MX346423B - Conjugados de polimeros zwiterionicos multifuncionales. - Google Patents

Conjugados de polimeros zwiterionicos multifuncionales.

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Publication number
MX346423B
MX346423B MX2012006970A MX2012006970A MX346423B MX 346423 B MX346423 B MX 346423B MX 2012006970 A MX2012006970 A MX 2012006970A MX 2012006970 A MX2012006970 A MX 2012006970A MX 346423 B MX346423 B MX 346423B
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MX
Mexico
Prior art keywords
polymer conjugates
zwitterionic polymer
multifunctional
multifunctional zwitterionic
random copolymers
Prior art date
Application number
MX2012006970A
Other languages
English (en)
Other versions
MX2012006970A (es
Inventor
A Charles Stephen
Victor Perlroth D
A Clizbe Lane
g benoit Didier
To Wayne
Original Assignee
Oligasis *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oligasis * filed Critical Oligasis *
Publication of MX2012006970A publication Critical patent/MX2012006970A/es
Publication of MX346423B publication Critical patent/MX346423B/es

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    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10Esters
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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Abstract

La presente invención proporciona copolímeros aleatorios que contienen zwiteriones y uno o más agentes funcionales, y métodos de preparación de dichos copolímeros aleatorios.
MX2012006970A 2009-12-18 2010-12-20 Conjugados de polimeros zwiterionicos multifuncionales. MX346423B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28812709P 2009-12-18 2009-12-18
PCT/US2010/061358 WO2011075736A1 (en) 2009-12-18 2010-12-20 Multifunctional zwitterionic polymer conjugates

Publications (2)

Publication Number Publication Date
MX2012006970A MX2012006970A (es) 2012-10-03
MX346423B true MX346423B (es) 2017-03-21

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10363290B2 (en) 2014-10-17 2019-07-30 Kodiak Sciences Inc. Butyrylcholinesterase zwitterionic polymer conjugates
US10702608B2 (en) 2013-09-08 2020-07-07 Kodiak Sciences Inc. Factor VIII zwitterionic polymer conjugates
US11066465B2 (en) 2015-12-30 2021-07-20 Kodiak Sciences Inc. Antibodies and conjugates thereof
US11155610B2 (en) 2014-06-28 2021-10-26 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2657628T3 (es) 2006-02-28 2018-03-06 Kodiak Sciences Inc. Conjugados poliméricos que contienen acriloiloxietilfosforilcolina y su preparación
CA2665493A1 (en) 2006-08-07 2008-02-14 University Of Washington Mixed charge copolymers and hydrogels
WO2011075185A1 (en) * 2009-12-18 2011-06-23 Oligasis Targeted drug phosphorylcholine polymer conjugates
KR20130097636A (ko) * 2010-04-15 2013-09-03 올리가시스 고분자량 쌍성이온-함유 중합체
CN102977275B (zh) * 2011-09-07 2014-12-10 佛山市博新生物科技有限公司 一种经过预处理的含有磷酰胆碱基团的单体改善吸附树脂生物相容性的应用
WO2013059137A1 (en) * 2011-10-17 2013-04-25 Oligasis High molecular weight zwitterion-containing polymers
JP6234064B2 (ja) * 2012-05-23 2017-11-22 キヤノン株式会社 重合体、前記重合体を用いた核磁気共鳴分析用または磁気共鳴イメージング用の造影剤、化合物、前記重合体を用いた核磁気共鳴分析方法および磁気共鳴イメージング方法
US10159735B2 (en) * 2012-06-26 2018-12-25 The Curators Of The University Of Missouri Photocleavable drug conjugates
CN102875733B (zh) * 2012-10-25 2014-06-11 西安科技大学 具有仿细胞外层膜结构的纳米颗粒及其制备方法
WO2014144744A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Aptamer methods and compositions
JP6148556B2 (ja) 2013-07-22 2017-06-14 東レ・デュポン株式会社 ポリイミドフィルム
WO2015069669A1 (en) 2013-11-05 2015-05-14 Elena Molokanova Nanostructure conjugates for modulation of location-specific subtypes of receptors and ion channels
WO2015073579A1 (en) * 2013-11-12 2015-05-21 University Of Washington Through Its Center For Commercialization Random copolymer therapeutic agent carriers and assemblies thereof
EP3079668A1 (en) * 2013-12-09 2016-10-19 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
US10588564B2 (en) 2014-09-30 2020-03-17 Moein Health, LLC Method and kit for diagnosing and treating neoplastic tissue
EP3188764B1 (en) * 2014-10-24 2023-08-23 Canon Kabushiki Kaisha Polymer and contrast agent for photoacoustic imaging including the polymer
IL243285A0 (en) 2015-12-22 2016-04-21 Yeda Res & Dev Analogues of lipids and liposomes containing them
WO2018112551A1 (en) * 2016-12-23 2018-06-28 Commonwealth Scientific And Industrial Research Organisation Biocompatible and hydrophilic polymer conjugate for targeted delivery of an agent
AU2018250695A1 (en) 2017-04-14 2019-11-07 Kodiak Sciences Inc. Complement factor D antagonist antibodies and conjugates thereof
US20210161894A1 (en) * 2017-12-04 2021-06-03 David Le Couteur Compositions and Methods for Modulating Liver Endothelial Cell Fenestrations
JP2019112533A (ja) * 2017-12-24 2019-07-11 国立大学法人千葉大学 貴金属分離回収可能なコポリマー及びそのコポリマーを用いた貴金属回収方法
EP3831909A1 (en) * 2019-12-03 2021-06-09 Université de Strasbourg Luminescent zwitterionic polymeric nanoparticles
JP7425405B2 (ja) * 2020-03-13 2024-01-31 日油株式会社 共重合体およびその用途
KR20220164547A (ko) * 2020-04-06 2022-12-13 티바 바이오테크 엘엘씨 효율적인 핵산 전달을 위한 운반체
CN112033943B (zh) * 2020-08-17 2021-03-30 中南民族大学 一种基于量子点-铜离子荧光基底传感器的精氨酸检测方法
JP7765173B2 (ja) * 2020-10-01 2025-11-06 積水化学工業株式会社 重合体、検査薬、アナライト濃度測定法、及び、アナライト濃度測定装置
WO2022235329A1 (en) * 2021-05-06 2022-11-10 University Of South Carolina Brain-targeted antibody nanoparticle for neurodegenerative diseases therapy
WO2022255204A1 (ja) * 2021-06-01 2022-12-08 デンカ株式会社 リン酸基又はリン酸エステル基を有するコポリマー、その製造方法、及び樹脂組成物
CN117897152A (zh) 2021-08-16 2024-04-16 蒂巴生物技术有限公司 含有糖官能化核酸载体的纳米颗粒组合物
CN114410735B (zh) * 2022-01-25 2023-10-27 河南中医药大学 以氨磷汀为底物利用atrp信号放大策略检测碱性磷酸酶的电化学试剂盒及使用方法
KR20250123762A (ko) * 2022-12-16 2025-08-18 바이오미미르 인코퍼레이티드 치료용 중합체, 및 그것의 전구체
WO2025015005A2 (en) * 2023-07-11 2025-01-16 The Uab Research Foundation Polymer-protein conjugate, pharmaceutical composition comprising said conjugate, therapeutic use thereof
WO2025029860A1 (en) * 2023-08-03 2025-02-06 Adcentrx Therapeutics Inc. Drug conjugates and methods of preparing and using the same
US12491262B2 (en) 2023-10-31 2025-12-09 Tiba Biotech Llc Gene delivery agents
WO2025122670A1 (en) * 2023-12-05 2025-06-12 Kodiak Sciences Inc. Formulations for dual vegf/il-6 inhibitors, anti-vegf antibodies, and conjugates thereof
CN118063689B (zh) * 2024-01-26 2025-01-28 锐康九域(厦门)医药科技有限公司 成纤维细胞激活蛋白-α响应水解致电荷翻转的聚合物-药物偶联物及其制备方法和应用

Family Cites Families (241)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH652145A5 (de) 1982-01-22 1985-10-31 Sandoz Ag Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
US4757006A (en) 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4634666A (en) 1984-01-06 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Human-murine hybridoma fusion partner
JPH0788399B2 (ja) 1985-04-12 1995-09-27 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド 新規プロコアギュラント蛋白質
US5198349A (en) 1986-01-03 1993-03-30 Genetics Institute, Inc. Method for producing factor VIII:C and analogs
US5250421A (en) 1986-01-03 1993-10-05 Genetics Institute, Inc. Method for producing factor VIII:C-type proteins
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
JPH0387173A (ja) 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体
US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5162218A (en) 1988-11-18 1992-11-10 The Regents Of The University Of California Conjugated polypeptides and methods for their preparation
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
ES2087997T3 (es) 1990-01-12 1996-08-01 Cell Genesys Inc Generacion de anticuerpos xenogenicos.
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
ES2108048T3 (es) 1990-08-29 1997-12-16 Genpharm Int Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DK0584082T3 (da) 1991-01-31 2000-10-16 Univ California Domæner i den ekstracellulære region af humane blodpladeafledte vækstfaktorreceptorpolypeptider
US5858657A (en) 1992-05-15 1999-01-12 Medical Research Council Methods for producing members of specific binding pairs
US5871907A (en) 1991-05-15 1999-02-16 Medical Research Council Methods for producing members of specific binding pairs
EP0940468A1 (en) 1991-06-14 1999-09-08 Genentech, Inc. Humanized antibody variable domain
DK0593561T3 (da) * 1991-07-05 2000-08-21 Biocompatibles Ltd Polymere overfladecoatinger
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5817310A (en) 1991-12-02 1998-10-06 Cor Therapeutics, Inc. Inhibitory immunoglobulin polypeptides to human PDGF beta receptor
EP0746609A4 (en) 1991-12-17 1997-12-17 Genpharm Int NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
CA2134773A1 (en) 1992-06-04 1993-12-09 Robert J. Debs Methods and compositions for in vivo gene therapy
CZ290342B6 (cs) 1992-10-02 2002-07-17 Genetics Institute Inc. Kompozice stabilní při skladování, obsahující koagulační faktor VIII a neiontovou povrchově aktivní látku a způsob její výroby
DK0672142T3 (da) 1992-12-04 2001-06-18 Medical Res Council Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse
GB9301701D0 (en) 1993-01-28 1993-03-17 Biocompatibles Ltd New zwitterionic materials
GB9301702D0 (en) 1993-01-28 1993-03-17 Biocompatibles Ltd New materials
US5643575A (en) 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
GB9324033D0 (en) 1993-11-23 1994-01-12 Biocompatibles Ltd Ethylenically unsaturated compounds
US5914349A (en) 1994-01-10 1999-06-22 Teva Pharmaceutical Industries, Ltd. Compositions containing and methods of using 1-aminoindan and derivatives thereof and process for preparing optically active 1-aminoindan derivatives
US5681746A (en) 1994-12-30 1997-10-28 Chiron Viagene, Inc. Retroviral delivery of full length factor VIII
US6541580B1 (en) 1995-03-31 2003-04-01 Carnegie Mellon University Atom or group transfer radical polymerization
US5763548A (en) 1995-03-31 1998-06-09 Carnegie-Mellon University (Co)polymers and a novel polymerization process based on atom (or group) transfer radical polymerization
GB9521234D0 (en) 1995-10-16 1995-12-20 Biocompatibles Ltd Synthesis of polymerisable phospho diesters
KR19990064280A (ko) 1995-10-16 1999-07-26 존 바드웰 인 함유 화합물의 산화방법
US5807937A (en) 1995-11-15 1998-09-15 Carnegie Mellon University Processes based on atom (or group) transfer radical polymerization and novel (co) polymers having useful structures and properties
US5663425A (en) 1996-01-26 1997-09-02 Lignotech Usa, Inc. Production of acid soluble humates
US5882644A (en) 1996-03-22 1999-03-16 Protein Design Labs, Inc. Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof
US6100071A (en) 1996-05-07 2000-08-08 Genentech, Inc. Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
US5834597A (en) 1996-05-20 1998-11-10 Protein Design Labs, Inc. Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same
US5789487A (en) 1996-07-10 1998-08-04 Carnegie-Mellon University Preparation of novel homo- and copolymers using atom transfer radical polymerization
US6156884A (en) 1996-08-05 2000-12-05 Prolinx, Inc. Bifunctional boronic compound complexing reagents and complexes
JPH10139832A (ja) * 1996-11-08 1998-05-26 Nof Corp 共重合体およびグルコースセンサー
US7125938B2 (en) 1997-03-11 2006-10-24 Carnegie Mellon University Atom or group transfer radical polymerization
US20070059302A1 (en) 1997-04-07 2007-03-15 Genentech, Inc. Anti-vegf antibodies
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
KR100870353B1 (ko) 1997-04-07 2008-11-25 제넨테크, 인크. 항-vegf 항체
JP3052923B2 (ja) 1997-05-30 2000-06-19 日本油脂株式会社 (メタ)アクリレート誘導体の製造方法
JP2001520009A (ja) 1997-10-16 2001-10-30 ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド 鳥の導入遺伝子についてのマグナム特異的プロモーターを含むベクター
AU2485199A (en) 1998-01-30 1999-08-16 First Chemical Corporation Photopolymerization compositions including maleimides and processes for using the same
JP4162284B2 (ja) 1998-02-04 2008-10-08 日油株式会社 洗浄剤組成物
US6121371A (en) 1998-07-31 2000-09-19 Carnegie Mellon University Application of atom transfer radical polymerization to water-borne polymerization systems
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6159942A (en) 1998-06-19 2000-12-12 Bioenergy, Inc. Compositions for increasing energy in vivo
JP4145403B2 (ja) * 1998-09-29 2008-09-03 日油株式会社 免疫学的活性物質測定用高分子/酵素結合体
US6781030B1 (en) 1998-11-02 2004-08-24 Trustee Of Tufts College, Ballou Hall Methods for cloning mammals using telophase oocytes
US6379942B1 (en) 1998-12-21 2002-04-30 Genencor International, Inc. Chemically modified enzymes with multiple charged variants
WO2000059968A1 (en) 1999-04-05 2000-10-12 The Research Foundation Of State University Of New York Graft, graft-block, block-graft, and star-shaped copolymers and methods of making them
FR2794459B1 (fr) 1999-05-19 2004-09-03 Atofina Polyalcoxyamines issues de nitroxydes beta-substitues
US7070959B1 (en) 1999-06-08 2006-07-04 Regeneron Pharmaceuticals, Inc. Modified chimeric polypeptides with improved pharmacokinetic properties
US7306799B2 (en) 1999-06-08 2007-12-11 Regeneron Pharmaceuticals, Inc. Use of VEGF inhibitors for treatment of eye disorders
CZ299516B6 (cs) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
AU782496B2 (en) 1999-07-13 2005-08-04 Bolder Biotechnology, Inc. Immunoglobulin fusion proteins
US7049373B2 (en) 1999-08-06 2006-05-23 Carnegie Mellon University Process for preparation of graft polymers
EP1222217B1 (en) 1999-09-08 2005-06-15 Polytherics Limited Uniform molecular weight polymers
HK1049787B (en) 1999-10-01 2014-07-25 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6348554B1 (en) 1999-11-30 2002-02-19 Rohmax Additives Gmbh Method for preparation of a liquid polymer composition and use of this composition
GB9928956D0 (en) 1999-12-07 2000-02-02 Malik Navid Internally supported biomimetic coating systems
IL144815A (en) 2000-08-11 2005-07-25 Sumitomo Chemical Co Process for producing carbonyl or hydroxy compound
US6852816B2 (en) 2000-10-06 2005-02-08 Biocompatibles Uk Limited Zwitterionic polymers
EP1337563B1 (en) 2000-10-06 2006-12-20 Carnegie-Mellon University Polymerization process for ionic monomers
WO2002028914A2 (en) 2000-10-06 2002-04-11 Carnegie Mellon University A catalyst system for controlled polymerization
US6627314B2 (en) 2000-10-06 2003-09-30 Carnegie Mellon University Preparation of nanocomposite structures by controlled polymerization
US6979556B2 (en) 2000-12-14 2005-12-27 Genentech, Inc. Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
US7829084B2 (en) 2001-01-17 2010-11-09 Trubion Pharmaceuticals, Inc. Binding constructs and methods for use thereof
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
EP1377519B1 (en) 2001-04-06 2010-06-09 Carnegie-Mellon University A process for the preparation of nanostructured materials
US6858580B2 (en) 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
IL166244A0 (en) 2001-07-12 2006-01-15 Jefferson Foote Super humanized antibodies
US20040253596A1 (en) 2001-08-27 2004-12-16 Michael Pawlak Bioanalytical recognition surface with optimized recognition element density
JP2003064132A (ja) 2001-08-28 2003-03-05 Nof Corp 重合体、製造方法および乳化・分散剤
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
SE523617C2 (sv) 2001-10-01 2004-05-04 Sandvik Ab Skär för spånavskiljande bearbetning försedd med spånbrytande geometri
WO2003031480A2 (en) 2001-10-12 2003-04-17 Carnegie Mellon University Process for monomer sequence control in polymerizations
US6759491B2 (en) 2001-10-12 2004-07-06 Carnegie Mellon University Simultaneous reverse and normal initiation of ATRP
US6964859B2 (en) 2001-10-16 2005-11-15 Massachusetts Institute Of Technology Suppressor tRNA system
EP1446438A2 (en) 2001-11-07 2004-08-18 Nektar Therapeutics Al, Corporation Branched polymers and their conjugates
WO2003062290A1 (en) 2002-01-16 2003-07-31 Biocompatibles Uk Limited Polymer conjugates
EP1480680B1 (en) 2002-03-07 2010-11-03 Biocompatibles UK Limited Block copolymers complexed with nucleic acids
US20050220880A1 (en) * 2002-03-07 2005-10-06 Lewis Andrew L Drug carriers comprising amphiphilic block copolymers
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
US7196142B2 (en) 2002-04-04 2007-03-27 The University Of Akron Polyisobutylene-based block anionomers and cationomers and synthesis thereof
JP4248189B2 (ja) * 2002-04-09 2009-04-02 株式会社資生堂 ホスホリルコリン基含有多糖類及びその製造方法
WO2003099835A1 (en) * 2002-05-21 2003-12-04 Emory University Multivalent polymers with chain-terminating binding groups
ES2566761T3 (es) 2002-05-30 2016-04-15 The Scripps Research Institute Ligación de azidas y acetilenos catalizada por cobre
DK1545613T3 (da) 2002-07-31 2011-11-14 Seattle Genetics Inc Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
US7019082B2 (en) 2002-08-09 2006-03-28 Carnegie Mellon University Polymers, supersoft elastomers and methods for preparing the same
AU2003267602A1 (en) 2002-09-25 2004-04-19 Biocompatibles Uk Limited Polymer compositions for administration to animals
US7737237B2 (en) 2002-11-07 2010-06-15 Phodia Chimie Controlled structure copolymer comprising an amphoteric or zwitterionic part
US20070111279A1 (en) 2002-11-13 2007-05-17 Procell, Inc. Production of recombinant therapeutic bioscavengers against chemical and biological agents
GB0301014D0 (en) 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
JPWO2004065418A1 (ja) 2003-01-20 2006-06-29 中外製薬株式会社 抗pci中和抗体
WO2004069888A2 (en) 2003-02-05 2004-08-19 Biocompatibles Uk Limited Block copolymers
NO346070B1 (no) 2003-02-10 2022-01-31 Biogen Ma Inc Stabil, vandig, farmasøytisk formulering og fremgangsmåte for fremstilling derav.
ATE472338T1 (de) 2003-02-20 2010-07-15 Seattle Genetics Inc Anti-cd70 antikörper-arzneimittelkonjugate und ihre verwendung zur behandlung von krebs
BRPI0409322B8 (pt) 2003-04-11 2021-05-25 Antriabio Inc método para preparar um conjugado de insulina-polímero
JP4703566B2 (ja) 2003-05-14 2011-06-15 イムノゲン インコーポレーティッド 薬剤複合体組成物
US7887789B2 (en) * 2003-05-23 2011-02-15 Nektar Therapeutics Polymer derivatives having particular atom arrangements
TWI306458B (en) 2003-05-30 2009-02-21 Elan Pharma Int Ltd Humanized antibodies that recognize beta amyloid peptide
GB0314472D0 (en) * 2003-06-20 2003-07-23 Warwick Effect Polymers Ltd Polymer
CN1208358C (zh) 2003-07-31 2005-06-29 上海交通大学 含多羟基官能团多臂星状超支化聚合物刷及其制备方法
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
US7758859B2 (en) 2003-08-01 2010-07-20 Genentech, Inc. Anti-VEGF antibodies
AU2004268614C1 (en) 2003-08-27 2010-10-28 Ophthotech Corporation Combination therapy for the treatment of ocular neovascular disorders
EP2626083A1 (en) 2003-09-17 2013-08-14 Nektar Therapeutics Multi-arm polymer prodrugs
WO2005040229A2 (en) 2003-10-24 2005-05-06 Avidia, Inc. Ldl receptor class a and egf domain monomers and multimers
CN107213469A (zh) 2003-11-06 2017-09-29 西雅图基因公司 能够与配体偶联的单甲基缬氨酸化合物
JP2007531513A (ja) 2003-11-13 2007-11-08 ハンミ ファーム.インダストリー カンパニー リミテッド 薬物のキャリアとして有用なIgGFc断片およびその製造方法
EA018427B1 (ru) 2003-12-16 2013-07-30 Нектар Терапьютикс Химически модифицированный налоксон
US8298532B2 (en) 2004-01-16 2012-10-30 Regeneron Pharmaceuticals, Inc. Fusion polypeptides capable of activating receptors
KR100593443B1 (ko) 2004-02-11 2006-06-28 삼성전자주식회사 트랜지스터들 및 그 제조방법들
EP1718667B1 (en) 2004-02-23 2013-01-09 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
JP4727938B2 (ja) 2004-02-24 2011-07-20 泰彦 岩崎 リビングラジカル重合開始基を持つポリリン酸の製造方法および用途
DE602005027673D1 (de) 2004-03-05 2011-06-09 Vegenics Pty Ltd Materialien und verfahren für wachstumsfaktorbindende konstrukte
JP4727941B2 (ja) 2004-03-12 2011-07-20 泰彦 岩崎 生分解性重合体の製造方法および用途
US20050208093A1 (en) 2004-03-22 2005-09-22 Thierry Glauser Phosphoryl choline coating compositions
JP4950022B2 (ja) 2004-03-23 2012-06-13 コンプレックス バイオシステムズ ゲーエムベーハー 自壊性リンカーを有する高分子プロドラッグ
GB0412181D0 (en) 2004-06-01 2004-06-30 Celltech R&D Ltd Biological products
US7863238B2 (en) * 2004-06-10 2011-01-04 Saint Louis University Proteins with an attached short peptide of acidic amino acids
KR101270829B1 (ko) 2004-09-23 2013-06-07 제넨테크, 인크. 시스테인 유전자조작 항체 및 접합체
WO2006044643A2 (en) 2004-10-15 2006-04-27 Seattle Genetics, Inc. Anti-cd70 antibody and its use for the treatment and prevention of cancer and immune disorders
US7632921B2 (en) 2004-11-12 2009-12-15 Bayer Healthcare Llc Site-directed modification of FVIII
US7214759B2 (en) 2004-11-24 2007-05-08 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same
WO2006063055A2 (en) 2004-12-06 2006-06-15 Bolder Biotechnology, Inc. Enzyme conjugates for use as detoxifying agents
EP1838349A1 (en) 2004-12-15 2007-10-03 Neuralab, Ltd. Amyloid beta antibodies for use in improving cognition
ATE369486T1 (de) 2004-12-18 2007-08-15 Haldor Topsoe As Verfahren zur regelung der zugabe eines reduktionsmittels in das abgas einer brennkraftmaschine
AR054428A1 (es) 2005-03-08 2007-06-27 Pharmacia & Upjohn Co Llc Composiciones de anticuerpos anti factor estimulante de colonia de macrofagos (anti-m-csf) que tienen menores niveles de endotoxina
US20060234347A1 (en) 2005-04-13 2006-10-19 Harding Thomas C Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors
KR101504622B1 (ko) 2005-04-29 2015-03-20 에이전시 포 사이언스, 테크놀로지 앤드 리서치 고차가지구조 고분자 및 그들의 응용
US20070005130A1 (en) 2005-06-29 2007-01-04 Thierry Glauser Biodegradable polymer for coating
WO2008020827A2 (en) 2005-08-01 2008-02-21 Biogen Idec Ma Inc. Altered polypeptides, immunoconjugates thereof, and methods related thereto
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
DE602006017416D1 (de) 2005-08-26 2010-11-18 Univ Carnegie Mellon Polymerisationsverfahren mit katalysatorreaktivierung
JP5096363B2 (ja) 2005-12-16 2012-12-12 ネクター セラピューティックス Glp−1のポリマ複合体
US7906134B2 (en) 2005-12-21 2011-03-15 Abbott Laboratories Room temperature-curable polymers
DE102006009004A1 (de) 2006-02-23 2007-09-06 Sustech Gmbh & Co. Kg Multifunktionelle sternförmige Präpolymere, deren Herstellung und Verwendung
ES2657628T3 (es) 2006-02-28 2018-03-06 Kodiak Sciences Inc. Conjugados poliméricos que contienen acriloiloxietilfosforilcolina y su preparación
JP2007263935A (ja) 2006-03-30 2007-10-11 Canon Inc 磁性マーカー及びその製造方法
EP2010584A4 (en) 2006-04-14 2010-07-21 Interface Biologics Inc DIPPLETED POLYMERS AND APPLICATIONS THEREOF
WO2007130453A2 (en) 2006-05-02 2007-11-15 Allozyne, Inc. Non-natural amino acid substituted polypeptides
JP5030036B2 (ja) * 2006-05-23 2012-09-19 一彦 石原 生体成分固定化ポリマー組成物および三次元架橋体
WO2008003099A1 (en) 2006-06-29 2008-01-03 Invitrogen, Dynal As Particles containing multi- block polymers
US20080008736A1 (en) * 2006-07-06 2008-01-10 Thierry Glauser Random copolymers of methacrylates and acrylates
EP2041196B1 (en) 2006-07-14 2012-11-28 Biocompatibles UK Limited Polymer
CN101500548A (zh) 2006-08-18 2009-08-05 弗·哈夫曼-拉罗切有限公司 用于体内递送多核苷酸的多缀合物
KR100808116B1 (ko) 2006-08-22 2008-03-03 전남대학교산학협력단 미생물 점착 방지용 공중합체 수지 코팅재
EP2059527B1 (en) 2006-09-01 2014-12-03 Novo Nordisk Health Care AG Modified glycoproteins
JP5111016B2 (ja) 2006-11-01 2012-12-26 三井化学株式会社 表面親水性ポリオレフィン成形体およびその製造方法
AU2007317333A1 (en) 2006-11-02 2008-05-15 Seattle Genetics, Inc. Methods of treating neoplastic, autoimmune and inflammatory diseases
EP2097119A4 (en) 2006-11-21 2012-10-17 Abbott Lab USE OF A TERPOLYMER OF TETRAFLUOROETHYLENE, HEXAFLUORPROPYLENE AND VINYLIDENE FLUORIDE IN MEDICAMENTAL COATINGS
DK2099823T4 (da) 2006-12-01 2022-05-09 Seagen Inc Målbindingsmiddelvarianter og anvendelser deraf
US7651527B2 (en) 2006-12-15 2010-01-26 Medtronic Vascular, Inc. Bioresorbable stent
EP2114451A2 (en) 2007-01-09 2009-11-11 Wyeth a Corporation of the State of Delaware Anti-il-13 antibody formulations and uses thereof
JP2010518013A (ja) 2007-02-01 2010-05-27 ジェネンテック, インコーポレイテッド 血管形成阻害剤を含む組み合わせ治療の方法
WO2008098930A1 (en) 2007-02-14 2008-08-21 Biocompatibes Uk Limited Derivatisation of biological molecules
WO2008112289A2 (en) 2007-03-12 2008-09-18 Nektar Therapeutics Oligomer-protease inhibitor conjugates
AU2008226791B2 (en) 2007-03-12 2014-01-16 Nektar Therapeutics Oligomer-antihistamine conjugates
CN101053681B (zh) 2007-04-10 2010-05-19 天津大学 用于血管栓塞材料的温敏性MPC-b-NIPAM二嵌段星型共聚物及制备方法和应用
KR101136262B1 (ko) 2007-04-17 2012-07-05 임클론 엘엘씨 PDGFRβ-특이적 억제제
US8003097B2 (en) 2007-04-18 2011-08-23 Janssen Alzheimer Immunotherapy Treatment of cerebral amyloid angiopathy
WO2008144248A1 (en) * 2007-05-14 2008-11-27 Tyco Healthcare Group Lp Furanone copolymers
JP5019524B2 (ja) * 2007-06-01 2012-09-05 国立大学法人 東京大学 新規ポリ(メタ)アクリレート共重合体ならびに小胞体及びゴルジ体への送達方法
HRP20110368T1 (hr) 2007-06-21 2011-06-30 Technische Universitt Mnchen Biološki aktivni proteini s povećanom stabilnošću in vivo i/ili in vitro
JP2009042617A (ja) 2007-08-10 2009-02-26 Canon Inc 静電荷像現像用トナー及びその製造方法
US7943370B2 (en) 2007-08-23 2011-05-17 Canon Kabushiki Kaisha Structure, target substance detection element and target substance detection kit
CA2698541C (en) 2007-10-19 2018-01-09 Genentech, Inc. Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates
JP5314033B2 (ja) 2007-10-22 2013-10-16 メルク セローノ ソシエテ アノニム 突然変異IgGFcフラグメントと融合した単一IFN−ベータ
JP2009114283A (ja) 2007-11-05 2009-05-28 Asahi Kasei Chemicals Corp 吸引用シートおよびそれを用いた装置
JPWO2009066746A1 (ja) 2007-11-22 2011-04-07 国立大学法人 東京大学 組織癒着防止材および関節拘縮防止材
BRPI0907046A2 (pt) 2008-01-18 2015-07-28 Medimmune Llc Anticorpo de cisteína engenheirada, ácido nucleico isolado, vetor, célula hospedeira, conjugado de anticorpo, composição farmacêutica, métodos de detecção de câncer, doenças ou distúrbios autoimunes, inflamatórios ou infecciosos em um indivíduo e de inibição de proliferação de uma célula alvo
DK2265283T3 (da) 2008-03-18 2014-10-20 Seattle Genetics Inc Auristatin-lægemiddel-linker-konjugater
HUE034763T2 (en) 2008-04-30 2018-02-28 Immunogen Inc Crosslinkers and their use
WO2009138473A2 (en) 2008-05-15 2009-11-19 Biocompatibles Uk Limited Intracellular antibody delivery
US8187623B2 (en) * 2008-06-25 2012-05-29 Boston Scientific Scimed, Inc. Medical copolymers
US8268314B2 (en) 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
JP2010117189A (ja) 2008-11-12 2010-05-27 Sumitomo Bakelite Co Ltd 生理活性物質固定化用基板
WO2010068862A2 (en) 2008-12-12 2010-06-17 University Of Massachusetts Zwitterionic polymers with therapeutic moieties
US8822610B2 (en) 2008-12-22 2014-09-02 ATRP Solutions, Inc. Control over controlled radical polymerization processes
WO2010075423A2 (en) 2008-12-23 2010-07-01 The Regents Of The University Of Michigan Dendrimer based modular platforms
CN102448984A (zh) 2009-03-27 2012-05-09 酶遗传学股份有限公司 使用包含抗体-受体组合的多特异性结合蛋白的组合物和方法
WO2010126552A1 (en) 2009-04-30 2010-11-04 Immunogen, Inc. Potent cell-binding agent drug conjugates
EP3028707A1 (en) 2009-05-01 2016-06-08 Ophthotech Corporation Methods for treating or preventing ophthalmological diseases
CN101575402B (zh) 2009-05-31 2012-06-27 中国科学院化学研究所 一种多臂星型聚合物及其制备方法
DK2260873T3 (da) 2009-06-08 2019-09-16 Biocompatibles Uk Ltd Pcylering af proteiner
TWI510248B (zh) 2009-06-17 2015-12-01 Abbvie Biotherapeutics Inc 抗-vegf抗體及其用途
WO2011005481A1 (en) 2009-06-22 2011-01-13 Medimmune, Llc ENGINEERED Fc REGIONS FOR SITE-SPECIFIC CONJUGATION
CN102025901A (zh) 2009-09-23 2011-04-20 国基电子(上海)有限公司 相机模组及其检测方法
US20110165648A1 (en) 2009-11-04 2011-07-07 Menno Van Lookeren Campagne Co-crystal structure of factor D and anti-factor D antibody
US20120282211A1 (en) 2009-11-24 2012-11-08 Carnegie Mellon University Antibodies and conjugates for modulators of angiogenesis
EP2509626B1 (en) 2009-12-11 2016-02-10 F.Hoffmann-La Roche Ag Anti-vegf-c antibodies and methods using same
WO2011075185A1 (en) 2009-12-18 2011-06-23 Oligasis Targeted drug phosphorylcholine polymer conjugates
WO2011101242A1 (en) 2010-02-16 2011-08-25 Novo Nordisk A/S Factor viii molecules with reduced vwf binding
EP2536754A1 (en) 2010-02-16 2012-12-26 Novo Nordisk A/S Factor viii fusion protein
KR20130097636A (ko) 2010-04-15 2013-09-03 올리가시스 고분자량 쌍성이온-함유 중합체
JP2012025820A (ja) 2010-07-21 2012-02-09 Kansai Paint Co Ltd 親水化処理剤組成物
WO2012099376A2 (ko) 2011-01-17 2012-07-26 주식회사 엘지화학 신규한 화합물 및 이를 포함하는 유기 발광 소자
US10654916B2 (en) 2011-04-21 2020-05-19 The Regents Of The University Of California, A California Corporation Compositions and methods for the treatment of neuromyelitis optica
WO2013040501A1 (en) 2011-09-16 2013-03-21 Pharmathene, Inc. Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof
WO2013059137A1 (en) 2011-10-17 2013-04-25 Oligasis High molecular weight zwitterion-containing polymers
JP2015502397A (ja) 2011-12-23 2015-01-22 ファイザー・インク 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用
JP6244350B2 (ja) 2012-04-03 2017-12-06 ノーベルメッド セラピューティクス インコーポレイテッド. ヒト化およびキメラ抗因子Bb抗体、ならびにその使用
JP5846044B2 (ja) 2012-05-23 2016-01-20 日油株式会社 (メタ)アクリル酸誘導体の製造方法
JP6234064B2 (ja) 2012-05-23 2017-11-22 キヤノン株式会社 重合体、前記重合体を用いた核磁気共鳴分析用または磁気共鳴イメージング用の造影剤、化合物、前記重合体を用いた核磁気共鳴分析方法および磁気共鳴イメージング方法
EP2906693A1 (en) 2012-10-15 2015-08-19 Novo Nordisk Health Care AG Coagulation factor vii polypeptides
LT2968461T (lt) 2013-03-13 2022-12-27 Genzyme Corporation Sulieti baltymai, apimantys pdgf ir vegf surišančius fragmentus, ir jų panaudojimo būdai
CN103193819A (zh) 2013-03-13 2013-07-10 苏州蔻美新材料有限公司 一锅法合成mpc的方法
JP6824735B2 (ja) 2013-06-06 2021-02-03 ピエール、ファーブル、メディカマン 抗C10orf54抗体およびその使用方法
CN103421039B (zh) 2013-09-03 2015-12-23 重庆工商大学 2-甲基丙烯酰氧基乙基磷酰胆碱的合成方法
WO2015035342A2 (en) 2013-09-08 2015-03-12 Oligasis Llc Factor viii zwitterionic polymer conjugates
WO2015200905A2 (en) 2014-06-28 2015-12-30 Oligasis, Llc Dual pdgf/vegf antagonists
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
JP6849590B2 (ja) 2014-10-17 2021-03-24 コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. ブチリルコリンエステラーゼ両性イオン性ポリマーコンジュゲート
BR112018013407A2 (en) 2015-12-30 2018-12-18 Kodiak Sciences Inc. antibodies and conjugates thereof
GB2551979A (en) 2016-06-30 2018-01-10 Rs Arastirma Egitim Danismanlik Llac Sanayi Ticaret Ltd Cleavable polymer drug conjugates
AU2018250695A1 (en) 2017-04-14 2019-11-07 Kodiak Sciences Inc. Complement factor D antagonist antibodies and conjugates thereof
SG11202008242XA (en) 2018-03-02 2020-09-29 Kodiak Sciences Inc Il-6 antibodies and fusion constructs and conjugates thereof
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10702608B2 (en) 2013-09-08 2020-07-07 Kodiak Sciences Inc. Factor VIII zwitterionic polymer conjugates
US11590235B2 (en) 2013-09-08 2023-02-28 Kodiak Sciences Inc. Factor VIII zwitterionic polymer conjugates
US12214044B2 (en) 2013-09-08 2025-02-04 Kodiak Sciences Inc. Factor VIII zwitterionic polymer conjugates
US11155610B2 (en) 2014-06-28 2021-10-26 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
US10363290B2 (en) 2014-10-17 2019-07-30 Kodiak Sciences Inc. Butyrylcholinesterase zwitterionic polymer conjugates
US11071771B2 (en) 2014-10-17 2021-07-27 Kodiak Sciences Inc. Butyrylcholinesterase zwitterionic polymer conjugates
US11066465B2 (en) 2015-12-30 2021-07-20 Kodiak Sciences Inc. Antibodies and conjugates thereof
US12071476B2 (en) 2018-03-02 2024-08-27 Kodiak Sciences Inc. IL-6 antibodies and fusion constructs and conjugates thereof
US11912784B2 (en) 2019-10-10 2024-02-27 Kodiak Sciences Inc. Methods of treating an eye disorder

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