ME01598B - Jedinjenja pirola - Google Patents
Jedinjenja pirolaInfo
- Publication number
- ME01598B ME01598B MEP-2013-90A MEP9013A ME01598B ME 01598 B ME01598 B ME 01598B ME P9013 A MEP9013 A ME P9013A ME 01598 B ME01598 B ME 01598B
- Authority
- ME
- Montenegro
- Prior art keywords
- ulcer
- compound
- stress
- gastritis
- salt
- Prior art date
Links
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical group OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 title 1
- 231100000397 ulcer Toxicity 0.000 claims description 21
- 208000025865 Ulcer Diseases 0.000 claims description 17
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 14
- 150000003839 salts Chemical group 0.000 claims description 14
- 230000035882 stress Effects 0.000 claims description 12
- 208000008469 Peptic Ulcer Diseases 0.000 claims description 11
- 208000011906 peptic ulcer disease Diseases 0.000 claims description 11
- 230000002496 gastric effect Effects 0.000 claims description 7
- 208000007882 Gastritis Diseases 0.000 claims description 6
- 206010017866 Gastritis haemorrhagic Diseases 0.000 claims description 6
- 206010020601 Hyperchlorhydria Diseases 0.000 claims description 6
- 206010046274 Upper gastrointestinal haemorrhage Diseases 0.000 claims description 6
- 230000037328 acute stress Effects 0.000 claims description 6
- 201000006549 dyspepsia Diseases 0.000 claims description 6
- 125000005843 halogen group Chemical group 0.000 claims description 6
- 230000005764 inhibitory process Effects 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 230000002980 postoperative effect Effects 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 208000023514 Barrett esophagus Diseases 0.000 claims description 5
- 208000023665 Barrett oesophagus Diseases 0.000 claims description 5
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 5
- 206010017758 gastric cancer Diseases 0.000 claims description 5
- 208000017215 gastric mucosa-associated lymphoid tissue lymphoma Diseases 0.000 claims description 5
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 5
- 208000000689 peptic esophagitis Diseases 0.000 claims description 5
- 201000011549 stomach cancer Diseases 0.000 claims description 5
- 208000007107 Stomach Ulcer Diseases 0.000 claims description 4
- 206010042220 Stress ulcer Diseases 0.000 claims description 4
- 208000000718 duodenal ulcer Diseases 0.000 claims description 4
- 201000005917 gastric ulcer Diseases 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 238000011321 prophylaxis Methods 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 230000009858 acid secretion Effects 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 claims 3
- 201000000052 gastrinoma Diseases 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- DPRWORPFTHSTIE-UHFFFAOYSA-N 1-[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(4-methoxypyridin-2-yl)sulfonylpyrrol-3-yl]-n-methylmethanamine Chemical compound FC=1C(CNC)=CN(S(=O)(=O)C=2N=CC=C(OC)C=2)C=1C1=CC=CN=C1F DPRWORPFTHSTIE-UHFFFAOYSA-N 0.000 claims 1
- JDCBSVKVFVIKHL-UHFFFAOYSA-N 1-[4-fluoro-5-(2-fluoropyridin-3-yl)-1-(4-methylpyridin-2-yl)sulfonylpyrrol-3-yl]-n-methylmethanamine Chemical compound FC=1C(CNC)=CN(S(=O)(=O)C=2N=CC=C(C)C=2)C=1C1=CC=CN=C1F JDCBSVKVFVIKHL-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 2
- 206010025323 Lymphomas Diseases 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010030216 Oesophagitis Diseases 0.000 description 1
- 241000282320 Panthera leo Species 0.000 description 1
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000006881 esophagitis Diseases 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008218851 | 2008-08-27 | ||
| JP2008269099 | 2008-10-17 | ||
| PCT/JP2009/065279 WO2010024451A1 (en) | 2008-08-27 | 2009-08-26 | Pyrrole compounds |
| EP09788053.8A EP2318390B1 (en) | 2008-08-27 | 2009-08-26 | Pyrrole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME01598B true ME01598B (me) | 2014-09-20 |
Family
ID=41508823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2013-90A ME01598B (me) | 2008-08-27 | 2009-08-26 | Jedinjenja pirola |
Country Status (38)
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ591793A (en) | 2008-08-27 | 2012-11-30 | Takeda Pharmaceutical | Substituted 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-((pyrindin-2-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine compounds |
| US20110229879A1 (en) * | 2010-03-19 | 2011-09-22 | University Of Rochester | Methods and compositions for nuclear staining |
| CN102452979B (zh) * | 2010-11-03 | 2015-04-01 | 天津药明康德新药开发有限公司 | 5-氟-3-吡啶磺酰氯的合成方法 |
| CN102863371B (zh) * | 2011-07-06 | 2016-04-13 | 中国科学院上海有机化学研究所 | 氟代二氢吡咯或氟代吡咯 |
| WO2013119800A1 (en) | 2012-02-07 | 2013-08-15 | Massachusetts Institute Of Technology | Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness |
| NZ703528A (en) | 2012-06-27 | 2016-08-26 | Takeda Pharmaceutical | Liquid preparations of amines and organic acids stabilized by salts |
| JP6343600B2 (ja) * | 2013-02-28 | 2018-06-13 | 武田薬品工業株式会社 | スルホニルクロライド化合物の製造法 |
| US9724396B2 (en) | 2013-03-15 | 2017-08-08 | Massachusetts Institute Of Technology | Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness |
| KR102084185B1 (ko) * | 2013-08-29 | 2020-03-04 | 주식회사 대웅제약 | 테트라히드로사이클로펜타피롤 유도체 및 이의 제조방법 |
| CN105367550A (zh) * | 2014-08-11 | 2016-03-02 | 江苏柯菲平医药股份有限公司 | 四氢环戊二烯并[c]吡咯类衍生物、其制备方法及其在医药上的应用 |
| UY36547A (es) | 2015-02-05 | 2016-06-01 | Bayer Cropscience Ag | Derivados heterocíclicos condensados bicíclicos sustituidos por 2-(het)arilo como pesticidas |
| US10317418B2 (en) | 2015-02-24 | 2019-06-11 | Massachusetts Institute Of Technology | Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness |
| JP6778680B2 (ja) | 2015-07-30 | 2020-11-04 | 武田薬品工業株式会社 | 錠剤 |
| AR105607A1 (es) | 2015-08-07 | 2017-10-18 | Bayer Cropscience Ag | Derivados heterocíclicos condensados sustituidos por 2-(het)arilo como pesticidas |
| CN106430006B (zh) * | 2016-08-18 | 2018-06-12 | 国网湖南省电力公司带电作业中心 | 配电线路移动式绝缘登高作业装置及方法 |
| CN108203430A (zh) * | 2016-12-16 | 2018-06-26 | 天地人和生物科技有限公司 | 一种新型可逆性质子泵抑制剂及其制备方法和用途 |
| MY200542A (en) | 2017-07-10 | 2024-01-02 | Takeda Pharmaceuticals Co | Preparation comprising vonoprazan |
| KR102126576B1 (ko) | 2018-09-19 | 2020-06-24 | 주식회사 대웅제약 | 4-메톡시 피롤 유도체의 제조 방법 |
| CN113527536B (zh) * | 2020-04-21 | 2024-03-22 | 杭州德柯医疗科技有限公司 | 一种含氟多糖高分子化合物及其制备方法 |
| PT4148050T (pt) * | 2020-06-17 | 2025-01-29 | Ildong Pharmaceutical Co Ltd | Novo inibidor da secreção ácida e sua utilização |
| EP4074317A1 (en) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorus derivatives as novel sos1 inhibitors |
| AU2022280595B2 (en) | 2021-05-26 | 2024-11-14 | Daewoong Pharmaceutical Co., Ltd. | Medicine container comprising liquid pharmaceutical composition of 1-(5-(2,4-difluorophenyl)-1-((3- fluorophenyl)sulfonyl)-4-methoxy-1h-pyrrol-3-yl)-n-methylmethanamine |
| CN113620930B (zh) * | 2021-07-12 | 2022-08-16 | 南京烁慧医药科技有限公司 | 一种含磺酰胺结构的化合物及其制备方法和应用、一种药物组合物及应用 |
| WO2023113458A1 (en) * | 2021-12-15 | 2023-06-22 | Ildong Pharmaceutical Co., Ltd. | Novel salt of 1-sulfonyl pyrrole derivative, preparation method thereof and pharmaceutical composition comprising thereof |
| WO2023113474A1 (ko) * | 2021-12-15 | 2023-06-22 | 일동제약(주) | 1-설포닐 피롤 유도체의 신규 염, 이의 제조 방법 및 이를 포함하는 약학 조성물 |
| KR20230102353A (ko) * | 2021-12-30 | 2023-07-07 | 주식회사 대웅제약 | 삼중음성유방암의 예방 또는 치료용 약학적 조성물 |
| KR20260020368A (ko) * | 2024-08-02 | 2026-02-11 | 일양약품주식회사 | 4-사이클로프로필 피롤 유도체 및 이의 용도 |
| WO2026135359A1 (ko) * | 2024-12-20 | 2026-06-25 | 주식회사 유엔에스바이오 | 4-메틸티오 피롤 유도체 |
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| JPH0930967A (ja) | 1995-07-17 | 1997-02-04 | Chugai Pharmaceut Co Ltd | 抗潰瘍剤 |
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| TW575561B (en) | 1999-03-25 | 2004-02-11 | Hoffmann La Roche | 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives |
| AU3783100A (en) | 1999-06-14 | 2000-12-21 | Dow Agrosciences Llc | Substituted triazoles, imidazoles and pyrazoles as herbicides |
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| JP5173192B2 (ja) * | 2004-09-30 | 2013-03-27 | 武田薬品工業株式会社 | プロトンポンプ阻害薬 |
| EP1655284A1 (en) | 2004-10-26 | 2006-05-10 | Aponetics AG | 2-Phenylsulfopyrroles |
| KR101115857B1 (ko) * | 2005-08-30 | 2012-04-12 | 다케다 야쿠힌 고교 가부시키가이샤 | 산 분비 억제제로서 1-헤테로시클릴술포닐, 2-아미노메틸,5-(헤테로-) 아릴 치환된 1-ｈ-피롤 유도체 |
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| US20090318429A1 (en) * | 2008-04-28 | 2009-12-24 | Institute For Oneworld Health | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives |
| JP5513492B2 (ja) | 2008-05-16 | 2014-06-04 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
| NZ591793A (en) | 2008-08-27 | 2012-11-30 | Takeda Pharmaceutical | Substituted 1-(4-fluoro-5-(2-fluoropyridin-3-yl)-1-((pyrindin-2-yl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine compounds |
-
2009
- 2009-08-26 NZ NZ591793A patent/NZ591793A/xx not_active IP Right Cessation
- 2009-08-26 CA CA2735162A patent/CA2735162C/en not_active Expired - Fee Related
- 2009-08-26 TW TW98128638A patent/TWI473798B/zh not_active IP Right Cessation
- 2009-08-26 HR HRP20130653AT patent/HRP20130653T1/hr unknown
- 2009-08-26 DK DK09788053.8T patent/DK2318390T3/da active
- 2009-08-26 PE PE2013002359A patent/PE20141174A1/es not_active Application Discontinuation
- 2009-08-26 AU AU2009284867A patent/AU2009284867B2/en not_active Ceased
- 2009-08-26 JO JO2009322A patent/JO2871B1/en active
- 2009-08-26 PT PT97880538T patent/PT2318390E/pt unknown
- 2009-08-26 EA EA201170384A patent/EA019741B1/ru not_active IP Right Cessation
- 2009-08-26 KR KR1020117006779A patent/KR101629181B1/ko active Active
- 2009-08-26 JP JP2011508745A patent/JP5638515B2/ja active Active
- 2009-08-26 ME MEP-2013-90A patent/ME01598B/me unknown
- 2009-08-26 MY MYPI20110861 patent/MY152008A/en unknown
- 2009-08-26 ES ES09788053T patent/ES2423289T3/es active Active
- 2009-08-26 RS RS20130319A patent/RS52872B/sr unknown
- 2009-08-26 MX MX2011001955A patent/MX2011001955A/es active IP Right Grant
- 2009-08-26 US US12/547,778 patent/US8969387B2/en active Active
- 2009-08-26 AR ARP090103278A patent/AR073136A1/es unknown
- 2009-08-26 WO PCT/JP2009/065279 patent/WO2010024451A1/en not_active Ceased
- 2009-08-26 GE GEAP200912153A patent/GEP20135786B/en unknown
- 2009-08-26 PL PL09788053T patent/PL2318390T3/pl unknown
- 2009-08-26 EP EP09788053.8A patent/EP2318390B1/en active Active
- 2009-08-26 UY UY0001032074A patent/UY32074A/es not_active Application Discontinuation
- 2009-08-26 US US13/061,078 patent/US8592597B2/en active Active
- 2009-08-26 SI SI200930654T patent/SI2318390T1/sl unknown
- 2009-08-26 UA UAA201103600A patent/UA105185C2/uk unknown
- 2009-08-26 PE PE2011000194A patent/PE20110300A1/es not_active Application Discontinuation
- 2009-08-26 CN CN200980142371.0A patent/CN102197033B/zh active Active
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2011
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- 2011-03-18 MA MA33715A patent/MA32647B1/fr unknown
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- 2011-03-25 CO CO11036583A patent/CO6321166A2/es active IP Right Grant
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2013
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