029201A1 (en) 2000-06-19 2001-12-20 Basf Ag Retarded release oral dosage form, obtained by granulating mixture containing active agent and polyvinyl acetate-polyvinyl pyrrolidone mixture below the melting temperature
WO2002011875A2 (en) 2000-08-03 2002-02-14 The Procter & Gamble Company Methods and apparatus for producing granular compositions
US20200093744A1 (en) * 2017-01-30 2020-03-26 Case Western Reserve University Polymer constructs for controlled release of guest agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3146167A (en) * 1961-10-05 1964-08-25 Smith Kline French Lab Method of preparing sustained release pellets and products thereof
US3247065A (en) * 1963-10-14 1966-04-19 Hoffmann La Roche Free-flowing coated ascorbic acid
US3965256A (en) * 1972-05-16 1976-06-22 Synergistics Slow release pharmaceutical compositions
DE3024416C2 (en) * 1980-06-28 1982-04-15 Gödecke AG, 1000 Berlin Process for the production of medicaments with sustained release of active substances
FR2515035A1 (en) * 1981-10-26 1983-04-29 Rhone Poulenc Sante NEW SOLID GALENIC FORM FOR ORAL ADMINISTRATION AND METHOD OF MANUFACTURING THE SAME
IT1200217B (en) * 1986-09-30 1989-01-05 Valducci Roberto MEMBRANE FOR PHARMACEUTICAL AND INDUSTRIAL USE

Also Published As

Publication number Publication date
EP0204596A1 (en) 1986-12-10
EP0204596B1 (en) 1989-08-09
DK217286A (en) 1986-11-10
AU579012B2 (en) 1988-11-10
ATE45283T1 (en) 1989-08-15
NZ216082A (en) 1989-01-06
FR2581541A1 (en) 1986-11-14
DK217286D0 (en) 1986-05-09
FR2581541B1 (en) 1988-05-20
DE3664867D1 (en) 1989-09-14
ES8802206A1 (en) 1988-04-16
KR860008774A (en) 1986-12-18
JPS61260029A (en) 1986-11-18
ES554821A0 (en) 1988-04-16
CA1266841A (en) 1990-03-20
AU5722486A (en) 1986-11-13
FI861923A0 (en) 1986-05-08
FI861923A (en) 1986-11-10
MA20670A1 (en) 1986-12-31

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